Ventricular Tachycardia Induced Cardiomyopathy: Improvement with Radiofrequency Ablation

Cardiomyopathy and congestive heart failure due to ventricular and supraventricular tachycardia is a well-recognized phenomenon. The mechanism of such Cardiomyopathy is not clear. Ablation of the supraventricular tachycardia focus, either surgically or electrically, has been reported to result in the resolution of the left ventricular dysfunction. Similarly, the treatment of ventricular tachycardia with surgery or antitachycardia pacing has also been reported to result in improved ventricular systolic function. We present here a case of improvement in left ventricular systolic function after successful radiofrequency ablation of the ventricular tachycardia focus in the right ventricular outflow tract. We postulate that Cardiomyopathy was due to the incessant or frequent ventricular tachycardia. To the best of our knowledge, this is the first such case being reported.     

Successful Radiofrequency Current Catheter Ablation of Sustained Ventricular Tachycardia

We performed radiofrequency current catheter ablation in two patients with nonischemic sustained ventricular tachycardia (VT). In one patient, two morphologically distinct VTs were induced by electrical stimulation. One showed right bundle branch block pattern and the other left bundle branch block pattern. The earliest site of activation during each VT was determined at the septum of the right ventricle. However, these two sites were close to the His-bundle elecfrogram recording area. In the other patient, a VT with a left bundle branch block pattern occurred spontaneously after the administration of isoproterenol. The earliest site of activation during VT was determined at the outflow tract of the right ventricle. During tachycardia, radiofrequency current ablation (40 W ± 30 sec) was delivered to the earliest site of activation, A few seconds after fulguration, each VT was terminated and additional radio-frequency currents were given near these sites. After the ablation, VT could not be induced by the electrical stimulations, nor did it recur. No side effects were observed and the atrioventricular conduction remained intact. We feel that nonischemic VTs could possibly be treated by using radiofrequency current catheter ablation.     

First Lessons from Radiofrequency Catheter Ablation in Patients with Ventricular Tachycardia

Fourteen patients (12 men, 2 women; 61 ± 9 years) with ventricular tachycardia and underlying heart disease underwent an attempt at radiofrequency energy catheter ablation. Twelve patients had coronary disease and two patients had dilated cardiomyopathy. Two patients had two clinical tachycardias, the ejection fraction was 38%± 11%. All tachycardias were inducible and hemodynamically well tolerated (cycle length = 357 ± 56 msec). Ablation was initially successful in nine patients (no tachycardia inducible after ablation and before discharge). Two patients had recurrences (in-hospital and 4 months) and one patient had a tachycardia of a different morphology, which was also successfully ablated. Ablation was overall successful in seven patients and unsuccessful in seven patients (including all patients with cardiomyopaihy). Mid-diastolic potentials were observed in all the patients in whom ablation was successful but not observed in four of seven unsuccessful patients. The successful patients remain free of recurrences at 9 ± 8 months follow-up. Conclusions: (1) in ventricular tachycardia following an old infarction radiofrequency energy ablation is possible with a high success rate if a critical component of the tachycardia circuit can be localized. Localizing isolated mid-diastolic potentials and ensuring these potentials are part of the reentrant circuit with concealed entrainment can help to enhance the results. (2) A negative predischarge electrophysiological study may be predictive of success.     

Reversibility of "Tachycardia Induced Cardiomyopathy" Following the Cure of Idiopathic Left Ventricular Tachycardia Using Radiofrequency Energy

We report a cose of incessant ventricular tachycardia with right bundle branch block and left axis deviation morphology resulting in severe LV dysfunction and congestive heart failure. Radiofrequency ablation of the appropriate site in the region of posteroapical part of the LV septum resulted in the cure of the arrhythmia. On a 3-month follow-up, the LV size and function returned to normal.     

