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糖尿病主要分为1型糖尿病和2型糖尿病,其中2型糖尿病容易引起脂肪肝,而1型糖尿病较少引起脂肪肝。为什么2型糖尿病容易引起脂肪肝而1型糖尿病不易引起呢?研究发现,肥胖是脂肪肝形成的主要原因。90%的2型糖尿病患者为肥胖,所以,2型糖尿病易发生脂肪肝。血糖升高不是糖尿病导致脂肪肝形成的主要机制, 相似文献
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2型糖尿病(T2DM)患病率的全球增长和糖尿病心血管并发症的增加,给各国人民带来健康和经济上的巨大负担,使预防2型糖尿病成为重要的卫生保健问题。早期发现2型糖尿病的危险人群进行重点预防,是降低2型糖尿病和减少糖尿病并发症的关键。为此各国普遍开展糖尿病预防教育和人群筛查,但收效有限,特别是对广大人群通过测血糖进行筛查还存在不少困难。 相似文献
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过去,一提起儿童糖尿病,多是指1型糖尿病,而2型糖尿病似乎只有成人才会得。但报道称,在日本的儿童糖尿病中,2型糖尿病占80%。远远高于1型糖尿病。尽管我国目前尚缺乏这方面的统计资料,但临床上儿童2型糖尿病日益增多却是不争的事实。 相似文献
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曾凡宣 《心血管病防治知识》2013,(5):70
许多患者咨询,称听说减肥手术可以减轻2型糖尿病的症状。那么这个手术对1型糖尿病有效吗?肥胖的人更容易患上2型糖尿病。肥胖者和已经患有2型糖尿病的人发现,如果他们减肥,要控制他们的糖尿病很容易。肥胖和2型糖尿病之间的联系很紧密,减肥手术可以大幅度地减肥。所以,没有必要为手术对2型糖尿病的风险降低而感到惊讶。 相似文献
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目的:观察1型糖尿病和2型糖尿病血脂代谢特征。方法:比较两型糖尿病病人血脂代谢与空腹血糖、年龄、体重的关系。结果:①不论是1型糖尿病还是2型糖尿病,均以TG升高为主,TG值明显高于正常人;②两种类型糖尿病。空度血糖控制不好的病人血脂异常的患病率均较高;③1型糖尿病病人年龄与血脂无相关性;2型糖尿病病人年龄越大,血脂异常患病率越高;④1型糖尿病病人体重指数与血脂异常患病率不相关,2型糖尿病病人体重指数越大,血脂异常患病率越高。结论:1型糖尿病和2型糖尿病的血脂异常与空腹血糖、年龄及体重指数具有不同的相关性。 相似文献
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随着生活方式的改变,2型糖尿病在青少年人群中发病率不断增加。青少年2型糖尿病既不同于1型糖尿病,也不同于成人2型糖尿病,相比成人发病的糖尿病病程进展更为快速、也更难治疗,防控形势严峻。本文结合第81届美国糖尿病协会科学年会相关热点和最新临床试验,对青少年2型糖尿病的流行病学现状、病理生理机制、危险因素、合并症、并发症以... 相似文献
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高血压与糖尿病 总被引:65,自引:1,他引:64
陈国伟 《中国实用内科杂志》2002,22(4):199-200
1 流行病学特点流行病学研究证实 ,在糖尿病人群中高血压的发生率显著高于普通人群。据荷兰LouisVerschoor报道 ,约 40 %~ 5 0 %的糖尿病患者有高血压 ,而非糖尿病人群为 2 0 %。75岁以上的糖尿病患者高血压发生率可高达 6 0 % ,当糖尿病合并广泛肾损害时几乎 10 0 %有高血压。但 1型与 2型糖尿病患者原发性高血压的发生率不尽相同 ,2型糖尿病患者原发性高血压的发生率是非糖尿病人群的 2~ 3倍 ,而1型糖尿病患者原发性高血压的发生率与普遍人群相似 ,但当 1型糖尿病发生糖尿病肾病时易引起继发性高血压。2 2型糖尿病高血… 相似文献
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《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2019,13(3):2122-2125
AimsTo determine the distribution, clinical features and complications of the different types of diabetes in young age. Methods: The records of children and adolescents with age at the onset of DM (14–25 years) between January 2017 and August 2018, were reviewed. Clinical and laboratory characteristics of the patients at diagnosis and type of diabetes were recorded. Results: Out of 80 patients (48 males, 32 females), 53 had type 1 DM (66.2%) and 27 had type 2 DM (33.8%). Mean age at the onset of diabetes was 19.75 ± 4.01 years for type 1 DM and 21.37 ± 3.08 years for type 2 DM. Family history of DM was more common in type 2 DM (62.9% of parents, p = 0.000389). Mean BMI in type 2 DM (25.03 ± 5.88 kg/m2) was higher than in type 1 DM (p = 0.009). Osmotic symptoms were more common in type 1 DM (73.06%, p = 0.00151). Conclusion: Osmotic symptoms and ketosis were more common in young age type 1 DM. Family history of DM was more common in parents of type 2 DM. 相似文献
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Frequency of severe hypoglycaemia in type 1 and type 2 diabetes during conventional insulin therapy. 总被引:1,自引:0,他引:1
To determine the frequency of severe hypoglycaemia during conventional insulin therapy in juvenile-onset and adult-onset type 1 and in type 2 diabetes mellitus (DM), we retrospectively analysed the medical records of 165 Turkish diabetic patients who have been treated with conventional insulin. Patients were divided into 3 subgroups with respect to the type of diabetes: 33 had juvenile-onset Type 1 DM, 18 had adult-onset type 1 DM, and 114 had type 2 DM. The diabetic subgroups were found to be comparable with regard to mean frequency of severe hypoglycaemia (juvenile-onset type 1 DM: 0.20 episode x patient(-1) x year-1, adult-onset type 1 DM: 0.10 episode x patient(-1) x year(-1), type 2 DM: 0.15 episode x patient(-1) x year(-1)). Frequency of severe hypoglycaemia necessitating in-hospital treatment was 0.05 episode x patient(-1) x year(-1) for all diabetic subgroups. The data clearly indicate that the extent of the problem of severe hypoglycaemia during conventional insulin therapy in type 2 DM is comparable with both juvenile and adult-onset forms of type 1 DM in Turkish diabetic population. 相似文献
