Evaluation of Pre－and Post－Delivery Changes of Cardiac Function and Hemodynamics by Doppler Echocardiography in Pregnant Wome

ＥｖａｌｕａｔｉｏｎｏｆＰｒｅ－ａｎｄＰｏｓｔ－ＤｅｌｉｖｅｒｙＣｈａｎｇｅｓｏｆＣａｒｄｉａｃＦｕｎｃｔｉｏｎａｎｄＨｅｍｏｄｙｎａｍｉｃｓｂｙＤｏｐｐｌｅｒＥｃｈｏｃａｒｄｉｏｇｒａｐｈｙｉｎＰｒｅｇｎａｎｔＷｏｍｅｎＬｉＣｈｕｎｓｈｅｎｇ（李春...     

Effect of Domestically－made Levonorgestrel－releasing Intrauterine Device on the Endocrine System and Mensentruation in Monkey

ＥｆｆｅｃｔｏｆＤｏｍｅｓｔｉｃａｌｌｙ－ｍａｄｅＬｅｖｏｎｏｒｇｅｓｔｒｅｌ－ｒｅｌｅａｓｉｎｇＩｎｔｒａｕｔｅｒｉｎｅ　ＤｅｖｉｃｅｏｎｔｈｅＥｎｄｏｃｒｉｎｅＳｙｓｔｅｍａｎｄＭｅｎｓｅｎｔｒｕａｔｉｏｎｉｎＭｏｎｋｅｙｓＷＵＣｈａｎｇｊｉｅ（...     

Enzymatic Histochemistry of Retina with Experimental Intraocular Pressure Elevation in Rabbits

ＥｎｚｙｍａｔｉｃＨｉｓｔｏｃｈｅｍｉｓｔｒｙｏｆＲｅｔｉｎａｗｉｔｈＥｘｐｅｒｉｍｅｎｔａｌＩｎｔｒａｏｃｕｌａｒＰｒｅｓｓｕｒｅＥｌｅｖａｔｉｏｎｉｎＲａｂｂｉｔｓＹＡＮＧＺｈｉ－ｋｕａｎ（杨智宽）；ＤＵＳｕ－ｈｕａ（杜蜀华）（Ｄｅｐａｒｔｍｅｎ...     

体外循环期间瓣膜替换手术患者白细胞β2粘合素及血浆sICAM-1、sE-selectin的表达

为了解体外循环期间瓣膜替换手术患者白细胞、内皮细胞表面粘附分子的表达及这些粘附分子表达水平之间的关系,测定了１２例患者体外循环前后外周血白细胞β２粘合素（β２－ｉｎｔｅｇｒｉｎｓ）、血浆可溶性细胞间粘附分子－１（ｓｏｌｕｂｅｉｎｔｅｒｃｅｌｕｌａｒａｄｈｅｓｉｏｎｍｏｌｅｃｕｌｅ－１,ｓＩＣＡＭ－１）,和可溶性Ｅ－选择素（ｓｏｌｕｂｌｅＥ－ｓｅｌｅｃｔｉｎ,ｓＥ－ｓｅｌｅｃｔｉｎ）。结果：体外循环后β２－ｉｎｔｅｇｒｉｎｓ（ＣＤ１１ａ、ＣＤ１８、ＣＤ１１ａ／ＣＤ１８,ＣＤ１１ｂ,ＣＤ１１ｂ／ＣＤ１８）,ｓＩＣＡＭ－１和ｓＥ－ｓｅｌｅｃｔｉｎ表达上调（Ｐ＜０．０５）;β２－ｉｎｔｅｇｒｉｎｓ和ｓＩＣＡＭ－１、ｓＥ－ｓｅｌｅｃｔｉｎ表达水平之间存在明显的相关关系（Ｐ＜０．００５）。结果显示：①体外循环伴随着明显的白细胞－内皮细胞粘附反应;②体外循环期间有关的粘附分子以受体－配体形式表达;③血浆可溶性内皮细胞粘附分子ｓＩＣＡＭ－１、ｓＥ－ｓｅｌｅｃｔｉｎ可间接估计内皮细胞表面ＩＣＡＭ－１、Ｅ－ｓｅｌｅｃｔｉｎ表达情况     

Changes of Ca2＋－AT Pase Activity of Cellular Membrane in Experimenlal Atherosclerotic Rabbits and Effects o

ＣｈａｎｇｅｓｏｆＣａ２＋－ＡＴＰａｓｅＡｃｔｉｖｉｔｙｏｆＣｅｌｌｕｌａｒＭｅｍｂｒａｎｅｉｎＥｘｐｅｒｉｍｅｎｌａｌＡｔｈｅｒｏｓｃｌｅｒｏｔｉｃＲａｂｂｉｔｓａｎｄＥｆｆｅｃｔｓｏｆＤｒｕｇｓｏｎＣａ２＋－ＡＴＰａｓｅＡｃｔｉｖｉｔｙＷａｎｇＤ...     

