Psychédéliques,psychothérapie et symbolisation : une revue de littérature dans le champ de la dépression

AimThis article proposes a literature review focused on the so-called “classic” psychedelics (LSD, psilocybin, DMT, and mescaline) and, more specifically, on their use in the psychotherapy of major depressive disorders and the way they affect symbolization processes.MethodAfter some introductory remarks on psychedelics and depressive disorders, we describe some modern clinical trials, and then explore the peculiar phenomenology occurring in the psychedelic experience, as well as its therapeutic effects on depressive symptoms. The underlying mechanisms are discussed from a perspective at the crossroads of cognitive neurosciences and psychoanalysis. We conclude with some reflections on the crucial role of the setting.ResultsThe results already obtained suggest that a single dose, taken in a supportive environment, may be sufficient to produce significant and immediate therapeutic effects, which are still present six months after the dose, although less so for some patients. Clinical response depends on the subjective aspects of the individual experience. More specifically, it seems correlated with the ability to “let go” and to allow autobiographical memories to emerge, along with the intense emotions they carry. It also relies on the presence and intensity of mystical-type experiences, characterized by feelings of “ego dissolution,” unity with everything, transcendence of space and time, and ineffability.DiscussionPsychedelic-assisted therapy seems to promote the emergence of primary processes and the lifting of defense mechanisms. Psychedelics would thus catalyze the resumption of symbolization processes, favoring in particular the integration of unconscious conflicts as well as the remodeling of pathogenic object relationships. On the neurobiological level, these processes would be underpinned by a decrease in the activity of the default mode network – sometimes considered the primary biologic substrate of the Freudian ego –, associated with an increase in brain entropy and in neuroplasticity. These different elements entail a decrease in depressive symptomatology, particularly ruminations. Common factors identified as the cause of positive changes in classical psychotherapies appear naturally amplified in the psychedelic experience, which requires the containing function of a therapist and a supportive clinical setting to allow a resumption of symbolic processes. To ensure the perpetuation of the observed transformations, which often exceed the simple withdrawal of symptoms, an extended psychotherapeutic monitoring would be appropriate.ConclusionThe psychedelic substance acts as a catalyst, allowing an access to otherwise inaccessible unconscious materials, which can then be processed both spontaneously and within the therapeutic relationship. Considering the data discussed in this review, we emphasize the need for further research exploring the potential of this treatment, which also offers the hope of a renewed dialogue between psychiatry and psychology, neurosciences and psychoanalysis.     

Staging,réseaux de symptômes : les nouvelles approches cliniques de la schizophrénie

Debate on the clinic of psychiatric disorders has been, for several decades, largely occupied by nosographic considerations resulting from the work which led to the publication of the DSM in its third version in 1980. However, DSM is a nomenclature, not a psychiatry manual and researches focusing on the clinic of mental disorders are essential in the progress of knowledge. Recently, in the field of psychotic disorders, new clinical approaches were developed, having heuristic value and having an impact on clinical practices. The staging model and the network theory of schizophrenia will be successively evoked, which are two fertile areas of these new clinical perspectives. Recent works to validate the staging model in schizophrenia, in large retrospective and prospective cohorts, found out two clinical models, conceptually congruent, in which, stages of the illness can be discriminated using symptoms, functioning and episodes. Each model would need to be tested in other independent samples to evaluate their reliability and accuracy. One of the findings of these works is that patients can improve or deteriorate from one stage to another, but prediction of the evolution remains uncertain. The next goals of research are to combine clinical evaluation with biomarkers, and also to develop the use of innovative statistical tools and methodologies in the field, to operationalize the concept of precision staging. On the other hand, regarding the network theory of schizophrenia, recent works highlight the interest of identifying networks of highly interrelated symptoms to focus on target symptoms and to develop specific treatment strategies. Clinical approaches are the counterpart of the physiopathological and etiopathogenic researches on mental disorders, carried out in particular by research in the field of genetics and brain imaging. The staging model and the network theory have a heuristic virtue and contribute to a new approach not only to schizophrenia but to all psychiatric disorders. In the daily clinical practice, they allow a new approach to patients and their care. Their interest has led to the development of professional recommendations for the management of schizophrenia, based on the staging model and particularly useful for clinicians.     

