共查询到19条相似文献,搜索用时 203 毫秒
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糖尿病(diabetes mellitus,DM)是临床常见的全身代谢性疾病,高血糖能促进血管病变而致组织器官缺血,晚期可发生多种急、慢性并发症。因此,加强对糖尿病引发的大血管病变的研究,探讨其危险因素及发病机理、寻求最恰当的诊断方法,对糖尿病患者并发脑、颈动脉及周围血管病变的预防及改善预后十分必要。糖尿病大血管病变可以通过血管超声、DSA、CT血管成像(CTA)及磁共振血管成像(MRA)等进行检查。我们仅重点就血管超声对糖尿病大血管病变的检测进行综述。 相似文献
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2型糖尿病的发病机制为胰岛素抵抗和胰岛素分泌受损.最新的研究结果显示,氧化应激在糖尿病及其并发症的发病机制中起重要作用.在高游离脂肪酸(FFA)条件下,由于活性氧(ROS)产生过多引起的氧化应激可造成胰岛素抵抗和胰岛B细胞功能丧失,导致糖尿病的发生,而血糖升高进一步加重氧化应激,引发大血管和微血管病变,产生糖尿病并发症.通过研究氧化应激在糖尿病及其并发症发病中的作用机制,为防治糖尿病及其并发症提供新的理论依据.机体内多种酶体参与了ROS的生成,如NADPH氧化酶(NOX)、黄嘌呤氧化酶、线粒体呼吸链酶复合体、内皮型一氧化氮合酶(eNOS)及脂氧合酶(LOX)等.本研究旨在探讨NOX源性ROS在糖尿病及其血管并发症发生中的作用机制. 相似文献
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RNA干扰(RNAi)技术是基因分析和基因治疗的重要手段,它在2型糖尿病中的应用涉及功能基因组研究、2型糖尿病发病机制及其心血管并发症研究。RNAi具有高效特异性的特点。然而仍需克服如何避免RNAi衰减现象,如何合理调节多基因表达等困难。 相似文献
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糖尿病脑病研究进展 总被引:1,自引:0,他引:1
王悦 《中华现代内科学杂志》2008,5(5)
目的糖尿病脑病是糖尿病并发症之一,以认知功能障碍为主要表现。此病的发病机制复杂,其诊断标准不明确。本文从糖尿病脑病的发病机制、病理形态改变、临床表现及与Alzheimer病、神经营养因子之间的关系等方面阐述糖尿病脑病的研究现状和进展。 相似文献
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心钠素基因多态性与2型糖尿病肾病易感性的关联研究 总被引:10,自引:0,他引:10
糖尿病肾病是 2型糖尿病的主要晚期并发症之一 ,其确切发病机制及遗传学基础尚未完全阐明。在遗传学水平早期发现糖尿病肾病高危人群 ,并对其进行积极合理的治疗可预防或延缓糖尿病肾病的发生和发展。本研究通过对 2型糖尿病正常白蛋白尿组、临床肾病组 (包括微量白蛋白尿及大量白蛋白尿 )及正常对照组之间心钠素 (ANF)基因C/T多态性频率差异的研究 ,旨在观察ANP基因多态性与 2型糖尿病肾病之间的关联 ,进而评估该基因多态性在 2型糖尿病肾病中的作用。一、对象和方法1.对象 :据 1985年WHO诊断标准确诊的 2型糖尿病患者 (DM组 … 相似文献
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Vascular function in Type 2 diabetes mellitus and pre-diabetes: the case for intrinsic endotheiopathy. 总被引:1,自引:0,他引:1
Diabetic angiopathy is a major cause of morbidity and mortality in Type 2 diabetes mellitus (DM). The pathogenesis of vascular complications in this condition appears to be complex, with distinct differences being observed between Type 1 and Type 2 DM. This review outlines the evidence for these differences and identifies endothelial dysfunction as an important associate and antecedent of Type 2DM, which predisposes to characteristic vascular complications and may also have implications for fetal development. 相似文献
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糖尿病是一种临床常见多发的慢性代谢疾病,严重危害着人类健康与生命。糖尿病的药物治疗对控制血糖和延缓并发症发生十分重要,其中二甲双胍在2型糖尿病药物治疗中具有基石地位。 相似文献
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2型糖尿病(T2DM)的病因和发病机制较为复杂,至今末完全明了.最新研究发现,能量代谢失调或宫内营养障碍等环境因素可以导致DNA甲基化和组蛋白修饰等表观遗传学变化,进而产生"代谢记忆",影响胰岛β细胞的发育和分泌功能,降低机体对胰岛素的敏感性等,最终导敛T2DM的发生.这些表观遗传学改变可被诸如特殊饮食、药物及生活方式重塑等方法予以纠正和逆转,这为T2DM的预防提供了新的思路,为治疗提供了潜在的药物靶点.本文就表观遗传学在T2DM发病及防治中作用的研究进展进行综述,并展单未来表观遗传学在T2DM领域的研究重点和方向. 相似文献
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Metabolic syndrome as a predictor of type 2 diabetes,and its clinical interpretations and usefulness
Jeong‐Ah Shin Jin‐Hee Lee Sun‐Young Lim Hee‐Sung Ha Hyuk‐Sang Kwon Yong‐Moon Park Won‐Chul Lee Moo‐Il Kang Hyeon‐Woo Yim Kun‐Ho Yoon Ho‐Young Son 《Journal of diabetes investigation.》2013,4(4):334-343
