阴囊Paget病5例报告

目的：探讨阴囊Paget病的临床特点及诊治方法。方法：对5例阴囊Paget病的临床资料进行回顾性分析。结果：所有病例均经病理诊断证实，在抗感染治疗的基础上，均行病灶扩大切除术，1例腹股沟淋巴结转移者同时行清扫术，该病例于术后2a死于全身转移，其余病例健在。结论：对久治不愈的阴囊皮炎、湿疹应行病灶活组织检查，确诊患者应行病灶扩大切除术。     

阴囊Paget病6例报告

分析6例阴囊Paget病的典型表现及治疗方法，认为对于久治不愈的阴囊皮炎或湿疹，应怀疑Paget病，尽早行病灶活检，治疗首选手术切除。     

阴囊Paget病9例临床资料分析

目的探讨阴囊Paget病的诊断及治疗。方法回顾9例阴囊Paget病患者临床资料，全部患者均在术前病理证实为阴囊Paget病，采用病灶广泛切除术治疗。结果A1期4例，A2期3例，B期2例。7例获得随访，随访时间为6个月—5年。2例淋巴结转移者，分别于术后1年与2年死于广泛转移；1例术后2年复发而行二次手术治疗；其余无复发。结论对经久不愈的阴囊皮损应尽早行活检确诊，病灶广泛切除术是治疗本病的有效手段。     

阴囊Paget病的临床和病理研究

目的：探讨阴囊Paget病的临床特点和诊治方法。方法：对14例阴囊Paget病患者的临床、病理资料以及治疗和随访情况进行回顾性研究。结果：14例患者经病理检查证实并行手术治疗，随访2－12年，1例腹股沟淋巴结阳性者1例后死于全身转换，3例死于非癌疾病，3例行腹股沟淋巴结清扫者2例发和皮肤坏死、淋巴瘘等并发症。结论：本病的诊断主要依靠病理学检查，阴囊局部扩大切除是首选治疗方法。预后主要取决于病变浸润的程度，淋巴结有无转换以及是否伴有邻近内脏器官的恶性肿瘤，早期诊断是提高生存率的关键。     

阴囊Paget病的诊断和治疗（附13例报告）

阴囊Ｐａｇｅｔ病又称阴囊湿疹样癌,系一种少见的恶性肿癌,临床极易被误诊而延误治疗。我们收治其患者１３例,现报告如下。     

阴囊Paget氏病：附9例报告

阴囊Paget氏病又称阴囊炎性癌,临床较少见.我科从1980年7月至1993年9月共收治9例,报告如下.1 一般资料9例,年龄56岁~76岁,平均65岁.发病时间1年至10年不等.检查:阴囊病变区域皮肤潮红,呈红色丘疹样隆起,结节状不光滑,表面有渗出液、糜烂、结痂.病灶范围0.8cm×1cm~12cm×8cm,3例患者病变区域累及全部阴茎皮肤,其中1例右侧睾丸受累粘连.均未见腹股沟淋巴结肿大,术前均经咬检证实,为阴囊Paget氏病.6例行广泛病     

阴囊Paget病的诊疗分析（附28例报告并文献复习）

目的：探讨阴囊Paget病的临床特点,提高对其诊断、治疗及预后的认识。方法：回顾性分析我院28例阴囊Paget病的诊治资料,复习相关文献,并进行随访。28例患者术前均经病理活检证实为阴囊Paget病。Ray分期标准,A,期15例,A：期8例,B期5例。手术治疗27例,其中21例行根治性病灶切除术,6例因病灶较大行病灶扩大切除及股部带蒂皮瓣修补术,5例经病理证实腹股沟淋巴结有转移者行单侧或双侧腹股沟淋巴结清扫术。放疗、化疗1例。结果：术后均经病理学检查确诊。术后26例获随访,随访3个月-15年,平均4年。2例分别于术后5个月、1年局部复发,均再次手术治愈。1例术后2年死于多发骨转移。其余无局部复发及转移。结论：阴囊Paget病是一种易发于老年男性的少见恶性肿瘤,极易误诊为阴囊湿疹、皮炎等疾病,确诊需依靠病理检查;治疗以病灶根治切除术为首选方法,早期治疗预后较好。     

阴囊Paget病的诊疗分析(附28例报告并文献复习)

