共查询到17条相似文献,搜索用时 187 毫秒
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目的 探讨胶囊结肠镜下结肠黏膜损伤的内镜影像学特点对诊断溃疡性结肠炎的临床价值.方法 连续收集2009年7月至2010年6月间19例患者,其中男12例、女7例,平均年龄(44.2±14.6)岁,入组者以血便、腹泻、腹痛为主要临床表现,具备溃疡性结肠炎相关诊断依据.研究中将胶囊结肠镜和传统结肠镜下结肠黏膜病变严重程度分为轻、中、重三级,以传统结肠镜诊断为金标准,统计胶囊结肠镜与传统结肠镜下黏膜分级的一致性(Kappa值和P值),并同时观察胶囊结肠镜检查过程中肠道清洁度、全结肠检查完成率、患者不良反应等情况.结果 胶囊结肠镜下黏膜轻度病变2例,中度8例,重度9例;而传统结肠镜下则轻度3例,中度8例,重度8例.经统计Kappa=0.826,确切概率计算P<0.001,提示一致性良好.胶囊内镜全结肠检查完成率达100%(19/19),肠道清洁度优良率达79%(15/19),检查全过程中未出现明显不良反应.结论 胶囊结肠镜能客观反映溃疡性结肠炎患者黏膜病变程度,具有部分替代传统结肠镜进行结肠病变监测的价值. 相似文献
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目的 探讨胶囊结肠镜下结肠黏膜损伤的内镜影像学特点对诊断溃疡性结肠炎的临床价值.方法 连续收集2009年7月至2010年6月间19例患者,其中男12例、女7例,平均年龄(44.2±14.6)岁,入组者以血便、腹泻、腹痛为主要临床表现,具备溃疡性结肠炎相关诊断依据.研究中将胶囊结肠镜和传统结肠镜下结肠黏膜病变严重程度分为轻、中、重三级,以传统结肠镜诊断为金标准,统计胶囊结肠镜与传统结肠镜下黏膜分级的一致性(Kappa值和P值),并同时观察胶囊结肠镜检查过程中肠道清洁度、全结肠检查完成率、患者不良反应等情况.结果 胶囊结肠镜下黏膜轻度病变2例,中度8例,重度9例;而传统结肠镜下则轻度3例,中度8例,重度8例.经统计Kappa=0.826,确切概率计算P<0.001,提示一致性良好.胶囊内镜全结肠检查完成率达100%(19/19),肠道清洁度优良率达79%(15/19),检查全过程中未出现明显不良反应.结论 胶囊结肠镜能客观反映溃疡性结肠炎患者黏膜病变程度,具有部分替代传统结肠镜进行结肠病变监测的价值. 相似文献
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胶囊结肠镜(CCE)是一种检查结肠黏膜病变的新型胶囊内镜。最初用于结肠癌的筛查,目前逐渐用于炎症性肠病,尤其是溃疡性结肠炎的诊断和病情评估。CCE在临床应用方面与传统结肠镜相比各有优劣。本文就CCE的临床应用现状作一综述。 相似文献
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老年性溃疡性结肠炎的内镜下表现分析 总被引:1,自引:0,他引:1
目的探讨老年性溃疡性结肠炎(UC)内镜下表现和特点。方法行充分的肠道准备后电子结肠镜插至回盲部。观察各段肠管病变情况。发现病变或有息肉、肿块等行病理活检。结果病变范围以左半结肠常见(86%),病例100%可见黏膜广泛充血水肿,94%见点片状糜烂、溃疡,但溃疡面浅小,未见不典型增生及癌变。结论老年UC具有病情轻、病程短,左半结肠常见,广泛充血水肿、糜烂、浅小溃疡、癌变率低等特点,其他有黏膜质脆易出血、血管纹理模糊或消失、黏膜粗糙颗粒感和炎性息肉形成等表现。经济、安全、痛苦少的电子结肠镜应成为诊断老年性UC的主要方法,值得临床推广。 相似文献
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454例溃疡性结肠炎的临床及内镜检查分析 总被引:8,自引:0,他引:8
目的探讨结肠镜结合黏膜染色及活检组织病理学检查在溃疡性结肠炎(Ulcerative colitis,uc)诊断中的意义。方法 回顾分析我院5年来确诊的454例UC。结果本组454例UC中。发病以21~50岁为主(75.2%),临床表现以黏液血便或脓血便(60.6%)及腹痛(41.2%)为主。病变分布以直肠、直乙状结肠及左半结肠最多见(63.7%)。结肠镜下表现以黏膜充血水肿(93.6%)伴糜烂(91.4%)或浅溃疡(62.6%)最常见。结论结肠镜检查结合黏膜染色及活检组织病理学检查对UC的诊断具有重要价值。 相似文献
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目的探讨儿童结肠镜检查的临床应用价值及安全性。方法对北京军区总医院2008年1月-2012年12月192例因腹痛、便血、腹泻、腹胀等症状就诊的患儿行结肠镜检查,并对患儿的临床资料进行分析。结果共129例患儿首次结肠镜检查完成全结肠镜检查,结肠镜检查完成率67.2%。32例患儿进镜过程中发现病变后退镜。病变部位主要为乙状结肠及直肠。病变主要为结肠息肉、结肠炎、过敏性紫癜、嗜酸粒细胞性肠炎、移植物抗宿主病、炎症性肠病等。91例便血患儿中61例发现大肠息肉。结论结肠镜检查及内镜下治疗对小儿肠道疾病诊断安全有效,并发症发生率低。小儿结肠病变常见部位为乙状结肠及直肠。小儿便血最常见原因为结肠息肉。 相似文献
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朱明钦 《中华消化内镜杂志》1995,(2)
内镜及组织学对溃疡性结肠炎病变范围的估价朱明钦我院自1976~1990年进行全结肠镜检共2264例次,其中诊断为溃疡性结肠炎(简称溃结)64次(56例),占结肠镜检查数的2.8%,内镜检查中除详细描述溃结炎症病变所累及的肠段外,并常规作6个肠段的活检... 相似文献
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Masahiko Tsujij Sunao Kawano Shingo Tsuji Ichizo Kobayashi Yoshiyuki Takei Kouichi Nagano Hideyuki Fusamoto Takenobu Kamada Tatsuo Ogihara Nobuhiro Sato 《Journal of gastroenterology》1995,30(2):183-188
Colonic mucosal hemodynamics were investigated at the rectosigmoidal region of the colon in 46 patients with ulcerative colitis and in 18 normal subjects by organ reflectance spectrophotometry under colonoscopy. The value for the index of mucosal hemoglobin concentration (IHb) was significantly higher, and value for the index of mucosal hemoglobin oxygen saturation (ISO2) was significantly lower in patients with active ulcerative colitis than values in the normal controls or in patients with inactive ulcerative colitis. The results indicate mucosal congestion and hypoxemia in patients with active ulcerative colitis. The changes in IHb and ISO2 correlated well with the severity of ulcerative colitis scored by endoscopic findings and with the number of infiltrating inflammatory cells in the mucosa analyzed histologically in biopsy samples. In conclusion, the colonic mucosal microcirculation in patients with active ulcerative colitis was disturbed and showed congestion and hypoxemia. The analysis of hemodynamic changes may be helpful for assessing the activity of ulcerative colitis. 相似文献
