^99mTc—MIBI显像在恶性肿瘤中的应用进展

99mTc－MIBI（99m锝-甲氧基异丁基异腈）作为一种心肌显像剂，广泛应用于心肌显像，诊断冠心病及各种心肌疾患。实践中人们发现心肌并不是它唯一的靶器官。1989年，Hassan等[1]首次报道99mTc－MIBI显像可诊断肺癌,其后，国内外的许多研究均证实了多种恶性肿瘤细胞可特异性摄取99mTc－MIBI，摄取量远高于正常细胞，并且排出又慢于正常细胞[2]。因此99mTc－MIBI目前又作为一种肿瘤阳性显像剂，在肺癌、乳腺癌、甲状腺癌等各种恶性肿瘤的诊断中普遍应用［3，4］。199mTc－MIBI恶性肿瘤显像的机制恶性肿瘤细胞摄取99mTc－MIBI的机…     

^99mTc—MIBI心肌灌注断层显像的定量研究

~(99m)-Tc－MIBISPECT心肌灌注断层显像已应用多年,如何准确、定量分析心肌供血状况及心肌细胞活力,各医院都进行一定的尝试,我科通过计算心肌各节段的摄取分数作为定量分析指标,为冠心病、心肌梗塞的诊断、治疗。预后判断提供了较为可靠的依据。三资料和方法1．1临床资料正常人41例,男对例,女20例,年龄30～65岁,经活动平板、心电图、超声心动图和X胸片等检查,证实无心血管疾病症状和体征。心肌前壁缺血10例、下壁缺血刀削、心肌梗塞13例。1．2检查方法1．2．1心肌灌注显像方法受检者静脉注射”To－MIBI555－740MBq（15－2…     

乳腺肿块的^99mTc—MIBI显像

~(99m)Tc-MIBI显像用于乳腺肿块的良恶性鉴别诊断已有不少报道。我科一年来对42例单个可触及的乳腺肿块的病人行~(99m)Tc-MIBI显像。现将我们所做的工作报道如下: 1.研究对象:42例病人均为女性,年龄最小20岁,最大79岁,平均年龄37.9岁。均为我院门诊及住院病人。ECT检查后均作手术并行病理检查。42例病人中左乳腺肿物有11人,右乳腺肿物有31人。肿物最小为1.0×1.9cm~2,最大为15×10cm~2。 2.方法:标记药盒为甲氧基异丁基异腈(MIBI),由北京师范大学应用化学研究所提供。     

^99mTc—HL91乏氧显像与^99mTc—MIBI亲肿瘤显像诊断肺肿瘤的对比分析

目的：评价^99mTc—HL91乏氧显像和^99mTc—MIBI亲肿瘤显像诊断肺癌的临床价值。方法：70例肺肿瘤患行^99mTc-HL91乏氧显像和^99mTc—MIBI亲肿瘤显像两项检查，对比分析诊断效能和半定量分析结果。结果：^99mTc—HL91乏氧显像和^99mTc—MIBI亲肿瘤显像诊断肺癌的灵敏度、特异性和准确率分别为91．1％、100％、94．3％和84．4％、76.0％、81．4％。半定量分析结果明显高于^99mTc—MIBI亲肿瘤显像。两种显像结合诊断肺癌的灵敏度、特异性和准确率分别为95．6％、100％、97．1％。结论：^99mTc—HL91乏氧显像诊断肺癌有较高的临床价值，结合^99mTc—MIBI亲肿瘤显像可进一步提高诊断的准确性。     

^99mTc—MIBI乳腺亲肿瘤显像的诊断价值：装置组与非装置组的？…

探讨采用乳腺显像装置和非装置方法＾９９ｍＴｃ－ＭＩＢＩ乳腺亲肿瘤显像对乳腺肿物的诊断价值。方法：采用乳腺显像装置屏蔽心肌，肝胆和乳房之间，以及无屏蔽两种方法对准乳房行前、左右侧位平面显像。     

^99mTc—MIBI甲状腺阳性显像诊断甲状腺癌的相关应用研究

2002—04以来我院应用^99mTC—MIBI对甲状腺^99mTcO4^-显像为冷（凉）结节的40例患者进行检查，用以鉴别甲状腺结节的良恶性质，取得较好的效果，现报道如下。     

