胰腺实性假乳头状瘤33例临床病理特点及诊治分析

目的 探讨胰腺实性假乳头状瘤临床病理特点、免疫组化特征、生物学行为及诊治经验.方法 回顾性分析2001年5月至2010年7月收治的33例胰腺实性假乳头状瘤患者的临床及病理资料,其中男性7例,女性26例;年龄13 ～ 66岁,平均34.3岁.结果 肿瘤位于胰头10例,胰颈部5例,胰体尾部18例.8例行单纯胰腺肿瘤切除,6例行胰十二指肠切除,3例行胰腺肿物切除加胰肠吻合,1例行胰腺肿物切除加胰胃吻合,11例行胰腺体尾切除,4例行胰腺体尾切除加脾切除(其中1例因合并肝转移加行肝中叶切除);其中16例为经腹腔镜手术.3例证实有胰腺和血管浸润,其中1例合并肝转移.免疫组化显示α1抗胰蛋白酶、α1抗胰凝乳蛋白酶、β-连环蛋白、CD56、CD10和波形蛋白均阳性;神经元特异性烯醇化酶阳性3例,突触素阳性6例,嗜铬粒素A阳性4例,孕激素受体阳性28例,雌激素受体阳性3例,S-100阳性6例.33例均获随访,中位随访时间49个月,肿瘤无复发.结论胰腺实性假乳头状瘤多发生在年轻女性,肿瘤可位于胰腺任何部位,免疫组化对诊断和鉴别诊断有比较重要的价值,选择适当患者行胰腺远端切除或肿瘤切除安全、可行.     

胰腺实性假乳头状瘤的病理特点及诊治体会

目的总结胰腺实性假乳头状瘤临床病理特点及诊治经验。方法回顾性分析1996年6月至2005年9月收治的13例胰腺实性假乳头状瘤患者的临床病理资料。结果所有患者均为女性,平均年龄29.2岁。上腹疼痛10例,腹部肿块9例。影像学检查均能发现腹部肿块但未能明确诊断。肿块平均直径10.3cm,包膜完整者9例,包膜不完整4例,质地呈实性5例,呈囊实性8例。术中快速冰冻病理6例,3例获得确诊。病理特征为肿瘤细胞围绕纤细血管轴心形成特征性的假乳头状结构,细胞形态一致,异型不明显。2例证实有胰腺和血管浸润。8例免疫组化结果均为波形蛋白(Vimentin)、神经元特异性烯醇化酶(NSE)、α1抗胰蛋白酶(α1-AT)、突触素(Syn)、孕激素(PR)阳性,上皮膜抗原(EMA)、雌激素(ER)、嗜铬颗粒素A(CgA)、S-100蛋白阴性。4例行胰十二指肠切除术,4例行肿瘤局部切除术。4例行胰体尾加脾切除术,1例胰体部肿瘤行胰腺节段切除术。12例获随访,中位随访时间41(2～103)个月,肿瘤无复发,除1例出现营养不良外,余患者生存满意。结论胰腺实性假乳头状瘤为低度恶性肿瘤,确诊需依赖病理组织学检查。手术切除是治疗本病的良好方法。     

胰腺实性-假乳头状瘤4例报告

对4例胰腺实性假乳头状瘤（SPT）的临床病理资料进行回顾性分析。 4例中3例为女性,年龄15～63（平均23）岁。2例以腹部肿块就诊;1例体检时偶然发现胰腺肿物;1例以腰背部隐痛为主诉入院。肿瘤位于胰头部2例,胰颈体部1例,胰体部1例。肿瘤直径4.5～8.0（平均7）㎝,均有包膜,囊实相间。镜检示,肿瘤由假乳头和囊实区混合组成,瘤细胞围绕纤维血管轴心形成特征性假乳头结构。免疫组化检查,4例Vim,AT阳性,2例NSE阳性。均行手术切除,术后随访0.5~4年,均无复发。提示SPT好发于青少年女性,有独特的临床病理表现,免疫组化提示SPT可能起源于胰腺多潜能干细胞。应视为低度恶性肿瘤。切除率高,预后好。     

