大鼠脾虚证模型的胃肠粘膜形态学研究

目的：探讨利血平法脾虚证模型大鼠的胃肠粘膜形态学变化。方法：肉眼，光镜及透射电镜观察实验脾虚证大鼠胃肠粘膜形态学变化，并用四君子汤反证。结果；脾虚证大鼠胃肠粘膜出现糜烂破溃的状态，经四君子汤预防及治疗后得到明显改善，明显优于脾虚自然恢复大鼠。     

实验脾虚证胃窦及十二指肠粘膜G、D细胞的变化及意义

目的：探讨Ｇ细胞（分泌胃泌素）、Ｄ细胞（分泌生长抑素）与脾虚证发生的关系。方法：应用抗－胃泌素、抗－生长抑素的多克隆抗体和免疫组织化学技术标记胃窦、十二指肠粘膜Ｇ、Ｄ细胞,运用医学图像分析系统（ＭＩＰＳ）对Ｇ、Ｄ细胞进行定量分析,并与四君子汤组对照。结果：脾虚时Ｇ、Ｄ细胞数均减少,Ｄ细胞面积缩小,Ｇ细胞灰度值增高,Ｇ／Ｄ细胞数和细胞面积比值均增高。经四君子汤预防和治疗的脾虚大鼠,Ｇ、Ｄ细胞数有所增加,Ｄ细胞面积明显增大,Ｇ细胞灰度值、Ｇ／Ｄ细胞数和细胞面积比值均接近或略低于正常。脾虚自然恢复大鼠也有一定程度的改善,但与脾虚四君子汤预防和治疗大鼠相比有显著性差异。结论：研究结果从形态学上揭示Ｄ细胞分泌ＳＳＴ亢进、Ｇ细胞释放Ｇａｓ不足、Ｇ／Ｄ细胞比例失调,是导致脾虚证胃肠功能障碍的一个重要病理机制。     

脾虚老龄大鼠肠黏膜sIgA、CD3、CD8水平变化及四君子汤对其的影响

目的研究脾虚老龄大鼠肠道黏膜分泌型免疫球蛋白IgA(sIgA)、CD3细胞及CD8细胞变化,探讨四君子汤对他们的影响。方法老龄大鼠随机分为正常对照组、长期造模组、造模恢复组和四君子汤组,酶联免疫吸附(ELISA)测定肠黏膜sIgA变化,流式细胞术检测肠黏膜CD3、CD8细胞百分率的变化。结果与正常对照组相比,脾虚各组大鼠肠黏膜sIgA分泌及CD3、CD8细胞百分率减少。治疗后,四君子汤组大鼠肠黏膜sIgA分泌及CD3、CD8细胞百分率增多,效果优于造模恢复组(P<0.01或P<0.05)。结论肠黏膜局部免疫功能紊乱可能是脾虚的重要病理生理学改变之一,四君子汤治疗脾虚证的一条重要途径可能是通过调节肠黏膜局部免疫功能来实现的。     

大鼠脾虚证模型的胃肠粘膜形态学研究

目的：探讨利血平法大鼠脾虚证模型的胃肠粘膜形态学变化。方法，内眼、光镜受透射电键观察实验脾虚证胃肠粘膜形态学变化，并用四君子汤反证。结果；脾虚证大鼠胃肠粘膜出现麇烂破溃的状态，经四君子汤预防及治疗后得到明显改善，明显优于脾虚自然恢复大鼠。结论；结果韧步表明胃肠粘膜形态学变化是揭示脾虚证本质的主要病理学依据之一。     

实验脾虚证胃窦及十二指肠粘膜G,D细胞的变化及意义

目的：探讨Ｇ细胞（分泌胃泌素）、Ｄ细胞（分泌生长抑素）与脾虚证发生的关系。方法：应用抗－胃泌素、抗－生长抑素的多克隆抗体和免疫组织化学技术标记胃窦、十二指肠粘膜Ｇ、Ｄ细胞,运用医学图像分析系统（ＭＩＰＳ）对Ｇ、Ｄ细胞进行定量分析,并与四君子汤组对照。结果：脾虚时Ｇ、Ｄ细胞数均减少,Ｄ细胞面积缩小,Ｇ细胞灰度值增高,Ｇ／Ｄ细胞数和细胞面积比值均增高。经四君子汤预防和治疗的脾虚大鼠,Ｇ、Ｄ细胞数有所增     