A Study on Extension－Flexion Dynamic Lumbar Spine Radiographsin Patients with Lumbar Intervertebral Disc Herniation

ＡＳｔｕｄｙｏｎＥｘｔｅｎｓｉｏｎ－ＦｌｅｘｉｏｎＤｙｎａｍｉｃＬｕｍｂａｒＳｐｉｎｅＲａｄｉｏｇｒａｐｈｓｉｎＰａｔｉｅｎｔｓｗｉｔｈＬｕｍｂａｒＩｎｔｅｒｖｅｒｔｅｂｒａｌＤｉｓｃＨｅｒｎｉａｔｉｏｎＡＳｔｕｄｙｏｎＥｘｔｅｎｓｉｏｎ－Ｆｌｅｘｉ...     

Review of “English-Chinese Chinese-English Dictionary of Chinese Medicine”

Ｒｅｖｉｅｗｏｆ＂ＥＮＧＬＩＳＨ－ＣＨＩＮＥＳＥＣＨＩＮＥＳＥ－ＥＮＧＬＩＳＨＤＩＣＴＩＯＮＡＲＹｏｆＣＨＩＮＥＳＥＭＥＤＩＣＩＮＥ＂ＥｄｉｔｅｄｂｙＮｉｇｅｌＷｉｓｅｍａｎ，ＨｕｎａｎＳｃｉｅｎｃｅａｎｄＴｅｃｈｎｏｌｏｇｙＰｒｅｓｓ，Ｃｈａｎｇｓ...     

Effects of Plasma Cortisol and Its Receplor on Patients with Deficiency－Cold and Deficiency－Heat Syndromes

ＥｆｆｅｃｔｓｏｆＰｌａｓｍａＣｏｒｔｉｓｏｌａｎｄＩｔｓＲｅｃｅｐｌｏｒｏｎＰａｔｉｅｎｔｓｗｉｔｈＤｅｆｉｃｉｅｎｃｙ－ＣｏｌｄａｎｄＤｅｆｉｃｉｅｎｃｙ－ＨｅａｔＳｙｎｄｒｏｍｅｓＸｉｅＺｈｕ－ｆａｎ；（谢竹藩）；ａｎｄＺｈａｎｇＧｕａｎｇ－ｙ...     

Protective Effect of Anisodsmine on Brain Edema Induced by Pertussis Bacilli in Rabbits

ＰｒｏｔｅｃｔｉｖｅＥｆｆｅｃｔｏｆＡｎｉｓｏｄｓｍｉｎｅｏｎＢｒａｉｎＥｄｅｍａＩｎｄｕｃｅｄｂｙＰｅｒｔｕｓｓｉｓＢａｃｉｌｌｉｉｎＲａｂｂｉｔｓ￥ＹＵＥＳｈａｏ－ｊｉｅ；ＹＵＰｅｉ－ｌａｎ；ＹＡＮＧＹｕ－ｊｉａ（ＤｅｐａｒｔｍｅｎｔｏｆＰｅｄｉ...     

The Influence of Thymectomy on Germ-cells of the Testis in Mice

ＴｈｅＩｎｆｌｕｅｎｃｅｏｆＴｈｙｍｅｃｔｏｍｙｏｎＧｅｒｍ－ｃｅｌｌｓｏｆｔｈｅＴｅｓｔｉｓｉｎＭｉｃｅＺＥＮＧＪｉｎ（曾进），ＺＨＡＮＧＹｏｎｇ－ｓｈａｎｇ（章咏裳）；Ｓ．ＰＯＭＥＲ，Ｇ．ＳＴＡＥＨＬＥＲＲＥＮ；Ｄａ－ｈｏｎｇ（任大洪）（Ｄｅｐａ...     

Therapeutic effect of berberine on 60 patients with non-insulin dependent diabetes mellitus and experimental research

The effects of berberine on 60 cases with non-insulin dependent diabetes mellitus and experimental research results were observed in this study. The results suggest berberine has significant effects on non-insulin dependent diabetes mellitus patients and experimental diabetes in animals in the reduction of blood glucose levels. The clinical symptoms basically disappeared and the level of serum insulin rose. The total effective rate was up to 90 percent and there were no significant side-effects. It was found that berberine has an effect on the recovery of pancreas islet β-cells, through pathological examination on the animal subjects.     