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AIMS: Subcutaneous microdialysis has been used for continuous glucose monitoring in patients with diabetes mellitus (DM) to facilitate tight regulation of blood glucose levels. The aims of this study were therefore to investigate (i) the relationship between capillary and interstitial glucose in patients with type 1 or 2 DM and healthy subjects and (ii) the feasibility of using microdialysis to assess local insulin sensitivity in adipose tissue. METHODS: Using subcutaneous microdialysis, interstitial glucose, lactate, pyruvate and glycerol were determined as measures of glucose and lipid metabolism in adipose tissue, before and after an oral glucose tolerance test (OGTT) in 14 patients and seven controls. The results were correlated to whole-body insulin sensitivity and insulin sensitivity in liver estimated from the levels of insulin-like growth factor-binding protein 1 (IGFBP-1). RESULTS: Capillary and interstitial glucose correlated before and after OGTT in healthy subjects and in type 1 DM but not in type 2 DM. In fasting state, the glycerol levels were higher in both type 1 and type 2 DM compared with controls. After the OGTT, the insulin levels were sufficient to suppress lipolysis in type 1 but not in type 2 DM. The glucose/lactate ratio was higher at fasting in type 1 DM and after OGTT in type 1 and 2 DM. In type 1 DM, basal interstitial glycerol levels correlated to whole-body glucose utilization. In type 2 DM, correlations were found between the basal glycerol levels and whole-body insulin sensitivity and between glucose/lactate and per cent decrease in IGFBP-1 levels 120 min after OGTT. CONCLUSION: Capillary and interstitial glucose correlated before and after OGTT in healthy subjects and patients with type 1 DM. Correlations were also found between insulin sensitivity in whole body and in adipose tissue in both type 1 and type 2 DM and between insulin sensitivity in subcutaneous adipose tissue and liver in type 2 DM. This study shows that microdialysis technique can be used to study in vivo insulin sensitivity in adipose tissue over time and may be useful in the evaluation of, for example, the effects of new drugs on insulin sensitivity. 相似文献
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We measured pancreatic volume (PV) using helical computed tomography (CT) in 26 patients with type 1 diabetes mellitus (DM),
29 patients with type 2 DM, and 22 healthy individuals. We also evaluated the relationship between PV and the body surface
area (BSA), established the pancreatic volume index (PVI) by dividing PV by BSA to correct PV for the body build, and examined
its relationships with the duration of illness, serum C-peptide immunoreactivity level (CPR), and serum immunoreactive trypsin
level (IRT). BSA and PV were correlated significantly (p<0.0001, r=0.645) in healthy individuals, and they were correlated also in the diabetic patients, (p=0.0023, r=0.563 in type 1 DM; p=0.0346, r=0.392 in type 2 DM). PV was significantly smaller in the type 1 DM group than in
the healthy group and type 2 DM group (p<0.001 for both). PVI was also significantly smaller in the type 1 DM group than in the healthy group and type 2 DM group
p<0.001 for both). PVI and IRT were significantly correlated in both DM groups (p<0.0001, r=0.732 in type 1 DM; p=0.0469, r=0.731 in type 2 DM). PVI was not correlated with the duration of illness or CPR. Helical CT was useful for the
measurement of the pancreatic volume, and the pancreatic volume was reduced particularly in the patients with type 1 DM. A
strong correlation was observed between PV and exocrine pancreatic function in type 1 DM, but the correlation between PV and
exocrine pancreatic function was weak in type 2 DM.