Metabolic syndrome is defined as a cluster of glucose intolerance, hypertension, dyslipidemia and central obesity with insulin resistance as the source of pathogenesis. Although several different combinations of criteria have been used to define metabolic syndrome, a recently published consensus recommends the use of ethnic‐specific criteria, including waist circumference as an indicator of central obesity, triglyceride and high‐density lipoprotein (HDL) cholesterol as indicators of dyslipidemia, and blood pressure greater than 130/85 mmHg. The definition of dysglycemia, and whether central obesity and insulin resistance are essential components remain controversial. Regardless of the definition, the prevalence of metabolic syndrome is increasing in Western and Asian countries, particularly in developing areas undergoing rapid socioenvironmental changes. Numerous clinical trials have shown that metabolic syndrome is an important risk factor for cardiovascular disease (CVD), type 2 diabetes mellitus and all‐cause mortality. Therefore, metabolic syndrome might be useful as a practical tool to predict these two major metabolic disorders. Comprehensive management of risk factors is very important to the improvement of personal and public health. However, recent studies have focused on the role metabolic syndrome plays as a risk factor for CVD; its importance in the prediction of incident diabetes is frequently overlooked. In the present review, we summarize the known evidence supporting metabolic syndrome as a predictor for type 2 diabetes mellitus and CVD. Additionally, we suggest how metabolic syndrome might be useful in clinical practice, especially for the prediction of diabetes. 相似文献
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Potentially important new findings have recently been reported concerning the so-called metabolic syndrome in relation to the renin-angiotensin system, ie, that treatment with inhibitors of the angiotensin-converting enzyme (ACE) not only decreases blood pressure levels but prevents the development of diabetes mellitus. The new findings described in this article highlight the potential role of the ACE system in the regulation of insulin sensitivity, thus contributing to the development of type 2 diabetes and metabolic syndrome. In addition to the well known selective effects of ACE inhibitors and angiotensin II receptor blockers in reducing microalbuminuria in diabetic patients, the potential ability of these drugs to reduce the risk of diabetes and the metabolic syndrome would support their use as first line agents not only in diabetic patients but also in selected groups of hypertensive patients, who are particularly at risk of developing metabolic complications. This information supports the Joint Guidelines for the Management of Arterial Hypertension by the European Society of Hypertension and the European Society of Cardiology, which highlight the crucial role of ACE inhibitors and the angiotensin II receptor blockers in preventing the development of diabetes in hypertensive patients. 相似文献
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陈莉明 《国际内分泌代谢杂志》2009,29(3)
餐后状态是指从进食到血浆葡萄糖、游离脂肪酸、氨基酸和甘油三酯等物质恢复到餐前水平的过程.糖尿病患者延迟恢复的餐后高血糖和血脂紊乱造成诸多致动脉粥样硬化的病理生理改变.餐后代谢紊乱早于空腹代谢异常,这是致大血管并发症早发的重要原因.由于餐后代谢紊乱明显影响糖尿病的预后,因此将糖尿病患者餐后血脂、血糖控制在理想范围,是糖尿病长期治疗的目标. 相似文献
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Relationship of residual beta-cell function, metabolic control and chronic complications in type 2 diabetes mellitus 总被引:5,自引:0,他引:5
As the relationships between C-peptide levels and metabolic control and chronic complications are poorly known in type 2
diabetes, due to the slow decline of beta-cell function, we evaluated these associations in a cohort of type 2 diabetic patients.