Development of an Interactive Computer-Guided Method for Radiofrequency Catheter Ablation of Ventricular Tachycardia

The purpose of this study was to develop a simple computer-guided approach to localizing ventricular tachycardias during ventricular mapping. Six patients with sustained monomorphic ventricular tachycardia were connected to a 32-lead computer body surface mapping system. Isoarea maps of induced ventricular tachycardia were recorded. Then a pacing probe was placed in either the right or left ventricle, and maps were generated from a variety of sites. Differences between ventricular tachycardia and pace map maxima X,Y coordinates were utilized to guide catheter manipulation and localization. In 6 of 6 patients (100%) this method appeared to provide a systematic approach to ventricular tachycardia localization. Computer-generated correlations as well as the X,Y coordinates of the QRS isoarea maxima were used to determine proximity to the ventricular tachycardia foci and direct catheter manipulation. In the next three patients this method was applied prospectively to help guide catheter manipulation during ventricular tachycardia (two right ventricular outflow tract tachycardias, and one left ventricular tachycardia). After a mean of 4.0 ± 1.7 radiofrequency applications, ventricular tachycardia was no longer inducible, and at 7 ± 0 months follow-up there have been no arrhythmia recurrences. We conclude that online computerized body surface mapping can assist in localizing ventricular tachycardia. Differences in maxima during pace maps and in-situ ventricular tachycardias can help with catheter manipulation as well as with more precise identification of focal tachycardias. This technique appears to hold the promise of a simple computer-guided method that may facilitate radiofrequency catheter ablation.     

Implantable Cardioverter Defibrillator Detection During Radiofrequency Catheter Ablation of Ventricular Tachycardia

Right ventricular radiofrequency catheter ablation was performed in an ICD patient with frequent ventricular tachycardia without prior inactivation of the device. The registrations of inlracardiac ECG and marker channel were excellent during energy delivery: the surface ECG was affected. The device did not show dysfunction during and after energy delivery.     

Successful Transcatheter Ablation of Congenital Junctional Ectopic Tachycardia in a Ten-Month-Old Infant Using Radiofrequency Energy

Congenital junctional tachycardia is a difficult-to-control rhythm in children which has a high mortality rate with current management. A 10-month-old child followed since birth with the diagnosis of congenital junctional ectopic tachycardia is reported. He failed treatment with multiple antiarrhythmic agents, and underwent an electrophysiology study. The junctional focus was successfully ablated using transcatheter radiofrequency energy. This technique may be safer than high voltage DC shock ablation, particularly in small children.     

经导管射频消融治疗特发性室性心动过速患者的护理

目的探讨经导管射频消融治疗特发性室性心动过速患者的护理方法。方法回顾性分析75例行导管射频消融治疗的特发性室性心动过速患者的临床资料。结果发生术后并发症3例,其中穿刺点血肿2例、心脏压塞1例,经精心治疗和护理后均痊愈出院。结论经导管射频消融治疗特发性室性心动过速患者安全有效,手术前后需要密切观察、精心护理、及时发现并协助处理各种并发症。     

Radiofrequency Catheter Ablation of Refractory Ventricular Tachycardia

Transcatheter radiofrequency ablation of the arrhythmia focus was attempted in a 68-year-old patient with recurrent ventricular tachycardia, both spontaneous and inducible by programmed ventricular stimulation despite treatment with multiple antiarrhythmic drugs. The procedure was performed under local anesthetic without complication. The arrhythmia was not inducible immediately following ablation or 5 days later, and during 5 months follow-up there has been no spontaneous recurrence.     

Transcatheter Radiofrequency Ablation of Ventricular Tachycardia Following Surgical Correction of Tetralogy of Fallot

Ventricular arrhythmias occur in up to 13.5% of patients after tetralogy of Fallot repair. We describe a patient with a 30-year history of recurrent ventricular tachycardia, which followed the surgical repair of tetralogy of Fallot. Findings at electrophysiological study were consistent with reentry involving an area of slow conduction in the right ventricular outflow tract. Following the transcatheter application of radiofrequency energy in the right ventricular outflow tract, ventricular tachycardia could no longer be induced and has not occurred spontaneously during follow-up (28 months). Thus, transcatheter radiofrequency ablation is an acceptable therapeutic option in some patients with ventricular tachycardia after the surgical repair of tetralogy of Fallot.     

