Absence of depression in elderly adults

Depressive symptomatology has been reported to be most prevalent over the age of 65. This study examined the effects of age (young less than or equal to 60 years, old greater than 60 years) and sex on the Beck Depression Inventory (BDI), MMPI Scale 2 (Depression), and Geriatric Depression Scale (GDS). Responses to somatic versus psychological complaints on the BDI were examined separately, and the physical malfunctioning subscale (D3) of the MMPI-2 was also evaluated. No age effects were found on any of the depression scales' total scores. On the BDI, the older group reported more somatic complaints than the younger group. Psychological complaints were reported equally for young and old groups. Women reported more depressed items on the MMPI-2 and reported a greater number of symptoms of physical malfunctioning (D3) than men for both age groups. No age by sex interaction reached significance. A report of greater physical malfunctioning (D3) was significantly associated with higher scores on all the depression scales. The increased prevalence of somatic complaints on self-report depression scales probably results in higher scores, which are misinterpreted as representing more depression in the elderly population. It is recommended that a depression scale such as the GDS, which excludes somatic items, be used to assess depression in older adults.     

Confirmatory factor analysis of the geriatric depression scale

PURPOSE: The Geriatric Depression Scale (GDS) is widely used in clinical and research settings to screen older adults for depressive symptoms. Although several exploratory factor analytic structures have been proposed for the scale, no independent confirmation has been made available that would enable investigators to confidently identify scores for the subdimensions of depression represented in the scale. DESIGN AND METHODS: This article describes a confirmatory factor analysis of the 30-item GDS, with the factor structure based on an exploratory principal components analysis that was published earlier. The original study sample consisted of 327 community-dwelling adults aged 65-94 years. The confirmatory factor analysis was performed on data from an independent sample of 294 adults aged 60-98 years who resided in retirement facilities. RESULTS: The proposed final measurement model uses 26 of the items from the GDS in five factors and obtains a goodness-of-fit index of.90. The resulting distinct subdimensions are Dysphoric Mood, Withdrawal-Apathy-Vigor, Hopelessness, Cognitive, and Anxiety. IMPLICATIONS: Although results should be considered preliminary, the use of these five subdimensions as subscales for scoring purposes may improve the precision and utility of the GDS as an assessment tool for older adults in health, mental health, and research contexts.     

Self-rated depression scales and screening for major depression in the older hospitalized patient with medical illness

Until now, no self-rated depression scale had been validated as a screening measure for major depression in the older patient hospitalized with medical illness. The present report establishes the validity of two brief, easily administered depression screening tests, the Geriatric Depression Scale (GDS) and the Brief Carroll Depression Rating Scale (BCDRS), in this population. Structured psychiatric interviews were performed and self-rated depression measures administered to 128 men, aged 70 and over, consecutively admitted to medical and neurological services of a VA hospital. The GDS and BCDRS were both shown to have high sensitivity and specificity for detecting major depression in this setting. Optimal cut-off scores determined by the receiver operating curve characteristics of these tests were 11 for the GDS and 6 for the BCDRS. At a cutoff score of 11, the GDS had a sensitivity of 92%, a specificity of 89%, and a negative predictive value of 99%; lowering the break point to 8 did not increase sensitivity. At a cutoff score of 6, the BCDRS achieved a 100% sensitivity, 93% specificity, and 100% negative predictive value. Whether clinicians decide to implement either of these depression screens in their practice will depend to a large degree on the importance ascribed to the detection of these disorders and on attitudes toward the benefits of treatment.     

The Short Geriatric Depression Scale

This study was undertaken to determine the test-retest reliability and the classification congruence between two popular depression screening instruments, the Short Geriauic Depression Scale (S-GDS) and the Geriatric Depression Scale (GDS). The GDS was administered to 73 independent, community dwelling older adults (mean ± SD: 62 ± 5, range 55-75 years); the S-GDS was extracted from the GDS for comparison. A subset of 49 subjects was reassessed 8 weeks after the initial assessment. There was systematic classification disagreement between the two instruments. Thus, of 15 cases categorized as depressed by the GDS, 9 (60%) were categorized as not depressed by the S-GDS. Of 7 cases categorized as depressed by the SGDS, 1 (14%) was categorized as not depressed by the GDS. Test-retest reliability was high for the GDS (r = .85), but only moderate for the S-GDS (r = .67). The current findings do not support the use of the S-GDS as a surrogate for the GDS. In light of the relatively extensive validation for the GDS and the lack of same for the S-GDS, as well as the demonstrated superior reliability of the former, prudence requires that the S-GDS not be used as a depression screening instrument pending the outcome of criterion-related validation studies.     