大鼠脾虚证模型的胃肠粘膜形态学研究

目的探讨利血平法脾虚证模型大鼠的胃肠粘膜形态学变化。方法肉眼、光镜及透射电镜观察实验脾虚证大鼠胃肠粘膜形态学变化．并用四君子汤反证。结果脾虚证大鼠胃肠粘膜出现糜烂破溃的状态,经四君子汤预防及治疗后得到明显改善,明显优于脾虚自然恢复大鼠。结论胃肠粘膜形态学变化是揭示脾虚证本质的主要病理学依据之一。     

大鼠脾虚证模型的胃肠粘膜形态学研究

目的:探讨利血平法大鼠脾虚证模型的胃肠粘膜形态学变化。方法:肉眼、光镜及透射电镜观察实验脾虚证胃肠粘膜形态学变化,产用四君子汤反证。结果:脾虚证大鼠胃肠粘膜出现糜烂破溃的状态,经四君子汤预防及治疗后得以明显改善,明显优于脾虚自然恢复大鼠。结论:胃肠粘膜形态学变化是揭示脾虚证本质的主要病理学依据之一。     

大鼠脾虚证模型的胃肠粘膜形态学研究

目的:探讨利血平法大鼠脾虚证模型的胃肠粘膜形态学变化。方法:肉眼、光镜及透射电镜观察实验脾虚证胃肠粘膜形态学变化,并用四君子汤反证。结果:脾虚证大鼠胃肠粘膜出现糜烂破溃的状态,经四君子汤预防及治疗后得到明显改善,明显优于脾虚自然恢复大鼠。结论:结果初步表明胃肠粘膜形态学变化是揭示脾虚证本质的主要病理学依据之一。     

大鼠脾虚证模型的胃肠粘膜形态学研究

引言探讨利血平法大鼠脾虚证模型的胃肠粘膜形态学变化方法动物分组：健康成年合SD大鼠，随机分成以下5组，每组5只正常对照组：生理盐水0．smLL·kg‘·d’，lp，同时于每日上、下午各喂饲蒸馏水2mL，连续14d脾虚模型组：利血平0．5mp·kg‘·d－‘，巾，余处理同正常对照组脾虚中药预防组：每日上、下午各喂饲四君子汤2mL，余处理同牌虚模型组．脾虚自然恢复组：按牌虚模型组方法制模14d成型后，于每日上。下午各喂饲蒸馏水2mL，继续观察6d．牌虚中药治疗组：按脾虚模型组方法制模14d成型后，于每日上、下午各喂饲四君子汤ZmL，继续观…     

实验脾虚证胃肠粘膜细胞的增殖动力学研究

目的探索脾虚时胃肠粘膜细胞的增殖能力。方法应用抗-BrdU 的单克隆抗体和免疫组织化学技术分析胃肠道粘膜细胞的增殖情况。结果 BrdU 的免疫标记显示,脾虚时胃肠粘膜细胞的增殖能力下降(P<0.01),经四君子汤预防和治疗的脾虚大鼠胃肠粘膜细胞的增殖能力明显增强,与脾虚自然恢复大鼠有显著差异(P<0.05或 P<0.01)。结论脾虚时胃肠粘膜细胞的增殖能力低下,四君子汤能显著改革其增殖状态。     

经胸超声心动图对法洛氏四联症手术的评价

目的:探讨经胸超声心动图技术评价法对法洛氏四联症(TOF)手术疗效的价值。方法:用经胸超声心动图常规测量43例法洛氏四联症患者术前左、右室内径,主动脉骑跨程度,右室流出道、肺动脉狭窄程度和跨瓣压差,左室射血分数(LVEF),二、三尖瓣E、A峰值等,术后随访6-24个月。结果:术后主动脉根部内径缩小,左室舒张末内径增大,主肺动脉和右室流出道增宽,跨瓣压力阶差降低(P<0.05-P<0.01);LVEF在1-6个月时为0.520±0.058,仍低于正常值。结论:经胸超声心动图对于TOF手术后疗效的评价具有重要作用。     

胶原酶抑制因子及其在大骨节病发病机理中的意义

我们使用胶原酶抑制因子的单克隆体和酶免疫夹心法测定了大骨节病病儿血清中的胶原酶抑制因子的含量。发现大骨节病儿血清中胶原酶抑制因子的含量不仅明显高于沈阳对照,而且明显高于病区对照(P<0.01)。在这一点上不同于以往的大骨节病儿血浆酶的生化分析。胶原酶抑制因子在调节胶原酶活性中起着重要作用,特别是控制结缔组织的降解。由于大骨节病的主要病理改变为软骨坏死,我们的结果似乎对于了解大骨节病的病因学和病理学,尤其是大骨节病的生化诊断有着重要的意义。     