ORIGINAL ARTlCLES Silybin Decreases Erythrocytic Sorbitol Leveland Improves Peripheral Nerve Conduction Velocity in Patients with No

ＯＲＩＧＩＮＡＬＡＲＴｌＣＬＥＳＳｉｌｙｂｉｎＤｅｃｒｅａｓｅｓＥｒｙｔｈｒｏｃｙｔｉｃＳｏｒｂｉｔｏｌＬｅｖｅｌａｎｄＩｍｐｒｏｖｅｓＰｅｒｉｐｈｅｒａｌＮｅｒｖｅＣｏｎｄｕｃｔｉｏｎＶｅｌｏｃｉｔｙｉｎＰａｔｉｅｎｔｓｗｉｔｈＮｏｎ－ｌｎｓｕｌｉ...     

Influence of berberine on protein tyrosine kinase of erythrocyte insulin receptors from type 2 diabetes mellitus

Objective： Bererine has been used to treat type 2 diabetes mellitus in Chinese traditional medicine because of its hypoglycemic effect. In this report, we compared the intrinsic tyrosine kinase activities of erythrocyte insulin receptors from type 2 diabetes mellitus with or without stimulation by berberine in vitro. Methods- Preparations containing insulin receptors were obtained from soluble human erythrocytes, and the insulin receptors were partially purified by affinity chromatography. The tyrosine kinase activity was measured by the exogenous substrate phosphorylation. Results： Both the membrane tyrosine kinase activity and the purified receptor tyrosine kinase activity from diabetics decreased significantly compared with those of normal individuals （reduced by 67.4% and 47.2%, respectively）. After incubation with berbefine, there is a statistical difference in the activity of membrane tyrosine kinase for diabetic patients （ a 150% increase）. Berefine had no effect on the tyrosine kinase activity of purified insulin receptors. Conclusion： We concluded from these results that berbefine was able to improve the insulin sensitivity by increasing the protein tyrosine kinase activity of membrane-bound insulin receptors from type 2 diabetes mellitus.     

小檗碱对实验性2型糖尿病大鼠心脏、肾脏的保护作用

目的：观察小檗碱对实验性2型糖尿病大鼠心肌组织、肾脏组织SOD活性的影响。方法：采用小剂量链脲佐菌素加高糖高脂饲料喂养的方法建立Wistar大鼠2型糖尿病模型,成模后给予小檗碱0.1g/kg·d灌胃治疗8周,检测血脂、心肌组织和肾脏组织中超氧化物歧化酶（SOD）活性。结果：与糖尿病组相比,小檗碱治疗组甘油三酯、胆固醇、低密度脂蛋白明显下降（P〈0.05）,均具有统计学意义,高密度脂蛋白有所升高,但差异无显著性。心肌组织、肾脏组织中SOD活性明显升高,并可改善2型糖尿病大鼠心肌、肾脏病变。结论：小檗碱可以明显改善2型糖尿病大鼠的心肌、肾脏损害,延缓其病变的发生和发展,可能与其降低甘油三酯、胆固醇、低密度脂蛋白,提高高密度脂蛋白,清除自由基等机制有关。     

Clinical study on Jiang Tang San in treating non-insulin dependent diabetes mellitus patients) in treating non-insulin dependent diabetes mellitus patients

The therapeutic effect of Jiang Tang San (JTS) on 30 cases with non-insulin dependent diabetes mellitus (NIDDM), was observed, whose fasting blood glucose ranged from 11. 1 mmol/L to 13. 8 mmol/L. The results suggested that JTS has significant effect on NIDDM patients in lowering blood glucose, blood lipid and blood pressure levels. Clinical symptoms and blood glucose improved rapidly. JTS promoted the elevation of serum insulin level 1 hour after meal. The total effective rate of lowering blood glucose reached 86.7%. The results showed JTS is better than berberine on lowering blood glucose (P<0.01) and when patients failed to respond to other hypoglycemics or on recurrence JTS was still effective. There were no marked side-effects during the course of treatment.     