胰腺实性假乳头状瘤的诊断和治疗

目的 总结胰腺实性假乳头状瘤的诊断和治疗经验。方法 对2000年8月至2004年2月收治的12例胰腺实性假乳头状瘤病例进行回顾性研究。结果 12例患者年龄13—53岁,平均29．1岁,其中女性11例,男性1例。肿瘤位于胰头6例,胰颈部1例,胰体尾部5例。无特异性临床表现。B超发现胰腺低回声实性或囊实性占位。CT检查发现胰腺低密度占位病变,增强扫描肿瘤周边出现明显不规则强化。血清肿瘤标记物均为阴性。2例行胰十二指肠切除术,3例行胰头肿物切除术及胰管空肠吻合术,1例行胰头肿物切除术,1例行胰腺节段切除术及远端胰管空肠吻合术,5例行胰体尾及脾切除术。对10例患者进行随访,平均随访时间14．3个月,均未发现肿瘤复发转移。结论 胰腺实性假乳头状瘤是一种罕见的低度恶性胰腺肿瘤,多发于青年女性,切除肿瘤后能获得良好的预后。     

胰腺实性假乳头状肿瘤临床病理分析

目的 探究胰腺实性假乳头状肿瘤(SPTP)的临床病理学特征.方法 对12例SPTP患者的临床资料进行回顾性分析.结果 12例SPTP患者中,女11例,男1例;患者平均年龄31.7岁.术后随访均无复发.肿瘤平均直径约7.6 cm,组织学示瘤细胞大小一致,片块区与乳头状结构相混,细胞核圆,核分裂不常见.免疫组化观察a-AT阳性(11/12),Vim阳性(12/12),CD10阳性(11/12),PR阳性( 10/12),Syn阳性(4/12),EMA阴性(0/10).结论 胰腺实性假乳头状肿瘤是一种罕见的肿瘤,恶性程度低,多发于中年女性,治疗效果较好.     

胰腺实性假乳头状瘤临床特点（附19例报道）

目的 探讨胰腺实性假乳头状瘤的临床特点及预后,提高对此病的认识.方法 19例胰腺实性假乳头状瘤患者均行手术治疗,收集其临床资料,总结临床特点及预后.结果 肿瘤直径57～140mm.位于胰头部2例,胰体尾部11例,胰腺尾部6例.18例患者随访5～67个月,1例肝转移瘤患者二次手术后随访11个月,均无复发转移.结论 胰腺实性假乳头状瘤一般无特异性临床表现,影像学检查多能早期发现病变.此病多能完整切除,预后好.     

胰腺实性假乳头状瘤43例诊疗及预后分析

目的探讨胰腺实性假乳头状瘤的诊断,治疗方法及预后。方法回顾分析2005年1月至2015年12月我院收治的43例胰腺实性假乳头状瘤行手术治疗病例的临床资料并随访其预后。结果男性5例,女性38例;年龄16～70岁,平均32. 4岁,多数患者因腹痛就诊。手术治疗包括胰十二指肠切除术6例,胰体尾加脾切除术15例,保脾胰体尾切除术6例,中段胰切除术5例,肿瘤局部剜除术11例。术后出现并发症13例(30. 2%),其中7例胰漏,2例切口液化,1例早期上消化道出血。32例获得随访,随访15～142个月,所有病人术后无复发、转移及死亡。结论胰腺实性假乳头状瘤好发于年轻女性,手术治疗效果较好。     

胰腺实性假乳头状瘤2O例临床与病理特点分析

目的探讨胰腺实性假乳头状瘤（solid—pseudopapillarytumorofpancreas,SPTP）的,l缶床病理特点及诊治预后。方法回顾性分析20例SPTP的临床病理特点,免疫组化结果及治疗预后。结果病理特征具有纤维膜,肿瘤细胞形态温和单一,异型不明显,呈实性巢片状围绕纤细血管轴心形成特征性的假乳头状结构伴出血坏死。免疫组化SYN、CD56、CD10、NSE、PR、B—catenin、VIM、AAT、AACT等多为阳性表达,CK、CK7、CGA多为阴性表达,Ki-67约1％～5％。结论SPTP组织学具有特征性的实性假乳头状结构,免疫组化检测对其辅助诊断有较大意义,治疗以手术为主,完整切除预后良好。     