Diagnostic accuracy of various forms of geriatric depression scale for screening of depression among older adults: Systematic review and meta-analysis

ObjectivesDepression is under-reported and under-identified by the healthcare professionals. Geriatric depression scale (GDS) is one of the most commonly used instruments for screening the older adults for depression. The current review was done to determine the diagnostic accuracy of various forms of GDS for screening of depression among older adults.MethodsWe conducted systematic search in various databases like Medline, Cochrane library, Sciencedirect and Google Scholar from inception till May 2019. Quality of trials was assessed by Quality Assessment of Diagnostic Accuracy Studies-2 tool. We performed bivariate meta-analysis to obtain the pooled sensitivity, specificity, positive, negative likelihood ratio and diagnostic odds ratio for each of the GDS forms.ResultsTotally 53 studies with 17,018 participants were included in the review. We found the pooled sensitivity and specificity of GDS 30 to be 82 % and 76 % with near higher diagnostic accuracy (AUC = 0.85). GDS 15 had pooled sensitivity and specificity of 86 % and 79 % with higher diagnostic accuracy (AUC = 0.90). GDS 10 had pooled sensitivity and specificity of 87 % and 75 % with AUC = 0.83. Our study found GDS 4 to have sensitivity of 74 % with specificity of 71 %. All the four forms of GDS belonged to right lower quadrant of LR scatter-gram indicating neither confirmation nor exclusion.ConclusionCurrent study found that all the forms of GDS are highly useful for detecting depression among elderly with higher sensitivity and specificity. The diagnostic performance was much better for shorter forms of GDS such as GDS 15 and GDS 10 when compared to GDS 30.     

Bright light treatment decreases depression in institutionalized older adults: a placebo-controlled crossover study

BACKGROUND: An important parallel exists between patients with seasonal affective disorder and institutionalized older adults. Many older patients, as a result of global physical decline and immobility, are confined to their rooms, experiencing little natural sunlight. Thus, institutionalized older adults are at risk for chronic light deprivation. Testing the hypothesis that chronic light deprivation might be responsible, at least in part, for some depression among institutionalized older adults, the aim of this study was to investigate the efficacy of morning bright light treatment on depression among older adults residing in a long-term care facility. METHODS: In a placebo controlled, crossover design, participants (N = 10, six women and four men; M age = 83.8) received each of the following: (i) 1 week (5 days) of 10,000 lux (therapeutic dose); (ii) 1 week (5 days) of 300 lux (placebo); or 1 week of no treatment (control). Each week of light treatment was 5 consecutive days, 30 minutes daily, with a wash-out period consisting of 1 week between conditions. RESULTS: Geriatric Depression Scale (GDS) scores at baseline during all treatment conditions were positively correlated (r = .81, p < .01) with months of institutionalization, where participants with higher GDS scores experienced more time institutionalized. Scores on the GDS remained unchanged during the placebo and control conditions, but depression scores decreased significantly during the 10,000 lux treatment (pretest GDS M = 15 vs posttest GDS M = 11, p < .01). After the 10,000 lux treatment, 50% of the participants no longer scored in the depressed range. Improvement during the 10,000 lux condition was positively correlated (r = .62, p < .05) to baseline GDS scores, where participants with higher GDS scores experienced greater improvement following the 10,000 lux treatment. CONCLUSIONS: The results of the present study suggest that bright light treatment may be effective among institutionalized older adults, providing nonpharmacological intervention in the treatment of depression. Furthermore, the length of institutionalization may play an important role in determining the efficacy of bright light treatment for older adults in the nursing-home setting.     