Étudiants à risque de décrochage selon le profil de personnalité : Resilients,Overcontrollers et Undercontrollers

IntroductionPreventing students from dropping out of higher education, and particularly university, requires understanding the different factors that can lead to individuals failing to complete their studies. The role of personality in academic success or failure remains poorly understood. Block's personality profile model (Resilients, Overcontrollers, Undercontrollers) has been used to link personality traits to academic performance. The objective of this study is to apply this model to the risk factors of dropping out of higher education courses, including psychological vulnerability, level of autonomy, and the feeling of not being able to keep up. This involved validating Block's profiles in relation to the Big Five personality traits (Extraversion, Agreeableness, Conscientiousness, Neuroticism and Openness), and their links with the risk factors for dropping out.MethodsThis study is based on a quantitative survey of 196 students (mean age 21.32 years ± 3.11 years, with 63% females) taking higher education courses in France. Three measuring instruments were used: a French scale of Autonomy-situnomy, the French version of the Big Five Inventory (BFI-Fr) for personality traits, and the French version of the General Health Questionnaire (GHQ-28) for psychiatric morbidity. One item empirically evaluated the feeling of not being able to keep up. Data was processed using a k-average cluster analysis to establish the personality profiles, then by analysis of variance measures to evaluate the differences between them, and Bravais-Pearson correlation coefficient to identify links between risk factors and profiles.ResultsConscientiousness (Control) was the trait most strongly associated with high autonomy and a low feeling of not being able to keep up. There was also a positive influence of Extraversion and Agreeableness on autonomy. On the other hand, Neuroticism scores were related to greater psychiatric morbidity, a greater feeling of not keeping up, and lower autonomy. The results for personality profiles confirm the stability of Block's profiles (Resilients, Overcontrollers and Undercontrollers) and their relevance in higher education contexts. Resilients and Overcontrollers had greater autonomy and a lower feeling of not keeping up, but Resilients had the lowest psychiatric morbidity. Undercontrollers were associated with the greatest risk factors: lowest autonomy, the highest psychiatric morbidity and the strongest feeling of not keeping up. Gender comparisons indicated that women were more affected by psychiatric morbidity, but had higher Conscientiousness and autonomy.     

Ataxie familiale du lapin,différente de la maladie héréditaire de Sawin-Anders

Résumé Présentation anatomoclinique de quatre lapins (dont trois avec vérification anatomique) appartenant à la race Chinchilla-Tchécoslovaque, provenant de deux nichées issues de la même femelle, mais de deux pères différents, atteints d'une ataxie et de parésie spastique des pattes.L'affection diffère de l'ataxie héréditaire du lapin deSawin-Anders par son début périnatal et par sa survie prolongée.Anatomiquement il s'agit d'une atteinte généralisée de tous les neurones du système nerveux central et même des ganglions. La lésion se présente comme un oedème cellulaire suivi d'une fonte des structures intraneuronales. D'importantes réactions gliales (oligodendrocytaires et astrocytaires) accompagnent les changements des neurones.Tous les sujets malades étaient mâles. La femelle de la même nichée avait un système nerveux intact.L'image anatomique fait penser à des troubles du métabolisme de l'eau et des electrolytes probablement conditionnés génétiquement. La souche des lapins reste en observation.Zusammenfassung Klinisch-anatomische Beschreibung von vier Kaninchen (davon drei morphologisch untersuchte) der tschechoslovakischen Chinchilla0Rasse, die zwei Würfen desselben Weibchens, aber verschiedener Väter, entstammen und Ataxie sowie spastische Paresen der Extremitäten boten.Die Erkrankung unterscheidet sich von der hereditären Ataxie des Kaninchens (Sawin-Anders) durch ihren perinatalen Beginn und die verlängerte Überlebenszeit.Morphologisch handelt es sich um eine generalisierte Affektion sämtlicher Neurone des ZNS und der Ganglien. Die Veränderungen manifestieren sich als Zellödem, das von einem Verlust intraneuronaler Strukturen gefolgt ist. Erhebliche Gliareaktion (der Oligo- und Astroglia) begleiten die neuronalen Läsionen.Bei sämtlichen erkrankten Tieren handelte es sich um Männchen; die Weibchen desselben Wurfes boten ein intaktes Nervensystem.Das morphologische Bild läßt möglicherweise genetisch bedingte Störungen des Wasser- und Elektrolytstoffwechsels vermuten. Die betreffende Kaninchensippe bleibt in Beobachtung.     

Découvrir,connaître,transmettre : une passion de la Connaissance

Access to knowledge, the means to achieve it and the debates that surround it remain one of the questions that persist throughout time. The central theme of this article is the analysis of the elements involved in the passion for knowledge. The author proposes a conception of what can become a “passion for knowledge” from early mental states and stimulations and the dynamics of interactions. This passion is organized around three actions: to discover, to know, to transmit with as supports curiosity and learning. Access to knowledge, the means to achieve it and the debates that surround it remain one of the questions that persist throughout time. This is illustrated by historically recognized examples, the poetess and theologian Juana Inès de la Cruz (17th century), the pianist and essayist Glen Gould, the designer and theorist of color J. Itten. Two clinical cases followed by the author testify to the drifts of this passion. Knowledge covers several disciplinary areas and is directed at various directions by mobilizing different dimensions of cognition but always runs up against the question of certainty and acceptance of uncertainty.     

