沙丁胺醇联合布地奈德悬液雾化吸入治疗喘息性支气管肺炎的护理观察

目的：观察沙丁胺醇联合布地奈德悬液雾化吸入治疗喘息性支气管肺炎患儿的临床护理疗效。方法：75例喘息性支气管肺炎患儿随机分为两组,对照组35例,给予抗感染、止咳、化痰等常规治疗与护理;观察组40例在此基础上给予沙丁胺醇联合布地奈德悬液雾化吸入治疗,并进行综合护理措施,观察临床护理疗效。结果：两组患儿有效率差异有统计学意义（P〈0.05）,通过有针对性的护理,未见不良反应和并发症。结论：沙丁胺醇联合布地奈德悬液雾化吸入治疗结合临床综合护理可有效缓解喘息性支气管肺炎的发作。     

布地奈德与沙丁胺醇联合雾化吸入治疗毛细支气管炎疗效观察

目的 探讨布地奈德与沙丁胺醇联合雾化吸入治疗毛细支气管炎的临床疗效.方法 将80例毛细支气管炎患儿随机分为治疗组45例,对照组35例.两组均给予常规综合治疗,治疗组在常规治疗基础上加用布地奈德、沙丁胺醇雾化吸入治疗,对照组在常规治疗基础上加用病毒唑、地塞米松、α-糜蛋白酶雾化吸入治疗.结果 治疗组有效率明显高于对照组,气促缓解天数、哮鸣音消失天数及住院时间明显短于对照组,统计学差异有显著性意义(p＜0.01).结论 布地奈德与沙丁胺醇联合雾化吸入治疗毛细支气管炎可明显缩短疗程,提高治疗有效率.     

布地奈德与沙丁胺醇联合雾化吸入治疗毛细支气管炎疗效观察

目的探讨布地奈德与沙丁胺醇联合雾化吸入治疗毛细支气管炎的临床疗效。方法将80例毛细支气管炎患儿随机分为治疗组45例,对照组35例。两组均给予常规综合治疗,治疗组在常规治疗基础上加用布地奈德、沙丁胺醇雾化吸入治疗,对照组在常规治疗基础上加用病毒唑、地塞米松、α-糜蛋白酶雾化吸入治疗。结果治疗组有效率明显高于对照组,气促缓解天数、哮鸣音消失天数及住院时间明显短于对照组,统计学差异有显著性意义（p〈0.01）。结论布地奈德与沙丁胺醇联合雾化吸入治疗毛细支气管炎可明显缩短疗程,提高治疗有效率。     

联合应用沙丁胺醇与布地奈德雾化吸入治疗小儿毛细支气管炎的效果观察

目的:探讨布地奈德联合沙丁胺醇雾化吸入治疗小儿毛细支气管炎的效果。方法:选取100例小儿毛细支气管炎患者,随机分为观察组和对照组,每组50例。两组患儿均给予常规治疗,在此基础上,给予对照组患儿布地奈德混悬液雾化吸入治疗,给予观察组患儿布地奈德联合沙丁胺醇雾化吸入治疗。记录比较两组患儿的临床疗效、临床症状缓解时间、住院时间及疗效满意度。结果:观察组经治疗显效41例,总有效48例,对照组显效29例,总有效41例,观察组治疗显效率及总有效率均显著高于对照组,两组比较差异有统计学意义(P<0.05);观察组患儿咳嗽、喘息、憋气,肺部干湿啰音等症状体征消退时间及患儿住院时间均短于对照组(P<0.05);观察组疗效满意度显著高于对照组(P<0.05)。结论:布地奈德联合沙丁胺醇吸入治疗毛细支气管炎可有效减轻患儿临床症状,提高治疗总有效率,减少患儿住院时间,减轻患儿痛苦,提高疗效满意度,值得临床推广。     

沙丁胺醇联合布地奈德雾化吸入治疗小儿毛细支气管炎的效果观察

目的探讨布地奈德联合沙丁胺醇雾化吸入治疗小儿毛细支气管炎的效果。方法选取2011年8月至2013年12月就诊于龙岗区第三人民医院的100例小儿毛细支气管炎患者,随机分为观察组和对照组,各50例。两组患儿均给予常规治疗,对照组在此基础上给予布地奈德混悬液雾化吸入治疗,观察组给予布地奈德联合沙丁胺醇雾化吸入治疗。比较两组患儿的临床疗效、临床症状缓解时间、住院时间及疗效满意度。结果观察组总有效率高于对照组,患儿咳嗽、喘息、憋气,肺部干湿啰音等症状体征消退时间及住院时间均短于对照组,疗效满意度高于对照组,差异均有统计学意义(P<0.05)。结论布地奈德联合沙丁胺醇吸入治疗毛细支气管炎可有效减轻患儿临床症状,提高治疗总有效率,减少患儿住院时间,减轻患儿痛苦,提高疗效满意度,值得临床推广。     