Case-finding for depression in elderly people: balancing ease of administration with validity in varied treatment settings

BACKGROUND: Little is known about the performance of brief and ultrabrief (1- and 2-question) depression screens in older patients across varied treatment sites. This study (1) assesses their validity in clinics, hospitals, and nursing homes and (2) assesses cut-points for optimal clinical application. METHODS: 360 patients aged 60 years and older from 2 urban primary care practices (n = 125), 1 general hospital (n = 150), and 8 nursing homes (n = 85) were assessed using the Yale 1-question screen, the 2-question instrument derived from the Primary Care Evaluation of Mental Disorders, and long and short versions of the Center for Epidemiologic Studies Depression (CES-D) scale and Geriatric Depression Scale (GDS). Sensitivity and specificity were calculated for each screen compared with the criterion standard Diagnostic Interview Schedule (DIS) depression diagnosis and receiver operating characteristic curves generated. RESULTS: 9% of patients met DIS criteria for major depression and 7% for subsyndromal depression. Overall, the 10-item CES-D showed the best sensitivity/specificity for major depression in clinics (79%/81%) and hospitals (92%/77%), and the short GDS in nursing homes (86%/82%). Specificity of 1- and 2-question instruments was generally low. Established cut-points generally worked best for the short screens, while modifications were useful for longer versions. CONCLUSIONS: Consideration of site of use is important in selecting brief case-finding instruments for late-life depression, with the 10-item CES-D working best in medical settings and the 15-item GDS in nursing homes.     

Hospitalization and emergency department visits among seniors receiving homecare: a pilot study

Background

The objective of this study was to examine the Minimum Data Set (MDS) and Geriatric Depression Scale (GDS) as measures of depression among nursing home residents.

Methods

The data for this study were baseline, pre-intervention assessment data from a research study involving nine nursing homes and 704 residents in Massachusetts. Trained research nurses assessed residents using the MDS and the GDS 15-item version. Demographic, psychiatric, and cognitive data were obtained using the MDS. Level of depression was operationalized as: (1) a sum of the MDS Depression items; (2) the MDS Depression Rating Scale; (3) the 15-item GDS; and (4) the five-item GDS. We compared missing data, floor effects, means, internal consistency reliability, scale score correlation, and ability to identify residents with conspicuous depression (chart diagnosis or use of antidepressant) across cognitive impairment strata.

Results

The GDS and MDS Depression scales were uncorrelated. Nevertheless, both MDS and GDS measures demonstrated adequate internal consistency reliability. The MDS suggested greater depression among those with cognitive impairment, whereas the GDS suggested a more severe depression among those with better cognitive functioning. The GDS was limited by missing data; the DRS by a larger floor effect. The DRS was more strongly correlated with conspicuous depression, but only among those with cognitive impairment.

Conclusions

The MDS Depression items and GDS identify different elements of depression. This may be due to differences in the manifest symptom content and/or the self-report nature of the GDS versus the observer-rated MDS. Our findings suggest that the GDS and the MDS are not interchangeable measures of depression.     

A Preliminary Report on the Validation of the Geriatric Depression Scale in Arabic

Abstract

The validity of an Arabic translation of the Geriatric Depression Scale (GDS) is examined in this preliminary report. The GDS and Mini-Mental Status Exam (MMSE) were administered to 200 elderly Arab-Americans, and the GDS Collateral (GDSCOL) was completed by related informants. The prediction of GDS from GDSCOL scores was significant at the p < .01 level, with addition of the MMSE scores providing a slight increment in prediction. With reported prior diagnosis of depression as a criterion, the specificity of the scales is strong (GDS = .90, GDSCOL = .91), but the sensitivity appeared relatively low. Factors derived from the GDS paralleled those found in prior studies. Additional research is needed to evaluate concordance of the self-report GDS with psychiatrically determined diagnosis of depression.     

