Bevacizumab prior to vitrectomy for diabetic traction retinal detachment

Purpose

To assess the efficacy and safety of preoperative intravitreal bevacizumab (IVB) before vitrectomy for diabetic tractional retinal detachment (TRD).

Methods

Using ICD-9 codes, we located all patients with diabetic TRD who underwent 3-port 20-gauge vitrectomy primarily performed by one surgeon between January 2004 and January 2009. Eyes receiving IVB were compared with those not. The following outcomes were compared: visual acuity (VA), duration of surgery, and complication rates.

Results

A total of 99 eyes of 90 patients were included in the analysis. In all, 34 patients received IVB on an average of 11.5 (range, 3–30) days previtrectomy. Age was 46.5 and 51.6 in the IVB and non-IVB groups, respectively. VA was improved significantly in both groups: from 20/617 to 20/62 in the IVB group, and from 20/443 to 20/86 in the non-IVB group (P=0.11 between groups). Operating time and postoperative complications (glaucoma, RD, and revitrectomy rate) were similar in both groups. On comparing IVB and non-IVB eyes in younger patients (≤40), operating time was shorter (P=0.02) and a trend to better VA in the IVB group was seen.

Conclusions

Preoperative IVB may be a useful adjunct to vitrectomy for severe PDR complicated by TRD, particularly in younger diabetics.     

糖尿病视网膜病变黄斑牵拉视网膜脱离的手术治疗

目的 报告增殖性糖尿病视网膜病变黄斑部牵拉性视网膜脱离的手术结果。方法 对2000年3月～2003年4月初次采用玻璃体切除，并追踪观察6个月以上的49例51眼，术后解剖复位率。视力预后进行回顾性研究。结果 手术后解剖学复位51眼中41眼，占80．3％，最终视力提高24眼(47％)。不变16眼(31．3％)，下降者11眼(21．7％)，术中医源性裂孔29眼(56．9％)，术后视力0．1以上者多为黄斑脱离≤2个月，为12眼中6眼(50％)，与2个月以上者(39眼中5眼，占2．8％)相比有显著性差异。结论 在增殖性糖尿病性视网膜病变黄斑部牵拉性视网膜脱离患者中。黄斑视功能低下者较多，为了提高术后视力，早期玻璃体手术是必要的。     

Clinical variables and their relation to visual outcome after vitrectomy in eyes with diabetic retinal traction detachment

Background To analyse vitrectomy results in diabetic eyes with retinal traction detachment and to investigate which variables are associated with a worse visual outcome.Methods Forty-four diabetic eyes (33 patients) with central retinal traction detachment were analyzed retrospectively.Results After a median follow-up of 10 months, median visual acuity significantly improved from 20/800 to 20/160 (P=0.02), despite the fact that the majority of patients had a long-standing macular traction detachment (median 120 days). Twenty-two eyes (50%) achieved a visual acuity of >20/200. The retina was finally reattached in 38 eyes (86.3%). Univariate analysis showed that patients with type 2 diabetes, age older than 50 years, preoperative visual acuity <20/200, iris neovascularisation and macular detachment of >30 days had a significantly worse final visual outcome. After multiple logistic regression analysis, age and iris neovascularisation were the strongest predictors of a worse visual outcome; if both were present, the chance of a obtaining a visual outcome of <20/200 was almost 90%.Conclusions Age and iris neovascularisation were the strongest predictors for a low visual outcome. In a review of vitrectomy studies in eyes with severe diabetic traction detachment in the past 2 decades, we found a trend towards higher anatomic success rates, while visual outcome only slightly improved. The current study confirmed the importance of ophthalmic variables, but also indicates the importance of evaluating systemic variables in larger series in order to predict which eyes may truly benefit from vitrectomy.The authors have not received any financial support. The authors have no proprietary interest related to this article.     