胰腺实性假乳头状瘤的临床病理特点及诊治体会

目的 探讨胰腺实性假乳头状瘤（SPTP）临床病理特点及诊治经验。方法 回顾性分析2004年2月至2012年11月经病理证实的23例SPTP病例的临床特征、手术及病理资料和随访结果。结果 男7例,女16例;年龄10～63岁,中位年龄39岁。肿瘤位于胰头/颈部8例,胰体尾部15例。1例行单纯胰腺肿瘤局部切除,4例行胰十二指肠切除,2例行胰腺中段节段性切除（1例为腹腔镜手术）,5例行胰腺体尾切除（其中1例因合并肝癌加行肝右后叶切除）,11例行胰腺体尾切除加脾切除。术后住院6～35 d,中位术后住院日13 d。术后总并发症发生率43.5%（10/23）,无再手术及围手术期死亡病例。肿瘤直径1.5～15 cm,平均（5.9±0.7）cm。病理特征为肿瘤细胞围绕纤细血管轴心形成特征性的假乳头状结构,细胞形态一致,核异型性不明显。8例表现为胰腺组织、神经浸润或脾脏侵犯,诊断为恶性胰腺实性假乳头状瘤。免疫组化显示AAT/AACT、Vimentin、β-catenin、CD56阳性率均100%,Syn、CgA、CD10、PR部分阳性。23例均获随访,平均38个月,无术后复发转移及死亡,1例合并肝癌患者术后2年因肝癌复发再次行肝癌切除术,无SPTP复发转移。结论 SPTP临床表现无明显特异性;增强CT检查有助于肿瘤定位和手术风险评估;确诊依赖于病理学诊断和免疫组化;手术完整切除肿瘤能获得良好预后。     

胰腺实性假乳头状瘤肝转移误诊1例

胰腺实性假乳头状瘤（solid pseudopapillary tu-mor of pancreas,SPT）是少见的胰腺外分泌腺肿瘤,多见于青春期及青年女性,男女比例1∶9,转移至肝脏并以肝脏疾患就诊则更是少之又少,易引起误诊,现就1例胰腺实性假乳头状瘤肝转移误诊分析如下。     

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目的总结胰腺实性假乳头状瘤(SPT)的临床特征与诊断经验。方法对2000年2月至2007年3月在中国人民解放军总医院经术后病理证实的24例SPT的临床表现和实验室、影像学、术前及术中病理检查等资料进行回顾性分析。结果女性23例,男性1例,平均年龄24.4岁。首诊临床表现为腹部肿物5例、腹痛7例、腹泻1例、恶心腹胀2例等,9例无任何临床症状。血清肿瘤标记物水平均正常。影像学检查均提示胰腺或腹腔内边界清楚的实性或囊实性占位病变,肿瘤位于胰头部13例,胰体部4例,胰尾7例,核磁共振(MRI)的诊断符合率(40.0%)要高于CT(16.7%)。术前2例行超声引导下肿瘤活组织检查,6例行术中快速冰冻病理检查,分别有1例和3例诊断为SPT。结论SPT的正确诊断依赖于临床表现、影像学特征,尤其是病理学检查的综合分析。     

胰腺实性假乳头状瘤的诊治分析

目的:探讨胰腺实性假乳头状瘤的诊断与外科治疗方法。方法:回顾性分析2000年6月—2011年5月间收治的42例胰腺实性假乳头状瘤患者的临床资料。结果:42例中女性41例,男性1例;年龄16~63(平均31.1)岁。肿瘤位于胰头部10例,胰颈部3例,体尾部29例。瘤体最大直径2~15 cm,平均6.3 cm。就诊时无明显症状者20例,仅有上腹部胀痛不适者21例,1例由于肿物破裂出现剧烈腹痛伴发热。超声检查发现胰腺低回声或等回声或囊实混合性包块,CT检查多显示为胰腺区类圆形囊实性肿物,增强后实性部分不同程度强化。患者均行手术切除,经病理证实为胰腺实性假乳头状瘤。其中2例行保留幽门的胰头十二指肠切除术,2例行保留十二指肠的胰头切除术,10例行保留脾脏的胰体尾切除术,13例行胰体尾切除术,14例行局部切除术,1例行姑息切除术。40例患者获随访,随访时间6个月至11年,平均49个月,均存活,无远隔转移病例。1例肿瘤局部切除术后8年局部复发经再次手术局部切除,至今41个月未发现肿瘤复发。结论:年轻女性发生的囊实混合性胰腺肿瘤应高度怀疑胰腺实性假乳头状瘤,该肿瘤为低度恶性,在保证完整切除的前提下尽可能采用保留器官功能的手术方式患者可获长期生存。     

