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目的从血液质量管理角度分析冷链状态下罕见p血型引起血液外观异常现象。方法本血液中心在全血冷链运输过程中发现外观异常血液样本1例,经血型鉴定为罕见p血型。将该血液样本分别置于室温(25℃)、10℃和4℃条件下,进行全血细胞计数检测,比较不同温度下红细胞计数的差异。结果未经吸收-放散处理的血液样本在4℃贮存温度时,RBC计数、HCT明显低于25℃和10℃,而MCV、MCH、MCHC显著高于25℃和10℃,差异具有统计学意义(P<0.05)。观察组血液样本4℃下红细胞计数略有降低,与贮存温度为25℃和10℃时相比,差异无统计学意义(P>0.05)。结论 p血型人体内抗-P1抗体也是导致血液在低温状态下血细胞凝集、红细胞计数降低的因素。在寻找导致血液质量异常原因的过程中,应充分考虑献血者自身因素。 相似文献
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Mohammad Reza Keramati Hossein Shakibaei Mohammad Ismail Kheiyyami Hossein Ayatollahi Zahra Badiei Maliheh Samavati Mohammad Hadi Sadeghian 《Transfusion and apheresis science》2011,45(2):133-136
Background
Identification of blood group antigen frequencies in a population has various benefits in transfusion medicine. Most data in the literature include frequencies of these antigens in European and American countries. In this study for the first time we have reported frequencies of these antigens in the northeast of Iran.Materials and methods
Blood group antigens were characterized in the 522 blood donors in Mashhad, Iran. The following antigens including ABO, Rh (D, C, E, c, e), MNSs (M, N, S, s), Lutheran (Lua, Lub), P (P, P1), Kell (K, k, Kpa, Kpb), Lewis (Lea, Leb), Duffy (Fya, Fyb) and Kidd (Jka, Jkb) were typed and phenotypes frequencies were expressed as a percentage.Results
In the ABO blood group, the most common phenotype was O (33.9%) followed by A, B and AB. In the Rh blood group, the most common antigen was e (97.9%) and R1r (31.8%) being the most common phenotype. The most common phenotypes for MNSs, P, Lu and Kell blood group were M+N+, S−s+, P1, Lu (a−b+), K−k+ and Kp (a−b+). A very rare phenotype of Lu (a−b−) was also observed in 2.7% of cases. We found rare phenotypes of Le (a+b+) and Fy (a−b−) in 7.9% and 3.4% of subjects, respectively.Conclusion
We determined some differences in phenotype frequencies of blood group compared with other studies. We found higher frequencies of B blood group and also more frequencies of some rare phenotypes, Lu (a−b−), Le (a+b+) and Fy (a−b−). 相似文献4.
不同方法校准血液分析仪结果比较 总被引:39,自引:1,他引:39
目的 探讨血液分析仪校准的正确方法。方法 分别用配套校准物、非配套校准物物质控物在4台不同的血液分析仪上进行仪器校准后,再比较新鲜血用各仪器测定全血细胞计灵敏 可比性和偏差。结果 用配套校准物校的3台仪器测定新鲜 人一血细胞计数结果非常接近,无配套校准物的一台仪器测定新鲜血血小板时结果明显偏低,用非配套校准物或质控物校准仪器后,新鲜血的白细胞、血步板和血细胞比容的偏差明显增大。结论血液分析仪的校准 相似文献
