质子泵抑制剂对咽喉反流患者唾液胃蛋白酶浓度的影响

目的:探讨质子泵抑制剂(PPI)治疗对咽喉反流(LPR)患者唾液胃蛋白酶浓度的影响.方法:以2019年8月-2020年12月西安交通大学第二附属医院收治的以咽部异物感、咽干、痰多等非特异性症状为主诉的152例疑似LPR初诊患者为研究对象,应用反流症状指数量表(RSI)与反流体征指数量表(RFS)评分将所有患者分为LPR...     

咽喉反流性疾病患者精神心理状态分析

目的　通过对咽喉反流性疾病（laryngopharyngeal reflux disease,LPRD）患者的精神心理状态进行分析,明确LPRD患者是否存在焦虑、抑郁心理状态。方法　就诊福州总院耳鼻咽喉头颈外科门诊的LPRD患者作为研究对象,同时选取相同例数到我院进行健康体检的健康志愿者作为对照组。对实验组及对照组进行焦虑自评量表（SAS）评分和抑郁自评量表（SDS）评分,研究LPRD患者的精神心理状态。结果　LPRD患者焦虑、抑郁评分均明显高于对照组（焦虑状态评分50.59±7.24 vs 38.76±7.70,抑郁状态评分52.90±7.14 vs 40.63±8.17）。LPRD患者焦虑、抑郁的发生率均明显高于对照组（焦虑发生率56.68% vs 9.80%,抑郁发生率50.98% vs 11.76%）。LPRD患者反流症状指数评分与焦虑、抑郁评分有明显相关性（r =0.786,r =0.736,P均＜0.05）,多因素分析证实LPRD与焦虑、抑郁评分之间存在显著的相关性。结论　LPRD患者较健康对照组更容易出现焦虑、抑郁的精神心理状态,且LPRD症状的严重程度与焦虑、抑郁的心理状态有明显相关性。这提示在常规抗酸治疗此类LPRD患者的同时,也应该重视对患者心理状态的干预。     

Ryan指数与反流症状指数量表、反流体征量表在咽喉反流性疾病诊断中的相关性分析

目的 探讨Ryan指数与反流症状指数量表(RSI)、反流体征量表(RFS)在咽喉反流性疾病诊断中的相关性。 方法 回顾性分析以咽喉部不适症状就诊,病程1个月以上的行咽部pH检测的230例患者临床资料。所有患者均同时行电子喉镜检测,并行RSI、RFS评估。 结果 Ryan指数阳性率为15.2%(35/230)。RSI、RFS、RSI或RFS及RSI且RFS阳性率分别为46.5%、28.7%、60.9%、13.9%。Ryan指数阳性组患者RFS评分高于Ryan指数阴性组患者,RSI评分与Ryan指数阴性组患者差异无统计学意义。RFS阳性,RSI或RFS,RSI且RFS阳性组Ryan指数阳性率高于RFS阴性,RSI或RFS,RSI且RFS阴性组。Ryan指数阳性与RSI、RFS、RSI或RFS及RSI且RFS阳性的一致性检验的kappa值分别为-0.06,0.394,0.116和0.172。以pH监测作为金标准时,RSI、RFS、RSI或RFS及RSI且RFS的敏感性分别为37.1%,74.3%,82.9%,28.6%;特异性分别为51.8%,79.5%,43.1%,88.2%;阳性预测值分别为12.1%,39.4%,20.7%,30.3%;阴性预测值分别为82.1%,94.5%,93.3%,87.3%。RSI与直立位及平卧位Ryan指数的相关系数分别为-0.056和-0.083;RFS与直立位及平卧位Ryan指数的相关系数分别为0.425和0.166。 结论 咽部pH检测是直接反映咽喉部反流的客观、无创的检测方法。RFS与Ryan指数有一定的正相关性,但量表与Ryan指数一致性差。尚需进一步研究更准确的、反映咽喉反流的量表及pH诊断指数。     

中西医结合治疗咽喉反流性疾病

目的　探讨咽喉反流性疾病（laryngopharyngeal reflux disease,LPRD）有效的诊断和治疗方法。方法　对经反流症状指数量表（reflux symptom index,RSI）和反流体征评分量表（reflux finding score,RFS）评分诊断为LPRD 患者74例,给予质子泵抑制剂（proton pump inhibitor,PPI）雷贝拉唑钠肠溶片20 mg,1次/d,口服,持续2～3个月后如症状明显缓解则减量为10 mg,1次/d,维持治疗6～12个月;金嗓利咽丸,60～120粒,2次/d,持续1～3个疗程。分别于治疗2、6、12和18个月进行疗效观察。结果　治疗2、6、12、18总有效率分别为74.3%、90.5%、87.8%、86.5%。结论　咽喉反流是导致慢性咽喉炎难治的重要病因,使用雷贝拉唑钠肠溶片联合金嗓利咽丸治疗,可明显改善LPRD的症状和体征。     

