Study on Effect of Compound Salvia Pellet in Preventing Atrial Fibrillation with Left Atrial Thrombosis

Atrial fibrillation (AF) is a kind of common arrhythmia, which, besides affecting cardiac function, has another serious outcome, that is, it is easy to form atrial thrombosis and induce thrombus/embolus, especially cerebral embolus. The incidence of left atrial thrombosis ( LAT) could reach 25% - 30%(1) , the incidence of embol-     

Association of β3 Adrenergic Receptor and Peroxisome Proliferator-activated Receptor Gamma 2 Polymorphisms With Insulin Sensitivity： A Twin Study

Objective To study the effect of β3 adrenergic receptor(β3AR) Trp64Arg and peroxisome proliferator activated receptor gamma 2(PPARγ2) Pro12Ala polymorphisms on insulin resistance. Methods One hundred and eight dizygotic twin pairs were enrolled in this study. Microsatellite polymorphism was used to diagnose zygosity of twins. Insulin sensitivity was estimated with logarithm transformed homeostasis model assessment(HOMA). PCR-RFLP analysis was performed to detect the variants. As a supplement to the sib-pair method,identity by state(IBS) was used to analyze the association of polymorphisms with insulin sensitivity. Results The genotype frequencies of Trp64Trg,Trp64Arg,and Arg64Arg were 72.3%,23.8%,and 3.9%,respectively,while the genotype frequencies of Pro12Pro,Pro12Ala,and Ala12Ala were 89.9%,9.6%,and 0.5%,respectively. For β3AR Trp64Arg the interclass co-twin correlations of Waist-to-hip ratio(WHR),blood glucose(GLU),and insulin(INS),homeostasis model assessment insulin resistance index(HOMA-IR) of the twin pairs sharing 2 alleles of IBS were greater than those sharing 0-1 allele of IBS,and HOMA-IR had statistic significance. For PPARγ2 Pro12Ala most traits of twin pairs sharing 2 alleles of IBS had greater correlations and statistic significance in body mass index(BMI),WHR,percent of body fat(PBF) and GLU,but there were low correlations of either insulin or HOMA-IR of twin pairs sharing 1 or 2 alleles of IBS. The combined effects of the two variations showed less squared significant twin-pair differences of INS and HOMA-IR among twins sharing 4 alleles of IBS. Conclusions β3AR Trp64Arg and PPARγ2 Pro12Ala polymorphisms might be associated with insulin resistance and obesity,and there might be slight synergistic effects between this two gene loci,and further studies are necessary to confirm this finding.     

Expression of Extracellular Signal-regulated Kinase and Angiotensin-convetting Enzyme in Human Atria during Atrial Fibrillation

Severalstudieshaveshownthatatrialfibrillation(AF)isalwayscompaniedwithchangesintheelec trophysiologicpropertiesofatrialmyocytesandalter nationsinthestructureoftheatrialtissue[1— 4 ] .Atri alfibrosisisoneoftheimportantalternationsinthestructureoftheatrial…     

Study on the Association Between Helicobacter Pylori Infection and the Pathogenesis of Gastric Cancer by Using Molecuar Biolo

ＳｔｕｄｙｏｎｔｈｅＡｓｓｏｃｉａｔｉｏｎＢｅｔｗｅｅｎＨｅｌｉｃｏｂａｃｔｅｒ　ＰｙｌｏｒｉＩｎｆｅｃｔｉｏｎａｎｄｔｈｅＰａｔｈｏｇｅｎｅｓｉｓｏｆＧａｓｔｒｉｃＣａｎｃｅｒｂｙＵｓｉｎｇＭｏｌｅｃｕａｒＢｉｏｌｏｇｉｃａｌＴｅｃｈｎｉｑｕｅｓＹ...     

A Clinical Study on the Relationship Between DNA-P and ALT of Acute Hepatitis B

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Association of Estrogen Receptor Gene Polymorphisms and Primary Biliary Cirrhosis in a Chinese Population: A Case–Control Study

Background:

Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease characterized by destruction of the interlobular bile ducts and a striking female predominance. The aim of this study was to identify associations between estrogen receptor (ESR) gene polymorphisms with the risk of developing PBC and abnormal serum liver tests in a Chinese population.

Methods:

Thirty-six patients with PBC (case group) and 35 healthy individuals (control group) from the First Hospital of Jilin University were studied. Whole genomic DNA was extracted from all the participants. Three single-nucleotide polymorphisms (rs2234693, rs2228480, and rs3798577) from ESR1 and two (rs1256030 and rs1048315) from ESR2 were analyzed by a pyrosequencing method. Demographic data and liver biochemical data were collected.