布地奈德、沙丁胺醇联合给予雾化吸入治疗小儿支气管哮喘(急性发作期)临床观察

目的:本文主要探讨布地奈德、沙丁胺醇联合给予雾化吸入治疗小儿支气管哮喘(急性发作期)临床疗效。方法:选取我院患有小儿支气管哮喘的患者48例,分为两组进行分别讨论,其中对照组24例患儿给予布地奈德雾化吸入,研究组24例患儿经布地奈德、沙丁胺醇联合雾化吸入,比较两组患儿的治疗效果。结果:研究组临床疗效显著高于对照组,具有统计学意义(P0.05)。结论:布地奈德、沙丁胺醇联合给予雾化吸入治疗小儿支气管哮喘(急性发作期)可获得更为理想的临床疗效。     

布地奈德联合沙丁胺醇雾化吸入治疗慢性阻塞性肺疾病加重期53例疗效分析

目的:观察雾化吸入布地奈德、沙丁胺醇治疗慢性阻塞性肺疾病急性加重期(AECOPD)的效果。方法:106例AECOPD住院患者,随机分2组,对照组53例给予常规治疗,治疗组53例给予常规治疗的同时,吸入布地奈德、沙丁胺醇混悬液。分析治疗后患者临床呼吸困难症状改善、肺部罗音的吸收和住院天数的变化。结果:治疗组呼吸困难症状明显改善,肺部罗音明显吸收,住院天数明显缩短,与对照组差异均有统计学意义(P<0.05~P<0.01)。结论:布地奈德联合沙丁胺醇雾化吸入对AECOPD疗效肯定,并且副作用小,可作为治疗AECOPD的有效方案。     

沙丁胺醇与布地奈德雾化液治疗肺炎的效果分析

目的探讨沙丁胺醇与布地奈德雾化液治疗肺炎的效果。方法选取我院肺炎患儿86例,随机分为观察组和对照组,各组43例。对照组给予雾化吸入布地奈德,观察组给予雾化吸入布地奈德与沙丁胺醇。观察临床治疗效果,并对比症状消失时间和住院时间。结果观察组治疗有效率比对照组高(P0.05);观察组症状消失时间和住院时间均比对照组少(P0.05)。结论沙丁胺醇与布地奈德联合治疗肺炎的效果明显,值得应用和推广。     

布地奈德联合硫酸沙丁胺醇雾化吸入治疗毛细支气管炎疗效观察

目的:探讨布地奈德联合硫酸沙丁胺醇雾化吸入治疗小儿毛细支气管炎的临床疗效。方法:将118例毛细支气管炎患儿按照是否给予布地奈德联合硫酸沙丁胺醇雾化吸入分为治疗组与对照组各59例,2组患儿均给予常规治疗,治疗组在常规治疗的基础上给予布地奈德联合硫酸沙丁胺醇雾化吸入治疗,对照组只给予沙丁胺醇雾化剂吸入治疗。于治疗1周后对比2组治疗效果。结果:治疗组治愈率为93%,对照组为64%,组间比较有统计学意义(P<0.05);治疗组在憋喘、咳嗽、哮鸣音、湿罗音消失时间均较对照组短,组间比较有统计学意义(P<0.05)。结论:布地奈德联合硫酸沙丁胺醇雾化吸入治疗小儿毛细支气管炎疗效显著。     

布地奈德联合硫酸沙丁胺醇雾化吸入治疗小儿哮喘急性发作临床观察

目的:观察布地奈德联合硫酸沙丁胺醇雾化吸入治疗小儿哮喘急性发作的临床疗效。方法:将68例支气管哮喘患儿随机分为观察组38例和对照组30例,两组均给予综合治疗,观察组另加用布地奈德与硫酸沙丁胺醇雾化吸入治疗。结果:观察组显效率65.8%,总有效率94.7%;对照组显效率36.7%,总有效率66.7%。观察组显效率和总有效率均高于对照组(P<0.01)。观察组症状、体征消失时间及住院天数均显著短于对照组(P<0.01),且未见明显不良反应。结论:布地奈德与硫酸沙丁胺醇雾化吸入治疗小儿哮喘疗效肯定,副作用少,值得临床推广。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.