高清不放大窄带成像内镜对大肠隆起性病变的鉴别诊断作用

目的评价窄带成像技术(NBI)普通内镜在大肠隆起样病变诊断中价值。方法应用NBI普通内镜观察了80例患者共103个大肠隆起样病变的表面腺管开口形态。根据工藤进英腺管开口形态分型法,将NBI内镜诊断结果与病理检查结果进行比较。结果普通肠镜发现隆起样病变的敏感性为80.0%(80/103),切换NBI后,能清楚显示隆起样病变的形态和边界,发现隆起样病变的敏感性为100%(103/103);NBI普通内镜观察隆起样病变腺管开口,根据工藤进英腺管开口形态分型法进行诊断,其中腺管开口呈Ⅱ型18例,Ⅲ(L)型54例,Ⅳ型15例,Ⅴ型16例。NBI普通内镜对于大肠隆起性病变肿瘤及非肿瘤性的鉴别诊断的敏感性、特异性分别为95.3%(81/85)、83.3%(15/18)、NBI普通内镜对于大肠隆起性病变肿瘤及非肿瘤性的鉴别诊断的符合率为93.2%(96/103),与文献报道的NBI放大内镜的94.1%无统计学差异(P0.05)。结论应用NBI普通内镜,也可以通过观察腺管开口形态,比较准确地鉴别诊断大肠肿瘤与非肿瘤病变。     

窄带成像技术普通内镜诊断大肠肿瘤的价值

目的探讨窄带成像技术普通内镜（NBI）诊断大肠肿瘤的临床价值。方法 2012年6月至2012年8月行常规内镜和NBI普通内镜检查的患者225例,对发现的大肠新生性病变记录腺管开口形态,将NBI内镜诊断和病理组织学诊断结果进行对比分析,并比较NBI内镜与常规内镜在鉴别肿瘤性和非肿瘤性病变的敏感性、特异性和准确性。结果 NBI普通内镜对腺管开口类型的判断接近病理水平,鉴别病变是否为肿瘤的敏感性、特异性、准确率分别为93.6%,91.7%和93.0%,显著高于常规内镜（P〈0.01）。结论 NBI普通内镜能较准确判断病变的性质,为鉴别是否为肿瘤性病变的更有效的内镜方法。     

窄带成像放大内镜鉴别大肠肿瘤性与非肿瘤性病变的价值

目的 探讨窄带成像放大内镜（NBI—ME）鉴别大肠肿瘤性与非肿瘤性病变表面网状微血管结构改变的临床价值。方法选择常规内镜检出大肠肿瘤性、非肿瘤性病变144处（102例）,记录NBI—ME观察病变表面微血管结构（CP）形态和染色放大内镜观察病变黏膜表面腺管开口（pit）形态。分析pit周围CP形态变化,比较两者形态间的关系。所有病变经内镜或手术治疗后行组织病理学检查。结果常规内镜鉴别病变是否为肿瘤性的准确率75．7％、敏感性85．1％、特异性40．0％,明显低于NBI—ME和染色放大内镜（P〈0．005）,NBI—ME和染色放大内镜间则未见差异。CP分型与pit分型对照,CP—Ⅰ型、Ⅱ型、Ⅳ型、Ⅵa型分别与pitⅠ型、Ⅱ型、Ⅳ型、Ⅴ1型间一致性达100％。144处病变中,内镜治疗129处,手术治疗15处。组织病理学检查：非肿瘤性30处（增生性息肉17处、炎症性息肉13处）;肿瘤性114处（腺瘤95处、腺癌19处）。结论初步显示NBI—ME和染色放大内镜之间具有正相关性,两种检查方法互补可作为当前鉴别大肠病变是否为肿瘤性的重要手段。     

