Basal Cell Carcinoma Treated with Interferon

Human natural leukocytic interferon (HNLI) and recombinant interferon (rIFN) alpha 2c can be used in the therapy of basal cell carcinoma. Seventy-two patients were treated for 3 to 6 weeks with a single dose of 400,000 to 1,200,000 units (HNLI) and 2,000,000 to 5,000,000 units (rIFN alpha 2c). According to histopathologic and clinical findings, 52 patients were cured, and cancer cells were not found in the biopsy material taken after HNLI treatment for the second biopsy. In nine of 72 patients the cancer lesion was reduced 25% to 90%. In 11 patients it was not reduced or was reduced less than 25%. With rIFN alpha 2c therapy given five times per week for 4 weeks, histopathologic and clinical findings showed that five patients out of 12 were cured, and cancer cells were not found in the biopsy material taken after treatment. In seven patients out of 12 the cancer lesion was reduced 25% to 90%. Both types of interferons are effective in the treatment of basal cell carcinoma. Side effects were mild.     

Capecitabine Plus Oxaliplatin Combination Therapy for Basal Cell Carcinoma

No effective systemic chemotherapy is well-established in basal cell carcinoma. We report a case with three simultaneous malignancies: colon cancer, basal cell carcinoma, and smoldering multiple myeloma. The patient was treated with capecitabine and oxaliplatin after surgery for colon cancer. Surprisingly, he achieved a complete response for basal cell carcinoma. This is the first report of this chemotherapy regimen in basal cell carcinoma. This finding suggests that combination capecitabine and oxaliplatin can be a treatment option for patients unable to receive local therapy.     

ALA光动力治疗鲍温样丘疹病临床研究

目的观察5氨基酮戊酸(5aminolevulinicacid,ALA)光动力疗法(photodynamictherapy,PDT)治疗鲍温样丘疹病的临床疗效。方法治疗组38例采用ALAPDT治疗,每周治疗1次,共治疗4次;对照组15例予以二氧化碳激光治疗。结果治疗组痊愈12例,显效12例,有效率为61.2%,复发2例,复发率16.7%,无明显疼痛、创面等副作用;对照组痊愈9例,显效3例,有效率为80.0%,复发5例,复发率55.5%,15例均有术后明显创面疼痛,8例合并创面感染,9例出现表浅瘢痕。两组之间有效率和复发率无显著性差异(P>0.05)。结论ALAPDT是治疗鲍温样丘疹病的一种安全、有效、无明显痛苦和不良反应的新疗法。     

Unilateral Basal Cell Carcinomas: An Unusual Entity Treated with Photodynamic Therapy

Background

Unilateral localized basal cell carcinomas are an uncommon finding that presents both a diagnostic and therapeutic challenge. Exclusion of unilateral nevoid basal cell carcinoma syndrome is indicated. There are few reports in the literature regarding this entity and even less regarding therapeutic strategies.

Objective

We present a patient with unilateral localized basal cell carcinomas who was successfully treated with photodynamic therapy.

Methods

Photodynamic therapy was started using Levulan^® Kerastick^® as previously described. The topical solution was applied to the patient’s back and illuminated the following day via the BLU-U Blue Light Illuminator.

Results

The patient tolerated the procedure well and without complications. The patient had an excellent therapeutic response with no clinically apparent basal cell carcinomas for 18 months.

Conclusions

We report a patient with unilateral basal cell carcinomas successfully treated with photodynamic therapy. This uncommon entity represents a diagnostic challenge in its inherent absence of the classic clinical and radiographic findings of nevoid basal cell carcinoma syndrome. Like nevoid basal cell carcinoma syndrome, unilateral basal cell carcinomas poses a therapeutic challenge with the sheer number of cutaneous tumors. The use of photodynamic therapy carries a proven therapeutic efficacy, a low rate of adverse events and excellent cosmesis.     

