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1.
Aine Sakurada Taro Takahara Thomas C. Kwee Tomohiro Yamashita Seiji Nasu Tomohiko Horie Marc Van Cauteren Yutaka Imai 《European radiology》2009,19(6):1461-1469
The purpose of this study was to assess the value of diffusion-weighted magnetic resonance imaging (DWI) in detecting esophageal
cancer and assessing lymph-node status, compared with histopathological results. DWI was prospectively performed in 24 consecutive
patients with esophageal cancer, using the diffusion-weighted whole-body imaging with background body signal suppression (DWIBS)
sequence. DWIBS images were fused with T2-weighted images, and independently and blindly evaluated by three board-certified
radiologists, regarding primary tumor detectability and lymph-node status. Apparent diffusion coefficients (ADCs) of the primary
tumor and lymph nodes were also measured. Average primary tumor detection rate was 49.4%, average patient-based sensitivity
and specificity for the detection of lymph-node metastasis were 77.8 and 55.6%, and average lymph-node group-based sensitivity
and specificity were 39.4 and 92.6%. There were no interobserver differences among the three readers (P < 0.0001). Mean ADC of detected primary tumors was 1.26 ± 0.29×10−3 mm2/s. Mean ADC of metastatic lymph nodes (1.46 ± 0.35×10−3 mm2/s) was significantly higher (P < 0.0001) than that of nonmetastatic lymph nodes (1.15 ± 0.24 mm2/s), but ADCs of both groups overlapped. In conclusion, this study suggests that DWI only has a limited role in detecting
esophageal cancer and nodal staging. 相似文献
2.
Raya JG Dietrich O Birkenmaier C Sommer J Reiser MF Baur-Melnyk A 《European radiology》2007,17(11):2872-2879
The feasibility of a diffusion-weighted single-shot fast-spin-echo sequence for the diagnostic work-up of bone marrow diseases
was assessed. Twenty healthy controls and 16 patients with various bone marrow pathologies of the spine (bone marrow edema,
tumor and inflammation) were examined with a diffusion-weighted single-shot sequence based on a modified rapid acquisition
with relaxation enhancement (mRARE) technique; four diffusion weightings (b-values: 50, 250, 500 and 750 s/mm2) in three orthogonal orientations were applied. Apparent diffusion coefficients (ADCs) were determined in the bone marrow
and in the intervertebral discs of healthy volunteers and in diseased bone marrow. Ten of the 20 volunteers were repeatedly
scanned within 30 min to examine short-time reproducibility. Spatial reproducibility was assessed by measuring ADCs in two
different slices including the same lesion in 12 patients. The ADCs of the lesions exhibited significantly higher values,
(1.27 ± 0.32)×10−3 mm2/s, compared with healthy bone marrow, (0.21 ± 0.10)×10−3 mm2/s. Short-time and spatial reproducibility had a mean coefficient of variation of 2.1% and 6.4%, respectively. The diffusion-weighted
mRARE sequence provides a reliable tool for determining quantitative ADCs in vertebral bone marrow with adequate image quality. 相似文献
3.
Abdel Razek AA Gaballa G Elhawarey G Megahed AS Hafez M Nada N 《European radiology》2009,19(1):201-208
We aimed to assess the clinical usefulness of the ADCs calculated from diffusion-weighted echo-planar MR images in the characterization
of pediatric head and neck masses. This study included 78 pediatric patients (46 boys and 32 girls aged 3 months–15 years,
mean 6 years) with head and neck mass. Routine MR imaging and diffusion-weighted MR imaging were done on a 1.5-T MR unit using
a single-shot echo-planar imaging (EPI) with a b factor of 0.500 and 1,000 s mm−2. The ADC value was calculated. The mean ADC values of the malignant tumours, benign solid masses and cystic lesions were
(0.93 ± 0.18) × 10−3, (1.57 ± 0.26) × 10–3 and (2.01 ± 0.21 )× 10–3 mm2 s−1, respectively. The difference in ADC value between the malignant tumours and benign lesions was statistically significant
(p < 0.001). When an apparent diffusion coefficient value of 1.25 × 10–3 mm2 s−1 was used as a threshold value for differentiating malignant from benign head and neck mass, the best results were obtained
with an accuracy of 92.8%, sensitivity of 94.4%, specificity of 91.2%, positive predictive value of 91% and negative predictive
value of 94.2%. Diffusion-weighted MR imaging is a new promising imaging approach that can be used for characterization of
pediatric head and neck mass. 相似文献
4.