Depressive Symptoms Among Older Adults in Mexico City

BACKGROUND  Ageing and depression are associated with disability and have significant consequences for health systems in many other developing countries. Depression prevalence figures among the elderly are scarce in developing countries. OBJECTIVE  To estimate the prevalence of depressive symptoms and their cross-sectional association with selected covariates in a community sample of Mexico City older adults affiliated to the main healthcare provider. DESIGN  Cross-sectional, multistage community survey. PARTICIPANTS  A total of 7,449 persons aged 60 years and older. MEASUREMENTS  Depression was assessed using the 30-item Geriatric Depression Scale (GDS); cognitive impairment, using the Mini-Mental State Examination; and health-related quality of life with the SF-36 questionnaire. MAIN RESULTS  The prevalence of significant depressive symptoms was estimated to be 21.7%, and 25.3% in those aged 80 and older. After correcting for GDS sensitivity and specificity, major depression prevalence was estimated at 13.2%. Comparisons that follow are adjusted for age, sex, education and stressful life events. The prevalence of cognitive impairment was estimated to be 18.9% in depressed elderly and 13.7% in non-depressed. SF-36 overall scores were 48.0 in depressed participants and 68.2 in non-depressed (adjusted mean difference = −20.2, 95% CI = −21.3, −19.1). Compared to non-depressed elderly, the odds of healthcare utilization were higher among those depressed, both for any health problem (aOR 1.4, 95% CI = 1.1, 1.7) and for emotional problems (aOR 2.7, 95% CI = 2.2, 3.2). CONCLUSIONS  According to GDS estimates, one of every eight Mexican older adults had major depressive symptoms. Detection and management of older patients with depression should be a high priority in developing countries.     

Depression Screening in Congregate Meal Sites for Older Adults

Abstract

This study assessed the feasibility of depression screening in older adults attending congregate meal sites. The Geriatric Depression Scale (GDS-15) was administered to anonymous volunteers at 8 sites using self-scoring with group guidance. At 4 additional sites, attendees were offered the GDS with scoring instructions for individual completion on-site or for return by mail. Out of 227 attendees at the 12 meal sites, only 28% participated. Incomplete screens and scoring difficulties were common. Participants were observed comparing item responses with tablemates. Low energy, boredom, and memory problems were more commonly endorsed than hopelessness or poor spirits. We conclude that group depression screening, using self-scoring, was problematic. One-on-one assisted GDS administration appears to be necessary for accurate completion and scoring in this setting.     

Use of the Geriatric Depression Scale in dementia of the Alzheimer type

The Geriatric Depression Scale (GDS) has been shown to be an effective screening test for depression in selected geriatric populations. However, it has not been evaluated as a screening test for depression among elderly adults with dementia of the Alzheimer type. Over a two-year period 283 patients were seen in a geriatric assessment center and were screened for depression using the Geriatric Depression Scale. They also received a clinical psychiatric diagnosis by one of two geropsychiatrists. Patients with a Clinical Dementia Rating (CDR) of 0 (cognitively intact) (n = 70) and those with mild Alzheimer's disease (CDR of 1) (n = 72) were selected for comparison. The data were analyzed using Receiver Operating Characteristic Curves (ROCs) in order to compare the utility of the Geriatric Depression Scale in these two groups. ROC curves, which plot sensitivity against false positives, have come into increasing use as a method of examining the clinical performance of tests. The area lying beneath the curve (AUC) can be estimated and used as a quantitative measure of test performance (equivalent to the Wilcoxon rank sum). In the intact group, the Geriatric Depression Scale produced a ROC curve with an AUC of 0.85 (percent score = 1), which is significant (z = 7.28, P less than .0001). In the group composed of those with Alzheimer's disease, the Geriatric Depression Scale yielded a ROC curve with an AUC of 0.66, which was not significantly different from chance (z = 1.92, P = NS). This study provides empirical evidence that while the Geriatric Depression Scale is an accurate screening test for depression in cognitively intact geriatric populations, it does not maintain its validity in populations that contain large numbers of patients with dementia of the Alzheimer type.     

Validation of the five-item geriatric depression scale in elderly subjects in three different settings