Vitrectomy for diabetic traction retinal detachment involving the macula

We analyzed the surgical results for 197 eyes that underwent vitrectomy for diabetic traction detachment of the macula. The retina was successfully reattached in 130 of the 197 cases (66%), although the final level of vision depended on the amount of permanent macular damage from the previous detachment and on the effects of the retinal vascular disease. At the final examinations, 112 eyes (57%) had improved visual acuities, 68 eyes (35%) were worse, and 17 eyes (9%) were unchanged. Thirteen eyes (7%) had final visual acuities of 20/40 or better, 103 eyes (52%) had final visual acuities of 20/50 to 20/800, and 81 eyes (41%) had final visual acuities worse than 20/800. Two preoperative factors were associated with a worse prognosis for achieving a final visual acuity of 20/800 or better: preoperative vitreous hemorrhage (P less than .01) and the absence of preoperative scatter retinal photocoagulation (P less than .01). Additionally, two surgical factors, lens removal and the creation of iatrogenic retinal breaks, were associated with a poorer visual prognosis (P less than .002 and P less than .01, respectively). The group of eyes that underwent lens removal during vitrectomy also had a significantly higher incidence of postoperative iris neovascularization compared to eyes in which the lenses were not removed (P less than .05).     

Pars-plana vitrectomy in diabetic traction retinal detachments with holes

PURPOSE: To evaluate results and prognostic factors of pars-plana vitrectomy (ppv) using membrane peeling and C2F6-gas for diabetic traction retinal detachments with a hole. METHODS: We retrospectively reviewed the healing course of 84 eyes, which were treated in this way consecutively (follow-up 6-32 month). C2F6 was always used in case of a retinal hole at the posterior pole or in the upper part of the eye. The influence of HBA1c, type of diabetes, preoperative visual acuity, preoperative laser-coagulation and macular status over treatment results and rate of complications were studied using multivariate logistic regression analysis. RESULTS: Preoperatively 56% of the eyes showed premacular vitreous hemorrhage and 69% macular detachment. Using on an average 1.3 treatments in 73% retina was completely reattached and in 85% visual acuity remained unchanged or improved. The most important prognostic factors were HBA1c < 9.3, type II diabetes and bad vision preoperatively. Postoperative complications such as rubeosis, secondary glaucoma and repeated vitreous hemorrhages were more frequent in case of type I diabetes, HBA1c > or = 9.3 and insufficient laser treatment. CONCLUSION: Best corrected blood sugar levels preoperatively and sufficient laser treatment seem to be very important to decrease the risk for rubeosis and repeated vitreous hemorrhages especially for patients with type I diabetes.     

玻璃体切除术治疗人工晶状体眼视网膜脱离

目的探讨以玻璃体切除术治疗人工晶状体眼视网膜脱离的临床效果。方法对50例（50眼）人工晶状体眼视网膜脱离施用玻璃体切除术。其中16眼行硅油填充术，34眼行C3F8眼内填充。术后随访6～24月。结果术后视网膜最终完全复位49眼（98．00％）。15眼（30．00％）术中新发现裂孔。术后视力均有不同程度的提高。结论玻璃体切除术治疗人工晶状体眼视网膜脱离具有术野清晰、易于寻找隐匿性裂孔、提高视网膜复位率及复发率低的优点。     

Prognosis of traction retinal detachment in proliferative diabetic retiopathy

Considering the complications which may arise when traction retinal detachment (TRD) is treated surgically, the correct assessment of its course is important. The evolution of TRD in proliferative diabetic retinopathy is described and its pathogenesis discussed. In order to predict the course of a specific clinical situation we have to assess the activity of retinopathy and the localization and extension of vitreoretinal adhesions. Some guide lines for proper evaluation and proper management of the often complicated clinical picture of TRD in proliferative diabetic retinopathy are presented.     

Encouraging results of 25G+ minimally invasive vitrectomy surgery for diabetic tractional retinal detachment

Graefe's Archive for Clinical and Experimental Ophthalmology -     

Primary vitrectomy for pseudophakic retinal detachment.