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Wu HG Zhou LB Shi DR Liu SM Liu HR Zhang BM Chen HP Zhang LS 《World journal of gastroenterology : WJG》2000,6(6):861-865
AIM:To observe the therapeutic effect of moxibustion on ulcerative colitis and its influence on the colonic mucosal morphology.METHODS:Forty-six patients with ulcerative colitis were randomly divided into the moxibustion with herbal medicine underneath group and the western medicine group. Thirty patients were treated with the above moxibustion and 16 patients with Salicylaye fapyridine (SASP).The colonic mucosa of 13 patients in the moxibustion group was observed by colonoscopy before and after the treatment. Mucin was also analyzed by H.E and AB-PAS staining.RESULTS:Seventeen patients were clinically cured,12 were improved and 1 unchanged in the moxibustion group. In the control group, 5 patients were clinically cured,7 improved and 4 unchanged. Thirteen patients with active UC were taken as the subjects for histopathologic analysis in this study. The colonic mucosal lesions were remarkably improved and the characteristic of the mucin also changed. In most sections, the chronic inflammation of mucosa was geatly ameliorated (P< 0.01). The inflammatory cell infiltratation much decreased and neutrophils, disapeared in most sections (P<0.001). The goblet cells significantly increased (P<0.001); crypt paracrypt abscess or mucosal ulceration was seen(P<0.001).CONCLUSION:The rate of cure of ulcerative colitis by moxibustion with herbal medicine beneath is superior to that by SASP. This sort of moxibustion can effectively improve the colonic mucosal lesions and restore the proportion of mucoprotein to near normal. 相似文献
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Activation of enzyme phospholipase A2 (EC 3.1.1.4), the major liberator of arachidonic acid, has been proposed as a component in the pathogenesis of inflammatory bowel disease. To test the hypothesis that phospholipase A2 activity is increased in ulcerative colitis, enzyme activity was investigated in colonic biopsies using radiolabelled Escherichia coli as substrate. The study comprised patients with ulcerative colitis (n = 19) and controls without inflammatory bowel disease (n = 7). Ulcerative colitis patients were grouped into those with active disease (n = 8) and those in remission (n = 11) at the time of colonoscopy. No differences were found in mucosal phospholipase A2 activity between patients with active disease, patients in remission and controls. With the present assay we were unable to demonstrate activation of phospholipase A2 as a mechanism in the inflammatory process of ulcerative colitis. 相似文献
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DNA flow cytometric evaluation of cell cycle distribution in ulcerative colitis: a proposed method for assessing severity of disease. 总被引:1,自引:0,他引:1
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F Bortoluzzi M Valentini C Cernigoi G Toffoli M Boiocchi M Poletti M Sozzi M Fornasarig R Cannizzaro E Bertolissi 《Gut》1995,36(1):50-54