内镜醋酸染色结合窄带成像对大肠肿瘤性和非肿瘤性病变的鉴别诊断价值

目的 评价醋酸染色结合普通窄带成像(NBI)内镜观察对大肠新生性病变的病理组织学的预测能力.方法 105例接受结肠镜检查的患者,诊断大肠新生性病变148个,分别用普通白光、单一NBI及醋酸染色结合NBI的方法观察,根据腺管形态分型、微血管形态分型、黏膜白化时间预测病变为肿瘤性或非肿瘤性,并与病理结果对照判断其敏感度、特异度和准确率.结果 醋酸染色结合NBI对大肠肿瘤性病变诊断的总符合率为91.2％ (135/148),明显高于普通白光内镜的79.1％(117/148) (x2=8.649,P=0.003),高于单一NBI的86.5％(128/148),但醋酸染色结合NBI与单一NBI比较差异无统计学意义(x2=1.671,P=0.196).醋酸染色结合NBI的腺管形态分型、微血管形态分型、黏膜白化时间鉴别肿瘤性和非肿瘤性病变的敏感度分别是90.6％、94.1％、88.2％,特异度分别是90.5％、85.7％、92.1％,准确率分别是90.5％、90.5％、89.9％.结论 醋酸染色结合NBI对鉴别大肠肿瘤性或非肿瘤性病变具有可靠的诊断价值,可以初步判断病变的病理类型,对治疗方法的选择及疗效和预后的判断有指导意义.     

窄带成像放大内镜技术鉴别大肠肿瘤性病变与非肿瘤性病变的研究

[目的]探讨窄带成像放大内镜技术(NBI-ME)鉴别大肠肿瘤性病变与非肿瘤性病变的研究。[方法]本研究病例来源于我院内镜室2012年3月~2015年3月期间行结肠镜检查的413例患者,发现大肠新生物或息肉样病变者156例入选作为研究对象。分别采用普通内镜技术与NBI-ME内镜技术鉴别大肠肿瘤性病变与非肿瘤性病变准确性、特异性、敏感性及清晰度。[结果]NBI-ME内镜诊断肿瘤性病变准确性94.8%、特异性93.9%、敏感性94.3%,普通内镜诊断肿瘤性病变准确性68.5%、特异性71.2%、敏感性70.6%。NBI-ME内镜诊断肿瘤性病变准确性、特异性、敏感性均明显高于普通内镜(P0.05);NBI-ME内镜检测微血管、腺管开口形态及病变轮廓清晰度评分均明显高于普通内镜,且差异有统计学意义(P0.05)。[结论]NBI-ME鉴别大肠肿瘤性病变与非肿瘤性病变准确性高、特异性高、敏感性高,且能够更清晰地显示微血管形态、腺管开口形态及病变轮廓,故而该技术具有重要诊断鉴别意义。     

内镜窄带成像放大技术和染色放大技术诊断结直肠癌及其癌前病变的对比研究

目的 探讨窄带成像(NBI)放大内镜和染色放大内镜对结直肠肿瘤性和非肿瘤性病变的鉴别诊断价值.方法 75例患者92处病变分别在常规内镜模式、NBI放大模式及染色放大模式下进行观察,对发现的病变进行腺管开口分型及血管形态分型,将内镜诊断结果与病理诊断结果进行对比分析.结果 常规内镜检出87处(94.6％)病灶,NBI放大内镜检出90处(97.8％),染色放大内镜全部检出(100.0％).在病变轮廓、微血管形态的图像显示上NBI放大内镜明显优于染色放大内镜(P=0.000),在腺管开口形态的图像显示上NBI放大内镜与染色放大内镜比较差异无统计学意义(P=0.394).NBI放大内镜诊断结直肠肿瘤性病变的符合率、敏感度、特异度分别为91.3％(84/92)、83.9％ (26/31)、95.1％ (58/61),染色放大内镜则对应分别为89.1％(82/92)、80.6％(25/31)、93.4％(57/61),两者比较差异均无统计学意义(P＞0.05).结论 NBI放大内镜和染色放大内镜对结直肠肿瘤性、非肿瘤性病变的鉴别效果相似,但NBI放大内镜能更为清晰地显示病变轮廓、微血管形态,且操作转换简单快捷,更易于临床推广应用.     