The aim of this study was to retrospectively measure and compare pancreatic apparent diffusion coefficient (ADC) in patients
with acute pancreatitis (AP) with aged matched controls who underwent diffusion weighted imaging (DWI). The institutional
review board approved this retrospective Health Insurance Portability and Accountability Act compliant study with a waiver
for informed consent. Pancreatic ADC values from 27 patients with a clinical diagnosis of AP and 38 normal age-matched controls
evaluated with DWI (b = 0 and 800 mm2/s) were retrospectively and independently measured by two radiologists. The ADCs were compared between the groups and between
each of the pancreatic segments in the normal group. Inter-observer reliability was calculated and receiver operating characteristic
analysis was used to determine the sensitivity and specificity of DW imaging in the diagnosis of acute pancreatitis. P < 0.05 was considered statistically significant. The ICC for inter-observer reliability was 0.98 in the control and 0.97
in the AP group. The mean pancreatic ADC in the AP group (1.32 × 10−3 mm2/s ± 0.13) was significantly lower than in the normal group (1.77 × 10−3 mm2/s ± 0.32). There was no significant difference in mean ADCs between each of the pancreatic segments in the controls. A threshold
ADC value of 1.62 × 10–3 mm2/s yielded a sensitivity of 93% and specificity of 87% for detecting acute pancreatitis for b values of 0 and 800 s/mm2. Pancreatic ADCs are significantly lower in patients with AP than normal controls. 相似文献
5.
Bruegel M Holzapfel K Gaa J Woertler K Waldt S Kiefer B Stemmer A Ganter C Rummeny EJ 《European radiology》2008,18(3):477-485
The aim of this study was to determine apparent diffusion coefficients (ADCs) of focal liver lesions on the basis of a respiratory
triggered diffusion-weighted single-shot echo-planar MR imaging sequence (DW-SS-EPI) and to evaluate whether ADC measurements
can be used to characterize lesions. One hundred and two patients with focal liver lesions [11 hepatocellular carcinomas (HCC),
82 metastases, 4 focal nodular hyperplasias (FNH), 56 hemangiomas and 51 cysts; mean size, 16.6 mm; range 5–92 mm] were examined
on a 1.5-T system using respiratory triggered DW-SS-EPI (b-values: 50, 300, 600 s/mm2). Results were correlated with histopathologic data and follow-up imaging. The ADCs of different lesion types were compared,
and lesion discrimination using optimal thresholds for ADCs was evaluated. Mean ADCs (×10−3mm2/s) were 1.24 and 1.04 for normal and cirrhotic liver parenchyma and 1.05, 1.22, 1.40, 1.92 and 3.02 for HCCs, metastases,
FNHs, hemangiomas and cysts, respectively. Mean ADCs differed significantly for all lesion types except for comparison of
metastases with HCCs and FNHs. Overall, 88% of lesions were correctly classified as benign or malignant using a threshold
value of 1.63 × 10−3mm2/s. Measurements of the ADCs of focal liver lesions on the basis of a respiratory triggered DW-SS-EPI sequence may constitute
a useful supplementary method for lesion characterization. 相似文献
6.