Received: February 2001 / Accepted in revised form: July 2001 相似文献
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Geerlings SE Stolk RP Camps MJ Netten PM Collet JT Schneeberger PM Hoepelman AI 《Archives of internal medicine》2001,161(11):1421-1427
BACKGROUND: Women with diabetes mellitus (DM) have asymptomatic bacteriuria (ASB) more often than women without DM. It is unknown, however, what the consequences of ASB are in these women. OBJECTIVE: To compare women with DM with and without ASB for the development of symptomatic urinary tract infections (UTIs), renal function, and secondary complications of DM during an 18-month follow-up period. METHODS: In this multicenter study we monitored women with DM with and without ASB for the development of symptomatic UTIs, renal function, and secondary complications (ie, retinopathy, neuropathy, microvascular, or macrovascular diseases). Data on the first 18-month follow-up period are presented. RESULTS: At least 1 uncontaminated urine culture was available from 636 women (258 with type 1 DM and 378 with type 2 DM). The prevalence of ASB at baseline was 26% (21% for those with type 1 DM and 29% for those with type 2 DM). Follow-up results were available for 589 (93%) of the 636 women. Of these 589 women, 115 (20%) (14% with type 1 DM and 23% with type 2 DM) developed a symptomatic UTI. Women with type 2 DM and ASB at baseline had an increased risk of developing a UTI during the 18-month follow-up (19% without ASB vs 34% with ASB, P =.006). In contrast, there was no difference in the incidence of symptomatic UTI between women with type 1 DM and ASB and those without ASB (12% with ASB vs 15% without ASB). However, women with type 1 DM and ASB had a tendency to have a faster decline in renal function than those without ASB (relative increase in serum creatinine level 4.6% vs 1.5%, P = 0.2). CONCLUSION: Women with type 2 DM and ASB have an increased risk of developing a symptomatic UTI than those without ASB. 相似文献
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We have studied the prevalence of fibromyalgia syndrome (FMS) in patients with type 1 and type 2 diabetes mellitus (DM). Relationship
with disease control of DM and the presence of FMS was also evaluated. We have studied 93 consecutive patients with DM (85
with type 2 DM and 8 patients with type 1 DM) followed in Diabetes Center. Single researcher took the history and did physical
examination including manual tender point examination according to Manual Tender Point Survey instructions. For the diagnosis
of FMS, 1990 American College of Rheumatology Classification Criteria for FMS was used. We measured patients’ fasting blood
sugar levels and HbA1c levels around the same time period. Patients were excluded from the study if they had any other serious
disease, and if there was any history of drug use that interferes with the symptoms of FMS. Patients with rheumatoid arthritis
(RA) were accepted as controls. FMS was found in 18% of patients with DM type 2 (no patients with FMS in type 1 DM group),
in 34% of patients with RA. Female patients with DM type 2 had significantly higher FMS rates. Mean fasting blood sugar levels
and mean HbA1c levels were not significantly different between type 2 DM patients with FMS and DM patients without FMS. In
RA group, in RA patients without FMS, the use of steroids was significantly higher. We have found an increased prevalence
rate of FMS in patients with DM type 2 and RA. There was no correlation between the prevalence rate of FMS and good DM disease
control. 相似文献
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《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2019,13(2):1159-1164
