Liver exposure to xenobiotics: the aging factor and potentials for functional foods

Hepatocytes isolated from 20- and 4-month Wistar rats and cultured with or without alpha-linolenic acid (LNA) were then added with nutraceutical YHK or sylibin before the test with iron or copper. Overall, YHK proved to be more effective than sylibin in Fe/Cu-induced peroxidative damage on normal and LNA-loaded hepatocytes (p < 0.05). YHK exerted a significant protection against DPPH radical-scavenging activity in the "old" group (p versus sylibin) and against lipophilic generators in both age groups (p < 0.05 versus sylibin). Both compounds were ineffective on age-related increase of surface-charge density. These preliminary data suggest that age per se enhances the vulnerability of hepatocytes to xenobiotics, whereas some safe nutraceuticals seem to exert significant protective effects.     

皮肤老化和光老化

随着科学技术的发展和人类社会进步 ,人们对皮肤衰老的表现越来越重视 ,对其认识也越来越深刻。尤其是近年来臭氧层的逐渐破坏 ,到达地球表面紫外线量的增加 ,可加速皮肤的衰老。皮肤衰老包括自然老化 (intrinsicaging)和光老化(photoaging) ,两者的表现和发生机制各不相同 ,但     

自身免疫性肝病与肝移植

终末期自身免疫性肝病是肝移植的最佳适应证,应综合疾病的特点准确把握移植时机。肝移植术后原发病复发率较高。受排异、胆道并发症等因素的干扰,移植后疾病复发的鉴别诊断难度高,临床医师应重视对疾病复发的认识,及早发现,及时处理。     

微小RNA和衰老

微小RNA（miRNA）是一类非编码的单链小分子RNA,不仅是机体有目的编码RNA的重要调控分子,并且参与生长、发育、衰老的调控。本文主要描述了miRNA参与的有关衰老调控的一些可能通路和相关机制,如调控端粒酶的表达、p53信号通路、Rb通路;另外,本文还综述了通过调控miRNA合成的酶而影响衰老的一些特殊途径,以阐明当前miRNA与衰老关系的研究成果。     

Biomechanics and aging

Starting from the physical basics of the biomechanics of connective tissues, organ structures and the corresponding age-related changes of skin, tendons, ligaments, cartilage, bones, blood vessels, and lungs are described. Finally, exogenous factors such as nutrition, hormones, immobilization, activity and adaptive mechanisms and their influence on the biomechanical properties of connective tissue are represented.