The purpose was to investigate the potential value of apparent diffusion coefficient (ADC) measurement with MRI in the assessment
of cervix cancer. Diffusion-weighted MRI was performed in 47 patients with cervical carcinoma undergoing chemoradiation therapy
and 26 normal controls on a 1.5-T system with a b-value of 600 s/mm2. FIGO stage, tumor volume, nodal status, interstitial fluid pressure (IFP) and oxygen measurements were recorded. Response
was defined as no visible tumor 3–6 months following completion of therapy. The average median ADC (mADC) of cervical carcinomas
(1.09±0.20×10−3 mm2/s) was significantly lower than normal cervix (2.09±0.46×10−3 mm2/s) (P<0.001). There was no correlation between mADC, nodal status, tumor volume, IFP or oxygen measurements. mADC was significantly
lower in FIGO stages T1b/T2a (0.986 × 10−3 mm2/s) compared to T2b (1.21×10−3 mm2/s) and T3/T4 (1.10×10−3 mm2/s) (P<0.001). In patients with squamous carcinomas the 90th percentile of ADC values was lower in responders than non-responders
(P<0.05). Median ADC in cervix carcinoma is significantly lower compared to normal cervix. ADC may have predictive value in
squamous tumors, but further long-term study will determine the ultimate clinical utility. 相似文献
7.
Reiji Sugita Tetsuro Yamazaki Akemi Furuta Kei Itoh Naotaka Fujita Shoki Takahashi 《European radiology》2009,19(7):1794-1798
The aim of this preliminary study was to retrospectively evaluate the usefulness of high b-value diffusion-weighted MR imaging
(DWI) in the detection of gallbladder carcinoma. Fifteen patients with gallbladder carcinoma and 14 other patients were included
in this study. All patients and subjects underwent DWI, and images were evaluated by two radiologists. The area under the
receiver operating characteristic curve (AUC), apparent diffusion coefficient (ADC) measurement, sensitivity and specificity
were calculated. An AUC yielded 0.980 (95% CI, 0.850–0.999) and 0.941 (95% CI, 0.791–0.990) for the two radiologists. The
mean sensitivity and specificity were 83.3% and 100%, respectively. The mean ADC value of gallbladder carcinoma was (1.28 ± 0.41)×10−3 mm2/s and that of control gallbladder lesions was (1.92 ± 0.21)×10−3 mm2/s (P < 0.01). According to the results of our preliminary study, high b-value DWI might be a useful tool for detecting gallbladder
carcinoma by measuring the ADC value and direct visual assessment. 相似文献
8.
Eugene K. Choi Jeong Kon Kim Hyuck Jae Choi Seong Ho Park Bum-Woo Park Namkug Kim Jae Seung Kim Ki Chun Im Gyunggoo Cho Kyoung-Sik Cho 《European radiology》2009,19(8):2024-2032
The purpose of the study was to perform a node-by-node comparison of an ADC-based diagnosis and various size-based criteria
on T2-weighted imaging (T2WI) with regard to their correlation with PET/CT findings in patients with uterine cervical cancer.
In 163 patients with 339 pelvic lymph nodes (LNs) with short-axis diameter >5 mm, the minimum apparent diffusion coefficient
(ADC), mean ADC, short- and long-axis diameters, and ratio of long- to short-axis diameters (L/S ratio) were compared in PET/CT-positive
and -negative LNs. On PET/CT, 118 (35%) LNs in 58 patients were positive. The mean value of minimum and mean ADCs, short-
and long-axis diameters, and L/S ratio were different in PET/CT-positive (0.6436 × 10−3 mm2/s, 0.756 × 10−3 mm2/s, 10.3 mm, 13.2 mm, 1.32, respectively) and PET/CT-negative LNs (0.8893 × 10−3 mm2/s, 1.019 × 10−3 mm2/s, 7.4 mm, 11.0 mm, 1.49, respectively) (P < 0.05). The Az value of the minimum ADC (0.864) was greater than those of mean ADC (0.836), short-axis diameter (0.764), long-axis diameter
(0.640) and L/S ratio (0.652) (P < 0.05). The sensitivity and accuracy of the minimum ADC (86%, 82%) were greater than those of the short-axis diameter (55%,
74%), long-axis diameter (73%, 58%) and L/S ratio (52%, 66%) (P < 0.05). ADC showed superior correlation with PET/CT compared with conventional size-based criteria on T2WI. 相似文献
9.