After excluding insulin-trated subjects, 1533 patients were divided according to their C-peptide fasting levels in quartiles.
Patients within the lowest C-peptide quartile showed significantly higher duration of diabetes, prevalence of retinopathy
and values of HDL-cholesterol, albumin excretion rate and HbA1c, while BMI, diastolic blood pressure, percentages of hypertension
and metabolic syndrome, and values of triglycerides and uric acid were significantly higher in the highest C-peptide quartile.
The associations between C-peptide and duration of diabetes, AER, HbA1c, retinopathy and the components of the metabolic syndrome
remained significant, after multiple adjustments. In conclusion, these data support the hypothesis that a reduced insulin
secretion is associated with a longer duration of diabetes and a greater prevalence of microvascular complications, while
higher insulin levels are associated with the components of the metabolic syndrome.
Received: 21 August 2000 / Accepted in revised form: 5 December 2000 相似文献
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1型糖尿病是由胰岛β细胞自身免疫性破坏引起的一种代谢性疾病.患者体内存在多种针对胰岛细胞自身抗原的自身抗体,成为1型糖尿病的免疫诊断标记物.临床目前最为常用的是胰岛细胞抗体(ICA)、胰岛素自身抗体(IAA)、谷氨酸脱羧酶抗体(GADA)和胰岛细胞瘤相关蛋白(IA)-2抗体,此外,新近发现ZnT8A和胰岛特异性的葡萄糖-6-磷酸酶催化亚基相关蛋白抗体(IG-RPA)可能在诊断上也具有重要的价值.多种自身抗体的组合诊断具有更高的特异性和敏感性.本文针对国内外对1型糖尿病免疫诊断标记物的研究进展情况,详细分析了多种免疫诊断标志抗原的哪功能、特性及在诊断方面的意义和应用. 相似文献
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What does postprandial hyperglycaemia mean? 总被引:3,自引:0,他引:3
R J Heine B Balkau A Ceriello S Del Prato E S Horton M-R Taskinen 《Diabetic medicine》2004,21(3):208-213
AIMS: The potential importance of postprandial glucose (PPG) control in the development of complications in Type 2 diabetes is much debated. The recent American Diabetes Association (ADA) consensus statement discussed the role of postprandial hyperglycaemia in the pathogenesis of diabetic complications and concluded that the relationship between PPG excursions and the well-established risk factors for cardiovascular disease (CVD) should be further examined. Using the ADA statement as a starting point and including the more recent American College of Endocrinology guidelines on glycaemic control, a panel of experts in diabetes met to review the role of PPG within the context of the overall metabolic syndrome, in the development of complications in Type 2 diabetes. RESULTS: Post-prandial hyperglycaemia is a risk indicator for micro- and macrovascular complications, not only in patients with Type 2 diabetes but also in those with impaired glucose tolerance. In addition, the metabolic syndrome confers an increased risk of CVD morbidity and mortality. The debate focused on the relative contributions of postprandial hyperglycaemia, the metabolic syndrome and, in particular, raised triglyceride levels in the postprandial state, to the development of cardiovascular complications of diabetes. CONCLUSIONS: The panel recommended that in the prevention and management of microvascular complications of Type 2 diabetes, targeting both chronic and acute glucose fluctuations is necessary. Lowering the macrovascular risk also requires control of (postprandial) triglyceride levels and other components of the metabolic syndrome. 相似文献