咽喉反流伴阻塞性睡眠呼吸暂停低通气综合征患者的治疗及其咽喉反流体征评分、症状指数特点

目的 分析咽喉反流病(LPRD)伴阻塞性睡眠呼吸暂停综合征(OSAS)患者的咽喉反流体征评分(RFS)和咽喉反流症状指数(RSI)特点,探讨临床治疗效果。 方法 抽取100例LPRD患者,将其中合并有OSAS的患者作为观察组(n=39),其余作为对照组(n=61),观察两组RFS、RSI及呼吸暂停低通气指数(AHI)、血氧饱和度(SaO₂)、反流总数、总反流时间;比较治疗2个月后RSI、RFS评分。 结果 观察组RFS和RSI评分总分显著高于对照组,RFS体征差异均有统计学意义(P<0.05),咽喉反流伴OSAS患者声门下水肿、喉室消失、杓会厌襞红斑/充血、喉黏膜水肿、后联合肥厚或肿胀评分显著高于单纯的咽喉反流患者(P<0.05),RSI评分中咽喉反流伴OSAS患者呼吸困难、烧心胸痛胃酸反流评分显著高于单纯的咽喉反流患者(P<0.05);治疗后,观察组RSI评分总分高于对照组(P均<0.05),对照组在呼吸困难、烧心胸痛胃酸反流方面明显优于观察组(P<0.05)。治疗前后,两组AHI、SaO₂、反流总数比较均差异有统计学意义(P<0.05)。治疗后,观察组AHI、SaO₂均明显改善,与治疗前比较差异有统计学意义(P<0.05),两组反流总数、总反流时间改善显著,对照组优于观察组(P<0.05)。 结论 伴OSAS会加重LPRD患者咽喉反流相关症状,可能是LPRD患者治疗效果和症状改善较差的原因。     

悬雍垂腭咽成形术对OSAHS患者咽喉反流的影响

目的探讨悬雍垂腭咽成形术(uvulopalatopharyngoplasty,UPPP)对阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)患者咽喉反流(layrngopharyngeal relfux, LPR)的影响。方法对62例确诊为OSAHS的患者行UPPP手术,分别在术前、术后6个月时填写反流症状指数(reflux symptom index,RSI)和反流体征评分(reflux fineling score,RFS)量表,比较患者手术前后的症状及RSI、RFS评分结果。结果术后6个月时,患者睡眠打鼾、呼吸暂停和白天嗜睡等症状较术前均有明显改善。术前RSI>13分和/或RFS>7分的患者共24例(38.71%,24/62),术后6个月仅5例(8.06%,51/62)。术后6个月时,RSI和RFS量表总分较术前显著降低(P<0.01),除了吞咽困难和肉芽肿2个分项外,其余各分项评分差异均有统计学意义(P<0.05)。结论 UPPP手术可明显缓解OSAHS患者咽喉反流症状。     

中西医结合治疗咽喉反流合并咽喉炎的临床疗效

目的探讨雷贝拉唑与多潘立酮联合中药西青果颗粒对咽喉反流（laryngo pharyngeal reflux, LPR）合并咽喉炎患者的治疗效果,及对症状缓解和生活质量的影响。方法回顾性分析2014年3月~2015年5月接受治疗的LPR合并咽喉炎患者的临床资料,根据其治疗方式分为西药组和中西药联合治疗组,西药组采用雷贝拉唑和多潘立酮治疗,中西药联合治疗组采用雷贝拉唑、多潘立酮和西青果颗粒治疗。疗程为3个月,分析两组患者的治疗效果和不良反应发生率,比较两组患者治疗前后反流症状指数量表（feflux symptom index, RSI）评分、反流检查计分量表（reflux finding score, RFS）评分和症状缓解时间的差异。结果中西药结合组治疗的有效率（97.14%）明显高于西药组（80.00%）（χ2=5.195,P=0.023）;两组患者治疗前的RSI评分无显著差异（P>0.05）,治疗后中西药结合组患者的声嘶或发声问题、清喉和咽喉黏液增多等维度得分均低于西药组（P<0.05）;两组患者治疗前的RFS评分无显著差异（P>0.05）,治疗后中西药结合组患者的声门下水肿、喉室消失和红斑、充血等维度得分均低于西药组（P<0.05）;中西药结合组患者咽部异物感、慢性咳嗽、反复清嗓和声嘶缓解时间明显短于西药组（t=30.589、12.928、8.615和9.803,P<0.001）;两组肝肾功能受损、腹胀和倦怠发生率无显著差异（χ2=0.008,P=0.930）。结论中西药结合对咽喉反流合并咽喉炎有较好的疗效,可明显改善临床症状和体征,降低不良反应发生率,具有临床应用价值。     