Results:

Subjects with the T allele at ESR2 rs1256030 had 1.5 times higher risk of developing PBC than those with the C allele (odds ratio [OR] = 2.1277, 95% confidence interval [CI] = 1.1872–4.5517). Haplotypes TGC of ESR1 rs2234693, rs2228480, and rs3798577 were risk factors for having PBC. The C allele at ESR1 rs2234693 was associated with abnormal alkaline phosphatase (OR = 5.2469, 95% CI = 1.3704–20.0895) and gamma-glutamyl transferase (OR = 3.4286, 95% CI = 1.0083–13.6578) levels in PBC patients.

Conclusions:

ESR2 rs1256030 T allele may be a significant risk factor for the development of PBC. Screening for patients with gene polymorphisms may help to make early diagnoses in patients with PBC.     

Quantitative Study of Atherosclerosis Between Vasectomized and Non-vasectomized Men-22 Cases Reported

Autopsy subjects of 11 vasectomized men group and age-matched 11 non-vasectomised men group are used for study, the mean age was 40.5 yrs, And mean interval after vasectomy was 10.4 yrs. Quantitative study by intersection fraetion of the lesion outlines showed that the extent and severity of aortae and coronary arterial atherosclerotic lemons between the two groups are of no significant difference. The resuits of this study provide no evidence for an association between atherosclerotic coronary arterial heart disease ( AC HD ) and vasectomy.     

The Chinese Association of the Integration of Traditional and Western Medicine 1999 National Congresses

JuneKunmingThe5thNationalAcademicSymposiumonMedicalFirst-AidInformation:91MachangRoad,HexiDistrict,Tianjin,300050DeadlinetApril30,1999JuneJinggangMountainThe8thNationalITWMonTreatmentofSoresInformation:InstituteofSores,TianjinAcademyofTCM169DuolunRoad,HepingDistrict,Tianjin,300020Deadline:December30,1998JulyHuhhotSpecialAcademicSymposiumofOtorhinolaryngologicAllergyInformation:Dr.HouZhiliangHepingliHospital,Beijing,100013Deadline:April20,1999AugustHarbinThe11thNationalI…     

The Chinese Association of the Integration of Traditional and Western Medicine 2003 National Congress

（ＣａｌｌｆｏｒＰａｐｅｒｓ）ＯｃｔｏｂｅｒＳｈａｎｇｈａｉＴｈｅＹｅａｒＷｏｒｋｉｎｇＭｅｅｔｉｎｇｏｆＣＡＩＭ，2 0 0 3Ｉｎｆｏｒｍａｔｉｏｎ：ＮｏｃａｌｌｆｏｒｐａｐｅｒＯｃｔｏｂｅｒＸｉａｍｅｎＩＣＷＭＡｃａｄｅｍｉｃＣｏｎｆｅｒｅｎｃｅｏｆＢｏｔｈＳｉｄｅｓｏｆｔｈｅＳｔｒａｉｔＩｎｆｏｒｍａｔｉｏｎ：Ｍａｉｎｌａｎｄ：Ｄｒ．ＺｈｏｕＳｕｙｕｎ，ＴｈｅＡｃａｄｅｍｉｃＤｅｐａｒｔｍｅｎｔｏｆＣＡＩＭ，　　　 18Ｂｅｉｘｉｎｃａｎｇ，Ｄｏｎｇｚｈｉｍｅｎｎｅｉ，Ｂｅｉｊｉｎｇ（10 0 70 0）…     

An Experimental Comparative Study on the Characteristicsof Ventricular Fibrillation during Cardiac Arrest and Methoxamine Administration

Ventricularfibrillation(VF)isthemostcommoncauseofprimarycardiacar-rest.VFisusua1lyfatalunlessitisprompt-lydiagnosedandappropriatelytreatedwithdefibrillation.Theannualincidenceofcar-diacarrestisestimatedtobeaboutl24/1OOoooinUSA,ofwhichmorethanhalfwascausedbyVF[l'2].VFamplitudemaybere-latedtotheadequacyofmyocardialperfu-sionduringcardiopulmonaryresuscitation(CPR).HighamplitudeVFisknowntofa-cilitatedefibrillation.Methoxamineincreasecoronaryperfusionpressure(CPP)andsur-vivalaftercardiacarr…     

Correlation Between Uric Acid and Hemoglobin in Elderly Patients With Parkinson′s Disease

目的 探讨老年帕金森病(PD)患者血尿酸水平与性别、年龄、病情分级、血红蛋白之间的关系.方法 分别采用尿酸氧化酶传感器检测法、氰化高铁血红蛋白比色法测定100例老年PD患者和100例健康对照者血清尿酸浓度、血红蛋白浓度,比较两组的差异.结果 PD组血清尿酸浓度低于健康对照组(P＜0.05);PD组血红蛋白浓度与健康对照组比较,差异无统计学意义(P＞0.05);PD不同分期组血清尿酸浓度均低于健康对照组(P＜0.05),PD Ⅰ级尿酸浓度＞Ⅱ级＞Ⅲ级＞Ⅳ级＞Ⅴ级;PD组不同年龄段组间血清尿酸浓度差异均无统计学意义(P＞0.05);男性组与女性组尿酸、血红蛋白浓度差异均无统计学意义(P＞0.05).PD组血尿酸与血红蛋白无相关性(P＞0.05).结论 老年帕金森病患者血清尿酸水平降低,但其尿酸水平与性别、年龄无关联,血红蛋白浓度与尿酸无相关性.     

