A Pilot Study on Establishment and Evaluation of Quality of Life Questionnaire on Functional Dyspepsia

Chemotherapy and Radiotherapy induced diarrhea is not an uncommon clinical problem. If not controlled in time, then weight-loss and other features of malnutrition are unavoidable. Therefore, management of such cases is of utmost importance. Appropriate therapy should be initiated in time to control the intestinal losses in time. A randomized clinical trial was conducted from Jan/1994 to Dec/1998 to find out the efficacy of octreotide versus loperamide in the treatment of Chemotherapy and Radioherapy - induced diarrhea. 125 patients were studied. 63 patients were given octreotide 100 μg, S/C,     

Standing on the shoulders of giants

The cover of this well-illustrated,monochrome book has mini-portraits of eight surgical pioneers that suggest the scope of this coffee table sized hardback.Andreas Vesalius     

Curse of schistosomiasis on Egyptian liver

INTRODUCTIONSchistosomiasis is a chronic parasitic disease caused by atrematode blood fluke of the genus schistosoma that belongsto the schistosomatidae family.The ancient Egyptianscontracted the disease more than 4 000 years ago.It wasrecognized through haematuria,the main sign of urinarybilharziasis was recorded in the Kahun papyrus 1900 B.C.as     

Influence of fever on biliary elements of guinea pigs

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Effects of Astragalus Membranaceus on oxygen consumption of intestine

ＥｆｅｃｔｓｏｆＡｓｔｒａｇａｌｕｓＭｅｍｂｒａｎａｃｅｕｓｏｎｏｘｙｇｅｎｃｏｎｓｕｍｐｔｉｏｎｏｆｉｎｔｅｓｔｉｎｅＬＩＳｈａｏＺｈｉ１ａｎｄＴＡＮＸｉａｏＨｏｎｇ２ＳｕｂｊｅｃｔｓｈｅａｄｉｎｇｓＡｓｔｒａｇａｌｕｓＭｅｍｂｒａｎａｃｅｕ...     

Study on improving the quality of low-dose PET images of children based on generative adversarial networks

<正>Objective To investigate the value of generative adversarial networks-based PET image reconstruction in improving the quality of low-dose¹⁸F-FDG PET images and lesion detection in pediatric patients.Methods Retrospective analysis of 61 PET images of children (38males,23 females,age (4.0±3.5) years) who underwent¹⁸F-FDG total-body PET/CT imaging in Beijing Friendship Hospital,Capital Medical University fromAugust 2021 to December 2021 was performed.     

Studies on molluscicidal effect of mechanized spraying of sodium pentachlorophenate with large quantity of water against snails on marshland.

A new method using mechanized spray with large quantity of water against snails was studied inlaboratory and field.Results showed that the new method was effective in decreasing the survival andmultiplication of snails on marshland formed less than 10 years.About 95％ snails.both on surfaceand under earth were dead and 99％ offspring snail population was decreased after sodium pentachloro-     

Effects of Exercise on the Flow of Blood and Lymph

One of the greatest benefits derived fromexerciser is the improved circulation of bloodand lymph to all parts of the body,whichitbrings about.The blood has several important functions,namely,(1) to absorb nutrient material fromthe intestine and distribute it throughout thebody,(2)to take oxygen from the lungs andconvey it to the tissues,(3)toremove wasteproducts from the tissues,and (4) to distri-bute and equalize body heat. To perform thesefunctions effectively the circulatory systemrequires the stimuli of muscular activity.Exercise causes the heart to beat more for     

Effect of hepatitis Bimmunoglobulin on interruption of HBV intrauterine infection