AIM/BACKGROUND: Viewing the peripheral retina is the major problem in the repair of pseudophakic retinal detachments. Conventional buckling procedures in pseudophakic eyes are complicated by persistent retinal (re-) detachment and proliferative vitreoretinopathy (PVR) more often than in phakic eyes. METHODS: Primary vitrectomy was performed in 33 consecutive cases for pseudophakic retinal detachment with the help of liquid perfluorocarbons and a wide angle viewing system, following a standardised procedure. All eyes have passed the 12 month follow up examination. RESULTS: The primary reattachment rate was 94%. PVR was observed in one case (3%). Seventy nine per cent (26 eyes) regained vision of 20/50 or better, with a median visual acuity of 20/30. The most frequent complication was transient glaucoma during the early postoperative period in 48% (16 eyes) requiring carboanhydrase inhibitors. CONCLUSION: The main advantage of primary vitrectomy over conventional buckling seems to be the better intraoperative sight to the most peripheral retinal holes, controlled removal of vitreous traction, and focused endolaser coagulation. This may explain the low rate of PVR after primary vitrectomy. Also, visual results tended to be better compared with conventional surgical techniques possibly because of removed vitreous opacities, and because of a superior retinal reattachment rate as well as the reduced rate of PVR.     

玻璃体切除术后视网膜脱离的临床观察

目的：探讨玻璃体切除术后视网膜脱离的原因、特点。方法：回顾性分析在我院近4 a行20 G标准三通道玻璃体切除手术的患者病例资料,术后发生视网膜脱离的病例纳入研究对象,分析视网膜脱离的特点及处理。术后发生视网膜脱离共23例24眼。年龄24～67（平均49．0±12．0）岁。男17例18眼,女6例6眼。右眼6眼,左眼18眼。结果：视网膜脱离的24眼中,18眼（75％）无任何症状,为常规检查时所发现;6眼（25％）为视力下降或眼前黑影遮挡就诊时发现。视网膜脱离距离玻璃体切除术后的时间1～223（平均40．7±54．2）d,其中10眼（42％）发生于1wk内,14眼（58％）发生于1 mo内。视网膜脱离的直接原因中：新发视网膜裂孔19眼,共27个裂孔;增殖性玻璃体视网膜病变（ PVR）4眼;原裂孔未封闭1眼。所有视网膜脱离最终均完全复位。结论：视网膜新裂孔的发生是导致玻璃体切除术后视网膜脱离的最主要原因,应重视术后早期周边视网膜的检查;经过及时的再次手术,视网膜均可得以复位。     

一期玻璃体切除术治疗人工晶体眼视网膜脱离的疗效观察

目的 探讨一期玻璃体切除术治疗人工晶体眼视网膜脱离的临床疗效.方法 对54例（54眼）人工晶体眼（ECCE＋IOL 45眼,PHACO＋IOL 9眼）视网膜脱离,均放弃单纯巩膜外扣带术,直接采用一期玻璃体切除术.其中,12眼（22.22%）行硅油填充,其余42眼均行C3F8内填充,术中同时取出人工晶体者14眼（25.93%）.术后随访6～18个月.结果 一期玻璃体切除术中发现新裂孔17眼（31.48%）,视网膜最终完全复位48眼（88.89%）,部分复位2眼（3.70%）,未复位1眼（1.85%）,后者系严重aPVR所致,术后视力均有不同程度的提高.结论 对人工晶体眼视网膜脱离行一期玻璃体切除术,术中具有良好的手术野,可发现术前未检出的周边部隐匿性视网膜新裂孔,彻底解除玻璃体视网膜牵引,同时可去除混浊的屈光间质,从而减少PVR的形成,提高患眼的视功能,临床上值得推广.     