Troubles de l’humeur et chirurgie de l’épilepsie : une revue de la littérature

AimsHistorically, there is a strong link between depression and epilepsy. Patients with epilepsy are four to five times more likely to develop a depressive syndrome. It seems that the link between epilepsy and depression is bidirectional. There is little data on mood disorders secondary to epilepsy surgery. The goal of epilepsy surgery is to reduce the number and frequency of attacks, which in turn would allow improvements in mood disorders and cognitive impairment.MethodsA systematic search of the international literature was performed using the bibliographic search engines PubMed and Embase. The following MESH terms were used: epilepsy surgery AND (depression OR depressive disorder OR mood disorder). We also used the “related articles” of PubMed, bibliography surveys, conference abstracts and Google Scholar to identify additional relevant papers.ResultsOf the 130 studies found by the systematic search, 112 are excluded because they did not take into account the mood disorders secondary to epilepsy surgery. Fifteen studies are included in this review of the literature with a case study. Depression is the psychopathological condition that is the most frequently studied. According to several studies, the prevalence of depression is approximately 30% with nearly 70% of cases diagnosed during the first three months following epilepsy surgery. The majority of patients presented depressive symptoms during the first 3 to 12 months after epilepsy surgery. In these studies, the risk of developing depression is correlated with the existence of previous depressive elements relative to the epilepsy surgery. A small number of studies reported cases of de novo depression. Studies have shown a correlation between very good to excellent control of epileptic seizures and a persistent improvement of mood disorders. It would seem that depressive symptoms post-surgery are more common when the surgical intervention concerns the temporal lobe and in particular mesial resections. There are only very few cases of maniac episodes. Hamid et al. showed an increased risk of suicide waning after the epilepsy surgery over a period of 5 years.ConclusionMood disorders are common psychiatric comorbidities in epilepsy surgery. The detection, prevention, and treatment of these symptoms in patients eligible for epilepsy surgery pose major challenges for psychiatrists and neurologists, requiring their close collaboration.     

La SEP de l’enfant : est-elle différente de celle de l’adulte ?

IntroductionMultiple sclerosis (MS) is not uncommon in children. The aim of this study was to compare early onset MS (EOMS) with adult onset MS (AOMS).MethodsA retrospective study including MS cases between 1997 and 2010. EOMS was defined by age at MS onset < 18 years. Data were collected using the EDMUS database (European Database of Multiple Sclerosis) including: sex, age at onset, disease duration, EDSS, score after relapse. The MSSS and the Progression Index were calculated. Patients with disease duration less than one year were excluded. MS symptoms at onset and at further relapses were also noted. These parameters were compared between the EOMS and the AOMS groups.ResultsTwo hundred fifty-nine cases were included including 31 EOMS (11.96%). The mean follow-up was 96 months. The relapsing-remittent form was significantly more frequent in the pediatric group (94% vs 79%). Mean EDSS and MSSS scores and the percentage of fast progressors (MSSS > 5) were lower in the EOMS group. Analysis of neurological symptoms at the first MS attack and further neurological events showed a lower frequency of gait disturbances, motor symptoms and bladder symptoms in the EOMS group compared with the AOMS group. The 10-year mean EDSS score was 1.9 for EOMS and 4.1 for AOMS, after 25 years it was 4.5, and 7.27 respectively.ConclusionThis study highlights the relative frequency of EOMS in our MS population. However, different severity scores showed less disability progression in EOMS patients compared with AOMS patient; irreversible disability was reached at an early age.     

Prise en charge de la crampe de l’écrivain : 14 ans d’expérience de la toxine botulique

