共查询到20条相似文献,搜索用时 15 毫秒
1.
S. B. Cheknev Ya. G. Ashmanova O. L. Latysheva S. Zh. Toksambaeva E. B. Mysyakin A. Ya. Kul'berg 《Bulletin of experimental biology and medicine》1994,118(1):751-754
The cytotoxicity of natural killer cells (NK) against3H-uridine-labeled target cells (TC, human erythromyeloleukosis cells K-562) and the intensity of conjugate formation in the
NK:TC system in the presence of γ-interferon, C-reactive protein, and human fibronectin are studiedin vitro in 14 patients with multiple sclerosis. It is shown that γ-interferon and C-reactive protein decrease the cytotoxic activity
of NK with a simultaneous stimulation of conjugate formation in the NK:TC system. The correlation between the studied parameters
becomes weaker. Human fibronectin induces collateral changes in the activity of NK and in the number of effector:target conjugates
formed in the natural cytotoxicity reaction.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
7, pp. 67–70, July, 1994 相似文献
2.
S. B. Cheknev Ya. G. Ashmanova A. D. Pritsker O. L. Latysheva 《Bulletin of experimental biology and medicine》1994,118(6):1311-1314
The interferon content in the plasma of 6 healthy donors and 10 patients with multiple sclerosis and the effect of an 1-h
treatment of mononuclear cells with autologous plasma on their natural killer activity are studiedin vitro using3H-uridine-labeled (3 μCi/ml) human erythromyeloleukosis cells K-562. The serum interferon content in healthy donors is 2.3±0.82
IU/ml, whereas that in patients is higher: 5.2±0.8 IU/ml. Autologous plasma does not affect the activity of natural killer
cellsin vitro, whereas it increases the cytotoxicity of mononuclear cells obtained from patients with multiple sclerosis by 35–64%.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
12, pp. 619–622, December, 1994
Presented by S. V. Prozorovskii, Member of the Russian Academy of Medical Sciences 相似文献
3.
S. B. Cheknev D. V. Kuyavskaya I. A. Tarkhanova E. E. Babaeva L. M. Bartova A. Ya. Kul'berg 《Bulletin of experimental biology and medicine》1994,118(1):737-742
The cytotoxic activity of natural killer cells and the intensity of conjugate formation are studiedin vitro in the natural cytotoxicity reaction against3H-uridine-labeled human erythromyeloleukotic cells K-562 in the presence of fibronectin, γ-globulin, and fibronectin/γ-globulin
combination. It is demonstrated that fibronectin does not change natural cytotoxicity, γ-globulin increases the activity of
human natural killer cells, and the fibronectin — γ-globulin combination increases both the intensity of conjugate formation
and the cytotoxic activity of natural killer cells.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
7, pp. 54–59, July, 1994 相似文献
4.
I. V. Maiborodin Yu. I. Borodin V. N. Grigor'ev V. N. Gavrilin 《Bulletin of experimental biology and medicine》1994,118(6):1300-1303
Changes in the thymus of male Wistar rats were studied under a light microscope at various times after intranasal administration
of α-interferon. The relative mass of the organ, the cortex volume, the total number of cells, the number of small and medium
lymphocytes, and the number of mitoses decrease 14 days after interferon administration. At the same time, the number of macrophages,
neutrophils, mature plasmacytes, eosinophils, and erythrocytes increases, and mast cells appear. Thus, α-interferon probably
suppresses the formation of T cells, facilitates allergization of the organism, and increases the permeability of the vascular
endothelium.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
12, pp. 609–612, December, 1994 相似文献
5.
S. B. Cheknev 《Bulletin of experimental biology and medicine》1995,119(4):396-399
The proliferative activity of human natural killers (CD16+CD56+ cells) in the presence of 100 and 1000 IU/ml human recombinant interleukin-3 is investigatedin vitro. It is shown that recombinant interleukin-3 reliably enhances natural killer proliferation, causing a 9–15.2-fold increase
of3H-thymidine uptake by CD16+CD56+ cells both in complete culture medium and in conditioned medium. The effect of the factor is 3.9–6.4 and 3.6–8.9-fold more
potent than that of recombinant interleukin-2 and granulocyte-macrophage colony-stimulating factor, respectively, in the same
doses.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
4, pp. 409–412, April, 1995
Presented by S. V. Prozorovskii, Member of the Russian Academy of Medical Sciences 相似文献
6.
S. B. Cheknev Ya. G. Ashmanova E. E. Babaeva I. A. Tarkhanova A. Ya. Kul'berg 《Bulletin of experimental biology and medicine》1994,118(6):1317-1321
The cytotoxic activity of natural killer cells against3H-uridine-labeled target cells (human erythromyeloleukosis cells K-562) and the intensity of spontaneous blast transformation
are studiedin vitro in the presence of human serum γ-globulin. It is shown that spontaneous blast transformation is 49–51% due to the presence
of aggregated γ-globulin, while the aggregate-free γ-globulin fraction does not induce this reaction. The cytotoxic activity
of natural killer cellsin vitro declines in the presence of native γ-globulin, which is related to the influence of aggregated γ-globulin, the intensity
of whose formation may increase upon a manyfold decrease in the γ-globulin content of the preparation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
12, pp. 625–630, December, 1994 相似文献
7.
