肢端持续性丘疹性黏蛋白病

报告1例肢端持续性丘疹性黏蛋白病.患者男,64岁.双前臂泛起丘疹2个月余.皮损组织病理检查示:真皮浅层水肿,成纤维细胞增多,真皮上中部大量黏蛋白沉积,阿新蓝染色阳性.     

肢端持久丘疹性黏蛋白沉积症一例

患者女,46岁,双手背、手腕伸侧对称多数肤色小丘疹4年,不伴瘙痒、疼痛.皮肤组织病理检查:真皮浅中层胶原断裂,可见片状淡染物质沉积,未见成纤维细胞增生.阿新蓝染色显示:真皮浅中层胶原纤维间黏蛋白沉积,证实为肢端持续丘疹黏性蛋白沉积症.肢端持续丘疹黏蛋白沉积症属于皮肤黏蛋白沉积症局限型中的一个亚型,临床上需要与黏液水肿性苔藓散发丘疹型、皮肤局灶性黏蛋白沉积症及伴甲状腺病性黏蛋白沉积症进行鉴别.     

肢端持久丘疹性黏蛋白沉积症一例

患者女,46岁,双手背、手腕伸侧对称多数肤色小丘疹4年,不伴瘙痒、疼痛.皮肤组织病理检查:真皮浅中层胶原断裂,可见片状淡染物质沉积,未见成纤维细胞增生.阿新蓝染色显示:真皮浅中层胶原纤维间黏蛋白沉积,证实为肢端持续丘疹黏性蛋白沉积症.肢端持续丘疹黏蛋白沉积症属于皮肤黏蛋白沉积症局限型中的一个亚型,临床上需要与黏液水肿性苔藓散发丘疹型、皮肤局灶性黏蛋白沉积症及伴甲状腺病性黏蛋白沉积症进行鉴别.     

肢端持久丘疹性黏蛋白沉积症一例

患者女,46岁,双手背、手腕伸侧对称多数肤色小丘疹4年,不伴瘙痒、疼痛.皮肤组织病理检查:真皮浅中层胶原断裂,可见片状淡染物质沉积,未见成纤维细胞增生.阿新蓝染色显示:真皮浅中层胶原纤维间黏蛋白沉积,证实为肢端持续丘疹黏性蛋白沉积症.肢端持续丘疹黏蛋白沉积症属于皮肤黏蛋白沉积症局限型中的一个亚型,临床上需要与黏液水肿性苔藓散发丘疹型、皮肤局灶性黏蛋白沉积症及伴甲状腺病性黏蛋白沉积症进行鉴别.     

肢端持续性丘疹性粘蛋白沉积症1例

1临床资料 患者男,51岁.双手背部、腕部及前臂散在分布白色丘疹5年.5年前无明显诱因右手背部及前臂出现数个粟粒大白色丘疹,无疼痛和瘙痒,皮疹缓慢增多,逐渐蔓延至双手背部、前臂.外院按"扁平疣"治疗,效果不佳.患者否认甲状腺疾病史,家族中无类似病史.体检:颈部未触及肿大甲状腺,心肺检查未见异常.皮肤科情况:双手背部、腕部及双前臂散在分布数十个粟粒大白色或近肤色半球形丘疹,表面光滑,具蜡样光泽,皮疹未见相互融合,右前臂、右手背皮疹较对侧稍密集.     

儿童丘疹性肢端皮炎一例

5岁男性患儿,面部、四肢出现大量扁平红色丘疹伴瘙痒10 d.10 d前,患儿手、足背侧出现散在红色小丘疹,3 d内迅速蔓延至于大腿、臀部、手臂和面颈部,躯干皮损较少.皮肤科情况:面部、四肢可见大量密集分布的针尖至黄豆大小的扁平、红色、有光泽丘疹,孤立不融合,表面轻度脱屑,肘部、膝部、踝关节处皮损呈线状分布.EB病毒衣壳...     

儿童丘疹性肢端皮炎—附15例临床分析

分析了１５例儿童丘疹性肢端皮炎的临床及实验资料，并对本病的病因、发病机理、诊断和流行病学进行了讨论。作者认为提高对本病的认识，有利于控制乙肝病毒在我国的传播。     

EB病毒相关儿童丘疹性肢端皮炎2例

2例患者均为男性儿童,皮损均位于面部及四肢,表现为对称分布的扁平丘疹及丘疹水疱性皮疹。实验室检查乙型肝炎表面抗原(HBsAg)为阴性,EB病毒衣壳抗原IgM抗体均>160 U/mL,根据临床表现及实验室检查结果,诊断为儿童丘疹性肢端皮炎(papular acrodermatitis of children, PAC)。     