IntroductionWriter's cramp is a focal dystonia; treatment remains disappointing. We report our 14-year experience with a population of 119 patients aged between 18 and 85 years (average age 43 years).MethodsTreatment was based on botulinum toxin injections (Dysport^®) and physiotherapy. Patients were reviewed every four to six months with clinical and video evaluation by three different observers and subjective analysis of the treatment efficiency by the patient (score of 1 to 3). The post-injection deficit, if present, was also quantified.ResultsIn the group treated with toxin and physiotherapy, cramps improved (score 2 and 3) in 61.6% of patients; a majority of patients (n = 14) reported they were moderately satisfied (score 2). In the group treated with toxin alone, 37.9% of patients were improved (score 2 and 3) with a majority (n = 18) very satisfied reporting normal writing (score 3). Age was not a predictor of therapeutic response. Good results were obtained with injections of the flexor carpi radialis followed by flexor digitorum profundus II and III and the flexor pollicis longus. Seventy-one per cent of injections caused moderate muscle weakness, minimally disabling compared to the benefit of injections. Twenty-seven patients were followed for more than two years and three patients, who had achieved score 3 with excellent response, were followed for 14 years with very efficient repeated injections. If the injections were not effective the first time, we re-assessed the situation and adjusted the injections; we considered that toxin treatment was unsuccessful after three injections without benefit.ConclusionThe choice treatment for writer's cramp remains well-targeted injections of botulinum toxin. Physiotherapy is useful when the toxin injections are ineffective in completely improving writing. This requires close cooperation between the injector, the physiotherapist and the patient.     

Neuroimagerie de l’insight dans la schizophrénie : revue de la littérature

ObjectivesInsight in psychiatry has been defined and conceptualized in a number of ways but none of them was found to be self-explanatory. There has been an exponential rise in studies of insight, in part accelerated by the availability of several psychometric scales for measuring insight. Lack of insight has been associated in schizophrenia with low treatment adherence, a high number of relapses, increased number of hospital admissions, and subsequently poorer psychological and cognitive functioning. For this reason, there is considerable interest in understanding the underlying neural mechanisms of insight, which may have important implications for the development of future insight-oriented neuro-psychiatric treatment. Neuroimaging may be considered an important technique to help understand the anatomical, functional and metabolic neurocircuitry underlying poor insight in schizophrenia. Growing neuroimaging research provides evidence for underlying brain impairment in insight deficits in schizophrenia. In order to expose a panoramic view to the readers, this article reviews the neuroimaging studies conducted to date, which have investigated the neural bases of insight in schizophrenia.MethodsElectronic searches were performed in PubMed, PsycINFO, Sciencedirect and Web of Science databases, using the following keywords: Imaging; neuroimaging; Positron Emission Tomography (PET); spectroscopy; functional Magnetic Resonance Imaging (fMRI); structural Magnetic Resonance Imaging (MRI); Single Photon Emission Computed Tomography (SPECT); Voxel Based Morphometry (VBM); Diffusion Tensor Imaging (DTI); Computed Tomography (CT); Insight; schizophrenia; awareness of illness. Searches were also performed from the references of the systematic review articles on neurobiological correlates of insight in schizophrenia. Animal studies and single case reports were excluded. Twenty-five articles were selected for the present review. From these; 12 used structural MRI; 6 used VBM; 3 used fMRI; 2 used CT; 1 used DTI and 1 used VBM combined to DTI.ResultsThe search showed that studies in this area were published recently and that the neuroanatomic substrate of insight in schizophrenia has not yet been consolidated. This inconsistency could arise from the complex nature of insight and the use of a variety of insight assessments. Most of the studies analyzed in this review used structural neuroimaging techniques to assess brain abnormalities associated with poor insight. The functional neuroanatomy of insight has only recently been investigated and to our knowledge, there are only 3 studies that have examined brain activity with fMRI in relation to insight in schizophrenia.ConclusionThis review investigated the neural deficiencies underlying poor insight in schizophrenic patients. In spite of methodological differences among studies, results provide evidence of structural and functional brain abnormalities in frontal, parietal and temporal region related to insight deficits. Some studies have found a hemispheric asymmetry in relationship to poor in insight (the majority of brain abnormalities concern the right hemisphere). In addition, growing research indicated that the prefrontal cortex, particularly the dorsolateral prefrontal cortex, the anterior cingulated cortex, the insula, the precuneus and the cerebellum can also underlying insight in schizophrenia. It is interesting to mention that some authors have suggested that each dimension of insight can be specifically linked to certain brain structures. Taking together, data on the neuropsychological and neuroanatomical correlates of clinical insight suggested that lack of insight in schizophrenia could be conceived as a neurocognitive deficit, analogously to anosognosia in brain injury and dementia. On the contrary, to date, the neuroanatomical correlates of cognitive insight have been scarcely studied. Only two studies reported that Self-reflectiveness was positively related to gray matter volume of the right ventro-lateral prefrontal cortex, the BCIS composite index was positively correlated with total left hippocampal volume, and Self-certainty was inversely correlated with bilateral hippocampal volumes. However, it is important to note that neuroimaging research on cognitive insight in schizophrenia is in a preliminary, and the results on this are inconclusive. Further research is needed to better understand the causal relationships between brain abnormalities and degradation of insight in schizophrenia.