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Five HLA-A variant alleles HLA-A*030108, A*2491, A*2498, A*330303, A*3317 were identified in Chinese individuals. 相似文献
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Hersee J Dodd R Greville WD Chapman G Taverniti A Le T Wallace R Kennedy A Dunckley H 《Tissue antigens》2004,63(6):587-588
Anew human leukocyte antigen (HLA) class I allele, HLA-A*0252, has been found during routine typing of samples for the Australian Bone Marrow Donor Registry. A*0252 differs from A*020101 at four codon positions, with all the new polymorphisms resulting in an amino acid change. The amino acids involved are located in the antigen-binding region of the HLA protein. 相似文献
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A new HLA-A*02 null allele, HLA-A*9213N 总被引:1,自引:0,他引:1
A novel HLA-A*02 null allele, differing from HLA-A*02010101 at codon 60 (TGG tryptophan-->TAG stop), is described. 相似文献
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In this report, we describe the identification of a human leucocyte antigen-A*11 (HLA-A*11) nucleotide sequence variant, a new HLA-A*1120 by using sequence-based typing (SBT). The new allele was detected during routine HLA typing by high-resolution SBT. Allele A*1120 showed one nucleotide difference with A*110101 at codon 152 (GCG-->GAG) resulting in an amino acid change from alanine to glutamate. Residue 152 is located on alpha(2)-helix of HLA class I molecule and involved in peptide binding by constructing E pocket of peptide-binding groove, implying that the change of the residue 152 would affect the binding affinity of peptides to A*1120 allele. 相似文献
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In this report, we describe two new HLA-A alleles, A*2419 and A* 3011, that were initially recognized by an aberrant serological pattern. Sequence-based typing revealed sequence differences with other known HLA-A alleles. Allele A*2419 showed 4 nucleotide differences with A*2404, resulting in 4 amino acid differences at codons 70, 76, 77 and 90. Compared with other A*24 alleles, A*2419 lacks the Bw4 motif, as do A*2404 and A*2428. The A*3011 allele showed 2 mismatches with A*3001, resulting in one amino acid difference at codon 80. 相似文献
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In this report, we describe the identification of an HLA-A*31 nucleotide sequence variant, a new HLA-A*3111, in three members of a Korean family by using sequence-based typing (SBT). The new allele was detected during routine HLA typing by high-resolution SBT. Allele A*3111 showed one nucleotide difference with A*310102 at codon 165 (GTG-->CTG) resulting in an amino acid change from valine to leucine (V165L). Serologic reactivity was shorter than normally expected. 相似文献
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目的发现和认定1个HLA新等位基因。方法应用PCR-SSO基因分型技术筛选可能的HLA新等位基因,PCR产物测序,确认与最同源HLA等位基因序列的差异。结果发现一个样品的HLA-A位点结果异常。其序列与已知所有HLA—A等位基因序列不一致,与同源性最高等位基因A*24020101的差异只是在第2外显子区域中的230位碱基发生了C→T碱基的替换,但并未改变第77密码子编码的氨基酸。结论该等位基因为HLA-A位点的1个新等位基因,已被WHOHLA因子命名委员会于2006年8月23日正式命名为HLA-A*240212。 相似文献
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A novel human leukocyte antigen-A allele, A*240212, has been identified during routine sequence-specific oligonucleotide typing and sequence-based typing in a sample from a registered donor of Chinese Marrow Donor Program. The A*240212 allele differs from the most closely matching allele A*24020101 by one nucleotide substitution in Exon 2, at position 230, while the nucleotide exchange is silent mutation. 相似文献
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A novel human leukocyte antigen (HLA) A*24 allele was identified in the Korean population and designated HLA-A*2475. The HLA-A*2475 allele shows one nucleotide difference from A*24020101 in exon 3 at nucleotide position 575 (T→C), resulting in an amino acid change, Leu168Arg. 相似文献
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A novel HLA-A*9208 allele was identified in a Chinese individual by polymerase chain reaction sequence-based typing. 相似文献
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In this report, we describe the identification of a novel human leukocyte antigen-A*24 (HLA-A*24) allele, designated HLA-A*2467. The new allele differs from the most closely related allele HLA-A*2408 at five nucleotide positions all located in exon 2. Four of the five nucleotide changes result in amino acid substitution. 相似文献
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The new HLA-A*680202 differs from HLA-A*680201 by one synonymous nucleotide substitution at position 618 (ACG → ACT). 相似文献
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M. Laforet N. Froelich A. Parissiadis A. Schell B. Pfeiffer J.-P. Cazenave M.M. Tongio 《Tissue antigens》1999,53(6):573-575
The authors describe an A*68 allele present at the molecular level but not expressed at the cell surface. This non expression results from the deletion of one nucleotide in exon 1, which causes a shift of the reading frame leading to an early non-sense codon in the same exon. 相似文献
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We describe a novel HLA-A*02 allele, A*0224, that was identified after a comparison of DNA and serological typing revealed a discrepancy in the HLA-A types: HLA-A2 was defined by serology but was not detected by the polymerase chain reaction using sequence-specific primers (PCR-SSP). DNA sequencing indicated the presence of a variant HLA-A*02 allele that differed from A*0201 by a single base (C/A) at position 453. This base substitution corresponded to the annealing site of a primer common to the two A*02-amplifying PCR-SSP mixtures used in the method. This provides an explanation for the results and highlights a limitation of PCR-SSP methods even where two PCR mixtures are used to detect alleles. Serological titration studies suggested that A*0201, A*0205 and A*0224 are unlikely to be differentiated during routine serological typing. 相似文献
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