Utilization of National Cancer Institute-Designated Cancer Centers by Medicare Beneficiaries with Cancer

Annals of Surgical Oncology - Little is known about which patients use National Cancer Institute-designated cancer centers (NCICCs) nationally. This study aimed to identify sociodemographic...     

Second Primary Digestive Cancer After Resection of Lung Cancer

Purpose We evaluated the clinical findings of patients with second primary digestive cancers (SPDC) after the resection of lung cancer.Methods Among 772 patients who underwent resection of primary lung cancer at Saitama Cardiovascular and Respiratory Center between 1993 and 2002, 10 (1.3%) were diagnosed with SPDC during follow-up. These ten patients were classified into two groups based on whether the SPDC was incidentally (group I) or symptomatically (group S) diagnosed.Results The median interval to the detection of SPDC was 17 months in group I and 66 months in group S, and the disease was at an earlier stage in group I than in group S (P = 0.008). Comparing body weight at the time of lung resection to that at the time of abdominal surgery, significant weight loss was evident in group S (P = 0.009). The postoperative disease-specific survival rate was 100% in group I. No long-term survivor died of lung cancer.Conclusion Special attention must be paid to the possibility of SPDC after the resection of lung cancer to improve the prognosis of patients with lung cancer.     

Late Kidney Effects of Childhood Cancer and Cancer Therapies

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中断肋骨后外侧开胸切口施行食管、贲门癌切除术

目的 为了减小开胸手术切口的创伤，获得良好的手术视野，探讨中断肋骨后外侧开胸切口的临床效果。方法 采用中断肋骨后外侧开胸方法施行食管、贲门癌切除、淋巴结清扫术126例；介绍该技术的要点，比较中断肋骨开胸切口法与其他保留肋骨方法的显露面积、创伤大小及手术效果。结果 本组无1例发生术后肺不张和胸壁切口出血而需再次开胸止血，患者均恢复良好。结论 中断肋骨开胸切口方法手术操作简单，手术视野显露好，且手术创伤小。     

Ovarian Cancer in Hereditary Cancer Susceptibility Syndromes

Hereditary breast and ovarian cancer (HBOC) syndrome and Lynch syndrome (LS) are associated with increased risk of developing ovarian carcinoma. Patients with HBOC have a lifetime risk of up to 50% of developing high-grade serous carcinoma of tube or ovary; patients with LS have a 10% lifetime risk of developing endometrioid or clear cell carcinoma of the ovary. Testing all patients with tubo-ovarian high-grade serous carcinoma for mutations associated with HBOC syndrome, and all patients presenting with endometrioid or clear cell carcinoma of the ovary for mutations associated with LS can identify patients with undiagnosed underlying hereditary cancer susceptibility syndromes.     

胰腺癌现有血清肿瘤标记物的诊断价值

胰腺癌的早期诊断不易 ,近年各地开展多种血清肿瘤标记物检查 ,为减少不必要人力和物力的浪费 ,须对现有的标记物检查真正的诊断价值进行一次客观评估。血清肿瘤标记物的意义　　肿瘤标记物是指肿瘤组织在其发生、发展过程中分泌的物质 ,这些物质在质和量上的变异可以反映肿瘤的存在 ,这一名词是Ｈｏｒｂｅｒｍｅｎ于 1 978年在美国召开的肿瘤免疫诊断会议上提出的。　　一般而言 ,正常机体不存在肿瘤标记物 ,即使存在 ,其含量很少。在实际应用中 ,肿瘤标记物是以肿瘤组织与其相应的正常组织相比 ,其量增高明显才有临床显著意义 ,但谋求组织…