窄带成像技术在大肠肿瘤性病变与非肿瘤性病变的鉴别诊断中的价值

目的探讨窄带成像技术(narrow band imaging,NBI)在大肠肿瘤性病变与非肿瘤性病变的鉴别诊断中的价值。方法收集2010年1月-2013年10月在梧州红十字会医院内镜室进行结肠镜检查的患者98例,通过普通肠镜、NBI检查结果与病理学检查结果进行对比分析,鉴别诊断大肠肿瘤性病变与非肿瘤性病变。结果 98例患者中共发现136个病变。普通内镜诊断肿瘤性病变的敏感性、特异性及准确性分别为75.5%、78.6%及76.5%;NBI诊断肿瘤性病变的敏感性、特异性及准确性分别为95.7%、95.2%及95.6%,后者明显高于前者,差异有统计学意义(P0.01)。病变轮廓、pit及CP显示清晰度比较,NBI明显优于普通内镜,差异均有统计学意义(P0.01)。结论相对于普通内镜,NBI内镜能更清晰地显示病变的轮廓、腺管开口的分型及微血管的形态,在大肠肿瘤性病变与非肿瘤性病变的鉴别诊断中有重要价值。     

内镜智能分光比色与染色技术对大肠肿瘤诊断价值的研究

目的 探讨内镜智能分光比色技术(FICE)与染色技术鉴别大肠肿瘤及非肿瘤性病变的价值.方法 选择2007年3月至2008年5月间245例入选病例,分别采用常规放大技术、FICE放大技术及染色放大技术对病变进行腺管开口分型及毛细血管形态观察,对病变做出诊断,并与病理组织学诊断相比较.结果 在245例患者中发现新生性病变480个,其中常规放大内镜下发现病变90.0%(432/480),FICE放大模式下发现病变98.8%(474/480),差异有统计学意义(P<0.01).FICE放大内镜比染色放大内镜更能清晰显示黏膜毛细血管结构形态(P<0.01),在显示腺管开口方面两者差异无统计学意义.FICE放大内镜对肿瘤性及非肿瘤性病变判断的符合率为92.2%(437/474),染色放大内镜符合率为81.0%(389/480),前者高于后者(P<0.01).结论 FICE放大内镜可以观察黏膜表面微细结构及毛细血管形态,比普通放大内镜及染色放大内镜对大肠肿瘤性及非肿瘤性病变鉴别诊断的符合率高,操作转换简便,可指导对病变进行靶向活检,有良好的临床实用价值.     

内镜智能分光比色技术对大肠肿瘤性病变的诊断价值

目的探讨内镜智能分光比色技术（HCE）在诊断大肠肿瘤性病变的价值。方法581例患者进行常规内镜检查，其中197例入选。分别采用常规放大技术、HCE放大技术及染色放大技术对病变进行腺管开口分型及毛细血管形态观察，并与病理学诊断相比较。结果在197例病人中发现新生性病变398个，其中常规放大内镜下发现病变361个（90．8％），FICE放大模式下发现病变393（98．7％）。HCE放大内镜对肿瘤性及非肿瘤性判断符合率为90．2％（359／398），高于染色放大内镜82．4％（328／398）（P=0．001）。结论HCE放大内镜对大肠肿瘤性及非肿瘤性病变诊断的符合率高于普通放大内镜及染色放大内镜．有利于发现平坦型病变。     

内镜窄带成像与染色技术诊断大肠肿瘤的对比研究

目的通过窄带成像技术（NBI）和染色放大方法对大肠新生性病变进行观察，比较这两种技术对大肠肿瘤及非肿瘤性病变的鉴别诊断精度差异。方法2006年6月至9月间，共302例年龄在加至80岁之间的患者进行了NBI肠镜检查，其中98例入选。内镜插入至回盲部，退镜时分别采用常规模式、NBI模式观察，发现病变后，分别用NBI模式及染色放大方法进行血管分型及腺管开口分型，然后行病理检查进行评价比较。结果在98例患者发现新生性病变147个，其中常规内镜下发现的病变有90．5％（133／147），采用NBI发现病变有98．6％（145／147），差异有统计学意义（P〈0．01），漏诊的主要为平坦型病变。NBI观察对肿瘤性或非肿瘤的判断符合率为91．8％，染色内镜为82．3％（P〈0.01）。结论NBI技术观察黏膜表面变化，判断肿瘤或非肿瘤病变的符合率比普通内镜和染色内镜高，敏感性强；操作转换简单易行，尤其有利于平坦型病变的发现及诊断。     