窄带成像技术在咽喉反流诊断中的优势应用

目的 探讨窄带成像技术(NBI)在咽喉反流(LPR)诊断中的作用.方法 根据我国2015年咽喉反流性疾病诊断与治疗专家共识的标准招募39例咽喉反流阳性患者(LPR组)和19例阴性对照,参与者均完成反流症状指数评分量表(RSI)和反流体征评分量表(RFS)评分及NBI下的电子喉镜检查.结果 39例LPR患者中2例失访.与...     

咽喉反流与广基型、非广基型声带息肉的相关性研究

目的　探讨咽喉反流（laryngopharyngeal reflux,LPR）与广基型声带息肉和非广基型声带息肉的相关性,为临床有效治疗声带息肉提供依据。方法　选取2018年9月~2019年9月于重庆医科大学第一附属医院耳鼻咽喉头颈外科声带息肉切除术患者99例,术前喉镜分为广基型声带息肉和非广基型声带息肉。通过反流症状指数量表（Reflux symptom index,RSI）和反流体征评分量表（Reflux finding score,RFS）初步诊断为LPR,比较广基型声带息肉与非广基型声带息肉人群咽喉反流率,并对可能影响广基型声带息肉的因素（性别、吸烟史、饮酒史、环境暴露、用嗓过度、年龄和声音嘶哑的病程）一并纳入统计。利用卡方检验与独立样本t 检验先进行单因素分析,P <0.05为标准筛选出可能相关的因素,再进行多因素的Logistic 回归分析,P <0.05表示存在显著性差异。结果　单因素分析为用嗓过度、环境暴露、年龄和声音嘶哑的病程差异均无统计学意义,LPR、性别、吸烟史、饮酒史可能与广基型声带息肉相关（P <0.05）,多因素Logistic回归分析显示,饮酒史和LPR的差异有统计学意义,与广基型声带息肉的发生密切相关。结论　LPR和饮酒史不仅是声带息肉发病的相关因素,相比较非广基型声带息肉,LPR和饮酒史与广基型声带息肉之间存在更大相关性,是广基型声带息肉发生的危险因素。     

Laryngopharyngeal reflux finding scores correlate with gastroesophageal reflux disease and Helicobacter pylori expression

Conclusion. The expression of Helicobacter pylori (HP) positivity and degree of gastroesophageal reflux disease (GERD) correlate with laryngopharyngeal reflux (LPR). HP positivity and degree of GERD were more adverse in patients with a reflux finding score (RFS) of 7 or more. Objective. We aimed to investigate the relationship between RFS and inflammation of the lower part of the esophagus as well as RFS and HP infection. Patients and methods. Forty-five consecutive patients were analyzed prospectively. The degree of LPR was evaluated using the RFS method. The degree of GERD, lower esophageal mucosal inflammation, and antral HP positivity were evaluated using endoscopic surveys. Results. The mean RFS of the whole population was 11.5±4.4. The mean RFS of patients who had lower esophageal mucosal inflammation was 7±0.1, 8.1±1.3, 13.9±3.7, and 16.6±3.5, for grades A, B, C and D, respectively. The RFS of patients according to HP expression was as follows: 7.2±0.4, 9.3±3.07, 12.7±3.16, and 17.8±2.1, for normal (score 0), score I, score II, and score III, respectively.     

Characteristics of laryngopharyngeal reflux in patients with chronic otitis media

Objective

To summarize the characteristics of laryngopharyngeal reflux (LPR) in patients with chronic otitis media.

