共查询到20条相似文献,搜索用时 46 毫秒
1.
ABSTRACT
Introduction
Between 5 and 25% of patients with cutaneous lupus erythematosus (CLE) can progress to systemic lupus erythematosus (SLE) during the course of the disease. There is no clear predictive guideline for the progression of CLE to SLE. 相似文献2.
ABSTRACT
Background
Regulatory T cells
(Tregs) play an important role in the maintenance of immunological tolerance. Tregs deficiency or suppressor functions reduction may be associated with autoimmune diseases development. 相似文献3.
Mario Di Gioacchino Claudia Petrarca Alessia Gatta Gilda Scarano Anila Farinelli Loredana Della Valle 《Expert Review of Clinical Immunology》2020,16(5):513-525
ABSTRACT
Introduction
For several years now, medicine has been benefiting from the contribution of nanoparticles (NPs) technology for both diagnosis and therapy. They can be used as adjuvants, being capable per se of immune-modulating activity, or as carriers for molecules to be transported to a specific target, eventually loaded with specific ligands favoring specific uptake. 相似文献4.
Vinod Chandran 《Expert Review of Clinical Immunology》2020,16(5):471-478
ABSTRACT
Introduction
Biomarkers may help influence long-term outcomes of psoriatic disease by improving the objective assessment of the presence and severity of psoriatic arthritis (PsA) and by guiding treatment selection. However, there are no validated biomarkers for PsA. 相似文献5.
Dinu Stanescu-Segall Thomas Sales de Gauzy Rhianon Reynolds Livia Faes Dominika Pohlmann Kaivon Pakzad-Vaezi 《Expert Review of Clinical Immunology》2020,16(7):651-657
ABSTRACT
Introduction
Routine medical and ophthalmic care is being drastically curtailed in the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Uveitis patients require particular attention because of their theoretical risk of viral infection, in the context of therapeutic immunosuppression. 相似文献6.
A Manfredi F Luppi G Cassone C Vacchi C Salvarani 《Expert Review of Clinical Immunology》2020,16(8):751-770
ABSTRACT
Introduction
Main clinical manifestations of SARS-CoV-2 infection are characterized by fever, dyspnea, and interstitial pneumonia, frequently evolving in acute respiratory distress syndrome (ARDS). 相似文献7.
Wafaa M. Elzefzafy Soheir Abd Elrahman Nesreen Atef 《Journal of immunoassay & immunochemistry》2020,41(4):729-744
ABSTRACT
Background
Colorectal cancer (CRC) is considered a major cause of morbidity and mortality in Egypt. Colonoscopy is the standard for detection of lesions. The combination of screening methods is effective. Decrease and loss of DPP-IV/CD26 expression and activity are found in microenvironments of specific tumors which are related to impaired immune functions. 相似文献8.
Thomas H. Yates Steven R. Cooperman David Shofler Devendra K. Agrawal 《Expert Review of Clinical Immunology》2020,16(8):839-845
ABSTRACT
Introduction
With a complex and often misunderstood etiology, acute Charcot neuroarthropathy (ACN) is a devastating complication of peripheral neuropathy. In patients with diabetes, timely diagnosis of ACN in the foot and ankle is essential to prevent loss of both limb and life. 相似文献9.
Maria Fernanda Villavicencio 《Expert Review of Clinical Immunology》2020,16(5):451-455
ABSTRACT
Introduction
HAE is a very debilitating disease that causes significant distress for patients not only during an acute attack but also constant fear for a subsequent attack. It is important to address long-term prophylactic (LTP) therapy to prevent attacks, decrease morbidity and increase the quality of life. When discussing LTP, the drug burden, convenience and efficacy must be taken into account. 相似文献10.
Maryam Balibegloo 《Expert Review of Clinical Immunology》2020,16(7):689-709
ABSTRACT
Introduction
Treatment of colorectal cancer as one of the most commonly diagnosed and a frequent cause of cancer-related deaths is of great challenges in health-related issues. 相似文献11.
Su Han Lum 《Expert Review of Clinical Immunology》2020,16(5):493-511
ABSTRACT
Introduction
Hematopoietic cell transplantation (HCT) is a curative treatment for an expanding number of primary immunodeficiencies (PIDs). Malignancies are more common in patients with PID than in the general population, and this review will discuss whether a successful HCT is expected to abolish or alter this risk. Second malignancy post HCT for a malignant disease is well known to occur, but generally less expected in patients transplanted for PID. 相似文献12.
Sonja Senner Marlene Seegräber Surina Frey Benjamin Kendziora Laurie Eicher 《Expert Review of Clinical Immunology》2020,16(7):641-650
ABSTRACT
Introduction
Dupilumab is a treatment option newly licensed for adolescents with moderate to severe atopic dermatitis (AD). It reduces type 2 inflammation by blocking the shared receptor subunit for IL-4/-13. Dupilumab affects three disease mechanisms in atopic dermatitis: the skin barrier, the Th2-cell differentiation and the class switch to IgE. This report is based on a systematic literature search of the PubMed Database. 相似文献13.