Introduction Distinguishing between vasogenic edema and reactive astrogliosis may be difficult in some instances. This study was performed
to test the hypothesis that diffusion-weighted (DW) imaging with apparent diffusion coefficient (ADC) maps can be used to
differentiate these two types of changes.
Methods The study population included 11 patients with perilesional vasogenic edema and 11 patients with gliosis examined with conventional
MR imaging and DW imaging. The signal intensities of conventional pulse sequences and ADC values were calculated in regions
of interest placed in the hyperintense edematous or gliotic regions and compared with those of normal-appearing white matter.
Signal intensity ratios and ADC values in gliosis were compared with those in vasogenic edema using the Mann-Whitney U-test.
Results While considerable overlap was present for signal intensity ratios on conventional MR images, areas of gliosis demonstrated
significantly higher ADC values (1.76 ± 0.09 × 10−3 mm2/s) than areas of vasogenic edema (1.35 ± 0.06 × 10−3 mm2/s; P < 0.0001) without overlap.
Conclusion ADC values are helpful in differentiating reactive gliosis from vasogenic edema. 相似文献
10.
Gourtsoyianni S Papanikolaou N Yarmenitis S Maris T Karantanas A Gourtsoyiannis N 《European radiology》2008,18(3):486-492
The purpose of this study was to measure apparent diffusion coefficient values of normal liver parenchyma and focal liver
lesions utilizing a respiratory gated diffusion sequence with multiple b-values and to investigate whether apparent diffusion
coefficient (ADC) measurements may be utilized to characterize and differentiate between malignant and benign focal hepatic
lesions. Thirty-eight consecutive patients underwent MRI of the liver including diffusion-weighted imaging (DWI). A single-shot
echo planar imaging sequence was applied in coronal orientation with multiple b-values (0, 50, 500, 1,000 s/mm2) and respiratory gating. ADC values were recorded on corresponding maps utilizing region of interest measurements in patients
with benign (group A), malignant (group B) focal lesions and liver parenchyma (group C). Statistical analysis was applied
to check whether differences in mean ADC values were significant (p<0.05). No focal lesions were detected in 11 patients,
with a mean ADC value (CI 95%) of liver parenchyma 1.25×10−3 mm2/s (1.21×10−3 mm2/s−1.29×10−3 mm2/s). Differences in mean ADC of liver parenchyma between group A and B were not significant (p=0.054, 1.30×10−3 mm2/s and 1.31×10−3 mm2/s, respectively). Mean ADC value (95% CI) of 22 benign lesions found in 18 patients was 2.55×10−3 mm2/s (2.35×10−3 mm2/s−2.74×10−3 mm2/s), while the mean ADC value (95% CI) of 16 malignant lesions recorded in 9 patients was 1.04×10−3 mm2/s (0.9×10−3 mm2/s−1.17×10−3 mm2/s). The difference between mean ADC values of benign and malignant focal lesions was statistically significant (p<0.0001).
Respiratory gated diffusion-weighted imaging in the liver is technically feasible. Apparent diffusion coefficient measurements
can be useful in differentiating malignant from benign focal liver lesions. 相似文献
11.
Fujii S Matsusue E Kigawa J Sato S Kanasaki Y Nakanishi J Sugihara S Kaminou T Terakawa N Ogawa T 《European radiology》2008,18(2):384-389
Our purpose is to evaluate the diagnostic accuracy of apparent diffusion coefficient (ADC) measurement in differentiating
malignant from benign uterine endometrial cavity lesions. We retrospectively evaluated 25 uterine endometrial cavity lesions
in 25 female patients: endometrial carcinoma (n = 11), carcinosarcoma (n = 2), submucosal leiomyoma (n = 8), and endometrial
polyp (n = 4). Diffusion-weighted images were performed at 1.5 T with b factors of 0–1,000/mm2. The region of interest was defined within the tumor on T2-weighted EPI image and then manually copied to an ADC map. Thereby,
the ADC value was obtained. We compared ADC values between malignant and benign lesions using Student’s t-test. The mean and
standard deviation of ADC values (×10−3 mm2/s) were as follows: endometrial carcinoma, 0.98±0.21; carcinosarcoma, 0.97±0.02; submucosal leiomyoma, 1.37±0.28; and endometrial
polyp, 1.58±0.45. The ADC values differed significantly between malignant (0.98±0.19) and benign lesions (1.44±0.34) (P < 0.01).
