经闭孔经阴道无张力尿道中段悬吊术治疗女性压力性尿失禁

目的观察经闭孔经阴道无张力尿道中段悬吊术（TVT-0）治疗女性压力性尿失禁的临床疗效及并发症。方法回顾性分析采用经闭孔经阴道无张力尿道中段悬吊术治疗女性压力性尿失禁9例。结果9例患者术后尿失禁得到控制,平均手术时间35min,平均出血量30ml,1例发生轻微性排尿困难,后未经特殊处理症状消失。术后随访6个月无再次尿失禁发生。结论TVT-0手术创伤小、恢复快,手术并发症低,是治疗女性压力性尿失禁安全有效的方法。     

TVT-O治疗女性压力性尿失禁疗效分析

应用经闭孔经阴道无张力尿道中段悬吊术(TVT-O)治疗8例女性压力性尿失禁。8例患者平均手术时间20min,平均术中出血18ml,TVT-O手术全部成功。TVT-O手术微创、简单、恢复快,治疗女性压力性尿失禁安全有效。     

TVT-O治疗女性压力性尿失禁8例临床体会

[目的]观察经闭孔经阴道无张力尿道中段悬吊术(TVT-O)治疗女性压力性尿失禁(SUI)的效果。[方法]女性压力性尿失禁8例采用经闭孔经阴道无张力尿道中段悬吊术(TVT-O)治疗。[结果]手术时间平均30min,术中出血量平均30ml。2例出现轻微尿频,1例大腿内侧有不适,未特殊处理症状消失。术后随访8(2~18)个月,8例患者均获得满意尿控。[结论]该术式操作简便、手术创伤小、手术时间短,无膀胱损伤并发症,治愈率高,是治疗女性压力性尿失禁的有效方法。     

经闭孔经阴道无张力尿道中段悬吊带术治疗女性压力性尿失禁疗效分析

目的本课题旨在探讨女性压力性尿失禁患者应用经闭孔经阴道无张力尿道中段悬吊带术的临床效果。方法通过随机数字法的分组方法将本院2015年2月至2017年6月在院治疗的女性压力性尿失禁患者112例分配到试验组和对照组。试验组56例患者经闭孔经阴道无张力尿道中段悬吊带术治疗,对照组56例采用常规治疗,对比两组并发症发生率与临床指标。结果试验组女性压力性尿失禁患者并发症发生率低于对照组,手术时间、住院时间和术中出血量都少于对照组,均有统计学差异(P0.05)。结论女性压力性尿失禁患者的并发症发生率可通过经闭孔经阴道无张力尿道中段悬吊带术显著降低,临床指标能够得到明显改善,值得推广。     

经闭孔尿道中段阴道无张力悬吊术治疗女性压力性尿失禁72例临床分析

目的探讨经闭孔尿道中段阴道无张力悬吊术(TVT-O)治疗女性压力性尿失禁的临床效果。方法于2007年1月1日至2011年6月1日对收治的72例压力性尿失禁女性患者采用行经闭孔尿道中段阴道无张力悬吊术治疗,分析其临床疗效及并发症。结果 72例压力性尿失禁患者接受经闭孔无张力阴道吊带术,术后随访12～24个月,平均14个月。65例(90%)治愈,4例(6%)有效,3例(4%)尿失禁复发。结论经闭孔尿道中段阴道无张力悬吊术具有微创、易操作、恢复快、疗效好等特点,是治疗女性压力性尿失禁的安全有效方法。     

TOT术治疗女性压力性尿失禁的护理体会

目的 探讨经闭孔阴道无张力尿道中段悬吊术(TOT)治疗女性压力性尿失禁的护理.方法 40例女性压力性尿失禁患者,通过术前心理护理、阴道准备,术后排尿的观察、指导.结果 40例患者通过2-24个月随访,均达到排尿自控的目的.结论 经闭孔阴道无张力尿道中段悬吊术是治疗女性压力性尿失禁的有效方法,配合积极的护理、有效的膀胱功能锻炼,可提高术后效果,预防尿失禁的发生.     

无张力阴道吊带尿道中段悬吊术在压力性尿失禁中的应用

目的 探讨经阴道无张力阴道吊带尿道中段悬吊术治疗压力性尿失禁的疗效.方法 对压力性尿失禁患者采用经阴道无张力尿道中段悬吊术治疗85例.结果 85例患者均有效.经阴道无张力尿道中段悬吊术尿失禁得到控制,治愈率92.6%,改善率7.4%,平均手术时间30～45min,平均住院日2～5天,平均置留尿时间30.6h,术后随访5～12个月无再次尿失禁发生.结论 经阴道无张力阴道吊带尿道中段悬吊术治疗压力性尿失禁手术操作简单,安全,手术创伤小,手术并发症低,费用低廉,是一种可推广的治疗压力性尿失禁的有效的手术方式.     

经闭孔手术治疗压力性尿失禁19例疗效观察

目的探讨经闭孔阴道无张力尿道中段悬吊带术治疗女性压力性尿失禁的疗效,及在基层医院开展的安全性。方法我院采用经闭孔阴道无张力尿道中段悬吊带术（TVT-O）治疗女性压力性尿失禁患者19例,并对术后治疗效果进行追踪随访。结果 19例患者手术均顺利完成,随访6个月～18个月,治愈17例,明显改善2例。术中、术后并发症少,对性生活无影响。结论 TVT-O手术操作简单,并发症少,疗效好,在基层医院开展是安全可行的,尤其对合并阴道前后壁脱垂者可同时行修补术,以减轻其经济负担。     

改良经闭孔尿道中段悬吊术治疗女性压力性尿失禁的临床资料研究

目的：评价改良经闭孔尿道中段悬吊术治疗女性压力性尿失禁的临床效果。方法：选取压力性尿失禁患者64例平分为两组,治疗组采用改良经闭孔尿道中段悬吊术,对照组采用经阴道耻骨后无张力尿道中段悬吊术,对比分析两组手术的临床效果。结果：两组患者手术均顺利,术后6h去除导尿管后均能自行排尿。治疗组的手术时间、住院时间都明显短于对照组（P〈0.05）,术中出血量明显少于对照组（P〈0.05）,治疗有效率明显好于对照组（P〈0.05）。结论：改良经闭孔尿道中段悬吊术治疗女性压力性尿失禁手术时间与住院时间短、出血量少、治愈率高、复发率低、避免闭孔血管和神经损伤、膀胱损伤,明显提高患者术后的生活质量,值得临床推广。     

TVT-O手术治疗女性压力性尿失禁(33例)疗效评价

目的：观察经闭孔经阴道尿道中段悬吊术（TVT0）治疗女性压力性尿失禁的疗效,并进行评价。方法：对33例女性压力性尿失禁患者经临床、尿动力学检查或膀胱尿道造影确诊,均为稳定性膀胱,无膀胱出口梗阻。确诊后行TVT-O手术疗。结果：30例患者术后拔尿管后尿失禁症状消失,随访6～24个月无复发,2例出现排尿困难,行尿道扩张后症状消失,1例出现急迫性尿失禁口服舍尼亭后好转。结论：TVT—O术操作简便,手术创伤小,手术时间短,并发症少,治愈率高,是治疗女性压力性尿失禁的有效方法。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.