^99mTc—MDP早期肺显像诊断肺肿瘤与纤支镜检的对比研究

目的　探讨99m Tc- MDP(亚甲基二磷酸盐 ) SPECT显像 ,诊断肺癌的临床价值。方法　对 6 3例经病理证实的肺肿瘤患者进行早期99m Tc- MDP显像 ,同期进行了纤维支气管镜 (FB)检查。以病理结果为标准 ,比较分析诊断效能。结果　肺癌对 99m Tc- MDP的摄取明显高于良性病灶 ,以摄取比值 >1.8为判断标准 ,MDP显像诊断肺癌的灵敏度和特异性分别为 84 .3%和 83.3% ;FB为 90 .2 %和 91.7%。MDP显像和 FB联合诊断肺癌的灵敏度、特异性分别为 96 .1%和95 .5 %。结论　 MDP显像对肺癌的诊断和鉴别诊断有较高的临床价值 ,与 FB结合分析可进一步提高定性定位诊断肺癌的准确性。     

多巴酚丁胺^99mTc—MIBI心肌断层显像与冠状动脉造影诊断冠心病对比分析

为进一步评价多巴酚丁胺99Tc-MIBI心肌断层显像（Dobu-ECT）诊断冠心病的价值，对31例做了冠状动脉造影（CAG）和DobU-ECT两项检查的病例进行对比分析，旨在探讨DobU-ECT诊断冠心病的临床价值。1资料与方法1．1对象：1996年12月～1997年9月，因可疑冠心病或心肌梗塞进行CAG及DobU-ECT检查的患者共31例，男26例，女5例，平均年龄61±7岁。其中心肌梗塞11例。1．2试验方法1．2．1多巴酚丁胺负荷试验：试验前停用β受体阻滞剂48小时和硝酸酯类制剂8小时以上。多巴酚丁胺用生理盐水稀释后分级由输液泵控制连续静脉输注。由5μg·kg-…     

联合99mTc-MIBI与99mTcO-4显像鉴别甲状腺结节的临床价值

目的：探讨核医学99mTcO-4与99mTc-MIBI联合显像鉴别甲状腺结节良恶性的临床价值。方法对入选的40例甲状腺结节病例术前行甲状腺99mTcO-4显像、99mTc-MIBI显像,根据结节的99mTc-MIBI与99mTcO-4摄取值,计算99mTc-MIBI /99mTcO-4摄取比值（即M/T值）。根据术后病理,分析M/T值及血清人促甲状腺激素（hTSH）水平与结节良恶性的关系。结果40例中,5例甲状腺结节M/T比值≥2.0,病理结果为恶性结节（乳头状癌、滤泡状癌）,与M/T值存在相关性（P〈0.05）;其余35例为良性结节（腺瘤、囊腺瘤）,M/T值均〈2.0。联合甲状腺99mTcO-4和99mTc-MIBI显像诊断甲状腺恶性结节的灵敏度为100%,特异度为94.3%,准确率为95%。良性结节与hTSH水平增高有关（P〈0.05）。结论联合甲状腺99mTcO-4和99mTc-MIBI显像可对甲状腺结节的良恶性进行鉴别诊断,具有临床应用价值。     

99Tcm—MIBI显像预测小细胞肺癌化疗疗效的临床研究

目的探讨99Tcm-MIBI显像预测小细胞肺癌化疗疗效的价值。方法53例小细胞肺癌患者根据胸部CT结果分为化疗有效组（完全缓解＋部分缓解）39例和无效组（病情稳定＋疾病进展）14例,于化疗前行99Tcm-MIBI肺显像,静脉注射99Tcm-MIBI740MBq后10—30min及2—3h分别行早期及延迟显像,分别获得早期相肿瘤与正常肺组织摄取比值（ER）和延迟相肿瘤／正常肺摄取比值（DR）,计算滞留指数（RI）。采用t检验及秩和检验分析化疗有效组与化疗无效组ER、DR和RI之间的差别。结果99Tcm-MIBI显像结果中,化疗有效组的ER、DR分别为2．33±0．21、2．44±0．19,均显著高于化疗无效组的2．02±0．31、1．86±0．30,差异有统计学意义（t=-3．401、-6．724,P均〈0．05）。化疗有效组的RI中位值为5．31％,高于化疗无效组的-9．26％,差异有统计学意义（Z=-3．612,P〈0．05）。结论99Tcm-MIBI显像在预测小细胞肺癌化疗疗效方面具有重要的临床价值。     