Radiofrequency Catheter Ablation of the Slow Reentrant Pathway of Sustained Ventricular Tachycardia

The article reports the cases of two patients with severe coronary artery disease and associated recurrent sustained ventricular tachycardia successfully treated with radiofrequency catheter ablation. In the first patient, two different types of ventricular tachycardia (one incessant) were eliminated. In all procedures, an area of slow conduction critical for tachycardia maintenance was localized by endocardial mapping techniques. Radiofrequency energy delivered to this area could permanently modify the anatomical substrate of the arrhythmia. After single follow-ups of 19, 14, and 13 months regarding the arrhythmic entities, the patients are well and free from spontaneous recurrences.     

Alternation of QRS Morphology and Effect of Radiofrequency Ablation in Idiopathic Ventricular Tachycardia

We performed electrophysiological studies in 13 patients with idiopathic VT and attempted radiofrequency (RF) catheter ablation in 4 of them.Results: VT was induced by programmed stimulation in all patients and the mean cycle length was 363 ± 58 msec. In 8 of 13 patients (62%), alternation of either the cycle length and/or morphology of VT was observed. Transient entrainment was achieved in all patients by rapid pacing from the right ventricular outflow tract so reentry was considered the underlying mechanism of VT. The site of earliest activation (EAS) during VT was located at the apicoposterior portion of the left ventricular septum and used as the target site for RF catheter ablation. Spikelike presystolic activity was detected 20–40 msec prior to the large deflection of the local electrogram in four patients. VT was terminated by a few seconds of RF current in all four patients, but subsequently new VTs with a slightly different morphology were induced in three of them and re-mapping showed a shift of the EAS. After additional RF ablation at the new EAS, VT was no longer induced. No complication was noted and VT did not recur during a follow-up period for a mean of 9.3 ± 5.2 months.Conclusion: RF catheter ablation seems useful and safe for idiopathic VT. The alternation of QRS morphology and the findings at the time of catheter ablation suggest that an alternative pathway or multiple exits may be present in some patients with idiopathic VT, because the change in VT morphology was associated with a shift of the EAS.     

Catheter Ablation of Idiopathic Left Ventricular Tachycardia

ZARDINI, M., etal .: Catheter Ablation of Idiopathic Left Ventricular Tachycardia . Idiopathic left ventricular tachycardia (ILVT) characterized by right bundle branch block, left axis morphology, response to verapamil and inducibility from the atrium in patients without structural heart disease may represent a distinct clinical entity. We report our experience with catheter ablation of this uncommon arrhythmia using radiofrequency energy (RF) and/or direct current (DC) shocks. Six men and 2 women, aged 16–50 years (mean ± SD, 32 ± 13), had recurrent VT for 16 ± 16 years with a mean frequency of 4 ± 3 episodes/ year. Three patients had syncope during VT. None had identifiable structural heart disease. Catheter ablation was guided by earliest endocardial activation, presence of a high frequency presystolic potential and/or pacemapping of the left ventricle. The left ventricle was accessed via a retrograde aortic approach in 6 patients, a transeptal approach in 1 patient, and a combined approach in the remaining patient. All patients had inducible right bundle branch block morphology, left axis VT with a mean cycle length (CL) of 361 ± 61 ms. A presystolic potential preceding ventricular activation and the His potential during VT was identified in 4 patients. All ablation sites were identified in a relatively uniform location, in the inferoapical left ventricle. Noninducibility of VT was obtained with RF in 3 patients and with DC in 5 patients. In 1 patient, DC delivery after unsuccessful RF prevented further inducibility. Similarly, RF was successful in 1 patient in whom an initial DC attempt was ineffective. Mean total procedure time was 282 ± 51 minutes and mean total fluoroscopy time was 40 ± 15 minutes. There were no complications. One patient treated with DC shock had recurrence of VT during treadmill test the day after ablation and refused repeat ablation. During a mean follow-up of 17 ± 13 months, no VT recurrences or other cardiovascular events occurred. In conclusion, catheter ablation in the inferoapical left ventricle is an effective treatment for this type of ILVT. RF energy can be safely complemented by low energy DC shocks when the former is ineffective.     