肢端角化性类弹性纤维病

患者女性，４７岁。主诉：双手背、手腕屈侧、双足背丘疹２年。现病史：患者２年前开始在双手背、手腕屈侧、双足背内外侧出现半透明的丘疹，逐渐增大，无症状。半透明丘疹可逐渐转变为白色扁平丘疹。丘疹逐渐增多，反复有新起丘疹。患者为家庭劳动妇女。否认家族中有相同疾病者。体格检查：全身系统检查未见异常。皮肤科检查：双手背，大小鱼际处多发扁平白色扁平角化丘疹，呈“铺路石”样，部分皮疹融合（见照片１）。皮疹分布以背屈侧交界处为显著。双手腕屈侧半透明丘疹，为半球形粟粒至绿豆大小，表面光滑（见照片２）。双足缘内外侧于…     

Acral persistent papular mucinosis: a case report and literature review

Acral persistent papular mucinosis is a rare subtype of localized lichen myxedematosus. It shows symmetric, asymptomatic, chronic, ivory to flesh‐colored, 2–5 mm sized papules arranged on the dorsa of the hands and extensor aspects of the distal forearms. Thirty‐two cases including two from China, appear to fit the proposed diagnostic criteria. We report a 31‐year‐old Chinese woman who presented with papules on the extensor aspects of her hands and distal forearms. Histopathology revealed a circumscribed area in the upper and mid reticular dermis with splaying of collagen fibers caused by amorphous deposits. The material was mucin, as it stained positively with alcian blue at pH 2.5. The thyroid profile was normal, and there was no evidence for lupus erythematous. The lesions were treated with electrofulguration and resolved leaving mild scars; there has been no recurrence at follow‐up after one year. We also review the literature on this rare form of mucinosis.     

Acral persistent papular mucinosis

Acral persistent papular mucinosis is a rare subtype of localized lichen myxedematosus. For half a century, this disease has endured a controversial and constantly evolving classification. We describe a patient who presented with discrete, flesh-colored papules on the hands, wrists, and forearms in a distribution consistent with acral persistent papular mucinosis. Histology was also constant with this disease, showing a well-circumscribed deposition of mucin in the upper and mid dermis that spared a small grenz zone. The changing nomenclature and diagnostic requirements of acral persistent papular mucinosis that have allowed it to remain a topic of debate are examined through a comprehensive review of the literature. All reported cases are reviewed.     

Acral persistent papular mucinosis

Acral persistent papular mucinosis (APPM) is a subtype of localized lichen myxedematosus (LM) characterized by the chronic development of white to skin-colored papules and limited to the extensor surfaces of the hands and distal part of forearms, in the absence of systemic or laboratory manifestations. There is a strong predominance in women. Histopathology shows focal accumulation of mucin in the upper portion of the dermis sparing the grenz zone. The etiology is unknown. It is a benign condition, although dynamic changes occur with the progressive development of additional lesions. No specific treatment is required, and patients should be reassured about the prognosis.     

Acral persistent papular mucinosis

The case is reported of a 56-year-old man with an unusual papular eruption on the forearms with deposition of mucin in the dermis. The clinical and histopathological features were consistent with acral persistent papular mucinosis, a recently described focal type of cutaneous mucinosis.     

Acral persistent papular mucinosis

Cutaneous mucinoses, also called lichen myxoedematosus, are a group of diseases characterized by mucin deposit on the skin. They may be associated to systemic diseases (scleromyxedema) or be primary ones (papular mucinosis, localized lichen myxoedematous), although they share common findings (intermediate or atypical forms) in some cases. Acral persistent papular mucinosis (APPM) is a type of papular mucinosis that is located exclusively on the back of the hands and in the distal zone of the forearms and is not associated to any systemic disease. We present the case of a 52-year-old healthy woman who had skin lesions on the back of her hands and whose histological study confirmed an APPM.     

Discrete papular mucinosis on the back

A rare case of papular mucinosis on the back of a 78-year old man is described. The patient developed approximately 20 discrete papules on the upper back. His serum glucose concentration was borderline elevated, but no other systemic symptoms or signs were apparent. A biopsy revealed mucin deposits only in the upper reticular dermis. The papules were distinctly different from lichen myxedematosus in clinical and histochemical appearance. The present case may represent very early-stage lichen myxedematosus complicated by borderline diabetes mellitus.     

Acral persistent papular mucinosis in two sisters

We describe two young sisters with an asymptomatic papular eruption on the forearms, the clinical, histopathological and ultrastructural features of which were consistent with acral persistent papular mucinosis. Familial occurence of this uncommon disease is exceptional.