Diethyl thiourea as a cause of dermatitis in a car factory

White, W. G., and Vickers, H. R. (1970).Brit. J. industr. Med.,27, 167-169. Diethyl thiourea as a cause of dermatitis in a car factory. Fifteen car assembly workers became sensitized to self-skinning neoprene foam weather strips by contact with the bare forearms for the greater part of the working day. A series of patch tests showed 11 out of 11 tested to be sensitive to diethyl thiourea present in the neoprene as an accelerator. The condition cleared on modification of the assembly process.     

Airborne irritant contact dermatitis due to sewage sludge

An outbreaks of cases of airborne irritant contact dermatitis developed among incinerator workers employed in a sewage treatment facility. Contamination of the workplace and workers' clothing by sludge from the interstices of an incinerator exhaust fan proved to be the cause of the problem. The irritancy of the sludge was determined by tests in rabbits. There was no recurrence of the problem after the institution of hygienic measures designed to control contact with the sludge during subsequent fan maintenance procedures.     

某铸钢厂工人职业性接触性皮炎患病调查

对某铸钢厂工人职业性接触性皮炎患病原因进行调查,结果发现皮炎的发生与使用的钢水结晶器保护渣的刺激和未采取正确的个人防护以及高温等因素有关。经采取相应的防护措施后,职业性接触性皮炎患病得到有效的控制。     

A case of occupational contact dermatitis due to hydroxylamine

A 36-year-old man, working in a chemical industry, had a generalized pruritic eruption. A forty-eight hour patch test revealed positivity for 1% hydroxylamine. Prevention of exposure to this chemical resulted in a dramatic improvement of the symptoms. Based on these findings, we diagnosed this case as occupational contact dermatitis due to hydroxylamine. There has been few case reports of contact dermatitis due to hydroxylamine. Histopathological examination revealed a marked spongiosis and a spongiotic bulla formation in the epidermis and follicular infundibulum, suggesting an allergic reaction.     

Allergic contact dermatitis due to urethane acrylate in ultraviolet cured inks

Seven workers exposed to ultraviolet printing inks developed contact dermatitis. Six cases were allergic and one irritant. A urethane acrylate resin accounted for five cases of sensitisation, one of which was also sensitive to pentaerythritol triacrylate and another also to an epoxy acrylate resin. One instance of allergy to trimethylpropane triacrylate accounted for the sixth case of contact dermatitis in this group of workers. An irritant reaction is presumed to account for the dermatitis in the individual not proved to have cutaneous allergy by patch tests. In this instance trimethylpropane triacrylate was thought to be the most likely irritating agent. Laboratory investigation proved urethane acrylate to be an allergen. The results of investigations of the sensitisation potentials of urethane acrylate, methylmethacrylate, epoxy acrylate resins, toluene-2,4-diisocyanate, and other multifunctional acrylic monomers in the albino guinea pig are presented. The interpretation of such predictive tests is discussed.     

Allergic contact dermatitis due to urethane acrylate in ultraviolet cured inks.

Seven workers exposed to ultraviolet printing inks developed contact dermatitis. Six cases were allergic and one irritant. A urethane acrylate resin accounted for five cases of sensitisation, one of which was also sensitive to pentaerythritol triacrylate and another also to an epoxy acrylate resin. One instance of allergy to trimethylpropane triacrylate accounted for the sixth case of contact dermatitis in this group of workers. An irritant reaction is presumed to account for the dermatitis in the individual not proved to have cutaneous allergy by patch tests. In this instance trimethylpropane triacrylate was thought to be the most likely irritating agent. Laboratory investigation proved urethane acrylate to be an allergen. The results of investigations of the sensitisation potentials of urethane acrylate, methylmethacrylate, epoxy acrylate resins, toluene-2,4-diisocyanate, and other multifunctional acrylic monomers in the albino guinea pig are presented. The interpretation of such predictive tests is discussed.     

镍接触性皮炎的斑贴试验及其组织病理学特征

目的 探讨斑贴试验在金属过敏等环境与职业性皮炎中的诊断价值,了解镍接触性皮炎的组织病理学特征。方法 应用欧洲标准抗原系列斑贴试验检测110例疑诊为接触性皮炎患者,并对13例硫酸镍(5％)斑贴试验不同时段阳性反应皮肤进行活检。结果 39例接触性皮炎患者对硫酸镍敏感(占35．5％),其中阳性反应皮肤组织学特征为：24h时表皮轻度海绵变性和灶状空泡变性,少许嗜酸性粒细胞外渗;48-72h时表皮和真皮炎症达高峰,主要是CD45RO^ T细胞和CD68^ 巨噬细胞分布于炎症表皮及真皮血管周围。916h-5d时表皮轻度增生,不同细胞成分参与修复过程。结论 硫酸镍是引起湿疹皮炎类疾病的主要接触变应原,镍皮炎病理学改变符合变应性接触性皮炎的特征。     

Occupational asthma and contact dermatitis in a spray painter after introduction of an aziridine cross-linker.

A 23-year-old spray painter developed contact dermatitis and respiratory difficulty characterized by small airways obstruction shortly after the polyfunctional aziridine cross-linker CX-100 began to be used in his workplace as a paint activator. The symptoms resolved after he was removed from the workplace and was treated with inhaled and topical steroids. Painters may have an increased risk of asthma due to exposure to a variety of agents, such as isocyanates, alkyd resins, and chromates. This case illustrates the importance of using appropriate work practices and personal protective equipment to minimize exposure. Occupational asthma is diagnosed by a history of work-related symptoms and exposure to known causative agents. The diagnosis is confirmed by serial pulmonary function testing or inhalational challenge testing. The risk of asthma attributable to occupational exposures is probably underappreciated due to underreporting and to inappropriate use of narrow definitions of exposure in epidemiologic studies of attributable risk.     

石化行业职业性接触性皮炎调查分析及其试点干预

目的 调查石化行业工作职业性接触性皮炎特点及发病原因.方法 对石化行业工作进行了现场调查,并进行试点干预.结果 职业性接触性皮炎患病率为13.11%,皮炎的发生与化学物质接触、未采取正确的个人防护措施有关.结论 采取正确的防护措施,可有效控制石化行业职业性接触性皮炎的发生.