特发性室性心动过速射频导管消融方法探讨

目的：探讨特发性室性心动过速（IVT）的消融方法。方法：对12例IVT患者进行射频消融治疗，源于右心室IVT采用消融导管起搏标测法，以起搏时与VT发作时的12导联心电图QRS波形态与振幅完全相同的起搏部位为消融靶点。并在周围做巩固消融，起源于左心室IVT以激动标测法或寻找P电位。结果：IVT消融成功率91．6％（11／12），1例ILVT在第3次复发射频消融后发生双束支阻滞而安装了VVI永久起搏器。结论：起源于左心室的IVT宜采用激动顺序标测法，起源于右心室的IVT宜采用起搏标测法。对有效靶点周围进行线状或环状消融，有利于提高手术成功率。     

Ventricular Tachycardia: Pathophysiology and Radiofrequency Catheter Ablation

Limitations of pharmacological therapy for VT have led to great interest in alternative nonpharmacological therapies. The appeal of a curative therapy for VT initially led to the search for operative techniques to identify and destroy the underlying substrate, and more recently, has resulted in the development of catheter techniques to achieve the same goal in the electrophysiology laboratory. Investigations into the pathophysiology of VT have resulted in the recognition that this arrhythmia reflects a mechanistically and anatomically heterogeneous set of disorders. Recent growth in our understanding of these distinctions has both led to, and resulted from, simultaneous advances in catheter ablation techniques. The clinical electrophysiology laboratory has served as a testing ground for theories derived from in vitro and animal experiments while also providing its own set of human experimental data regarding the pathophysiology and treatment of VT. As a result of this process, several distinct forms of VT that are amenable to catheter ablation have been characterized. This article will summarize current knowledge of the pathophysiology of various VT subtypes and of techniques for catheter mapping and ablation.     

Radiofrequency Catheter Ablation of Ventricular Tachycardia Following Implantation of an Automatic Cardioverter Defibrillator

The present study reports on the complementary role of two nonpharmacological options of antiarrhythmic therapy. Background: Catheter ablation, antitachycardia surgery, and the implanfahie cardioverter de/ibrillator (ICD)have become important tools in the management of ventricuiar tachyarrhythmias. However, the emergence of ventricuiar tachyarrhythmias after implantation of an ICD is possihie because the arrhythmogenic suhstrate is not affected. Patients and Methods:Six of 180 patients developed frequent episodes of monomorphic ventricular tachycardia (n = 2) or incessant ventricular tachycardia (n = 4) following implantation of an ICD and underwent radio/requency (RF)catheter ablation. Catheter ablation was performed using a HF generator HAT 200. Energy was delivered between a 4-mm tip electrode of the ahiation catheter and a patch electrode. Results: Catheter ablation was done 6.8 ± 5 months following ICD implantation; 6 ± 2.2 RF impulses were delivered at the site of origin of ventricuiar tachycardia chararcterized by early endocardial activation during ventricular tachycardia, identical pace mapping and long latency between stimulus, and QRS-complex in five patients. New bundle branch reentry was the underlying mechanism of ventricular tachycardia in one patient. RF catheter ablation resulted in termination o/ incessant ventricular tachycardia. Immediately postabiation, the documented ventricular tachycardia was rendered noninducible in all patients. No ICD malfunctions have been observed. One patient died due to heart failure 24 hours after successful ablation of the incessant ventricular tachycardia. During a follow-up of 5–19 months, episodes of ventricular tachycardia recurred in four patients. All episodes could be controlled by the ICD without frequent cardioversions. Conclusion: RF catheter ablation is o complementary therapeutic option in case of frequent or incessant ventricular tachycardia after ICD implantation.     