~(99)Tc~m-MIBI显像预测小细胞肺癌化疗疗效的临床研究

目的 探讨~(99)Tc~m-MIBI显像预测小细胞肺癌化疗疗效的价值.方法 53例小细胞肺癌患者根据胸部CT结果分为化疗有效组(完全缓解+部分缓解)39例和无效组(病情稳定+疾病进展)14例,于化疗前行~(99)Tc~mMIBI肺显像,静脉注射~(99)Tc~m-MIBI 740 MBq后10～30 min及2～3 h分别行早期及延迟显像,分别获得早期相肿瘤与正常肺组织摄取比值(ER)和延迟相肿瘤/正常肺摄取比值(DR),计算滞留指数(RI).采用t检验及秩和检验分析化疗有效组与化疗无效组ER、DR和RI之间的差别.结果 ~(99)Tc~m-MIBI显像结果中,化疗有效组的ER、DR分别为2.33±0.21、2.44±0.19,均显著高于化疗无效组的2.02±0.31、1.86±0.30,差异有统计学意义(t=-3.401、-6.724,P均<0.05).化疗有效组的RI中位值为5.31%,高于化疗无效组的-9.26%,差异有统计学意义(Z=-3.612,P<0.05).结论 ~(99)Tc~m-MIBI显像在预测小细胞肺癌化疗疗效方面具有重要的临床价值.     

^99mTc-MDP骨显像在肺癌骨转移诊断中的临床意义

目的探讨肺癌骨转移的临床特点及早期观察骨显像在诊断肺癌骨转移中的临床价值。方法应用99mTc-MDP全身骨显像技术,分析1550例肺癌患者的临床资料和首次骨显像及病理检查结果。结果本实验观察1550例肺癌患者中,肺癌骨转移率为34.8%（540/1550）,其中腺癌41.7%（365/876）,鳞癌23.8%（114/478）,未分化癌为37.1%（33/89）,腺鳞癌26.1%（28/107）。本组460例（85.2%）为多发性明显的放射性浓聚,其余88例（16.3%）呈单发者均经MRI、CT及X线平片证实为骨转移。转移部位分别为：胸部骨68.7%,脊柱39.3%,骨盆32.5%,四肢骨17.8%,颅骨8.8%。结论肺癌患者早期进行99mTc-MDP全身骨显像,对病程分期、治疗方案的选择及预后的评价均有重要的临床意义;99mTc-MDP骨显像肺癌骨转移常见部位是胸部和脊柱,腺癌骨转移率最高。放射性核素骨显像对诊断肺癌骨转移有很高灵敏度。     

Discordance between dipyridamole technetium-99m-sestamibi myocardial perfusion single photon emission computed tomography and two-dimensional echocardiography in Kawasaki disease--a preliminary report

This study attempts to establish a noninvasive diagnostic method for early assessment of cardiac involvement in Kawasaki disease (KD), 36 children with KD were studied. The presence of abnormal coronary arteries (CA) with aneurysms was determined by experienced pediatric cardiologists using two-dimensional echocardiography (2D-Echo). Rest and dipyridamole-stress technetium-99m sestamibi (Tc-MIBI) single photon emission computed tomography (SPECT) was performed on the 36 children with KD for the assessment of myocardial perfusion and for comparison with 2D-Echo findings. The results showed that (1) 17/36 (47.2%) of the cases had no aneurysm and 19/36 (52.8%) had significant aneurysms; (2) 16/36 (44.4%) of the cases had normal myocardial perfusion and 20/36 (55.6%) had myocardial perfusion defects; (3) 9/36 (25.0%) cases showed both normal 2D-Echo and Tc-MIBI SPECT findings and 12/36 (33.3%) showed both abnormal 2D-Echo and Tc-MIBI SPECT findings; and (4) There was poor agreement between 2D-Echo and Tc-MIBI SPECT findings (-value = 0.161, p = 0.332). We concluded that the most of the KD children had aneurysms or abnormal myocardial perfusion. However, poor agreement exists between 2D-Echo and Tc-MIBI SPECT findings with aneurysms and abnormal myocardial perfusion in patients with KD.     