AIM:To evaluate the efficacy of hepatitis B immunoglobulin(HBIG)in interrupting hepatitis B virus(HBV)intrauterineinfection during late pregnancy.METHODS:We allocated 112 HBsAg positive pregnantwomen into 2 groups randomly.Fifty seven cases in the HBIGgroup received 200 IU(unit)HBIG intramuscularly every 4 wkfrom the 28 wk of gestation to the time of delivery,while55 cases in the control group received no special treatment.HBsAg,HBeAg,HBcAb,HBeAb,HBsAb and HBV DNA levelswere tested in the peripheral blood specimens from all ofthe mothers at 28 wk of gestation,just before delivery,andin blood from their newborns within 24 h before administrationof immune prophylaxis.RESULTS:The intrauterine infection rate in HBIG group andcontrol group were 10.5% and 27.3%,respectively,withsignificant difference(P<0.05).It showed ascendant trendas HBV DNA levels in the peripheral blood increased beforedelivery.CONCLUSION:HBIG is potent to cut down HBV intrauterineinfection rate significantly when administered to pregnantwomen regularly during late pregnancy.The possibility of HBVintrauterine infection increases if maternal blood HBV DNA≥10~8 copies/mL.Li XM,Shi MF,Yang YB,Shi ZJ,Hou HY,Shen HM,Teng BQ.Effect of hepatitis B immunoglobulin on interruption of HBVintrauterine infection.World J Gastroenterol 2004;10(21):3215-3217http://www.wignet.com/1007-9327/10/3215.asp     

Follow-up study of Influence of antihyperuricemic therapy on primary gout

8.5·other me加加lie derangeme.ts9‘肠44 Foll脾一仰s加dy of Influe.ee of antiby衅卜urieomic thera盯姐primary gout.HUA Hongbao(华鸿宝),et al.伦a吃:玩u 4th氏ople‘s物sp,Yang比ou,225002.Chin J Endoerinol乙Metabol 1996;12(3)135一137. This study was condueted to assess the effeets ofover ten界ars of antih”erurieemie follow一up therapyon 65 patients out of 118 eases of primary gout.It wasfound that redueed tophaeeous de卯sition eorrelatedwith normalization of the serum urie aeid eoneentre-tion.…     

Effect of cholesterol on the virulence of Entamoeba histolytica.

27 guinea pigs were divided into 6 groups, 5 animals in each of the groups 1-5and 2 animals in group 6. The 1st group was inoculated intracaecally with a strain ofEntamoeba histolytica trophozoites which were cultured in the presence of cholesteroland the 2nd with the same strain cultured in a medium without cholesterol. The 3rd     

Effect of staurosporine on cycle of human gastric cancer cells

AIM:TO study the effect of staurosporine (ST) on the cellcycle of human gastric cancer cell lines MGC803 andSGC7901.METHODS:Cell proliferation was evaluated by trypan bluedye exclusion method.Apoptotic morphology was observedunder a transmission electron microscope.Changes of cellcycle and apoptotic peaks of cells were determined by flowcytometry.Expression of p21~(WAFl)gene was examined usingimmunohistochemistry and RT-PCR.RESULTS:The growth of MGC803 and SGC7901 cells wasinhibited by ST.The inhibitory concentrations against 50?lls (IC_(50)) at 24 h and 48 h were 54 ng/ml and 23 ng/ml forMGC803,and 61 ng/ml and 37 ng/ml for SGC7901.Typicalapoptotic bodies and apoptotic peaks were observed 24 hafter cells were treated wth ST at a concentration of 200ng/ml.The percentage of cells at G_0/G_1 phase was decreasedand that of cells at G_2/M was increased significantly in thegroup treated wth ST at the concentrations of 40 ng/ml,60 ng/ml,100 ng/ml for 24 h,compared with the controlgroup (P<0.01).The expression levels of p21~(WAFl)gene inboth MGC803 and SGC7901 cells were markedly up-regulatedafter treatment with ST.CONCLUSION:ST can cause arrest of gastric cancer cellsat G_2/M phase,which may be one of the mechanisms thatinhibit cell proliferation and cause apoptosis in these cells.Effect of ST on cells at G_2/M phase may be attributed to theup-regulattion of p21~(WAFl) gene.     