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目的观察无偿献血者献血400ml后相关血液学指标的恢复情况,以获取我国献血者献全血的适当限量及频次的科学资料。方法选择各年龄自愿无偿献血者123名,其年龄、体格检查与血液检验均符合现行我国法规要求,在其献血前及献血后24h、7d、1个月和3个月采集血样,检测WBC、RBC、HGB、HCT、PLT、TP、ALB、血清铁,并对各项数据进行统计学分析。结果献血后3个月内各项血液学指标均可恢复到献血前水平。结论献血后3个月的恢复期是安全的,全血献血间隔期3个月、献血量400ml对献血者身体健康无影响。 相似文献
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Michael Müller-Steinhardt Christian Weidmann Markus Wiesneth Eberhard Weck Erhard Seifried Joachim Brade Harald Klüter 《Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie》2012,39(1):17-22
Background
The implementation of a new national German blood donor questionnaire was proposed to improve donor and recipient safety.Methods
We compared deferral/exclusion rates of whole blood donors before (May 2010, n = 64,735) and after (May 2011, n = 71,687) the implementation of a new blood donor questionnaire. Considering seasonal variations, analysis was performed with respect to collection site (mobile vs. fixed), sex, donor status (first-time vs. repeat), age, and the frequencies of sexual risk behavior and other reasons for deferral.Results
We observed a statistically significant increase (p < 0.001) of the overall deferral/exclusion rate from 6.2 to 8.1%, irrespective of type of collection site (fixed: from 6.0 to 8.5%; mobile: from 6.2 to 8.0%), sex (females: from 7.5 to 9.9%; males: from 5.1 to 6.6%), donor status (first-time donors: from 19.7 to 24.7%; repeat donors: from 4.6 to 6.3%) or age (18–29 years: from 9.1 to 11.7%; 60–71 years: from 5.1 to 6.6%). Confidential self-exclusion increased from 0.08 to 0.14% (p < 0.001). Besides risk behavior, various medical reasons could be identified that explain this increase.Conclusions
The new blood donor questionnaire resulted in an increased deferral/exclusion of all donor groups. Thus the impact on future blood supply must be considered carefully, and long-term studies and investigation of donor acceptance will be needed. 相似文献7.
献血者血红蛋白、红细胞、血小板、血液流变学、脂蛋白的调查研究 总被引:3,自引:0,他引:3
本文采用职业、性别、年龄配对分析的方法,对70例献血者与70例非献血者血液成分、血脂、血液流变学指标进行比较。经配对 t 检验,提示献血组虽多项指标明显降低,但仍然在生理范围之内,结合体格检查和 ECG 无异常发现,表明根据我国人口的一般体质及现在的饮食条件,献血者每次间隔3个月,献血量不超过300ml 是安全的。 相似文献
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Human blood was withdrawn, anticoagulated with citrate, and centrifuged, yielding platelet rich plasma (PRP). Recalcification times (i.e. the time taken to form a clot following the addition of sufficient calcium ions) were measured with a semiautomatic device. There were no changes in the recalcification time of PRP sample immediately following exposure to continuous wave 1 MHz ultrasound at intensities in the range 0·065–2W/cm?2. However, subsequent measurements showed an irreversible time dependent decrease of the recalcification time of an asymptotic value which was invariably less than that of the controls. This behavior can be interpreted as a time dependent alteration to the platelet population. 相似文献