Personality and fatigue in patients with benign or malignant breast disease

Goals of work The aim of the study was to examine the role of five general personality traits in fatigue in a group of patients with breast cancer (BC) and a group with benign breast problems (BBP). Materials and methods Of the 304 participating women, 127 patients had BC and 177 BBP. A fatigue scale was completed before diagnosis and 1, 3, and 6 months after diagnosis (benign patients) or surgical treatment (BC patients). A personality questionnaire (NEO-FFI) and a depression scale (CES-D) were completed before diagnosis. Main results The BC group was less tired before diagnosis, more tired 1 month after diagnosis, and equally tired 3 and 6 months after diagnosis. In the total group, women were more tired over time when they were more neurotic, less agreeable, or more introverted. After controlling for depressive symptoms, demographics, and medical factors, baseline depressive symptoms (β = 0.29, p < 0.05), neuroticism (β = 0.29, p < 0.05), and extraversion (β = −0.25, p < 0.05) predicted fatigue 6 months later. After also including baseline fatigue, only neuroticism (β = 0.22, p < 0.05) and baseline fatigue (β = 0.79, p < 0.001) predicted fatigue. Conclusions Personality is more strongly related to fatigue than demographics, the diagnosis cancer, receiving cancer treatment, and baseline depressive symptoms and fatigue. When replicated, screening and treating women who are at risk to experience high levels of fatigue is recommended.     

Determination of cerebral perfusion by means of planar brain scintigraphy and99mTc-HMPAO in brain death,persistent vegetative state and severe coma

A total of 24 patients with clinical evidence of brain death (n=17), severe coma (n=2; GCS3) and apallic syndrome (n=4) underwent a comparative investigation with^99mTc-HMPAO brain scintigraphy, EEG, auditory and somatosensory evoded potentials. Accompagnied by EEG and evoked potentials, brain scintigraphy enabled confirmation of cerebral death in 15/17 patients. In one case clinical examination and evoked potentials suggest brain death, but cerebral perfusion and EEG were normal (brain stem death). One patient with evidence of cerebral death in clinical examination, brain scintigraphy and evoked potentials, showed questionable focal EEG activity; however, autopsy revealed intravital autolysis of the entire brain. All patients with apallic syndrome and deep coma showed a distinct cerebral perfusion, but gross EEG abnormalities; evoked potentials were delayed or absent. Planar scintigraphy with^99mTc-HMPAO appears to be superior to neurophysiological techniques discriminating patients with agonal cerebral dysfunction from those with brain death.     

Increased technetium-99 m hydroxy diphosphonate soft tissue uptake on bone scintigraphy in chronic kidney disease patients with secondary hyperparathyroidism: correlation with hyperphosphataemia

In bone scan patients with dialysis-treated chronic kidney disease (CKD) and hyperparathyroidism, soft tissue accumulation of technetium-99 m hydroxy/methylene diphosphonate (Tc-99 m-HDP/MDP) has been reported primarily in case reports and usually explained by hypercalcaemia and/or hyperphosphataemia. As human vascular smooth muscle cells produce hydroxyapatite during cell culture with increased phosphate levels and as Tc-99 m-HDP/MDP primarily binds to hydroxyapatite, we hypothesized that soft tissue accumulation would be found in patients with hyperphosphataemia. We identified 63 CKD patients diagnosed with secondary hyperparathyroidism admitted for Tc-99 m-HDP bone scan. Baseline characteristics and mean concentrations of biochemical markers (including P-calcium and P-phosphate) taken 0–3 months prior to the bone scans were collected. Soft tissue uptake was detected on bone scans in 37 of 63 (59%) patients. Primary locations were in the heart (27/37 = 73%), muscles (12/37 = 32%), lung (9/37 = 24%) and gastrointestinal tract (6/37 = 16%), and 13 of 37 (35%) patients had simultaneous uptake in more than one location. Regarding biochemical markers, patients with soft tissue uptake only differed from patients without in terms of plasma phosphate levels (1·95 ± 0·15 (n = 37) versus 1·27 ± 0·08 (n = 26), P = 0·0012). All patients with myocardial uptake (n = 27) had a coronary arteriography-verified history of coronary artery disease (CAD), whereas CAD was only present in six of the 36 patients without myocardial uptake. In conclusion, dialysis-treated CKD patients with secondary hyperparathyroidism have a high incidence of soft tissue uptake, and this finding is strongly correlated with elevated phosphate, but not calcium values.