We defined malignant tumors as cases with an ADC value less than 1.15 × 10−3 mm2/s for obtaining the highest accuracy. Sensitivity, specificity, and accuracy were 84.6%, 100%, and 92%, respectively. ADC
measurement can provide useful information in differentiating malignant from benign uterine endometrial cavity lesions. 相似文献
12.
Tomohiro Namimoto Yasuyuki Yamashita Kazuo Awai Takeshi Nakaura Yumi Yanaga Toshinori Hirai Tetsuo Saito Hidetaka Katabuchi 《European radiology》2009,19(11):2756-2764
The objective of our study was to compare diffusion-weighted imaging (DWI) alone and DWI combined with T2-weighted MRI for
the differentiation of uterine sarcomas from benign leiomyomas. T2-weighted imaging and DWI were performed in 103 patients
with 103 myometrial tumours, including 8 uterine sarcomas and 95 benign leiomyomas on 3-T MR imaging. The signal intensity
(SI) of the tumour on T2-weighted images was quantified as the tumour–myometrium contrast ratio (TCR) by using the following
formula: (SItumour − SImyometrium)/SImyometrium. The TCR or apparent diffusion coefficient (ADC) value alone and then the ADC value combined with T2-weighted imaging were
evaluated for differentiation between sarcomas and leiomyomas. The mean ADC value of sarcomas was 0.86 ± 0.11 × 10−3 m2/s, which was significantly lower than that of leiomyomas 1.18 ± 0.24 × 10−3 m2/s; however, there was a substantial overlap. The mean TCR of sarcomas was 0.66 ± 0.71, which was significantly higher than
that of the leiomyomas, –0.37 ± 0.34; however, again, there was a considerable overlap. When ADC was less than 1.05 × 10−3 mm2/s and TCR was greater than 0 this condition was considered to confirm a sarcoma; a combination of ADC and TCR achieved a
significant improvement without any overlap between sarcomas and leiomyomas (sensitivity 100%, specificity 100%). Our preliminary
results indicate that combined DWI and T2-weighted MR imaging is better than DWI alone in the differentiation of uterine sarcomas
from benign leiomyomas. 相似文献
13.
Introduction Epidural spinal cord compression is one of the most critical emergency conditions requiring medical attention and requires
prompt and adequate treatment. The aim of our study was to assess the role of diffusion-weighted magnetic resonance (MR) imaging
(DWI) in the diagnosis and differentiation of epidural spinal lesions.
Methods Three patients with epidural lymphoma, two with sarcoma and three with epidural metastatic disease were imaged on a 1.5T MRI
unit. DWI was performed using navigated, interleaved, multi-shot echo planar imaging (IEPI). Three region of interest (ROI)-measurements
were obtained on corresponding apparent diffusion coefficient (ADC) maps, and the mean ADC value was used for further analysis.
The cellularity of tumors was determined as the N/C ratio (nucleus/cytoplasma ratio) from histological samples. The ADC values
and N/C ratios of lesions were compared using a Kruskal-Wallis test.
Results The mean ADC of the lymphomas was 0.66 × 10−3 mm2/s, that of the sarcomas was 0.85 × 10−3 mm2/s and the ADC of the metastatic lesions was 1.05 × 10−3 mm2/s; however, the differences were not statistically significant. Mean N/C ratios in the lymphoma, sarcomas and metastases
were 4:1, 2:1, and 2.6:1, respectively, with a statistically significant difference between the groups (p < 0.025).
Conclusion Although not statistically significant due to the small patient sample, our results clearly show a tendency toward decreased
diffusivity in neoplastic lesions with higher cellularity. The data from our study suggest that DWI is a feasible and potentially
useful technique for the evaluation of epidural lesions that cause spinal cord compression on a per-patient basis. 相似文献
14.