智能染色内镜诊断结肠病变腺管开口的临床价值及Ang-2表达、MVD值与腺管开口相关性研究

目的探讨FICE放大内镜对结肠瘤性、非瘤性病变的诊断价值以及血管生成素-2（Ang-2）表达、肿瘤微血管密度（MVD）与腺管开口的相互关系。方法选择富士能智能染色内镜（FICE）放大观查判定腺管开口为Ⅰ～Ⅴ型的结肠病变标本（Ⅰ～Ⅴ型各20例）,Ⅰ、Ⅱ型纳入A组,Ⅲ、Ⅳ型纳入B组,Ⅴ型纳入C组。对照病理诊断结果,判断FICE放大内镜对结肠病变的诊断价值。并采用免疫组化SP法分别测定不同腺管开口结肠病变中Ang-2表达情况及MVD值,分析3者间的相互关系。结果FICE放大内镜对非瘤性病变诊断的敏感性和特异性分别为88．0％和92．5％,符合率为90．2％;对瘤性病变诊断的敏感性和特异性分别为94．8％和91．7％,符合率为93．2％;对结肠病变诊断的总符合率为92．0％。结肠病变中Ang-2的阳性表达率和MVD值在A组（Ⅰ、Ⅱ型合并组）、B组（Ⅲ、Ⅳ型合并组）、C组（腺管开口V型）3组逐渐升高。且Ang-2阳性表达组MVD值明显增高。结论FICE放大内镜对结肠病变腺管开口分型的判断可基本准确区别瘤性、非瘤性病变,结肠病变中Ang-2的阳性表达、肿瘤血管的生成与其腺管开口关系密切。     

Usefulness of magnifying narrow-band imaging endoscopy for the diagnosis of gastric and colorectal lesions

A series of studies about the potential usefulness of magnifying endoscopy with narrow-band imaging (NBI) for the diagnosis of gastric and colonic lesion is reviewed. Concerning the magnifying NBI appearances of gastric lesions, a light blue crest is a highly accurate sign of the presence of histological intestinal metaplasia. Also, the degree of irregularity of the mucosal and vascular pattern is correlated with the histological severity of Helicobacter pylori-associated chronic gastritis. According to the 'VS classification', an irregular microvascular pattern and/or an irregular microsurface pattern together with a clear demarcation line are characteristic for early gastric carcinoma, and a multicenter prospective randomized controlled trial demonstrated that magnifying endoscopy with NBI is superior to ordinary white light endoscopy for making a differential diagnosis of a small depressed lesion between carcinoma and non-carcinoma. Concerning the magnifying NBI appearances of colonic tumor, the vague or invisible microvascular pattern is mostly observed in hyperplastic polyp. The regular meshed microvascular pattern is mostly observed in adenoma. The irregular meshed microvascular pattern is mostly observed in intramucosal or shallow submucosal-invasive carcinoma. The decreased or loose microvasucular pattern is mostly observed in deep submucosal-invasive carcinoma. Thus, magnifying NBI endoscopy is useful for the differentiation of colorectal non-adenomatous lesions from adenoma, the differentiation of adenoma from carcinoma, and the assessment of invasion depth of early colorectal carcinoma. At present, several magnifying NBI classifications for the diagnosis of early colorectal neoplasia have been proposed in Japan. Recently, the NICE classification based on NBI findings with/without magnification for colorectal tumor was established by an international group.     

Narrow-band imaging endoscopy with and without magnification in diagnosis of colorectal neoplasia

AIM:To evaluate the diagnostic efficacies of narrowband imaging(NBI) endoscopy with and without high magnification in distinguishing neoplasia from nonneoplasia colorectal lesions.METHODS:A total of 118 patients with 123 colorectal lesions examined by NBI endoscopy in the Zhejiang Provincial People's Hospital from September 2008 to April 2010 were enrolled in this study.These lesions were classified by pit pattern and capillary pattern,and then assessed by histopathology.RESULTS:Ten lesions not meeting the ...     