Solid pseudopapillary tumor of the pancreas in children: report of a case and review of the literature

Solid pseudopapillary tumor (SPT) of the pancreas is an infrequent neoplasm of low malignant potential, first described by Frantz in 1933 and representing less than 3% of all exocrine tumors. SPT is rare in children, accounting for 6% of all cases and shows different clinical features compared with adults. Here, a pediatric case is reported and a review of the Literature is provided. A 15-year-old girl with a 12 × 14 × 10 cm solid mass growing from the tail and the body of the pancreas, involving spleen, left adrenal gland and kidney, stomach and some bowel loops, was referred for surgical treatment. A distal pancreasectomy with splenectomy was performed. Histopathological examination revealed that the tumor was a 14-cm well-circumscribed solid mass, with pseudopapillary cell architecture, showing strong cellular immunoreactivity for alpha-1 antitrypsin, vimentin, neurone-specific enolase, progesterone receptors and in part to CD10 and CAM 5.2, but not to sinaptofisin and chromogranin. A 24-month post-surgical follow-up after successful surgical resection showed no evidence of recurrent disease. SPT shows different clinical features in childhood. High survival rates can be achieved in most cases, warranting aggressive treatments even in metastatic disease.     

Clinical features of testicular tumors in children

AIM: Testicular tumors are not common pediatric solid tumors, especially in Asian children. There have been few reviews of cases in Japan to date. We present the clinical features of 14 pediatric testicular tumor patients. METHODS: Clinical features of 14 testicular tumor patients, such as chief complaints, age at diagnosis, pathology, stages, treatments and prognosis, were examined from medical records. Two patients had their semen tested at adolescence. RESULTS: Of the 14 prepubescent patients, 12 (85.7%) patients were diagnosed before 3 years of age. Ten cases (71.4%) were diagnosed as yolk sac tumors, three (21.4%) as mature teratomas and one case as an epidermoid cyst. Nine cases (90.0%) among the 10 cases of yolk sac tumor were diagnosed as stage I and one case was stage IV. One stage I yolk sac tumor patient developed lung metastasis later. Eventually, two yolk sac tumor patients died, despite chemotherapy. While all the cases with a diagnosis before 2 years of age survived, 67% (2/3) of cases with a diagnosis after the age of 2 died of tumors. Semen analysis in two patients showed normospermia. CONCLUSION: In the present study, the most common testicular tumors were yolk sac tumors and the patients diagnosed before 2 years of age showed favorable results. Age could be a relapse risk factor in yolk sac tumors. Guidelines for handling testicular tumors in children is not yet well established in Japan. An organized system seems necessary to gather and accumulate the results of the cases in Japan in order to develop better guidelines for treatment.     

Solid pseudopapillary tumor of the pancreas: a case series of 26 consecutive patients

Objective

Solid pseudopapillary tumor (SPT) of the pancreas, which predominantly affects young women, is a relatively indolent entity with favorable prognosis. The aim of this study is to describe the clinicopathologic features and surgical management of this disease in our institution.

Methods

A retrospective study of clinical data from 26 consecutive patients with SPT managed in a tertiary academic center between January 2002 and December 2007 was performed. Clinicopathologic factors were compared between benign and malignant cases to determine what features of the tumor could suggest malignant potential.