目的:探讨阴囊Paget病的临床特点,提高对其诊断、治疗及预后的认识.方法:回顾性分析我院28例阴囊Paget病的诊治资料,复习相关文献,并进行随访.28例患者术前均经病理活检证实为阴囊Paget病.Ray分期标准,A1期15例,A2期8例,B期5例.手术治疗27例,其中21例行根治性病灶切除术,6例因病灶较大行病灶扩大切除及股部带蒂皮瓣修补术,5例经病理证实腹股沟淋巴结有转移者行单侧或双侧腹股沟淋巴结清扫术.放疗、化疗1例.结果:术后均经病理学检查确诊.术后26例获随访,随访3个月-15年,平均4年.2例分别于术后5个月、1年局部复发,均再次手术治愈.1例术后2年死于多发骨转移.其余无局部复发及转移.结论:阴囊Paget病是一种易发于老年男性的少见恶性肿瘤,极易误诊为阴囊湿疹、皮炎等疾病,确诊需依靠病理检查;治疗以病灶根治切除术为首选方法,早期治疗预后较好.     

阴囊Paget病的诊断与治疗

目的探讨阴囊Paget病的诊断、治疗及预后.方法对我院自1986年9月至1994年9月收治的17例病人,术前取活检经病理证实为阴囊Paget病后施行手术,术后化疗、放疗.结果浸润程度浅、无淋巴转移者,5年生存率为100%,10年生存率为76.9%.浸润程度深,有淋巴转移者,5年生存率为25%,10年无存活.结论阴囊Paget病的治疗以手术为主,在未穿透基底膜、淋巴转移前施行手术,预后良好.临床上早期很易误诊为湿疹、皮炎、股癣等,故早期做出正确诊断、早期手术是影响预后的关键.     

阴囊Paget病合并大汗腺癌伴多发转移1例报告

1 病例报告 患者,男性,63岁,2009年9月因"阴囊潮湿,反复不愈"就诊于天津市中医药研究院行阴囊表皮活检示:"湿疹样癌".2009年11月于天津市肿瘤医院行局部病灶+左侧腹股沟淋巴结清扫术,术后病理示:(左阴囊Paget病伴大汗腺癌)左阴囊仍可见Paget病残留,区域淋巴结可见转移15/17,分组如下:左闭孔4/4,软组织(+),髂内髂外动脉交角2/2,髂总3/3,左腹股沟区6/8. 后行左侧阴囊表皮病灶切除术. 2014年7月患者因胸骨疼痛,就诊于我院. 住院期间辅助检查:①实验室检查(表1 ). ②上腹部高清晰螺旋CT增强扫描:肝脏多发占位性病变(转移瘤可能性大). 并于我院行"吉西他滨+奥沙利铂"方案化疗1个周期,后症状好转后出院. 2014年8月1日于天津医科大学肿瘤医院查ECT示:"广泛骨病变(考虑骨转移)". 2014年8月11日于我院继续行"吉西他滨+奥沙利铂"化疗1个周期,并定期行唑来膦酸抗骨转移治疗. 住院期间辅助检查:肝功能明显改善:ALT 15.3 U/L,AST 14.5 U/L,GGT 53.5 U/L. D-D二聚体定量较前也明显降低:608.22 ng/mlFEU. 肿瘤标志物也呈下降趋势:CEA 9.78 ng/ml,Ferritine 732.44 ng/ml,CA72-413.75 U/ml,CYFRA21-16.33 ng/ml. 2014年9月12日于我院行唑来膦酸抗骨转移治疗1疗程. 住院期间辅助检查:各项实验室检查指标趋于平稳. 腹部彩超回报:肝实质内可见多发不规则低回声团块,其中较大者约7.82 cm ×7.91 cm.     

阴囊Ｐａｇｅｔ病１５例临床分析

目的：探讨有关阴囊Ｐａｇｅｔ病的临床特点、治疗方法和预后。方法：对１５例阴囊Ｐａｇｅｔ病患者的临床资料进行回顾性研究,全部患者先行患处活检,后手术治疗。结果：所有患者术后病理检查均发现Ｐａｇｅｔ细胞。根据Ｒａｙ分期：Ａ１期１０例,Ａ２期３例,Ｂ期２例（９例肿瘤局限于表皮,６例侵及真皮）。７例淋巴结肿大者经病理活检证实２例为淋巴结转移。１２例获得随访,随访时间３个月～５年,均未复发。结论：阴囊Ｐａｇｅｔ病应尽早活检确诊,病变局部广泛切除是本病首选治疗方法,愈后较好。     