中西医结合综合治疗方案对404例急性脑出血患者日常生活能力与生存质量的影响

目的探讨中西医结合综合治疗方案对急性脑出血患者日常生活能力(ADL)及生存质量(QOL)的影响。方法采用多中心、单盲随机对照试验的设计方法,404例患者分别用中西医结合综合(试验组199例)和西医加中药安慰剂(对照组205例)治疗。在28d、3个月分别进行生活能力状态(Ability diary of life,ADL)、日常生活活动量表(BartherIndex,BI)、生存质量(包括Quality of life Index,QLI、Functional Activities Question-naire,FAQ)等指标评定。结果治疗后28d试验组的QLI、FAQ评分改善优于对照组(P<0.05),ADL评分、BI分级两组比较,差异无统计学意义(P>0.05)。治疗后3个月试验组在ADL评分、BI分级、QLI及FAQ评分改善均优于对照组(P<0.01)。结论中西医结合综合治疗能改善急性脑出血患者残障情况、提高生存质量。     

Asthma and health‐related quality of life – effect of adjusting for potential confounders

Background: Health‐related quality of life (HRQoL) is an increasingly important outcome measure in medical research. We wanted to evaluate how adjustment for potential confounders affected the relationship between HRQoL and asthma. Furthermore, we wanted to evaluate the relationship of environmental tobacco smoke (ETS) with HRQoL. Methods: We carried out a cross‐sectional Norwegian community study in 1996/1997 including 2306 randomly selected subjects aged 26 years–81 years. Data on HRQoL were measured by SF‐12. The data were analyzed by robust linear regression analyses with the physical component score (PCS) and the mental component score (MCS) as dependent variables. The effect of adjusting for the potential confounders was analyzed by bootstrap confidence intervals for differences between the adjusted and unadjusted models. Results: The difference in the asthma coefficients between the unadjusted and adjusted models for both PCS and MCS varied from 0.1 to 1.1. The confidence intervals for these differences for PCS were (?0.3, 1.6) and (0.4, 1.8), using the definition ‘asthma last 12 months’ and ‘physician's diagnosis of asthma’, respectively. The confidence intervals for the corresponding differences for MCS were (?0.01, 1.3) and (?0.6, 0.4), respectively. Univariately, PCS was lower among subjects reporting ETS at home compared to people not reporting ETS at home, but this difference did not persist in the multivariate analyses. ETS at home was associated with slightly improved MCS. Conclusion: Adjusting for potential confounders does not change the relationship between asthma and HRQoL overtly. Please cite this paper as: Voll‐Aanerud M, Eagan TML, Wentzel‐Larsen T, Gulsvik A and Bakke PS. Asthma and health‐related quality of life – effect of adjusting for potential confounders. The Clinical Respiratory Journal 2008; 2: 106–115.     

Non-Destructive Corrosion Inspection of Reinforced Concrete Using Ground-Penetrating Radar: A Review

Reduced maintenance costs of concrete structures can be ensured by efficient and comprehensive condition assessment. Ground-penetrating radar (GPR) has been widely used in the condition assessment of reinforced concrete structures and it provides completely non-destructive results in real-time. It is mainly used for locating reinforcement and determining concrete cover thickness. More recently, research has focused on the possibility of using GPR for reinforcement corrosion assessment. In this paper, an overview of the application of GPR in corrosion assessment of concrete is presented. A literature search and study selection methodology were used to identify the relevant studies. First, the laboratory studies are shown. After that, the studies for the application on real structures are presented. The results have shown that the laboratory studies have not fully illuminated the influence of the corrosion process on the GPR signal. Also, no clear relationship was reported between the results of the laboratory studies and the on-site inspection. Although the GPR has a long history in the condition assessment of structures, it needs more laboratory investigations to clarify the influence of the corrosion process on the GPR signal.     