丘疹结节型色素性基底细胞癌的电子皮镜所见

目的　探讨丘疹结节型色素性基底细胞癌的电子皮镜所见及其在临床诊断中的意义。方法　利用电子皮镜观察丘疹结节型色素性基底细胞癌 6例 8个病灶 ,术后做组织病理确认。结果　丘疹结节型色素性基底细胞癌在电子皮镜下所见具有特征性 ,术后病理均诊断为基底细胞癌。结论　电子皮镜检查可以为丘疹结节型色素性基底细胞癌的诊断及鉴别诊断提供依据 ,具有重要意义。     

Basal Cell Carcinoma with Eccrine Differentiation

We describe a light, electron microscopic, and immunohistochemical study of basal cell carcinoma with eccrine differentiation. The cytoplasm did not stain with fat stain on cryostat sections, but contained numerous gland-like structures. Immunohistochemistry on formalin fixed, paraffin embedded tissues using antibodies to human involucrin, thirteen kinds of cytokeratin, S-100 protein, and carcinoembryonic antigen (CEA) was performed. We found that tumor cells were positive for keratin, PKK1, MA-903, No 8, No 19, AE 1, AE 3, and 5+8. Tumor cells were negative for S-100 protein, CEA, and the other antigens examined. Electron microscopy demonstrated short microvilli and amorphous materials within the intracytoplasmic cavity. We concluded that this tumor is basal cell carcinoma with eccrine differentiation.     

Keratoacanthoma‐Like Growths of Incontinentia Pigmenti Successfully Treated with Intralesional Methotrexate

We report the case of a 17‐year‐old girl with incontinentia pigmenti who developed multiple large hyperkeratotic tumors within Blaschkoid hyperpigmented patches on her left leg. Biopsy demonstrated an endoexophytic nodule with irregular invaginations of keratinizing squamous epithelium and a central keratin‐filled crater, consistent with keratoacanthoma‐like lesions of incontinentia pigmenti. The tumors were successfully treated with intralesional methotrexate.     

Perianal Basal Cell Carcinoma

BACKGROUND: A case of basal cell carcinoma (BCC) of the perianal region is reported. This tumor is extremely rare in this location and behaves rather innocently. OBJECTIVE: Clinical and histopathologic characteristics of perianal BCC, as well as the choices of treatment, are outlined. CONCLUSION: The tumor should be histologically distinguished from basaloid carcinoma of the anus, which is much more aggressive and metastasizes early, thus requiring a different therapy.     

Juvenile Basal Cell Carcinoma

Abstract: A 17-year-old youth had a solitary basal cell carcinoma of the nose.This malignancy is rare in children and usually occurs withanother disease or syndrome. The de novo form in this patient is especially rare.     

艾拉光动力疗法治疗中度和重度宫颈上皮内瘤变7例

目的:光动力疗法是一种微创伤治疗宫颈上皮瘤变的方法.报告7例宫颈上皮内瘤变患者使用光动力疗法的可行性和有效性.方法:对确定诊断7例CIN 2 或 CIN 3合并高危型HPV感染的患者进行妇科检查、宫颈细胞学检查、HPV DNA检测分型和阴道镜检查并取活检.2克5-氨基酮戊酸霜热凝胶(每克含118毫克5-氨基酮戊酸)涂布宫颈并用特殊塑料帽封包,随后使用635 nm半导激光直接照射宫颈并用柱状光纤导入宫颈口分别照射28分钟.每间隔2周治疗一次,3～5次后,于第3、6、9个月随访,检测HPV,做阴道镜、活检和病理.结果:7例均按时完成治疗,没有明显并发症,CIN2患者损害愈合,HPV转为阴性.治疗效果满意,1例CIN2和1例CIN3治疗4次和5次,6个月复查 HPV阳性.结论:光动力治疗是一种非侵入性可重复多次治疗宫颈上皮HPV感染和瘤变的方法,副作用小,治疗有效、安全,适合门诊治疗.     

Cell Processes in Basal Cell Carcinoma

Three cell process types are described in basal cell carcinoma. The most abundant are thin processes resembling microvilli; thick processes, mesa-like structures often surmounted by desmosomes; and large bulging processes. Processes occur in the intercellular spaces, and are more numerous in spinocellular cells than in basaloid cells. Despite the abundance of processes in basal cell carcinoma, they do not usually penetrate the basal lamina border of the tumor. This behavior differs from more rapidly invasive squamous cell carcinoma where processes extend through the fragmenting basal lamina into the stroma.