In Vivo Ventricular Lesion Growth in Radiofrequency Catheter Ablation

While radiofrequency catheter ablation has proved highly effective in the treafment of various supravenfricular tQchyarrhythmias, resulls in the trentment of ventricular tachycardia invite improvement. Knowledge of lesion growth in vivo might improve understanding of this discrepancy. So far only information from in vitro and in vivo studies using a small 2 mm tip eiectrode is available. Growlh of ventricular radiofrequency lesions created with a 4 mm ahlalion electrode was studied in 11 closed-chest dogs. Endocardia] ablations were performed at 31 left and 35 right ventricuiar sites at a power setting of 25 Watts and 5, 10, 20, 30 or 60 seconds pulse duration. Macroscopic and histopathologic lesion examination were performed after one week survival. Mean lesion volume increased from 52 mm³ after 5 seconds pulse duration to a maximum 388 mm³ and approximately 7 mm depth after 30 seconds. Lesions were prolate spheroid in form, with a sparing of subendocardial myocardium and maximum lesion diameter at some millimeters depth. Results indicate that catheter positioning at no more tlian 7 mm from the target is required for successful ablation. Due to lesion geometry, subendocardial targets demand even more exact catheter positioning, while subepicardial substrates may not be ammenable to ablation if ventricular wall thickness exceeds 7 mm at the ablation site. Repeated pulses at adjacent sites may be required for ablation of extended arrhytbmogenic areas. Volume at 5 seconds was only approximately 15% of mature lesions. Therefore, the use of a short'test pulse after careful mapping may be useful to pinpoint the most appropriate site for ablation in discrete pathways.     

Radiofrequency Ablation of Idiopathic Left Ventricular Tachycardia with Changing EGG Morphology

Idiopathic left ventricular tachycardia is a distinct clinical entity with a typical ECG of right bundle branch block and left axis deviation. We presented a 39-year-old man with idiopathic left ventricular tachycardia, which demonstrated change in the configuration of QRS complex during successive radiofrequency catheter ablation. We proposed that this idiopathic left ventricular tachycardia may have alternative pathways within the reentrant circuit leading to different exits.     

Loss of Late Potentials After Radiofrequency Catheter Ablation of Recurrent Ventricular Tachycardia in a Patient with Right Bundle Branch Block

The case of a patient with a history of myocardial infarction and recurrent ventricular tachycardia undergoing attempted radiofrequency catheter ahlation with loss of late potentials is described. Prior to energy delivery fractionated, late activation could be found using the signal-averaged ECC despite the presence of a right bundle branch block. After successful catheter ablation, the clinical ventricular tachycardia was no longer inducible and the signal-averaged ECG, recorded the next day, showed marked changes indicating loss of late potentials. Our report emphasizes the possibility of late potential recordings despite the presence of bundle branch block.     

Late Potentials Are Unaffected by Radiofrequency Catheter Ablation in Patients with Ventricular Tachycardia

Reentrant ventricular tachycardia is dependent on an area of myofibers, embedded in scar tissue, which exhibit slow conduction. Late potentials recorded by signal-averaged electrocardiography appear to correspond to these zones of slow conduction and frequently are present in patients with VT. We hypothesized that elimination of inducible VT by catheter-mediated ablation of critical areas of slow conduction would alter late potentials. Four patients underwent catheter ablation in which radiofrequency current was delivered to zones of slow conduction exhibiting isolated mid-diastolic potentials that could not be dissociated from the tachycardia. The four patients had developed VT (cycle length 382 ± 50 msec; mean ± SEM) 13–180 months after inferior myocardial infarction. Late potentials were present in each patient before catheter ablation was attempted. Although VT was not inducible in any patient immediately after ablation, late potentials were still present in all four patients and there was no significant difference in the QRS duration (136.5 ± 4.0 msec postablation; 135.7 ± 4.5 msec preablation), root mean square voltage in the terminal 40 msec of the QRS (10.0 ± 1.0 μV postablation; 5.9 ± 0.4 μV preablation). or in the duration of the low amplitude signal (69.2 ± 2.0 msec postablation; 62.7 ± 3.4 msec preablation). At follow-up electrophysiology study performed 14 ± 7 days after ablation, one of the four patients had inducible VT. In conclusion, late potentials persist even after successful radiofrequency catheter ablation and do not appear to be useful for predicting results of follow-up electrophysiology study.