Fateme Babaha Hassan Abolhassani Zahra Hamidi Esfahani 《Expert Review of Clinical Immunology》2020,16(7):733-738
ABSTRACT
Objectives
Human Ficolin-3 (FCN3) is an oligomeric-structured lectin encoded by the FCN3 gene with a pivotal role in the lectin complement pathway. It has anti-microbial activities against bacterial and viral infections and restrains opportunistic pathogens. Mutation in the FCN3 gene is associated with variable clinical manifestations particularly immunologic (infections and autoimmunity) and neurologic complications. 相似文献14.
Carla Gaggiano Jurgen Sota Stefano Gentileschi Valeria Caggiano Salvatore Grosso Gian Marco Tosi 《Expert Review of Clinical Immunology》2020,16(8):787-811
ABSTRACT
Introduction
Noninfectious uveitis represents one of the leading causes of blindness in developed Countries, compromising patients’ quality of life and social functioning. The main treatment goals are the control of ocular inflammation, to avert and treat sight-threatening complications, thus preserving and/or restoring visual function. 相似文献15.
Keum Hwa Lee HyunJeong Lee Cheol-hun Lee Jin Yeong Kim Jong Min Kim Se Seung Kim Seungmin Jeong In Sung Hwang Namsoo Kim Na Eun Kim Soogeun Shin Dongkwan Shin Joo Sang Song Dong Hyun Shin Jung Dong Kim Jeehoon Kim Yong Seok Lee Hansung Kang Jae Il Shin 《Autoimmunity reviews》2019,18(1):1-8
Background
Adrenal insufficiency (AI) is associated with high morbidity and mortality. The aim of this systematic review was to enhance diagnostic approaches and summarize therapeutic strategies in the management of AI in patients with systematic lupus erythematosus (SLE) or antiphospholipid syndrome (APS).Methods
A literature search of PubMed and Medline databases was performed and 91 publications containing 105 cases were included for the final analysis.Results
The following frequency of clinical signs and symptoms was noted: abdominal pain (39.04%) was the leading symptom, followed by fever (33.33%), vomiting (23.81%), and nausea (19.05%). APS was present in 73%, SLE in 17% of the patients, while 2% had a diagnosis of both, SLE and APS. ACTH stimulation test (ACTHst) was performed in 18% of cases and 76.6% of them were unresponsive towards stimulation. Variable treatment approaches were used: hydrocortisone was most commonly used (38.09%), followed by fludrocortisone (26.67%), prednisolone (20.00%) and volume replacement treatment (11.43%), respectively.Conclusions
This analysis highlights the importance of an early diagnosis and initiation of therapeutic management when AI is suspected. In line, signs and symptoms related to autoimmune diseases in patients with AI should be reviewed crtitically. 相似文献16.
ABSTRACT
Introduction
Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects almost every organ system and it is treated with immunomodulation and immunosuppression. SLE patients have an intrinsically dysfunctional immune system which is exacerbated by disease activity and leaves them vulnerable to infection. Treatment with immunosuppression increases susceptibility to infection, while hydroxychloroquine use decreases this risk. Infectious diseases are a leading cause of hospitalization and death. 相似文献17.
Discontinuation of immunoglobulin replacement therapy in patients with secondary antibody deficiency
Vishesh Patel 《Expert Review of Clinical Immunology》2020,16(7):711-716
ABSTRACT
Introduction
Secondary immunodeficiency is becoming a greater medical concern as the usage of immunosuppressive and biological treatments has increased. Individuals with certain medical conditions, such as hematological malignancies, can also have secondary immunodeficiency. Immunoglobulin replacement therapy (IGRT), which has been used for decades in inherited or primary immunodeficiency, provides some protection to patients with acquired and predominant antibody deficiency, i.e. secondary antibody deficiency (SAD). However, IGRT is costly, and supplies are limited. Although there are clinical guidelines on when to initiate IGRT, there is no guideline on when to discontinue it. 相似文献18.
Scott P. Commins 《Expert Review of Clinical Immunology》2020,16(7):667-677
ABSTRACT
Introduction
Alpha-gal Syndrome (AGS) is a unique allergy to non-primate mammalian meat (and derived-products) that is associated with tick bites and is due to a specific IgE antibody to the oligosaccharide galactose-α-1,3-galactose (alpha-gal). AGS has many novel features that broaden the paradigm of food allergy, including that reactions are delayed 3–6 hours after exposure and patients have frequently tolerated red meat for many years prior to the development of allergic reactions. Due to the ubiquitous inclusion of mammal-derived materials in foods, medications, personal products and stabilizing compounds, full avoidance is difficult to achieve. 相似文献19.
Yongjing Ju 《Expert Review of Clinical Immunology》2020,16(8):739-743
ABSTRACT
Introduction
Thyroid eye disease is a debilitating, disfiguring, and potentially blinding periocular condition. Teprotumumab is a human insulin-like growth factor-I receptor monoclonal inhibitor antibody which indicated for treating thyroid eye disease. 相似文献20.
Nikolai Dyrberg Loft Sofie Vaengebjerg Lone Skov 《Expert Review of Clinical Immunology》2020,16(5):479-492
ABSTRACT