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目的:探讨PASⅢM血小板保存添加液对保存期血小板质量的影响。方法:采集正常献血者标本15份,制备浓缩血小板。应用PASⅢM血小板保存添加液保存浓缩血小板(PASⅢM保存组),富含血小板的血浆作对照(血浆组)。分别在保存1、5、7、10d,检测血小板计数、平均血小板体积(MPV)、胶原诱导的聚集反应、血小板活化率及葡萄糖消耗和乳酸生成。结果:PASⅢM保存组血小板溶液的pH、pCO2和MPV比血浆组稳定。血小板活化率在血浆组随保存时间上升,在PASⅢM保存组比较稳定。血小板聚集率在PASⅢM保存组比血浆组下降幅度小。PASⅢM保存组葡萄糖消耗和乳酸生成幅度低于血浆组。结论:PASⅢM保存添加液在血小板的体外保存期维持血小板质量的作用上优于血浆。 相似文献
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目的探讨锌对血液流变指标的影响。方法:采用新西兰大白兔饮水中加葡萄糖酸锌喂养,设正常组对照,满12个月后取血测定血液流变学各指标。结果:加锌组较对照组全血粘度及血浆粘度明显升高,凝血酶原时间缩短,胆固醇,甘油三酯及血糖升高,红细胞沉降率增快。结论锌可能通过干扰脂肪谢引起血液粘度增加,合理用锌对于防治防血性心脑血管病有重要意义。 相似文献
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目的了解临沂市区学龄前儿童血铅和血镉水平及铅、镉超标状况。方法在严格质量控制下,应用高灵敏度原子吸收光谱法对临沂市区1228名学龄前儿童进行血铅和血镉含量检测并统计分析。结果122名学龄前儿童血铅和血镉水平均值分别为75.8ug/L和2.33ug/L。其中,血铅含量≥100ug/L者210例,铅中毒率为17.10%;血镉>5ug/L者14例,超标率为1.14%。不同性别间学龄前儿童血铅水平均值和铅中毒率差异均无显著性(P>0.05);而血镉均值和超标率差异均有显著性(P<0.05)。结论临沂市区学龄前儿童血铅和血镉水平均较高,铅和镉超标状况不容乐观,应引起儿童家长乃至全社会的高度重视。 相似文献
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目的 探讨血清基质金属蛋白酶(MMP-2)、睾酮(TES)、雌二醇(E2)与高血脂及颈动脉粥样硬化的关系.方法 对146例患者分别进行血脂测定、颈动脉超声检查,测定并记录颈动脉内中膜厚度(IMT)、斑块形态、回声强度、斑块数量.根据超声病理形态和血脂水平分为有斑块高血脂组(A组)45例、无斑块高血脂组(B组)41例和血脂正常组(C组)60例.采用酶联免疫双抗体夹心法(ELISA)测定患者血清MMP-2、化学发光法测定血清TES、E2水平.结果 血清MMP-2 A组高于B组和C组,差异有统计学意义(P<0.05),而B组与C组无统计学差异;血清TES、E2 A组低于B组和C组、B组低于C组,差异有统计学意义(P<0.05);A组和B组血清MMP-2与TES、E2成负相关(r=-0.597,P<0.05;r=-0.622,P<0.05).结论 血清MMP-2、TES、E2水平与高血脂及颈动脉斑块有关. 相似文献
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糖尿病患者血脂检测及其意义分析 总被引:1,自引:0,他引:1
关文锦 《临床和实验医学杂志》2011,10(13):1004-1004,1007
目的探讨糖尿病患者血脂异常原因,为相关疾病防治提供科学依据。方法对2007~2010年就诊的491例糖尿病患者检测血脂4项,血清总胆固醇(TC)用酶法(COD-PAP法)检测,血清三酰甘油(TG)用酶法(GP0-PAP法)检测,高密度脂蛋白胆固醇(HDL-C)用选择性抑制法(SPD法)检测,低密度脂蛋白胆固醇(LDL-C)用表面活性剂清除法(SUR法)检测。对糖尿病血脂异常患者,按照国际、国内诊断标准进行病因分析。结果 491糖尿病患者中,269例血脂异常,血脂异常发生率为54.79%,其中单项TC、TG、LDL-C升高分别为38、51、25例,TG、TC二者同时增高33例,TC、LDL-C同时升高18例,LDL-C、TG同时增高14例,HDL-C降低47例,其他异常组合模式合计43例。结论糖尿病患者以TC、TG、LDL-C增高,HDL-C下降为特征。及时纠正异常血脂,利于糖尿病患者归转及减少并发症。 相似文献
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张卫 《实用医院临床杂志》2014,(2):6-8
输血是围术期有效的治疗措施,但也存在很多风险。围术期血液管理以患者为中心,应用多学科技术,避免或减少异体血输注,改善患者临床转归。本文论述了输血治疗的相关风险及围术期血液管理的具体措施和实施方案。 相似文献