N. V. Malakhova K. M. Figurin N. S. Fedorova M. V. Kiselevskii S. N. Bykovskaya 《Bulletin of experimental biology and medicine》1996,121(2):174-177
A specific stimulation of mononuclear cellsin vivo was observed after 3 or 4 endolymphatic injections of autologous lymphokine-activated killers and recombinant interleukin-2
in male patients with disseminated bladder cancer. This activation presented as an increase of the cytotoxicity of mononuclears
towards target cells of bladder carcinoma. A statistically reliable increase of natural killer activity was observed, and
in one patient a reliable increase of the cytolytic activity of mononuclear cells against Mel-1 target cells. After 1 or 2
injections the activity of natural killers increased to 80–90% for an initial level of 23–50%.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
2, pp. 188–191, February, 1996
Presented by N. N. Trapeznikov, Member of the Russian Academy of Medical Sciences 相似文献
8.
O. V. Bukharin Yu. A. Brudastov V. A. Gritsenko D. G. Deryabin 《Bulletin of experimental biology and medicine》1996,121(2):160-162
A relationship is found between the resistance ofEscherichia coli, Staphylococcus aureus, andStaphylococcus epidermidis to human serum and whole blood and their ability to inactivate the factors of natural antiinfectious resistance (lysozyme,
complement, immunoglobulins, and a bactericidal fraction of leukocytic interferon).
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
2, pp. 174–176, February, 1996 相似文献
9.
A. V. Danilkovich K. V. Freze O. S. Targoni A. Yu. Karulin A. F. Sheval'e M. V. Gusev G. T. Sukhikh 《Bulletin of experimental biology and medicine》1994,117(1):75-78
Human α-2 interferon and peptides representing parts of the amino-acid sequence 124–138 of the IF molecule inhibit the proliferative
response of peripheral blood lymphocytes from healthy donorsin vitro induced by ConA. It is shown that neither interferon α-2 nor biologically active peptides change the level of interleukin-2
ConA-induced production by human blood mononuclears.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
1, pp. 72–74, January, 1994
Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences 相似文献
10.
A. P. Bezuglyi 《Bulletin of experimental biology and medicine》1994,117(1):4-8
Following microiontophoresis of propranolol, a β-adrenoblocker, and prasosine, an α-adrenoblocker, rearrangements of the impulse
flows are observed in a number of neurons of the lateral hypothalamus, which manifest themselves in the development of regular
activity with a monomodal distribution of interspike intervals.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
1, pp. 9–12, January, 1994.
Presented by K. V. Sudakov, Member of the Russian Academy of Medical Sciences 相似文献
11.
S. B. Cheknev D. V. Kuyavskaya S. Zh. Toksambaeva E. B. Mysyakin A. Ya. Kul'berg 《Bulletin of experimental biology and medicine》1994,117(3):283-287
It is demonstrated that in the presence of human recombinant γ-interferon and C-reactive protein the activity of natural killers
increases 9–43%, whereas the number of effector:target cell conjugates formed at the stage of recognizing and binding of target
cells decreases 14–80%. There is a weak positive correlation (ρ=0.35) between the activity of natural killers and the number
of effector:target cell conjugates.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
3, pp. 280–285, March, 1994 相似文献
12.
V. M. Khabibulina S. A. Korostelev O. B. Drize M. A. Shlyankevich 《Bulletin of experimental biology and medicine》1995,120(3):915-917
Data are presented on the ability of synthetic β-carotene to reduce the level of cyclophosphane-induced chromosome aberrations
in murine bone marrow cells. InSalmonella typhimurium cells β-carotene exhibits antimutagenic activity only against an indirect mutagen (2-acetylaminofluorene).
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
9, pp. 276–278, September, 1995
Presented by Yu. N. Solov'ev, Member of the Russian Academy of Medical Sciences 相似文献
13.
A. R. Tuguz M. V. Kiselevskii A. M. Buntsevich D. V. Komov B. E. Polotskii V. A. Normantovich I. G. Komarov E. M. Roschin T. S. Golubeva S. N. Bykovskaya 《Bulletin of experimental biology and medicine》1996,121(2):178-180
The cytotoxic activity of peripheral blood platelets and mononuclears from 82 patients with cancer, 9 with diseases other
than cancer, and 18 healthy donors towards a continuous cell line of pulmonary adenocarcinoma was studied. There were no appreciable
differences in the killer activity of platelets in cancer patients (32±3.5%), patients with diseases other than cancer (33±8.1%),
and healthy donors (30±6.7%). In contrast to platelets, mononuclears of cancer patients possessed a higher cytotoxicity than
mononuclears of healthy donors. The cytotoxicity of platelets of cancer patients was found to reliably drop in cases with
disseminated metastases and after polychemo-and radiotherapy.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
2, pp. 192–195, February, 1996
Presented by N. N. Trapeznikov, Member of the Russian Academy of Medical Sciences 相似文献
14.