糖尿病患者视觉诱发电位分析

目的 :探讨非胰岛素依赖型糖尿病 (又称Ⅱ型糖尿病 )患者视觉诱发电位 (PVEP)的改变及临床应用价值。方法 :对 30例 (6 0只眼 )Ⅱ型糖尿病患者和 30例 (6 0只眼 )正常对照组进行PVEP检测。结果 :糖尿病组PVEP的异常阳性率为 5 8 33% ,表现为P10 0潜伏期明显延长 ,波形分化差 ,波幅低。结论 :PVEP的异常可作为糖尿病患者视功能早期观察指标之一 ,PVEP的异常与空腹血糖、糖尿病的病程长短、周围神经病变及糖尿病视网膜病变有关     

湖北部分地区Ⅱ型糖尿病患病情况及其相关因素

对湖北省部分地区２５～７０岁的９４５０名居民进行了Ⅱ型糖尿病－非胰岛素依赖型糖尿病（ＮＩＤＤＭ）及糖耐量低减（ＩＧＴ）患病情况的流行病学调查。结果表明：２５～７０岁ＮＩＤＤＭ患病率为２．６２％,ＩＧＴ患病率为４．４８％,男女性别的ＮＩＤＤＭ与ＩＧＴ患病率差异无统计学意义（Ｐ＞０．０５）,城乡ＮＩＤＤＭ患病率差异无统计学意义,但ＩＧＴ患病率差异有极显著意义（Ｐ＜０．０１）,ＮＩＤＤＭ和ＩＧＴ的患病率均随着年龄增高而升高,ＮＩＤＤＭ和ＩＧＴ患病率还与糖尿病家族史、高血压病史和高体重指数有关。     

ESTABLISHMENT AND PRELIMINARY CLINICAL APPLICA- TION OF RADIORECEPTOR ASSAY FOR THE DETERMINATION OF INSULIN IN HUMAN SERA

A simple radioreceptor assay (RRA) of insulin has been established by using insulin receptor on human placental membrane (HPM). In this system, 60-7070 0f bound 12sl.insulin can be displaced when native insulin (338 mU/ml) is added. This method is suitable for clinical application as shown by its sensitivity, accuracy and precision. Serum insulin concentration of normal adults, patients with diabe- tes mellitus and other diseases determined both by RRA and radioimmunoassay (RIA) tend to be coin cident. Experiments showed that RRA as well as RIA, may distinguish nondiabetic and diabetic subjects and patients with insulin dependent diabetes meUitus (IDDM) and noninsulin dependent diabetes mellitus (NIDDM). Fasting sera obtained from 40 iiormal adults were determined by RRA and RIA simultaneously. The concentrations of insulin were 11251:42 ILU/ml and 11.19+3.9 LiU/ml respectively. The insulin release curves of 9 IDDM patients mea- sured by RRA and RIA were consistent. However, the values of insulin release of 7 normal adults and 8 NIDDM patients determined by RRA were slightly lower than those determined by RIA. Before and after oral administration of nipedipine in 4 cases of coronary heart diseases, insulin release curves, determined by RIA did not change significantly, but from those obtained by RRA, one could observe that the release curves of insulin were much lower or the peak value was delayed. These results are consistent with those of oral glucose tolerance test (OGTT) and suggest that RRA may be more specific than RIA.     

糖尿康对非胰岛素依赖型糖尿病的治疗作用

用糖尿病胰囊合并二甲双胍对非胰岛素依赖型糖尿病（ＮＩＤＤＭ）进行治疗观察，结果表明，治疗组血糖下降程度显著大于对照组，治疗有效率明显高于对照组；ＴＣ、ＴＧ下降，ＨＤＬ－Ｃ升高；主要临床症状缓解；没有明显不良反应。     

小檗碱对实验性2型糖尿病大鼠心脏、肾脏MDA含量水平的影响

目的：观察小檗碱对实验性2型糖尿病大鼠心肌组织、肾脏组织中丙二醛（MDA）含量水平的影响。方法：采用小剂量链脲佐茵素加高糖高脂饲料喂养的方法建立Wistar大鼠2型糖尿病模型,成模后给予小檗碱0.1g/kg.d灌胃治疗8周,检测血脂、心肌组织和肾脏组织中丙二醛（MDA）含量,各观察值均与糖尿病组存在显著性差异（P〈0.05）。结果：与糖尿病组相比,小檗碱治疗组甘油三酯、胆固醇、低密度脂蛋白明显下降（P〈0.05）,均具有统计学意义,高密度脂蛋白有所升高,但差异无显著性。小檗碱治疗组MDA含量均下降,并可改善2型糖尿病大鼠心肌病变。结论：小檗碱可以明显改善2型糖尿病大鼠的心肌、肾脏损害,延缓其病变的发生和发展,可能与其降低甘油三酯、胆固醇、低密度脂蛋白,提高高密度脂蛋白,清除自由基等机制有关。