The assessment of disease severity in ulcerative colitis depends mainly on subjective variables, and an objective method of assessing mucosal inflammation is needed. Determination of the synthetic phase of the cell cycle is an accurate expression of inflammatory activity in the colonic mucosa. The aim of the study was to find out if the proliferative index or the synthetic phase (S phase) of the colonic mucosa of patients with ulcerative colitis, as evaluated by DNA flow cytometry, is a reliable and reproducible marker of disease activity. Sixty consecutive patients with ulcerative colitis of different degrees of activity were entered into the study and submitted to colonoscopy plus multiple rectal biopsies. Disease severity was defined for each patient by means of a clinical, endoscopic, and histological score. Flow cytometry was used to calculate the proliferative index and the S phase of the cell cycle. A statistically significant correlation (p < 0.001) was found between all indices of severity. It is suggested that flow cytometric evaluation of the cell cycle in the rectal mucosa may be an efficient method of assessing severity of disease and efficacy of medical treatment in ulcerative colitis. 相似文献
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Colon capsule endoscopy (CCE) is designed for direct visualization of the colonic mucosa through passive propulsion. The role of CCE in the detection of colonic polyps has been extensively evaluated. As mucosal healing has emerged as a pivotal target for treatment of inflammatory bowel disease (IBD), there is increasing data to suggest that CCE can also be used in the monitoring of mucosal inflammation in patients with active IBD, particularly in ulcerative colitis (UC) and Crohn's disease (CD). Despite advantages such as its non‐invasive nature, patient's comfort, safety, and access to anatomical regions not easily reached by conventional endoscopy, CE has limitations including the lack of ability to obtain biopsies or therapeutic capabilities and no control over movement. In this review, the role and diagnostic value of CCE on diagnosis and monitoring of UC and CD patients, its safety and limitations are discussed. 相似文献
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Protection by recombinant human interleukin-11 against experimental TNB-induced colitis in rats 总被引:11,自引:0,他引:11
B. S. Qiu MD PhD Professor C. J. Pfeiffer PhD J. C. Keith Jr. DVM PhD 《Digestive diseases and sciences》1996,41(8):1625-1630
The potential effect of recombinant human interleukin-11 (rhIL-11) on trinitrobenzene sulfonic acid (TNB) -induced colitis was investigated in rats. Intrarectal TNB (40 mg in 0.25 ml 40% ethanol) produced significant ulcerative colitis. The lesions were most severe at three days after TNB instillation, and then declined, but lesions were still observed after two weeks. TNB administration also significantly enhanced the colonic mucosal myeloperoxidase (MPO) levels, which paralleled the severity of colitis. The rhIL-11 at subcutaneous doses of 300 or 1000µg/kg daily for seven days, or 1000µg/kg for three days when given after TNB significantly decreased lesion formation in TNB-induced colitis. These treatments also significantly reduced colonic mucosal MPO levels. TNB enhanced colonic mucosal levels of PGE2, LTB4, and TxB2, but these arachidonic acid derivatives were not affected by the present rhIL-11 treatments. TNB administration for three days caused a body weight loss that returned to normal after 14 days. The rhIL-11 significantly reduced colonic lesion severity and reduced colonic fecal blood loss. Given alone, rhIL-11 did not influence body weight. It can be concluded that rhIL-11 was protective against TNB-induced colitis and reactions of colonic MPO, but that these responses were not mediated through modulation of eicosanoid metabolism.Supported by Genetics Institute, Inc., Andover, Massachusetts. 相似文献