Results

The 26 cases included 22 female and 4 male patients, and the average age was 32.3 years (range 15 to 64). Clinical symptoms were nonspecific and included upper abdominal pain or discomfort, abdominal distention, and back pain. The neoplasm was localized in the pancreatic head/neck in 14 patients and in the body/tail in 12 patients. The median diameter of these lesions was 6.25 cm (range 2 to 15). All of the tumors-including 8 pancreaticoduodenectomies, 10 distal pancreatectomies, 6 local resections, 1 total pancreatectomy, and 1 central pancreatectomy-were resected successfully. No patient received chemotherapy or radiotherapy after surgery. All of the patients except 1 were alive at a median follow-up of 32.5 months (range 3 to 69). One of the 2 patients with malignant SPT, in whom Ki-67 immunoreactivity was >25%, developed local recurrence with liver metastasis 4 months and died 6 months after surgery. There were no significant associations between clinicopathologic factors and malignancy.

Conclusions

SPT is a rare neoplasm with low malignant potential. Characteristic computed axial tomography and magnetic resonance imaging scans combined with age and sex profile should be sufficient for the decision to operate. Patients with malignant SPT should have careful follow-up. The high proliferative index assessed by immunohistochemical staining for Ki-67 may predict poor outcome of malignant SPT.     

胰腺实性假乳头状肿瘤的诊断和治疗

目的 总结胰腺实性假乳头状肿瘤的诊治体会。 方法 回顾性分析1999年1月至2007年10月浙江大学医学院附属邵逸夫医院普外科及中国人民解放军117医院普外科诊治13例胰腺实性假乳头状肿瘤（SPT）的临床资料。 结果 13例均无特异性临床表现,以腹痛、腹部肿块为主。13例均行手术治疗。行胰十二指肠切除术6例,胰颈节段切除术1例,胰体尾加脾切除术2例,胰体尾切除术1例,腹腔镜胰体尾加脾切除术2例,胰体尾切除加肝脏结节活检及肝脏结节无水酒精注射、乙状结肠及降结肠部分切除术1例。12例术后恢复顺利,1例胰体尾切除术后发生胆胰瘘。10 例随访均未发现肿瘤复发转移。 结论 SPT好发于年轻女性,属潜在恶性或低度恶性胰腺肿瘤,积极的手术治疗能获得良好预后。     

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??Diagnosis and treatment of solid-pseudopapillary tumor of pancreas ZHANG Ren-chao*, MOU Yi-ping, JIANG Chao-hui, et al??*Department of General Surgery, the 117th Hospital of PLA, Hangzhou 310013, China Corresponding author??MOU Yi-ping??E-mail??mouyiping@yahoo.com.cn Abstract Objective To analyze the diagnosis and treatment of solid-pseudopapillary tumor of pancreas??SPT????Methods The clinical data of 13 cases of SPT admitted from January 1999 to October 2007 in the Department of General Surgery of Sir Run Run Shaw Hospital (Medical College of Zhejiang University) and Department of General Surgery of the 117th Hospital of the PLA were analyzed retrospectively??Results All the cases were female with the mean age of 32 years old??SPT had no specific clinical symptoms??Abdominal pain and space occupying symptoms were the mostly symptoms??All the cases received operation??Operative procedure included pancreaticoduodenectomy in 6 cases, pancreatic neck segmentectomy in 1 case, distal pancreatectomy in 1 case, distal pancreatectomy with splenectomy in 2 cases, laparoscopic distal pancreatectomy with splenectomy in 2 cases , distal pancreatectomy, sigmoid colectomy and ethanol injection of liver nodulars in 1 case??Twelve cases recovered successfully after the operation. One case received distal pancreatectomy suffered from postoperative biliary and pancreatic fistula??Ten cases were followed up without tumor recurrence??Conclusion SPT is a special type of pancreatic tumor with low degree malignancy, affecting in young women predominantly??Aggressive surgery could get good prognosis??     