OBJECTIVES: To test the effectiveness of a five-item version of the Geriatric Depression Scale (GDS) for the screening of depression in community-dwelling older subjects, hospitalized older patients, and nursing home residents. DESIGN: A cross-sectional study. SETTING: A geriatric acute care ward, a geriatric outpatient clinic, and a nursing home. PARTICIPANTS: One hundred eighty-one cognitively intact older subjects. MEASUREMENT: All the participants had a comprehensive geriatric assessment including a neuropsychological evaluation by a geriatrician experienced in the management of depression. The five-item GDS was compared with the 15-item version of the GDS using the clinical diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria as the criterion standard. The sensitivity, the specificity, the overall accuracy, positive and negative predictive values, and positive and negative likelihood ratios were calculated. The agreement between each of two different versions of the GDS and the clinical diagnosis and the test-retest and the interrater reliability of the five-item scale were also evaluated. RESULTS: In the whole sample, 48.1% of the subjects were depressed. The five-item GDS had a sensitivity of 0.94 (0.91-0.98), a specificity of 0.81 (0.75-0.87), a positive predictive value of 0.81 (0.75-0.87), a negative predictive value of 0.94 (0.90-0.97), a positive likelihood ratio of 4.92 (4.39-5.5), and a negative likelihood ratio of 0.07 (0.06-0.08). The five-item GDS and the 15-item GDS showed a significant agreement with the clinical diagnosis of depression (kappa = 0.74 for both scales). The five-item GDS had good interrater reliability (kappa = 0.88) and test-retest reliability (kappa = 0.84). Similar values were obtained in each setting and in both sexes. CONCLUSION: The five-item GDS is as effective as the 15-item GDS for the screening of depression in cognitively intact older subjects.     

帕金森病伴疼痛患者临床特征及认知功能研究

 目的 探讨伴慢性疼痛的帕金森病(PD)患者疼痛类型及危险因素,并分析疼痛与认知功能的相关性。方法 116例原发性PD患者分为伴疼痛组与不伴疼痛组,统一使用PD评分量表(UPDRS)、Hoehn-Yahr(H-Y)分期,汉密顿抑郁量表(HRSD,24项)、视觉模拟评分法(VAS)、蒙特利尔认知评估量表(MoCA)等进行评估。结果 伴慢性疼痛组UPDRS各项得分、H-Y分期及HRSD得分均高于不伴疼痛组,差异均有统计学意义(P值均<0.05)。logistic回归分析显示只有HRSD得分有统计学意义(OR=1.093,P=0.007)。伴慢性疼痛PD患者的“延迟记忆”得分低于不伴疼痛患者(1.9±1.3比2.5±1.3),差异有统计学意义(P=0.020);疼痛出现在运动症状之前患者的延迟记忆得分明显低于疼痛出现于运动症状以后的患者(1.2±1.2比2.2±1.3),差异有统计学意义(P=0.015)。结论 骨骼肌疼痛是PD患者最为常见的疼痛类型,抑郁可能是导致PD合并疼痛的独立危险因素,伴慢性疼痛PD患者的认知功能损害主要表现为延迟记忆障碍。     

Deutsche Adaptation der “Activities-Specific Balance Confidence (ABC) Scale„ zur Erfassung der sturzassoziierten Selbstwirksamkeit

The present study investigates the psychometric properties and the factorial structure of the German adaptation of the Activities-Specific Balance Confidence (ABC) scale (Powell & Myers, 1995) for the evaluation of falls-related self-efficacy in community-dwelling older adults. The German adaptation of the ABC using a forward-backward procedure was administered to 113 older adults (age 68.9+/-8.5 years). The following internationally accepted instruments were used for validation: The Short Form Health Survey SF 36, the Geriatric Depression Scale (GDS), the Trail Making Test and the Letter Number Sequencing Test, and motor tests (balance, strength, mobility). The internal consistency (0.91-0.95) as well as the test-retest reliability of the subscales was excellent (0.94-0.98). The correlation coefficients with the validation instruments ranged between 0.33 and 0.58. Significant differences in the ABC-D scores were found in older adults with and without falls. Older adults with a recent fall history scored lower on the ABC-D than older adults without a recent fall history. To conclude, the German version of the ABC has properties analogous to the original English version and is apparently useful in assessing falls-related self-efficacy.     

Development and testing of a five-item version of the Geriatric Depression Scale.