AimTo examine management of diabetes mellitus (DM) and patients' attitude towards DM in a random sample of the adult Greek population.Methodss: We selected a random sample of adults with self-reported DM (n = 1002) from a population-based nationwide study using the effective random sampling technique. Collection of data was performed through phone interviews.ResultsPrevalence of type 1 DM was 3.5% and of type 2 DM 96.5%. Prevalence of type 1 DM declined while of type 2 DM increased with age. No gender or residency differences were found between type 1 and type 2 DM. A total of 72.0% of subjects with type 2 DM were treated with oral antidiabetic drugs (OAD), 11.5% were treated with insulin and 7.1% were treated with both OAD and insulin. Internists specialized in DM were mainly doctors who started insulin treatment. Almost half of insulin naive subjects were skeptical towards insulin initiation and their main concern was the needle punch.ConclusionsIn a random nationwide sample of the adult population in Greece the majority of subjects with self-reported DM had type 2 DM. Most patients with type 2 were treated with OAD. Almost half of insulin naive subjects were skeptical towards insulin initiation. 相似文献
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Benja Muktabhant Monchai Duangjinda Pattara Sanchaisuriya Srinuan Kananit Frank P. Schelp 《International journal of diabetes in developing countries.》2013,33(4):236-240
Diabetes mellitus (DM) of a first degree relative is an important risk factor for developing type 2 diabetes mellitus (T2DM). The study investigated whether genetic polymorphism of the cytokine interleukine-1β (?511C/T) (IL-1B) was associated with the development of type 2 diabetes mellitus (T2DM) among first degree relative having diabetes mellitus (DM). Thirty five T2DM patients from north-eastern Thailand with a first degree relative with DM, 55 T2DM patients without a DM history of a first degree relative and 30 healthy controls were studied. Heterozygous individuals of IL-1B (CT) in the group of T2DM patients with a first degree relative with DM are significantly more frequent in comparison with the group of T2DM patients without a first degree relative with DM and with the controls. Genotypes between the T2DM patients without a DM relative and the controls were similar. The allele C did not differ between groups but the allele T significantly was more frequent for the T2DM patients with a relative with DM in comparison with the two other groups. 相似文献
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Chou CC Lin KH Ke GM Tung YC Chao MC Cheng JY Chen BH 《The Kaohsiung journal of medical sciences》2004,20(11):525-532
Enteroviruses are environmental triggers in the pathogenesis of type 1 diabetes mellitus (DM). A sequence of six identical amino acids (PEVKEK) is shared by the 2C protein of Coxsackie virus B and the glutamic acid decarboxylase (GAD) molecules. Between 1995 and 2002, we investigated 22 Coxsackie virus B5 (CVB5) isolates from southern Taiwan. Four of these isolates were obtained from four new-onset type 1 DM patients with diabetic ketoacidosis. We compared a 300 nucleotide sequence in the 2C protein gene (p2C) in 24 CVB5 isolates (4 diabetogenic, 18 non-diabetogenic and 2 prototype). We found 0.3-10% nucleotide differences. In the four isolates from type 1 DM patients, there was only 2.4-3.4% nucleotide difference, and there was only 1.7-7.1% nucleotide difference between type 1 DM isolates and non-diabetogenic isolates. Comparison of the nucleotide sequence between prototype virus and 22 CVB5 isolates revealed 18.4-24.1% difference. Twenty-one CVB5 isolates from type 1 DM and non-type 1 DM patients contained the PEVKEK sequence, as shown by the p2C nucleotide sequence. Our data showed that the viral p2C sequence with homology with GAD is highly conserved in CVB5 isolates. There was no difference between diabetogenic and non-diabetogenic CVB5 isolates. All four type 1 DM patients had at least one of the genetic susceptibility alleles HLA-DR, DQA1, DQB1. Other genetic and autoimmune factors such as HLA genetic susceptibility and GAD may also play important roles in the pathogenesis in type 1 DM. 相似文献