胰腺实性假乳头状瘤的外科治疗

目的探讨胰腺实性假乳头状瘤（SPT）的特点、外科治疗的方法及效果.方法回顾性分析1999年1月至2005年7月间14例胰腺实性假乳头状瘤的临床病理资料.结果本组患者中男性1例,女性13例.14例肿瘤均为单发,9例位于胰头,4例位于胰体,1例位于胰尾.肿瘤直径平均7.2 cm.无特异性临床表现.CT平扫：肿瘤囊性、实质部分均为低密度影,边界清楚,可见钙化;增强后：肿瘤实质轻度强化,囊性结构动、静脉期均无强化.14例患者均行手术治疗,8例行肿瘤局部切除,2例行胰体部分切除加胰肠吻合术,1例行胰体尾加脾切除术,3例行Whipple手术.随访2～58个月,平均随访20.1个月,所有患者均存活,无复发、转移.结论胰腺实性假乳头状瘤是一种低度恶性的肿瘤;手术切除是有效的治疗方法,术式选择与肿瘤位置、大小等因素相关;完整切除者预后良好.     

Clinically aggressive solid pseudopapillary tumors of the pancreas: a report of two cases with components of undifferentiated carcinoma and a comparative clinicopathologic analysis of 34 conventional cases

Solid pseudopapillary tumors (SPTs) are unusual neoplasms of the pancreas of uncertain histogenesis that occur mostly, but not exclusively, in young women. The pathologic features and immunophenotype of SPT are unique and well characterized. Despite its low malignant potential, proximately 15% of patients with SPT develop metastatic disease, mostly involving the liver or peritoneum. Even in the presence of disseminated disease, the clinical course is usually protracted, and the overall 5-year survival is reportedly 97%. We have encountered 2 cases of SPT possessing unusual pathologic features and exhibiting an aggressive clinical course. At the time of presentation, 1 patient had liver metastasis, and the other had a lymph node metastasis and developed liver metastases within 3 months. Both died of disease at 6 and 16 months, respectively, following the initial diagnosis. Review of other cases of SPT treated at Memorial Sloan-Kettering Cancer Center (New York, NY) revealed that 5 of 34 cases (15%) with conventional histologic features developed liver metastases. In contrast to the 2 cases reported here, all 5 patients survived for a mean of 106 months (39-193 months), and only 2 died of disease 5 and 10 years, respectively, following the initial resection. The pathologic features of the two rapidly fatal cases, which might have been indicative of their aggressive behavior, included a diffuse growth pattern, extensive tumor necrosis, significant nuclear atypia, an unusually high mitotic rate (35-70/50 high power fields), and in one a component of sarcomatoid carcinoma. However, regions displaying the typical histologic features of SPT were also evident. Abnormal beta-catenin distribution and markedly increased MIB1 expression were detected by immunohistochemistry in both cases. The immunohistochemical staining patterns were otherwise similar to those of conventional SPTs. Although precise pathologic criteria suggesting a high risk for aggressive behavior are uncertain, recognition of some of the unusual pathologic features displayed in these 2 cases may be useful in the prediction of potentially more aggressive SPTs. The possibility that these tumors represent high-grade malignant transformation of a conventional low-grade SPT is proposed.     

胰腺实性假乳头肿瘤组织起源分析

目的：总结胰腺实性假乳头肿瘤（solid-pseudopapillary tumor,SPT）的组织病理学特点,并分析该肿瘤组织细胞的起源。方法：回顾性分析我院43例SPT的组织病理学特点,其中30例标本经与代表不同组织来源的抗体进行免疫组化反应．由SPSS11．5软件进行数据分析。结果：SPT肿瘤的组织病理特点为假乳头结构形成和区域性坏死,无腺泡结构。SPT细胞对神经内分泌细胞来源的神经元特异性烯醇化酶蛋白（NSE）、CD56和CD10的阳性高表达率甚高,均超过90％,但对SYN的高表达率仅为16．7％;SPT细胞对神经干细胞来源的神经巢蛋白（NES）和波形蛋白（VIM）的阳性高表达率分别为70％和90％;对神经软组织来源的S-100蛋白的高表达率为86．7％;对间叶组织细胞来源的仪1抗糜蛋白酶（α1-AT）、仅1抗胰蛋白酶（α1-ACT）和溶菌酶（LYS）的高表达率达80．0％～86．7％;而SPT细胞对上皮细胞来源的抗体标记物很少呈阳性反应,多为低表达。结论：SPT可能起源于胰腺干细胞及与其发育密切相关的胚胎神经嵴的神经前体细胞,在干细胞发育过程中发生分化不成熟所致。