OBJECTIVE: To develop and test the effectiveness of a 5-item version of the Geriatric Depression Scale (GDS) in screening for depression in a frail community-dwelling older population. DESIGN: A cross-sectional study. SETTING: A geriatric outpatient clinic at the Sepulveda VA Medical Center, Sepulveda, California. PARTICIPANTS: A total of 74 frail outpatients (98.6% male, mean age 74.6) enrolled in an ongoing trial. MEASUREMENTS: Subjects had a comprehensive geriatric assessment that included a structured clinical evaluation for depression with geropsychiatric consultation. A 5-item version of the GDS was created from the 15-item GDS by selecting the items with the highest Pearson chi2 correlation with clinical diagnosis of depression. Sensitivity, specificity, diagnostic accuracy, and positive and negative predictive values were calculated for the 15-item GDS and the new 5-item scale. RESULTS: Subjects had a mean GDS score of 6.2 (range 0-15). Clinical evaluation found that 46% of subjects were depressed. The depressed and not depressed groups were similar with regard to demographics, mental status, educational level, and number of chronic medical conditions. Using clinical evaluation as the gold standard for depression, the 5-item GDS (compared with the 15-item GDS results shown in parentheses) had a sensitivity of .97 (.94), specificity of .85 (.83), positive predictive value of .85 (.82), negative predictive value of .97 (.94), and accuracy of .90 (.88) for predicting depression. Significant agreement was found between depression diagnosis and the 5-item GDS (kappa = 0.81). Multiple other short forms were tested, and are discussed. The mean administration times for the 5- and 15-item GDS were .9 and 2.7 minutes, respectively. CONCLUSIONS: The 5-item GDS was as effective as the 15-item GDS for depression screening in this population, with a marked reduction in administration time. If validated elsewhere, it may prove to be a preferred screening test for depression.     

Doctors' and nurses' observations on the Geriatric Depression Rating Scale

BACKGROUND: Screening older patients routinely for depression using the Geriatric Depression Scale is recommended, but there is little evidence that this practice is widespread. This study explored doctors' and nurses' attitudes towards the Geriatric Depression Scale in order to identify possibilities for improving practice. DESIGN: structured interviews. SETTING: Acute Care of the Elderly wards in the Royal Liverpool University Hospital. PARTICIPANTS: 20 junior doctors and 25 nurses. RESULTS: Only 10% of respondents would consider using the Geriatric Depression Scale for routine screening. Objections were to process as well as content. The Geriatric Depression Scale was felt to be 'too depressing' for routine use and a barrier to rapport with the patient. In addition to screening for possible depression, doctors and nurses expressed different requirements from a depression scale. Doctors wanted a formal method of rating and documenting symptoms. Nurses required a therapeutic structure within which they could help patients to explore feelings. Nurses also wanted the option of offering counselling for their patients but felt they needed training. CONCLUSIONS: Lack of enthusiasm for the Geriatric Depression Scale reduces its usefulness as a screening tool. A screening method that is more acceptable to nurses and doctors might improve depression screening practice.     

Validity and reliability of the Minimum Data Set Depression Rating Scale (MDSDRS) for older adults in nursing homes

OBJECTIVE: this research examined the psychometric properties of the Minimum Data Set Depression Rating Scale for use among older adults living in nursing homes. METHODS: interviews with 145 older adults in three nursing homes were conducted to complete the Hamilton Depression Rating Scale and the Geriatric Depression Scale. Information relevant to completing the Minimum Data Set Depression Rating Scale was gathered from the Minimum Data Set. RESULTS:the Minimum Data Set Depression Rating Scale did not perform well when validated against the Hamilton Depression Rating Scale and the Geriatric Depression Scale. Minimum Data Set Depression Rating Scale cut-off levels of > or =2 and > or =3 were associated with relatively low total score correlations and sensitivity rates, but acceptable specificity. CONCLUSIONS:findings suggest that the Minimum Data Set Depression Rating Scale may be of limited clinical value to identify depression among older adults living in nursing homes.     

Behavioral Activation as a Treatment for Geriatric Depression

By encouraging older adults to become more active, behavioral activation (BA) may help reduce depressive symptoms brought on by activity restriction. The purpose of this study was to determine, through a multiple-baseline design, whether BA could be successfully applied to older adults with depression. Nine depressed older adults (M = 75 years of age) underwent a course of in-home BA therapy (mean number of sessions = 14.7). Overall, participants' Geriatric Depression Scale and Hamilton Rating Scale for Depression scores decreased from pre- to post-treatment, and 71% of participants no longer met criteria for a depressive disorder. Behavioral activation shows promise as a treatment for geriatric depression.