Confluent and reticulated papillomatosis of Gougerot and Carteaud.

Confluent and reticulated papillomatosis is a rarely reported dermatosis of unknown origin. It is similar to nummular and confluent papillomatosis; punctate, pigmented verrucose papillomatosis; acanthosis nigricans; pseudoacanthosis nigricans; benign acanthosis nigricans; pseudoatrophoderma colli; tinea versicolor; Darier's disease; epidermodysplasia verruciformis; and verruca plana. Treatment may be temporarily successful, but the lesions usually recur within a period of months.     

Response of confluent and reticulate papillomatosis of Gougerot and Carteaud to topical tretinoin

Confluent and reticulate papillomatosis (CRP) of Gougerot and Carteaud is a rare cutaneous disorder characterized by persistent, usually asymptomatic, dark papules and plaques centrally located on the back, intermammary, and epigastric areas. The eruption spreads out peripherally into a fading reticulated pattern. The pathogenesis is poorly understood, but there are several theories. Many different treatments, with varying success rates, have been attempted. We present 3 patients with CRP who had excellent results in the areas treated with topical tretinoin. The only difficulty with therapy is applying the tretinoin to the back, which sometimes necessitates a second person. However, if this situation can be overcome, topical tretinoin provides an effective, safe alternative to systemic therapies. Response to tretinoin provides support that CRP is a disorder of keratinization. Finally, the fact that 2 of the patients were brothers may support the idea that CRP has a hereditary influence.     

Calcipotriol treatment of confluent and reticulated papillomatosis (Gougerot–Carteaud syndrome)

Gougerot-Carteaud syndrome or confluent and reticulated papillomatosis (CRP), was first described by Gougerot and Carteaud as dermatosis. It is generally considered a rare condition. The eruption consists confluent, flat, brown papules localized primarily to the intermammary and interscapular regions with subsequent spread to the breast and abdomen; at the periphery, the papules spread out forming a pigmented reticulated pattern. At present, the aetiology of CRP remains unknown. The two prominent theories are an abnormal host response to fungi and a keratinization defect. Other hypothesis include photosensitivity, genetic factor, amyloidosis cutis and endocrinopathy.     

融合性网状乳头瘤病21例临床分析

报告21例融合性网状乳头瘤病,其中男13例,女8例.发病年龄9～27岁(平均17.7岁),病程1个月～7年.临床上皮损以躯干中部为著,为密集分布的灰褐色丘疹或斑片,相互间融合呈网纹状.真菌检查均为阴性.组织病理学表现为表皮呈"城垛样"平顶或呈锥状.治疗给予米诺环素50 mg每日2次口服,0.1%维A酸乳膏外涂.4周后皮损开始好转,8周后皮损明显缓解.     

Confluent and reticulate papillomatosis of Gougerot-Carteaud and obesity: dermoscopic findings

Confluent and reticulated papillomatosis of Gougerot and Carteaud is a dermatosis that despite showing characteristic clinical signs is often poorly recognized and diagnosed. The authors present a case with extensive skin involvement, discuss its association with obesity and describe dermoscopic findings making the histopathological correlation.     

A case of early onset confluent and reticulated papillomatosis with an unusual localization

Confluent and reticulated papillomatosis is a relatively rare dermatosis of unknown origin. It is characterized by papules that become confluent in the center and reticulated at the periphery. The sites of predilection are the neck, interscapular region, inframammary area and abdomen. In a 15-year-old girl diagnosed with confluent and reticulated papillomatosis, the lesions first appeared on her knees and elbows when she was 4-years-old, and on the interscapular area when she was 13. Similar lesions arose on the left hand a few weeks previous to her visit. Two biopsy specimens were taken from the interscapular and elbow areas. The histopathological findings of this case fit the diagnosis of confluent and reticulated papillomatosis. We expect good results from azithromycin therapy.     

融合性网状乳头瘤病3例

报告3例融合性网状乳头瘤病,均有典型的临床表现和组织病理改变,临床上本病常误诊为花斑癣,本文讨论了这两种病之间的鉴别。     

Treatment of confluent and reticulated papillomatosis with azithromycin

Confluent and reticulated papillomatosis (CRP) is a relatively rare disorder of unknown origin, mostly affecting young female adults. We here present the case of a 21-year-old male patient with confluent and reticulated papillomatosis. Skin examination revealed brownish, verrucous, hyperkeratotic, 2 to 5 mm papules, which formed confluent patches and plaques with a reticulate network on the interscapular area. The patient was initially treated with ketoconazole cream for two weeks without improvement. The disease can be rather persistent and resistant to topical therapy. Our case showed a satisfactory response to treatment with azithromycin. Although this treatment is known to be effective in some cases, the action mechanism of azithromycin on CRP is not fully understood.     

Dietzia strain X: a newly described Actinomycete isolated from confluent and reticulated papillomatosis

Confluent and reticulated papillomatosis (CRP) is a rare skin disorder. To date its aetiology remains uncertain. The possibility of an infectious aetiology has been supported by case reports of therapeutic response to antibiotic therapy. We have isolated and identified a previously unknown Dietzia strain, an Actinomycete, from skin scrapings of a 17-year-old boy with CRP. We propose that this organism may be the aetiological agent of CRP. Further investigations are necessary to determine the potential role of this Actinomycete in the pathogenesis of CRP.     

A case of confluent and reticulate papillomatosis (Gougerot-Carteaud) with an unusual location

A 15-year-old female with a brown hyperkeratotic plaque in the pubic region confirming with the diagnosis of confluent and reticulate papillomatosis (CRP) is presented. The lesion disappeared rapidly after 3 weeks of treatment with 50% propylene glycol in water. The etiological role of Pityrosporum orbiculare in CRP is discussed.