补心逍遥饮治疗女性围绝经期失眠的疗效观察

目的评价补心逍遥饮治疗女性围绝经期失眠的临床疗效。方法收集2018年7月至2019年8月安徽省中医院门诊及住院收治的60例女性围绝经期失眠患者为研究对象。采用随机数表法分为观察组和对照组各30例,对照组予右佐匹克隆镇静催眠药治疗,观察组在对照组基础上加用补心逍遥饮治疗,总疗程为4周。采用匹兹堡睡眠质量指数表(PSQI)评价患者治疗前后的睡眠质量;治疗后比较两组的临床疗效、中医证候积分。结果两组治疗后PSQI各项评分及中医证候评分较治疗前均降低(P0.05);且观察组PSQI评分、中医证候评分下降多于对照组(P0.05)。两组临床疗效比较,差异无统计学意义(P0.05)。结论补心逍遥饮可有效改善女性围绝经期失眠患者总体睡眠质量,且不良反应少。     

天王补心丹治疗尿毒症失眠疗效观察

目的：观察天王补丹丸治疗长期血透的尿毒症患者失眠的疗效。方法：将尿毒症100例患者分成治疗组、对照组,治疗组：予以天王补心丹口服（8粒,1日3次）,对照组：予以舒乐安定口服（2.5 mg,每晚）,疗程4周。结果：疗程结束后,两组患者睡眠均有所提高,治疗组优于对照组（P〈0.05）,但安定组存在药物依赖性等副作用。结论：天王补心丹治疗尿毒症疗效优于地西泮,无药物依赖性,无明显副作用。     

解郁丸联合疏肝解郁胶囊治疗抑郁症的临床研究

目的探讨解郁丸联合疏肝解郁胶囊治疗抑郁症的疗效及安全性。方法将116例抑郁症患者随机分为对照组和观察组,每组58例。对照组给予帕罗西汀治疗;观察组给予解郁丸和疏肝解郁胶囊治疗。疗程为6周。观察并比较2组患者的临床疗效、汉密尔顿抑郁量表（HAMD）评分、临床疗效总评量表（CGI-SI）、抑郁自评量表（SDS）评分及副反应量表（TESS）评分。结果观察组的治愈率和总有效率明显高于对照组（P〈0.05或0.01）;2组患者治疗后的HAMD、CGI-SI及SDS评分明显低于治疗前（P〈0.05或0.01）,且观察组治疗2周后的HAMD、CGI-SI及SDS评分明显优于对照组（P〈0.05）;观察组的不良反应数及TESS评分均明显低于对照组（P〈0.05或0.01）。结论解郁丸联合疏肝解郁胶囊治疗抑郁症的临床效果显著,不良反应少,同时能改善患者睡眠质量。     

解郁丸联合黛力新治疗冠脉支架植入术后抑郁症的效果观察

目的探究解郁丸联合黛力新治疗冠脉支架植入术后抑郁症的临床效果。方法选取2014年3月至2017年1月鹤壁市人民医院收治的89例冠脉支架植入术后抑郁症患者,按随机数表法分为两组,对照组44例,接受黛力新治疗,观察组45例,接受黛力新+解郁丸治疗。治疗8周后,统计对比两组的治疗效果及治疗前后焦虑抑郁程度(HAMD评分)。结果观察组的治疗总有效率高于对照组(95.56%比77.27%),差异有统计学意义(P<0.05)。治疗前,两组HAMD评分比较,差异无统计学意义(P>0.05);治疗后,两组HAMD评分均降低,且观察组低于对照组,差异有统计学意义(P均<0.05)。结论解郁丸联合黛力新治疗冠脉支架植入术后抑郁症的效果显著,可降低患者焦虑抑郁程度,改善其心理状态,值得推广应用。     

探析天王补心丹加减治疗心阴虚型失眠临床疗效

目的分析在心阴虚型失眠患者中应用天王补心丹加减治疗模式的临床效果,以供工作参考使用。方法将100名我院收治的患者随机均分为两组,对照组:常规方法;治疗组:天王补心丹加减治疗,列表比较两组患者的临床应用效果。结果经试验后统计,治疗组各临床数据均好于对照组,P0.05比较两组数据后,有统计学意义。结论进行天王补心丹加减治疗者能够改善患者临床情况,促进康复。     

天王补心丹治疗中风后焦虑症30例疗效观察

目的观察天王补心丹治疗中风后焦虑症的效果与安全性。方法中风后抑郁患者60例根据入院顺序随机平为两组-治疗组与对照组各30例,对照组采用西药氟西汀口服治疗,治疗组口服天王补心丹治疗。结果经过治疗后,治疗组的有效率为95.0%,对照组的有效率为82.5%,治疗组的有效率明显高于对照组,两者比较具有统计学意义（P〈0.05）。治疗后神经功能缺损评分有明显下降（P〈0.05）,表明两组都有改善神经功能缺损的效果,组间比较,但是治疗组的下降幅度显著高于对照组（P〈0.05）。治疗组有1例早期发生恶心、呕吐等不良反应;对照组有5例早期发生恶心、呕吐等不良反应。治疗组的不良反应明显少于对照组（P〈0.05）。结论天王补心丹治疗中风后焦虑症能明显提高治疗疗效,改善神经功能缺损状况,且无明显不良反应,值得推广应用。     