Electrophysiological Characteristics and Radiofrequency Ablation of the Focal Atrial Fibrillation Originating From the Superior Vena Cava(摘要)

Electrophysiological Characteristics and Radiofrequency Ablation of the Focal Atrial Fibrillation Originating From the Superior Vena Cava(摘要)     

A Possible Association of Staphylococcus Enterotoxin B-induced Asthma and Sinusitis

Chronic rhinosinusitis is a multi-variant dis-ease.Bacterial infectionis the accepted cause of a-cute sinusitis in most circumstances,but the cau-ses of chronic sinusitis are more complicated.Staphylococcus aureus(S.aureus)is a commonpathogenthat contributes to both acute and chronicsinusitis[1].S.aureusproduces toxins which mayact as superantigens which may affect lymphocyteupregulation and therefore,have strong i mmuneactivity.It produces toxins such as Staphylococcusenterotoxin B(SEB),S.…     

Association Between IL-13 Gene Polymorphism and Asthma in Han Nationality in Hubei Chinese Population

In order to investigate whether Arg110Gln polymorphism in the coding region of the IL13 gene is associated with asthma and total plasma IgE level in Han nationality in Hubei Chinese population, the allele frequency of 4257 (g/a) site and Arg110Gln genotype of IL-13 was detected by using restriction fragment length polymorphism in Han nationality in Hubei Chinese population including 43 asthmatic children, 45 asthmatic adults, 31 control children and 46 control adults. Total plasma IgE was measured by Chemil.uminescence assay. The results showed that the frequency of allele A at 4257 bp of IL-13 in children and adults was 0.39 and 0.32, respectively. The GlnGln form of Arg110Gln polymorphism of IL-13 gene was associated with susceptibility of asthma and elevated total plasma IgE in children (P =0. 030 and 0. 0009, respectively), but not with them in adults (P=0. 219 and 0. 174, respectively). Our results suggest that the Arg110Gln polymorphism of IL-13 gene is associated with susceptibility of asthma and elevated total plasma IgE in Chinese children of Han nationality in Hubei, but not with them in adults.     

Study on the Relationship Between Neuropeptides,Acth,Cortisol and Polymyositis/Dermatomyositis

Polymyositisanddermatomyositis(PM/DM)isanautoimmunediseasewithunclearpathogenesisandrelatedwithdisturbanceofcellimmunityandhumoralimmunity.ACTHandcortisolplayimportantrolesinmaintainingtheimmunehomeostasis.Asimportantneuropeptides,neuropeptideY(NPY),beta?endorphin(β-EP)andcalcitoningene-relatedpeptide(CGRP)arecorrelatedwithsomeautoimmunediseases,butnorelatedreportabouttherelationshipbetweenNPY,β-EPandPM/DM.WedetectedthelevelsofNPY,β-EP,CGRP,ACTHandcortisolinbloodofPM/DMpati…     

Lupus Myocarditis: A Case–Control Study from China

Background:

Myocarditis is an uncommon but serious manifestation of systemic lupus erythematosus (SLE). This study aimed to investigate clinical characteristics and outcomes of lupus myocarditis (LM) and to determine risk factors of LM in hospitalized Chinese patients with SLE.

Methods:

We conducted a retrospective case–control study. A total of 25 patients with LM from 2001 to 2012 were enrolled as the study group, and 100 patients with SLE but without LM were randomly pooled as the control group. Univariable analysis was performed using Chi-square tests for categorical variables, and the Student''s t-test or Mann–Whitney U-test was performed for continuous variables according to the normality.

Results:

LM presented as the initial manifestation of SLE in 7 patients (28%) and occurred mostly at earlier stages compared to the controls (20.88 ± 35.73 vs. 44.08 ± 61.56 months, P = 0.008). Twenty-one patients (84%) experienced episodes of symptomatic heart failure. Echocardiography showed that 23 patients (92%) had decreased left ventricular ejection fraction (<50%) and all patients had wall motion abnormalities. A high SLE Disease Activity Index was the independent risk factor in the development of LM (odds ratio = 1.322, P < 0.001). With aggressive immunosuppressive therapies, most patients achieved satisfactory outcome. The in-hospital mortality was not significantly higher in the LM group than in the controls (4% vs. 2%,P = 0.491).

Conclusions:

LM could result in cardiac dysfunction and even sudden death. High SLE disease activity might potentially predict the occurrence of LM at the early stage of SLE. Characteristic echocardiographic findings could confirm the diagnosis of LM. Early aggressive immunosuppressive therapy could improve the cardiac outcome of LM.