Oto A Schmid-Tannwald C Agrawal G Kayhan A Lakadamyali H Orrin S Sethi I Sammet S Fan X 《Emergency radiology》2011,18(6):515-524
This study was conducted to determine the incremental value of diffusion-weighted MR imaging (DW-MRI) over T2-weighted imaging
diagnosing abdominopelvic abscesses and compare apparent diffusion coefficient (ADC) values of abscesses and non-infected
ascites. In this IRB-approved, HIPAA-compliant study, two radiologists retrospectively compared T2-weighted, T2-weighted + DW-MRI
and T2-weighted + contrast enhanced MR images of 58 patients (29 with abscess, 29 with ascites) who underwent abdominal MRI
for abscess detection. Confidence and sensitivity was compared using McNemar’s test. ADC of abscesses and ascites was compared
by t test, and a receiver operating characteristic (ROC) curve was constructed. Detection of abscesses and confidence improved
significantly when T2-weighted images were combined with DW-MRI (sensitivity: observer 1—100%, observer 2—96.6%) or contrast
enhanced images (sensitivity: both observers—100%) compared to T2-weighted images alone (sensitivity: observer 1—65.5%, observer
2—72.4%). All abscesses showed restricted diffusion. Mean ADC of abscesses (observer 1—1.17 ± 0.42 × 10−3 mm2/s, observer 2—1.43 ± 0.48 × 10−3 mm2/s) was lower than ascites (observer 1—3.57 ± 0.68 × 10−3 mm2/s, observer 2—3.42 ± 0.67 × 10−3 mm2/s) (p < 0.01). ROC analysis showed perfect discrimination of abscess from ascites with threshold ADC of 2.0 × 10−3 mm2/s (Az value 1.0). DW-MRI is a valuable adjunct to T2-weighted images diagnosing abdominopelvic abscesses. ADC measurements
may have the potential to differentiate abdominal abscesses from ascites. 相似文献
15.
We qualitatively assessed the regional distribution of vasogenic edema in a case of postpartum eclampsia. Although diffusion-weighted
imaging showed no abnormalities, bilateral high signal was seen on T2-weighted images and apparent diffusion coefficient (ADC)
maps. ADC of 1.45 ± 0.10 mm2/s × 10–3 for the posterior cerebral artery (PCA) territory and 1.22 ± 0.12 mm2/s × 10–3 for the watershed areas were significantly higher than those in the territories of the anterior (0.85 ± 0.07 mm2/s × 10–3) and middle cerebral (0.79 ± 0.06 mm2/s × 10–3)arteries (P < 0.05). The predilection of ADC changes within the PCA territory and in a previously undescribed watershed distribution
supports the hypothesis that vasogenic edema in eclampsia is due to hypertension-induced failure of vascular autoregulation.
Received: 8 July 1999 Accepted: 25 April 2000 相似文献
16.
Role of diffusion-weighted MR imaging in cervical lymphadenopathy 总被引:21,自引:0,他引:21
Abdel Razek AA Soliman NY Elkhamary S Alsharaway MK Tawfik A 《European radiology》2006,16(7):1468-1477
The role of diffusion-weighted magnetic resonance imaging (MRI) for differentiation between various causes of cervical lymphadenopathy
was evaluated. In a prospective study, 31 untreated patients (22 males and nine females, aged 5–70 years) with 87 cervical
lymph nodes underwent diffusion-weighted MRI before performance of neck dissection (n=14), surgical biopsy (n=9) or core biopsy (n=8). Diffusion-weighted MR images were acquired with a b factor of 0 and 1,000 s/mm2 using single-shot echo-planar sequence. Apparent diffusion coefficient (ADC) maps were reconstructed for all patients. The
signal intensity of the lymph nodes was assessed on images obtained at b=0 or 1,000 s/mm2 and from the ADC maps. The ADC value of lymph nodes was also calculated. On the ADC map, malignant nodes showed either low
(n=52) or mixed (n=20) signal intensity and benign nodes revealed high (n=13) or low (n=2) signal intensity. The mean ADC value of metastatic (1.09±0.11×10−3 mm2/s) and lymphomatous (0.97±0.27×10−3 mm2/s) lymph nodes was significantly lower than that of benign (1.64±0.16×10−3 mm2/s) cervical lymph nodes (P<0.04). When an ADC value of 1.38×10−3 mm2/s was used as a threshold value for differentiating malignant from benign lymph nodes, the best results were obtained with
an accuracy of 96%, sensitivity of 98%, specificity of 88%, positive predictive value of 98.5% and negative predictive value
of 83.7%. The smallest detected lymph node was 0.9 cm. In conclusion, diffusion-weighted MRI with ADC mapping is a new promising
technique that can differentiate malignant from benign lymph nodes and delineate the solid viable part of the lymph node for
biopsy. This technique provides additional useful physiological and functional information regarding characterization of cervical
lymph nodes. 相似文献
17.