Prominent role of y-glutamyl-transpeptidase on the growth of Helicobacter pylori

AIM:γ-glutamyl transpeptidase(GGT)has been reportedas a virulence and colonizing factor of Helicobacter pylori(H pylori).This study examined the effect of GGT on thegrowth of H pylori.METHODS:Standard H pylori strain NCTC 11637 and 4dinical isolates with different levels of GGT activity as measuredby an enzymatic assay were used in this study.Growthinhibition and stimulation studies were carried out by culturingH pylori in brain heart infusion broth supplemented withspecific GGT inhibitor(L-serine sodium borate complex,SBC)or enhancer(glutathione together with glycyl-glycine),respectively.The growth profiles of H pylori were determinedbased on viable bacterial count at time interval.RESULTS:Growth was more profuse for H pylori isolateswith higher GGT activity than those present with lower GGTactivity.However,in the presence of SBC,growth of H pyloriwas retarded in a dose dependent manner(P=0.034).Incontrast,higher growth rate was observed when GGTactivity was enhanced in the presence of glutathione andglycyl-glycine.CONCLUSION:Higher GGT activity provides an advantageto the growth of H pylori in vitro.Inhibition of GGT activityby SBC resulted in growth retardation.The study showsthat GGT plays an important role on the growth of H pylori.     

Inhibitory effects of berberine on ion channels of rat hepatocytes

AIM:To examine the effects of berberine,an isoquinolinealkaloid with a long history used as a tonic remedy for liverand heart,on ion channels of isolated rat hepatocytes.METHODS:Tight-seal whole-cell patch-clamp techniqueswere performed to investigate the effects of berberine onthe delayed outward potassium currents(I_K),inward rectifierpotassium currents(I_(K1)) and Ca~(2 )release-activated Ca~(2 )currents(I_(CRAC))in enzymatically isolated rat hepatocytes.RFSULTS:Berberine 1-300 μmol/L reduced I_K in a concentration-dependent manner with EC_(50) of 38.86±5.37μmol/L and n_Hof 0.82±0.05(n=8).When the bath solution was changedto tetraethylammonium(TEA)8 mmol/L,I_K was inhibited.Berberine 30 μmol/L reduced I_K at all examined membranepotentials,especially at potentials positive to 60 mV(n=8,P<0.05 or P<0.01 vs control).Berberine had mild inhibitoryeffects on I_(K1)in rat hepatocytes.Berberine 1-300 μmol/Lalso inhibited I_(CRAC) in a concentration-dependent fashion.The fitting parameters were EC_(50)=47.20 10.86μmol/L,n_H=0.71±0.09(n=8).The peak value of I_(CRAC)in the Ⅰ-Ⅴrelationship was decreased by berberine 30 μmol/L at potentialnegative to-80 mV(n=8,P<0.05 vs control).But the reversepotential of I_(CRAC) occurred at voltage 0 mV in all cells.CONCLUSION:Berberine has inhibitory effects on potassiumand calcium currents in isolated rat hepatocytes,which maybe involved in hepatoprotection.     

Long-term effect on carcinoma of esophagus of distal subtotal gastrectomy

AIM:To investigate the surgical treatment and long-termsurvival for patients with carcinoma of esophagus after distalsubtotal gastrectomy.METHODS:Resections of the tumor through leftthoracotomy were performed in 85 patients with esophagealcarcinoma following distal subtotal gastrectomy.Theprocedure involved preserving the left short gastric arteryand transporting the residual stomach,the spleen and tailof the pancreas into the left thoracic cavity,and using theresidual stomach to reconstruct the alimentary tract.RESULTS:The resectable rate was 91.8%,complicationrate 10.3%,and no death occurred in the postoperativeperiod.The 1-,3-,5-,and 10-year survival rates were85.7%,50.7%,30.6% and 18.8%,respectively.CONCLUSION:Surgical resection is the optimal managementmethod for the patients with esophageal carcinoma afterdistal subtotal gastrectomy.The reconstruction of digestivetract using anastomosis of the esophagus and the residualstomach is not only simple but also can achieve a bettercurative effect,promoting the digestive function andimproving the quality of life.