A comparison of magnifying and nonmagnifying colonoscopy for diagnosis of colorectal polyps: A prospective study

BACKGROUND: Discrimination between neoplastic and non-neoplastic colorectal polyps is essential for determining appropriate treatment. The mucosal crypt pattern of polyps can be observed with a nonmagnifying colonoscope; however, mucosal crypt patterns are better seen by magnifying colonoscopy, which can also be a noninvasive means for predicting histopathology. This study prospectively compared the ability to distinguish between neoplastic and non-neoplastic lesions by magnifying and nonmagnifying colonoscopy. METHODS: Six hundred sixty patients were randomly assigned to undergo magnifying or nonmagnifying colonoscopy (2 groups each of 330 patients). The mucosal crypt pattern of colorectal lesions was classified into types I through V after spraying with 0.2% Indigo carmine dye. The histopathology of all lesions was confirmed by evaluation of endoscopic resection specimens or biopsy specimens. Only lesions 10 mm or less in diameter were included in the study. RESULTS: The accuracy of magnifying colonoscopy in distinguishing neoplastic from non-neoplastic lesions (92%, 372/405) was significantly higher than for nonmagnifying colonoscopy (68%, 278/407). Insertion of magnifying and nonmagnifying colonoscopes to the cecum was successful in, respectively, 321 patients (97%) and 317 patients (96%), with no significant differences in the average time to reach the cecum or average total procedure time. No serious complication was observed during or immediately after the examinations. CONCLUSIONS: Observation of mucosal crypt pattern with magnifying colonoscopy is superior to nonmagnifying colonoscopy for distinguishing between neoplastic and non-neoplastic colorectal lesions.     

Diagnostic performance of magnifying endoscopy with narrow-band imaging in differentiating neoplastic colorectal polyps from non-neoplastic colorectal polyps: a meta-analysis

Colorectal polyps are commonly seen in colonoscopy and the management of neoplastic polyps and non-neoplastic polyps are different. It is necessary to distinguish neoplastic polyps from non-neoplastic polyps in real-time. Therefore, we conducted a meta-analysis to assess the diagnostic accuracy of magnifying endoscopy with narrow-band imaging (ME-NBI) in diagnosing neoplastic colorectal polyps from non-neoplastic colorectal polyps. PubMed and EMBASE were searched for trials that used magnifying endoscopy with ME-NBI for diagnosing neoplastic colorectal polyps. Sixteen articles and 20 fourfold tables were obtained. Sensitivity (Sen), specificity (Spe), positive likelihood ratios (+ LRs), negative likelihood ratios (− LRs) and diagnostic odds ratios (DORs) were calculated. A summary receiver-operating characteristic (SROC) curve was constructed, and the area under the ROC curve (AUC) was calculated. We performed subgroup analyses based on polyp size and assessment criteria: (1) According to data extracted from 20 fourfold tables, the pooled Sen and Spe of ME-NBI for diagnosing neoplastic colorectal polyps < 10 mm were 0.94 (95% CI 0.92–0.95) and 0.76 (95% CI 0.72–0.80),respectively. The pooled Sen and Spe of ME-NBI for diagnosing all neoplastic polyps were 0.98 (95% CI 0.98–0.99) and 0.88 (95% CI 0.85–0.90), respectively. (2) Data pertaining to the following three assessment methods were analysed from 15 fourfold tables: surface pattern (SP), vessel pattern (VP) and the combination of SP and VP. The AUCs for these assessment criteria were 0.9533, 0.9518 and 0.9954, respectively. Conclusions were made that ME-NBI has high diagnostic accuracy in diagnosing neoplastic colorectal polyps based on the combination of SP with VP and is helpful in making real-time diagnoses.