R. B. J. de Bondt M. C. Hoeberigs P. J. Nelemans W. M. L. L. G. Deserno C. Peutz-Kootstra B. Kremer R. G. H. Beets-Tan 《Neuroradiology》2009,51(3):183-192
Introduction The aim was to determine the diagnostic accuracy and additional value of diffusion-weighted imaging for detection of malignant
lymph nodes in head and neck squamous cell carcinoma.
Methods Two hundred nineteen lymph nodes, predominantly smaller than 10 mm (95.4%), in 16 consecutive patients were evaluated at 1.5 T.
Lymph nodes were evaluated for maximum short axial diameter, morphological criteria, and apparent diffusion coefficient (ADC)
values (b = 0 and b = 1,000 s/mm2). Sensitivity, specificity, positive and negative predictive values as well as diagnostic odds ratios (DORs) and areas under
the curves (AUCs) of ROC curves were calculated for the various magnetic resonance imaging (MRI) criteria individually and
in combination. Histological examination of lymph nodes in the neck dissection specimen was the gold standard to determine
malignant involvement.
Results The optimal ADC threshold was 1.0 × 10−3 mm2/s. Using this cutoff point, sensitivity and specificity were 92.3% and 83.9%, respectively. When used in combination with
size and morphological criteria, ADC value <1.0 × 10−3 mm2/s was the strongest predictor of presence of metastasis (DOR = 97.6). A model which added ADC values to the other MRI criteria
performed significantly better than a model without ADC values: AUC = 0.98 versus AUC = 0.91 (p = 0.036).
Conclusion In this study, with predominantly small lymph nodes, the ADC criterion is the strongest independent predictor of presence
of metastasis. The use of ADC values in combination with the other MRI criteria significantly improves the discrimination
between malignant and benign lymph nodes. 相似文献
18.
Diffusion-weighted MRI in cystic or necrotic intracranial lesions 总被引:11,自引:2,他引:9
Our purpose was to investigate the signal intensities of cystic or necrotic intracranial lesions on diffusion-weighted MRI
(DWI) and measure their apparent diffusion coefficients (ADC). We examined 39 cystic or necrotic intracranial lesions in 33
consecutive patients: five malignant gliomas, seven metastases, two other necrotic tumours, a haemangioblastoma, three epidermoids,
an arachnoid cyst, seven pyogenic abscesses, 12 cases of cysticercosis and one of radiation necrosis. DWI was performed on
a 1.5 T unit using a single-shot echo-planar spin-echo pulse sequence with b 1000 s/mm2. The signal intensity of the cystic or necrotic portion on DWI was classified by visual assessment as markedly low (as low
as cerebrospinal fluid), slightly lower than, isointense with, and slightly or markedly higher than normal brain parenchyma.
ADC were calculated in 31 lesions using a linear estimation method with measurements from b of 0 and 1000 s/mm2. The cystic or necrotic portions of all neoplasms (other than two metastases) gave slightly or markedly low signal, with
ADC of more than 2.60 × 10−3 mm2/s. Two metastases in two patients showed marked high signal, with ADC of 0.50 × 10−3 mm2/s and 1.23 × 10−3 mm2/s, respectively. Epidermoids showed slight or marked high signal, with ADC of less than 1.03 × 10−3 mm2/s. The arachnoid cyst gave markedly low signal, with ADC of 3.00 × 10−3 mm2/s. All abscesses showed marked high signal, with ADC below 0.95 × 10−3 mm2/s. The cases of cysticercosis showed variable signal intensity; markedly low in five, slightly low in three and markedly
high in four.