阴囊Paget病合并汗腺癌6例报道及临床分析

背景与目的：阴囊Paget病合并汗腺癌极为少见,本文总结阴囊Paget病合并汗腺癌的临床病理特点及其治疗情况。方法：回顾性分析1964—2004年我院收治的阴囊Paget病合并汗腺癌患者6例,复习文献并分析其典型表现、诊断及治疗方法。结果：阴囊Paget病合并汗腺癌典型表现以湿疹样皮肤改变为主。本组所有患者接受病灶切除并患侧腹股沟淋巴结清扫术,1例行腹直肌带蒂皮瓣转移术。术后15、26、38月各死亡1例,3例术后随访48,50,55个月,未见复发。结论：病灶手术切除及患侧腹股沟淋巴清扫是治疗阴囊Paget病合并汗腺癌的主要方法。     

乳腺外Paget＇s病五例报告

乳腺外Ｐａｇｅｔ＇ｓ病较罕见。本文报告病检证实的５例，其中男性４例，女性１例。年龄５４～７７岁，平均年龄６９．５岁。１例位于耻骨联合部，１例位于外阴部，３例位于腹股沟阴囊部。作者结合文献对本病的组织发生、临床特点、诊断、治疗和预后作了简要的讨论。     

Photodynamic Therapy for Extramammary Paget's Disease:5 Cases Report

Objective: To study the therapeutic effect of photodynamic therapy for extramammary Paget's disease. Methods: DIOMED 630 nm diode laser was used as light source and photofrin as photosensitizer. The patient's lesion was irradiated for 24-72 h after administrating of photofrin. The power density was 100-150 mW/cm2 and energy density was 150-300J/cm2. Dosage of photofrin was 2 mg/kg. Results: Lesion darkened 24 h after irradiation and formed a scar 96-120 h after irradiation. One patient's lesion disappeared, three patients' lesion diminished apparently and one patient's lesion was not controlled 3 months later. Conclusion: Photodynamic therapy is an effective modality for extramammary Paget's disease.     

Osteosarcoma arising in Paget's disease of the mandible

Although osteosarcoma is a well-known complication of Paget's disease of bone, it uncommonly develops in the jaw bones. We present an osteosarcoma arising in Paget's disease of the mandible with unique features of a normal serum alkaline phosphatase level, and histologic features of telangiectatic change in the osteosarcoma and association with cemento-osseous dysplasia. Sixteen reported cases of osteosarcoma arising in Paget's disease of the jaw bones (OPJ) are also reviewed and compared to osteosarcoma arising in Paget's disease occurring in the entire skeleton (OPS) and osteosarcoma arising de novo in the jaw bones (OJ). Females are more commonly involved in OPJ in contrast to a male predominance in OPS and OJ. OPJ also has a distinctively higher percentage involving blacks compared to OPS. The prognosis of OPJ is poor, with 69% of patients dying within two years after diagnosis. Early recognition, early and aggressive treatment are important to improve the prognosis and are hence emphasized.     

Scutular tinea of the scrotum: report of two cases

Infections caused by dermathophytes in the scrotal skin are uncommon especially due to Microsporum gypseum, which may form scutular or favus-like lesions. We report two patients with this type of tinea: one immune suppressed by HIV infection and another immunocompetent without comorbidity. In the literature we found only two reports in immunocompetent patients and some in immune suppressed with similar symptoms.     

Metastatic vulvar Paget's disease responding to combination chemotherapy: case report

No effective chemotherapy for advanced extramammary Paget's disease has yet been established. A case of vulvar Paget's disease with systemic metastases was treated with a mitomycin C, vincristine and cisplatin combination chemotherapy, by which the vulvar lesion and serum CEA were clearly decreased. After surgery and 5-fluorouracil treatment, a similar combination chemotherapeutic regimen was administered to treat a recurrence, however, the lesions became resistant.     

Photodynamic Therapy for Extramammary Paget＇s Disease： 5 Cases Report

Objective： To study the therapeutic effect of photodynamic therapy for extramammary Paget＇s disease. Methods： DIOMED 630 nm diode laser was used as light source and photofrin as photosensitizer. The patient＇s lesion was irradiated for 24-72 h after administrating of photofrin. The power density was 100-150 mW/cm^2 and energy density was 150-300J/cm^2. Dosage of photofrin was 2 mg/kg. Results： Lesion darkened 24 h after irradiation and formed a scar 96-120 h after irradiation. One patient＇s lesion disappeared, three patients＇ lesion diminished apparently and one patient＇s lesion was not controlled 3 months later. Conclusion： Photodynamic therapy is an effective modality for extramammary Paget＇s disease.