Vitrectomy for diabetic traction retinal detachment using the multiport illumination system

OBJECTIVE: To examine the visual and anatomic results of bimanual vitrectomy surgery with the multiport illumination system (MIS) in eyes with advanced diabetic traction retinal detachment. DESIGN: Retrospective, noncomparative interventional case series. PARTICIPANTS: Sixty-seven consecutive eyes in 62 patients having vitrectomy with the MIS. METHODS: During surgery, the vitreous, the posterior hyaloid membrane, and fibrovascular proliferative tissue were removed by using bimanual dissection made possible by the MIS. MAIN OUTCOME MEASURES: Retinal reattachment rate, visual function, and postoperative complications were compared with previously published series of vitrectomy for diabetic traction retinal detachment. RESULTS: With a minimum of 6 months of follow-up, complete retinal reattachment was achieved in 62 eyes (93%), and macular attachment was achieved in all 67 eyes. Vision was stabilized or improved in 51 eyes (72%), and 5/200 vision was achieved in 47 eyes (70%). No unique complications, such as incision-related retinal tears, occurred. CONCLUSION: MIS allows bimanual surgery during vitrectomy for diabetic traction retinal detachment, with good visual and anatomic results.     

Primary vitrectomy for rhegmatogenous retinal detachment

One hundred and twenty-four eyes with a rhegmatogenous retinal detachment, considered to be at high risk of failure if treated conventionally, underwent vitrectomy and internal tamponade, with or without scleral buckling, as the primary procedure. The retina was reattached in 64.5% of eyes after one operation, 75.0% after two, and in 83% of eyes after more than two operations, with no difference in the success rate between those eyes which underwent vitrectomy alone, and those that received adjunctive scleral buckling; duration of surgery was significantly shorter, however, in the former group. Twenty percent of eyes redetached in association with proliferative vitreoretinopathy, and 20% of phakic eyes developed posterior subcapsular lens opacities after surgery. Vitrectomy is now an established method in the management of selected cases of rhegmatogenous retinal detachments.     

视网膜脱离玻璃体切除术后护理

目的:通过手术后严密的病情观察和精心护理,提高手术的成功率,减少并发症。方法:对解放军总医院216例行玻璃体切除术的视网膜脱离患者进行术后护理分析。结果:体会到术后应做到与患者进行良好的沟通,训练正确体位,辅助心理护理,以利于消除患者紧张情绪,从而积极配合医护人员工作。结论:术后严密观察、精心护理,保持正确体位,可有效减少并发症的发生,缩短康复时间,取得满意的手术效果。     

玻璃体切除术后晶体变化的临床分析

观察孔源性视网膜脱离的玻璃体切除术后晶体改变及相关因素间的关系。报告一组有晶体眼视网膜脱离手术、冷冻、巩膜扣带、注气（ＳＦ６或Ｃ３Ｆ８）联合玻璃体切除术６８例７２只眼及未联合玻璃体切除术４６例４７只眼。随访１２个月以上，比较两组，玻璃体切除眼术后发生核硬化３８．９％，非玻璃体切除眼仅５．６％，Ｐ〈０．００１。晶体后囊下混浊，玻璃体切除眼为３４％，非玻璃体切除眼仅为４．２％，Ｐ〈０．００１。核硬化与     

雷珠单抗辅助玻璃体切除术治疗糖尿病性牵引性视网膜脱离

目的评价雷珠单抗辅助玻璃体切除术治疗糖尿病性牵引性视网膜脱离的临床疗效。方法回顾性研究2017年1月至2019年10月淮安市第二人民医院收治糖尿病性牵拉性视网膜脱离42例(42眼)的临床资料。患者分为两组:A组,雷珠单抗辅助玻璃体切除组,19例(19眼);B组,单纯玻璃体切除组,23例(23眼)。术后随访3个月,比较两组术后视力、手术时间及并发症。结果术后3个月A组视网膜复位成功18例(94.7%,18/19);B组视网膜复位成功21例(91.3%,21/23),两组比较差异无统计学意义(χ²=0.185,P=0.671)。两组视力(BCVA,logMAR)均较术前提高,但两组之间差异无统计学意义(t=1.100,P=0.278)。A组3例(15.8%,3/19)因术中出血行电凝,少于B组的14例(60.8%,14/23)(χ²=8.776,P=0.030)。A组术中硅油填充10例(52.6%,10/19),少于B组术中的19例(82.6%,19/23)(χ²=4.375,P=0.036)。结论雷珠单抗辅助玻璃体切除治疗糖尿病性牵引性视网膜脱离,可以有效改善术后视力,减少术中出血,降低硅油填充率。