Received: 17 November 1999/Accepted: 3 February 2000 相似文献
19.
Balassy C Kasprian G Brugger PC Csapo B Weber M Hörmann M Bankier A Bammer R Herold CJ Prayer D 《European radiology》2008,18(4):700-706
To quantify apparent diffusion coefficient (ADC) changes in fetuses with normal lungs and to determine whether ADC can be
used in the assessment of fetal lung development. In 53 pregnancies (20–37th weeks of gestation), we measured ADC on diffusion-weighted
imaging (DWI) in the apical, middle, and basal thirds of the right lung. ADCs were correlated with gestational age. Differences
between the ADCs were assessed. Fetal lung volumes were measured on T2-weighted sequences and correlated with ADCs and with
age. ADCs were 2.13 ± 0.44 μm2/ms (mean ± SD) in the apex, 1.99 ± 0.42 μm2/ms (mean ± SD) in the middle third, and 1.91 ± 0.41 μm2/ms (mean ± SD) in the lung base. Neither the individual ADC values nor average ADC values showed a significant correlation
with gestational age or with lung volumes. Average ADCs decreased significantly from the lung apex toward the base. Individual
ADCs showed little absolute change and heterogeneity. Lung volumes increased significantly during gestation. We have not been
able to identify a pattern of changes in the ADC values that correlate with lung maturation. Furthermore, the individual,
gravity-related ADC changes are subject to substantial variability and show nonuniform behavior. ADC can therefore not be
used as an indicator of lung maturity. 相似文献
20.
Takao Taniguchi Hisato Kobayashi Koji Nishikawa Etsushi Iida Yoshihiro Michigami Emiko Morimoto Rikiya Yamashita Ken Miyagi Motozumi Okamoto 《Japanese journal of radiology》2009,27(3):138-142
Purpose The aim of this study was to investigate the usefulness of diffusion-weighted magnetic resonance imaging (DWI MRI) for the
diagnosis and evaluation of autoimmune pancreatitis (AIP).
Materials and methods A total of 4 consecutive patients with AIP, 5 patients with chronic alcoholic pancreatitis (CP), and 13 patients without pancreatic
disease (controls) were studied. DWI was performed in the axial plane with spin-echo echo-planar imaging single-shot sequence.
Apparent diffusion coefficients (ADCs) were measured in circular regions of interest in the pancreas. In AIP patients, abdominal
MRI was performed before, and 2–4 weeks after steroid treatment. Follow-up study was performed chronologically for up to 11
months in two patients. The correlation between ADCs of the pancreas and the immunoglobulin G4 (IgG4) index (serum IgG4 value/serum
IgG4 value before steroid treatment) was evaluated.
Results In the AIP patients, DWI of the pancreas showed high signal intensity, and the ADCs of the pancreas (mean ± SD: 0.97 ± 0.18
× 10−3 mm2/s) were significantly lower than those in patients with CP (1.45 ± 0.10 × 10−3 mm2/s) or the controls (1.45 ± 0.16 × 10−3 mm2/s) (Mann-Whitney U-test, P < 0.05). In one AIP patient with focal swelling of the pancreas head that appeared to be a mass, DWI showed high signal intensity
throughout the pancreas, indicating diffuse involvement. The ADCs of the pancreas and IgG4 index were significantly inversely
correlated (Spearman’s rank correlation coefficient, r
s = −0.80, P < 0.05).
Conclusion Autoimmune pancreatitis showed high signal intensity on DWI, which improved after steroid treatment. ADCs reflected disease
activity. Thus, diffusion-weighted MRI might be useful for diagnosing AIP, determining the affected area, and evaluating the
effect of treatment.
T. Taniguchi and H. Kobayashi contributed equally to this study 相似文献