Ya. Yu. Bagrov N. I. Dmitrieva N. B. Manusova 《Bulletin of experimental biology and medicine》1995,120(3):892-894
The effects of M1 and M2 cholinoceptors on stimulated water transport in the urinary bladder of the common frogRana temporaria L. are described. In the presence of pirenzepine, a selective M1 cholinoceptor antagonist, carbachol stimulated water transport. Activation of M2 cholinoceptors by oxotremorine in concentrations of 0.5–5.0 μM inhibited water transport, whereas their activation by this
compound in higher concentrations (10–100 μM) stimulated it. The use of the phospholipase C inhibitor neomycin (0.5 mM) and
the calmodulin inhibitor W-7 (1 mM) indicated that activation of M2 cholinoceptors switches on phospholipid-Ca2+-calmodulin-dependent mechanisms.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
9, pp. 252–254, September, 1995
(Presented by P. V. Sergeev, Member of the Russian Academy of Medical Sciences) 相似文献
15.
M. V. Zvereva A. Yu. Sokolov A. K. Anosov D. I. Roshchupkin 《Bulletin of experimental biology and medicine》1994,117(2):139-141
Three transfusions of blood irradiated at 254 nm induce an increase of phagocytic activity of peritoneal macrophages in rats
with peritonitis in comparison with infusion of intact blood. Addition of aspirin, an inhibitor of enzymatic peroxidation
of lipids, to the irradiated portion of the blood before irradiation abolishes this stimulating effect.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
2, pp. 140–142, February, 1994
Presented by Yu. A. Vladimirov, Member of the Russian Academy of Medical Sciences 相似文献
16.
Yu. A. Kudryashov L. V. Silin V. A. Otellin B. I. Tkachenko L. A. Fedosikhina 《Bulletin of experimental biology and medicine》1994,118(3):1018-1022
The functional activity of vascular endothelium in a muscle preparation from the feline gastrocnemius is impaired with ethanol,
which results in an increase of an adrenergic responsiveness of the arterial compartment of the vascular bed. The exchange
function of the microvessels changes little. Veins exhibit nonuniform changes in their responsiveness after exposure of their
endotheliocytes to ethanol.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
9, pp. 315–318, September, 1994 相似文献
17.
E. O. Fedorovskaya N. G. Tsyshkova A. M. Poverennyi A. F. Tsyb 《Bulletin of experimental biology and medicine》1994,118(1):764-766
Arbidol, a new antiviral drug, is found to suppress metastases of Lewis' pulmonary carcinoma for various methods of transplantation.
The effects of arbidol are compatible with those of the standard interferon inductor poly-I-poly-C.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
7, pp. 80–81, July, 1994 相似文献
18.
G. V. Burlakov 《Bulletin of experimental biology and medicine》1994,118(3):949-952
The effect of lectins (phytohemagglutinin — PHA, concanavalin A — ConA,Pisum sativum lectin — PSL,Ricinus communis lectin — RCL, and pokeweed mitogen — PWM) on the cardiac cholinoceptors is studied in experiments on isolated hearts of maleRana temporaria frogs. The test lectins in concentrations from 10−23 to 10−3 are shown to exhibit cholinomimetic properties.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
9, pp. 252–255, September, 1994
Presented by A. D. Ado, Member of the Russian Academy of Medical Sciences 相似文献
19.
V. V. Ryvnyak V. S. Gudumak E. S. Onya 《Bulletin of experimental biology and medicine》1995,120(3):952-953
The activity of aminopeptidase M in rat liver is studied electron histochemically. The enzyme is shown to be localized in
the lysosomes of Kupffer's cells and endotheliocytes, and extracellularly on hepatocyte microvilli.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
9, pp. 312–314, September, 1995
Presented by D. S. Sarkisov, Member of the Russian Academy of Medical Sciences 相似文献
20.
S. B. Cheknev 《Bulletin of experimental biology and medicine》1999,128(5):1132-1134
Carbohydrate-rich components released from fractions of aggregated and protein aggregate-free γ-globulins decreased the cytotoxicity
of natural killer cells in relation3H-uridine-labeled standard human K562 erythroblasts. In a dose of 0.1 μg/ml, these components decreased activity of natural
killer lymphocytes by 57% and 42%, respectively. The data suggest that γ-globulin-associated fractions containing carbohydrate
components are involved in the regulation of human natural killer activity.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 11, pp. 545–547, November, 1999 相似文献