The influence of laryngopharyngeal reflux in the healing of laryngeal trauma

The aim of this clinical study was to evaluate the effect of laryngopharyngeal reflux (LPR) on the healing process of surgical laryngeal trauma. A total of 112 consecutive patients, who suffered from LPR and were scheduled for operation of Reinke edema or laryngeal polyps/nodules (40 and 72 patients, respectively) during a period of 5 years, were included. Diagnosis of LPR was made on the basis of both history and dual pH probe recording during 24 h in the inferior esophagus and the hypopharynx. The reflux finding score (RFS) and the reflux symptom index (RSI) were used to estimate the clinical severity of LPR. In patients with LPR, proton pump inhibitors (PPI) were initiated in half of them, randomly chosen. Fifty LPR-free subjects operated for Reinke edema or laryngeal polyps during the same time period (19 and 31 patients, respectively) were used as controls. In six patients who had been administered PPI, resolution of the disease was observed and no surgical treatment was undertaken. The remaining patients were operated on under general anesthesia by a single surgeon. All patients had 1-year postoperative follow-up. Epithelization was complete in all vocal cords of both the control group and the group of patients who had been administered PPI. Within the group of patients who had not taken PPI, six patients presented granulation tissue or recurrence of the polyps and in two of them revision surgery was needed. RFS and RSI scores showed significant improvement postoperatively, across all the three groups of patients, with major differences observed in the group treated by PPI. Comparison of the postoperative RFS and RSI scores between the two groups of patients with LPR showed statistically significant differences in both, indicating better treatment outcome in those patients who had received PPI. It may be thus concluded that LPR influences epithelization and recurrence of laryngeal polyps or Reinke edema in vocal cords, after partial or total decortication. Surgical outcome is superior in patients with LPR with preoperative and postoperative anti-reflux treatment.     

双探头24小时pH监测对咽喉反流的诊断价值及特点

目的对咽喉反流患者用食道测压定位法行双探头24小时pH监测,探讨其诊断价值及特点。方法对53例疑咽喉反流患者用食道测压定位法行双探头24小时pH监测同时用反流症状指数量表(reflux symptom index,RSI)、反流检查计分量表(reflux finding score,RFS)2个量表评估。结果 53例患者中31例咽喉反流阳性,与吸烟有相关性。RSI中以声嘶、咽异物感、持续清嗓为主要症状,RFS中以后连合增生、假声带沟、喉内黏液附着为主要体征。咽喉部酸反流主要发生在直立位,其中9例患者只有咽喉反流性疾病,10例只有胃食管反流性疾病;酸反流次数、酸暴露时间(即pH<4.0的总时间)与2个量表的评估有显著性差异。咽喉部pH监测结果与2个量表评估结果程度一致。结论咽喉反流性疾病可不伴发胃食管反流性疾病,减少酸反流次数及减少酸在咽喉部停留时间在治疗疾病中较为重要,RSI和RFS 2个量表可作为咽喉反流性疾病诊断的初筛。     

咽异物感伴有咽喉反流患者抗反流治疗的临床观察

目的 观察抗反流治疗对咽异物感伴有咽喉反流的临床疗效。 方法 将门诊以咽异物感自评超过3分,患病1个月以上的患者,进行反流症状指数量表(RSI)及反流临床表现量表(RFS)评分,对RSI超过13分及RFS超过7分的患者进行抗反流治疗,以能持续治疗8周以上为有效观察对象,共104例。分析入组患者反流各症状发生率、反流临床表现各体征发生率,并进行疗效评定。 结果 104例咽异物感患者多有反流症状清嗓动作(92/104,88.46%),主要反流体征为后连合肥厚(97/104,93.27%),红斑/充血(89/104,85.57%),喉内黏稠分泌物(87/104,83.65%),喉室阻塞(73/104,70.19%)等,经抗反流治疗,有效61例,有效率为58.65%;RSI治疗前后比较,差异有统计学意义(t=1.975,P<0.05);RFS治疗前后比较,差异无统计学意义(t=1.258,P>0.05)。 结论 咽异物感伴反流症状的患者,通过反流治疗是有效的。对于有咽异物感的患者,经过长期治疗效果不明显,应考虑是否有咽喉反流的可能。     

Effects of pepsin A on heat shock protein 70 response in laryngopharyngeal reflux patients with chronic rhinosinusitis

Objectives: We investigated the relationship between laryngopharyngeal reflux (LPR) and chronic rhinosinusitis (CRS), and explored the effects of pepsin A on the level of heat shock protein 70 (HSP70) in CRS.

Methods: We included 23 CRS patients with nasal polyps (CRSwNP), 26 CRS patients without nasal polyps (CRSsNP) and nine normal controls to measure pepsin A levels in nasal secretions, blood plasma and nasal tissues, to measure HSP70 levels in nasal tissues, and to detect pepsinogen A, HSPA5, cyclo-oxygenase-2 (COX-2), and carbonic anhydrase III (CAIII) mRNA expression levels in nasal tissues.

Results: Pepsin A levels in nasal secretions were significantly higher in CRSwNP/CRSsNP patients than in controls. HSP70 levels were significantly increased in pepsin A-positive turbinate mucosa compared to controls (p?p?=?.016). Furthermore, no association was found between the presence of pepsin A and HSPA5, COX-2, and CAIII mRNA expression levels.

Conclusions: These results suggest that LPR may play a role in the development of CRS through pepsin A reflux, and increased HSP70 expression may be associated with the pathogenic mechanism of mucosal injury in CRS.