共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
Maria Carolina Hardoy Mariangela Cadeddu Andrea Murru Bernardo Dell'Osso Bernardo Carpiniello Pier Luigi Morosini Joseph R Calabrese Mauro Giovanni Carta 《Clin Pract Epidemiol Ment Health》2005,1(1):8
The study measured the accuracy of the Italian version of the Mood Disorder Questionnaire (MDQ) as a screening instrument for bipolar disorders in a psychiatric setting. 相似文献
Methods
154 consecutive subjects attending the Division of Psychiatry of the University of Cagliari (Italy), were screened for bipolar disorders using the Italian translation of the MDQ, and diagnostically interviewed with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) by physicians.Results
On the basis of the SCID: 51 (33.1%) received a diagnosis of bipolar or schizoaffective bipolar type disorders, 63 (40.9%) were diagnosed as having at least one psychiatric disorder in Axis I (other than bipolar or schizoaffective bipolar type disorders), whilst 40 (25.9%) were unaffected by any type of psychiatric disorder. MDQ showed a good accuracy for bipolar or schizoaffective bipolar type disorders: the cut-off 4 had sensitivity 0.90 and specificity 0.58; the cut-off 5 had sensitivity 0.84 and specificity 0.70; and the cut-off 6 had sensitivity 0.76 and specificity 0.86. The accuracy for bipolar II disorders was sufficient but not excellent: the cut-off 4 had sensitivity 0.80 and specificity 0.45; the cut-off 5 had sensitivity 0.70 and specificity 0.55; and the cut-off 6 had sensitivity 0.55 and specificity 0.65.Conclusion
Our results seem to indicate a good accuracy of MDQ, and confirm the results of recent surveys conducted in the USA. Moreover the instrument needs to be validated in other settings (e.g. in general practice).3.
4.
5.
P. J. Wiffen BPharm & R. A. Moore DPhil 《Journal of clinical pharmacy and therapeutics》1996,21(1):23-27
When assessing a health-care intervention the main question is—does it work? Often, a more difficult question needs to be answered—how well does it work? Systematic reviews and meta-analyses help to provide answers to both questions. Too often though, the results are expressed in a way that leaves the reader asking, ‘what is the result?’ Numbers-needed-to-treat is a simple method for conveying the answers. It can be applied to any chosen clinical outcome with dichotomous data, and the results can be understood by doctor, patient and the public. This paper discusses the concept of numbers-needed-to-treat and gives worked examples using trials in H. pylori eradication and lowering of serumcholesterol. 相似文献
6.
7.
8.
9.
10.
11.
12.
13.
14.
Comparison of the CELLEX™ and UVAR‐XTS™ closed‐system extracorporeal photopheresis devices in the treatment of chronic graft‐versus‐host disease 下载免费PDF全文
Robert M. Whittle Helen Denney Andrew D. Chantry Arun Alfred Peter C. Taylor 《Journal of clinical apheresis》2017,32(6):462-473
Extracorporeal Photopheresis (ECP) is a cellular immunotherapy frequently used for steroid‐refractory graft‐versus‐host disease (GVHD). Chronic GVHD (cGVHD), response to ECP is associated with survival benefit. The UVAR‐XTSTM system and the more recently developed CELLEXTM device (both TherakosTM) are the mainstay for ECP‐delivery in the UK and US. No comparison of treatment outcomes has been reported. We retrospectively compared cGVHD response and steroid reduction and withdrawal in patients treated exclusively over 12 months with either the XTS (n = 51) or CELLEX (n = 50). Our hypothesis was that there would be no difference in clinical outcome or steroid changes in the 2 matched cohorts. We also compared infection incidence, infection‐related death (IRD), and treatment time. Significant clinical improvement and regular capacity to reduce or cease steroids was encountered in both cohorts; at 6 months of ECP 70% of cutaneous cGvHD patients had partial or complete responses and 85% of patients receiving steroids pre‐ECP had reduced dosage. In the XTS group we unexpectedly encountered both superior steroid reduction (86% dose at least halved vs. 61% for CELLEX, P = 0.01) and withdrawal (15 vs. 5 CELLEX, P = 0.01) and a trend for superior skin disease response in the CELLEX‐treated cohort at 3 months. No inter‐relationship was evident. Halving or greater reduction of steroid dose by 3 or 6 months was associated with reduced risk of IRD in the XTS cohort as was withdrawal at 6 months for the combined cohorts. By 6 months, XTS‐treated patients had experienced fewer antibiotic‐requiring infections (mean 1.9 vs. 2.8, P = 0.025). Origins for the disparities are unclear and warrant investigation. 相似文献
15.
Carl Djerassi 《Wiener klinische Wochenschrift》2009,121(23-24):727-728
16.
《Krankenpflege Journal》2004,42(5-6):176-7; discussion 177
17.
18.
19.