Application of cognitive Internet of Medical Things for COVID-19 pandemic

Background and aimIn the age of advanced digital technology, smart healthcare based on the Internet of Things (IoT) is gaining importance to deal with the current COVID-19 pandemic. In this paper, the novel application of cognitive radio (CR) based IoT specific for the medical domain referred to as Cognitive Internet of Medical Things (CIoMT) is explored to tackle the global challenge. This concept of CIoT is best suited to this pandemic as every person is to be connected and monitored through a massive network that requires efficient spectrum management.MethodsAn extensive literature survey is conducted in the Google Scholar, Scopus, PubMed, Research Gate, and IEEE Xplore databases using the terms “COVID-19” and “Cognitive IoT” or “Corona virus” and “IoMT”. The latest data and inputs from official websites and reports are used for further investigation and analysis of the application areas.ResultsThis review encompasses different novel applications of CIoMT for fighting the ongoing COVID-19 health crisis. The CR based dynamic spectrum allocation technique is the solution for accommodating a massive number of devices and a wide number of applications. The CIoMT platform enables real-time tracking, remote health monitoring, rapid diagnosis of the cases, contact tracking, clustering, screening, and surveillance thus, reducing the workload on the medical industry for prevention and control of the infection. The challenges and future research directions are also identified.ConclusionsCIoMT is a promising technology for rapid diagnosis, dynamic monitoring and tracking, better treatment and control without spreading the virus to others.     

PKERP与PKRP治疗良性前列腺增生症的疗效及术后对性功能影响的比较分析

目的分析经尿道前列腺等离子双极剜除术(PKERP)与经尿道前列腺等离子双极电切术(PKRP)治疗良性前列腺增生的临床疗效及对患者性功能的影响。方法将2017-01~2019-02收治的80例良性前列腺增生患者随机分成PKRP组和PKERP组,每组40例。两组患者均接受相同的基础治疗方案。PKERP组采用PKERP,PKRP组采用PKRP。比较两组患者术后膀胱冲洗时间、留置尿管时间,手术前及术后3个月国际前列腺症状评分(IPSS)、国际勃起功能指数-5(IIEF-5)、血清hs-CRP水平、膀胱残余尿量及治疗效果的差异。结果PKERP组患者术后膀胱冲洗时间显著短于PKRP组患者(P<0.01);PKERP组患者的留置尿管时间显著短于PKRP组患者(P<0.01);PKERP组患者的IPSS得分显著低于PKRP组患者(P<0.01);PKERP组患者的IIEF-5得分显著高于PKRP组患者(P<0.01);PKERP组患者的血清hs-CRP水平显著低于PKRP组患者(P<0.01);PKERP组患者的膀胱残余尿量显著少于PKRP组患者(P<0.01)。PKERP组患者治愈8例,显效21例,有效10例,无效1例。PKRP组治愈7例,显效11例,有效16例,无效6例。PKERP组疗效优于PKRP组(P<0.05)。结论PKERP治疗良性前列腺增生患者的效果良好,术后恢复快,对患者的性功能影响较少,与PKRP相比优势明显。     

Interlaboratory Comparison as a Source of Information for the Product Evaluation Process. Case Study of Ceramic Tiles Adhesives

In this study, the results obtained by 19 laboratories participating in 2 editions of the interlaboratory comparison (ILC) determining 2 properties of ceramic tiles adhesives (CTAs), i.e., initial tensile adhesion strength and tensile adhesion strength after water immersion following EN 12004, were analyzed. The results show that participating laboratories maintain a constant quality of their work. The use of z-score analysis, under ISO 13528, allows for classifying 89.5% to 100% of laboratories as satisfactory, depending on the measurement’s kind and edition. The remaining laboratories are classified as questionable. The investigation of the predominant mode of failure of the CTA’s samples tested in the two editions shows significant differences. From the perspective of laboratories, the goal of the ILC has been achieved. From the standpoint of a manufacturer who evaluates a product’s properties when placing it on the market, the results indicate the necessity of a particular treatment of the product evaluation process because the variability of the obtained results is significant. It increases the possibility of the product failing to meet the assessment criteria verified by the construction market supervision authorities. The manufacturer must consider all possible variations in the risk analysis, including the ILC results, to improve the assessment process of CTAs.     

The role of erythropoietin in the anaemia of chronic disease in rheumatoid arthritis

Summary We reviewed studies on the role of erythropoietin (Epo) in the anaemia of chronic disease (ACD) in rheumatoid arthritis (RA). A relatively impaired Epo response to the anaemia was found in a number of studies although in others serum Epo level was the same as in other types of anaemia. Some arguments are found in favour of a reduced bone marrow-Epo sensitivity although these reflect results mainly from in vitro experiments. It is not yet established whether bone marrow macrophage Epo production is impaired in ACD. In two cases Epo administration to RA patients resulted in increased erythropoiesis. It was concluded that impaired Epo production or reduced bone marrow Epo sensitivity might be associated with ACD but it is not certain whether these factors are causally linked with ACD or side phenomena of RA disease activity. Future Epo treatment in RA and ACD will possibly solve this question.