揿针疗法对围绝经期焦虑和抑郁患者血清神经递质的影响

目的观察揿针疗法对围绝经期焦虑和抑郁患者的治疗效果。方法选取本院就诊的围绝经期焦虑和抑郁患者60例,随机分为观察组和对照组,每组30例。对照组采用氟哌噻吨美利曲辛片口服治疗,观察组采用揿针治疗,2组患者均连续治疗12周。比较2组患者治疗前后血清神经递质(NE、5-HT、GABA)水平、SDS、SAS及KI评分的变化情况,根据KI下降率评价临床疗效。结果治疗后,2组患者血清NE水平均明显升高,5-HT及GABA水平均明显下降,且观察组改善程度显著优于对照组(P0.05);2组患者SAS、SDS和KI评分均较治疗前明显下降,且观察组改善程度显著优于对照组(P0.05);观察组总有效率显著高于对照组(P0.05)。结论揿针疗法治疗围绝经期焦虑和抑郁患者,可显著提高NE水平,降低5-HT及GABA水平,改善SAS、SDS和KI评分,提高临床疗效。     

解郁清心汤治疗肝郁血虚型失眠合并抑郁临床观察

目的 探讨解郁清心汤治疗肝郁血虚型失眠合并抑郁患者的临床疗效与安全性。方法 将84例失眠合并抑郁患者随机分为对照组和观察组,每组42例。对照组给予右佐匹克隆片治疗,观察组在对照组基础上给予解郁清心汤治疗,2组均治疗28天。应用匹兹堡睡眠质量指数(Pittsburghsleepqualityindex,PSQI)评估患者睡眠质量、疲劳严重程度(fatigueseverityscale,FSS)评估患者疲劳程度、汉密顿抑郁量表17项(Hamiltondepressionscale,HAMD-17)评估患者抑郁程度、治疗副反应量表(treatmentemergentsymptomscale,TESS)评估治疗安全性,同时记录2组治疗期间发生的不良事件,比较2组不良反应总发生率。结果 治疗后,观察组PSQI评分、FSS评分、HAMD-17评分、TESS评分均明显低于对照组(P<0.05)。观察组不良反应总发生率为9.52%,显著低于对照组的14.29%(P<0.05)。结论 解郁清心汤联合右佐匹克隆片可以明显改善肝郁血虚型失眠合并抑郁患者的睡眠质量、疲劳程度及抑郁情绪,减少药物的不良反应,提高生活质量。     

百合地黄汤联合镇静安神针法治疗女性围绝经期失眠的疗效及对焦虑抑郁的影响

目的研究百合地黄汤联合镇静安神针法对女性围绝经期失眠患者的疗效,并观察其对焦虑及抑郁情绪的影响。方法选取2019年1月—2020年1月期间航空总医院中医科收治的女性围绝经期失眠患者78例,根据随机数字表法分为对照组39例和治疗组39例。对照组给予镇静安神类西药治疗,治疗组给予百合地黄汤联合镇静安神针法治疗。两组患者均治疗4周。治疗后,观察比较两组临床疗效,性激素水平,睡眠情况及焦虑抑郁情绪评分。并记录不良反应发生情况。结果治疗后治疗组总有效率89.74%(35/39)高于对照组69.23%(27/39),差异有统计学意义(P0.05)。治疗后两组患者血清促卵泡生成素(FSH)、促黄体生成素(LH)水平均低于治疗前(P0.05),且治疗组治疗后血清FSH、LH水平均低于对照组(P0.05);治疗后两组患者血清孕酮(E_2)、雌二醇(P)水平均高于治疗前(P0.05),且治疗组治疗后血清E_2、P水平均高于对照组(P0.05)。治疗后两组患者PSQI评分均低于治疗前(P0.05);且治疗结束后1个月治疗组匹兹堡睡眠质量指数(PSQI)评分低于对照组,差异有统计学意义(P0.05)。治疗后两组患者HAMA、HAMD评分均低于治疗前(P0.05),且治疗组治疗后汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分均低于对照组(P0.05)。治疗期间,治疗组不良反应发生率7.69%(3/39)低于对照组25.64%(10/39),差异有统计学意义(P0.05)。结论百合地黄汤联合镇静安神针法治疗女性围绝经期失眠疗效显著,可改善患者性激素水平,提高睡眠质量,且不易产生药物依赖及不良反应,安全可靠,值得临床推广应用。     

天王补心丸伍知柏地黄丸治疗更年期综合征

目的:观察天王补心丸和知柏地黄丸用于妇女更年期综合征的临床效果.方法:将90例随机分为治疗组45例与对照组45例,对照组以常规西药对症治疗,治疗组仅以天王补心丸伍知柏地黄丸治疗.结果:治疗前后观察各项指标,经统计学处理,治疗组在改善症状、及提高总有效率明显优于对照组(P＜0.01).结论:天王补心丸伍知柏地黄丸可提高和改善更年期症状,减轻病人痛苦,值得临床应用.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.