     

A prospective comparative study of narrow-band imaging, chromoendoscopy, and conventional colonoscopy in the diagnosis of colorectal neoplasia

BACKGROUND: Discrimination between neoplastic and non-neoplastic lesions is crucial in colorectal cancer screening. Application of narrow-band imaging (NBI) in colonoscopy visualises mucosal vascular networks in neoplastic lesions and may improve diagnostic accuracy. AIM: To compare the diagnostic efficacy of NBI in differentiating neoplastic from non-neoplastic colorectal lesions with diagnostic efficacies of standard modalities, conventional colonoscopy, and chromoendoscopy. METHODS: In this prospective study, 180 colorectal lesions from 133 patients were observed with conventional colonoscopy, and under low-magnification and high-magnification NBI and chromoendoscopy. Lesions were resected for histopathological analysis. Endoscopic images were stored electronically and randomly allocated to two readers for evaluation. Sensitivity, specificity and diagnostic accuracy of each endoscopic modality were assessed by reference to histopathology. RESULTS: NBI and chromoendoscopy scored better under high magnification than under low magnification in comparison with conventional colonoscopy. The diagnostic accuracy of NBI with low or high magnification was significantly higher than that of conventional colonoscopy (low magnification: p = 0.0434 for reader 1 and p = 0.004 for reader 2; high magnification: p<0.001 for both readers) and was comparable to that of chromoendoscopy. CONCLUSION: Both low-magnification and high-magnification NBI were capable of distinguishing neoplastic from non-neoplastic colorectal lesions; the diagnostic accuracy of NBI was better than that of conventional colonoscopy and equivalent to that of chromoendoscopy. The role of NBI in screening colonoscopy needs further evaluation.     

Narrow‐band imaging (NBI) magnifying endoscopic classification of colorectal tumors proposed by the Japan NBI Expert Team

Many clinical studies on narrow‐band imaging (NBI) magnifying endoscopy classifications advocated so far in Japan (Sano, Hiroshima, Showa, and Jikei classifications) have reported the usefulness of NBI magnifying endoscopy for qualitative and quantitative diagnosis of colorectal lesions. However, discussions at professional meetings have raised issues such as: (i) the presence of multiple terms for the same or similar findings; (ii) the necessity of including surface patterns in magnifying endoscopic classifications; and (iii) differences in the NBI findings in elevated and superficial lesions. To resolve these problems, the Japan NBI Expert Team (JNET) was constituted with the aim of establishing a universal NBI magnifying endoscopic classification for colorectal tumors (JNET classification) in 2011. Consensus was reached on this classification using the modified Delphi method, and this classification was proposed in June 2014. The JNET classification consists of four categories of vessel and surface pattern (i.e. Types 1, 2A, 2B, and 3). Types 1, 2A, 2B, and 3 are correlated with the histopathological findings of hyperplastic polyp/sessile serrated polyp (SSP), low‐grade intramucosal neoplasia, high‐grade intramucosal neoplasia/shallow submucosal invasive cancer, and deep submucosal invasive cancer, respectively.     

基于蓝光成像放大结肠镜的JNET分型对结直肠肿瘤性病变诊断价值的研究

目的探讨蓝光成像放大内镜(blue-laser imaging magnifying endoscope,BLI-ME)下JNET(Japan NBI Expert Team)分型对结直肠肿瘤性病变的诊断效力。方法选取2016年9月—2018年12月间入院接受蓝光成像放大精查患者的内镜图片,4位高年资内镜医师对上述病变图片进行JNET分型并预测其病理类型。以病理结果为金标准评估读片的诊断效力。结果入选34例患者的40个病变,包括非肿瘤性病变3个、腺瘤20个、高级别上皮内瘤变/黏膜下浅层癌10个、黏膜下深层癌7个。4位医师诊断准确率为75.00%~87.50%,JNET各型准确率为65.38%~95.89%。分别计算JNET各型的诊断效力,灵敏度为60.71%~91.67%,特异度为84.17%~97.73%,阳性预测值为63.46%~95.89%,阴性预测值为88.51%~99.31%;对于表面结构判断的信心为73.08%~100.00%,表面微血管形态信心80.77%~100.00%,总体分型信心67.31%~100.00%。任意两位医师间契合度Kappa值为0.630~0.887,4位医师总体相关系数为0.880。结论基于蓝光成像放大观察对结直肠肿瘤性病变进行JNET分型具有较好的诊断能力。