色素性乳房和乳房外Paget病

报告12例色素性乳房和乳房外Paget病.男女各6例,年龄46～77岁.皮损表现为乳头、乳晕和外生殖器的色素性斑片和斑块,临床上类似于黑素瘤.组织病理表现为表皮内有大的、胞质有空泡化的肿瘤细胞增生.这些肿瘤细胞以单个或数个聚集在一起呈巢状分布.部分肿瘤细胞的胞质内可见黑素颗粒.免疫组化染色示所有患者的肿瘤细胞广谱细胞角...     

前列腺特异性抗原和雄激素受体在乳房外paget病中的表达

目的：了解前列腺特异性抗原（prostate specific antigen,PSA）和雄激素受体（androgen receptor,AR）在乳房外Paget病（EMPD）中的表达及其意义。方法：采用免疫组化ABC法检测PSA和AR在30例EMPD患者皮损中的表达情况。结果：①在30例EMPD患者皮损中13例PSA表达阳性,14例AR表达阳性,且在男性患者中PSA和AR的表达均明显高于女性患者（P〈0．01）;②在男性EMPD患者中,PSA和AR阳性表达间有明显相关性。结论：PSA和AR在男性EMPD患者中过度表达．PSA和（或）AR信号传导通路可能在男性EMPD形成机制中起重要作用。     

乳房外Paget病1例

患者男，72岁。因外阴部红斑、渗出伴瘙痒4年，于2005年5月6日就诊。患者4年前无明显诱因阴茎根部出现红斑伴瘙痒，皮损逐渐向邻近皮肤蔓延，时有渗液及脓性分泌物，曾多次在外院就诊，均诊断为湿疹，给予曲安奈德益康唑乳膏等药物治疗，皮损时好时坏，范围逐渐扩大，病程中无发热、消瘦、乏力等。既往有痛眦病史20年，高血压病史1年余。体格检查：系统俭查未见异常。[第一段]     

乳房外Paget病1例

患者男 ,64岁。阴囊皮疹偶伴渗出、瘙痒 10年。病理检查示 :全层表皮均见Paget细胞 ,有的成巢状 ,个别真皮乳头可见基底突破。诊断为 :乳房外Paget病 ,突破基底膜。     

乳房外Paget病1例

患者女,73岁.外阴及会阴红色斑片、糜烂3年伴疼痛1年,于2011年7月18日就诊.患者3年前无明显诱因外阴和阴唇部出现红斑,无糜烂,无自觉症状,未经治疗.皮损逐渐向会阴部发展,并且小阴唇红斑上出现点状糜烂伴少许渗液.曾在当地妇产科就诊,具体诊断与用药不详,未见好转.近1年患者自觉皮损持续性隐痛,且肛周出现红斑,无尿频、尿痛、无腹痛、腹泻,无发热.自起病以来患者精神、饮食、睡眠较差.2001年8月15日曾在当地医院行直肠腺癌手术治疗.     

乳房外Paget病1例

患者男,73岁。阴茎根部、阴囊出现红斑伴瘙痒13年,糜烂、渗出、溃疡、出现肿物伴异味1年。组织病理示局部区域有表皮下浸润,PAS(+),Alcianblue(-),免疫组化CEA(3+),CK(2+),HMB45(-),S-100(-)。诊断:乳房外Paget病。     

乳房外Paget病1例

患者男,58岁。左腹股沟反复起红斑,糜烂伴瘙痒8年,于2004年2月来我院就诊。患者8年前无明显诱因于左侧腹股沟出现红斑伴瘙痒,曾多次就医,以“湿疹”给予糖皮质激素类软膏外用,皮损可减轻,但易反复;随后皮损逐渐扩大,伴糜烂及渗出,俚未出现畏寒,发热等全身症状。     

乳房外Paget病1例

患者男,54岁.因阴囊右侧皮肤红斑、糜烂、渗液13个月于2011年10月14日就诊.13个月前无明显诱因患者阴囊右侧皮肤出现直径约1 cm大红斑,轻度瘙痒,搔抓后出现糜烂、渗液.曾在当地多家医院诊为"湿疹",给予多种药膏外用及抗组胺药物口服治疗(具体不详),病情无明显好转,近4个月来自觉皮疹明显增大,患者因惧怕恶变遂来我院诊治.既往体健,无其他肿瘤病史,家族中未见类似疾病患者.     

乳房外Paget病1例

<正>1病历摘要患者男,79岁。因阴囊及阴茎丘疹和糜烂伴瘙痒10余年,加重1个月,于2016年5月30日来我科就诊。患者10余年不明原因阴囊出现芝麻大淡红色丘疹,自觉轻微瘙痒,未予诊治。皮损逐渐增多,部分融合成片,瘙痒剧烈,搔抓后形成糜烂面伴渗液,曾多次在外院就诊,均诊断为阴囊湿疹,予静脉滴注复方甘草酸苷,肌内注射卡介菌素多糖核酸,口服左西替利嗪,外用卤米松、     

Expression of prostate-specific antigen and androgen receptor in extramammary Paget's disease and carcinoma

Prostate-specific antigen (PSA) is a kallikrein-like serine proteinase (human kallikrein 3) produced by epithelial cells of both benign and malignant prostate tissue. In this study, PSA expression was histologically examined in tissue specimens from 34 patients with extramammary Paget's disease (EPD; 31 cases) and extramammary Paget's carcinoma (EPC; three cases), but no associated prostate carcinoma. Tumour cells positive for PSA were found in 17 of the 34 cases. Based on this finding, we examined serum PSA level in the three EPC cases. A high level of serum PSA was observed in one case of EPC, which was correlated with disease progression. Because some reports suggest that 50-80% cases of EPD/EPC express androgen receptor (AR), we also examined expression of AR. Immunohistological staining showed correlation of PSA and AR in expression. These results suggest that PSA and the androgen signalling pathway may be involved in the pathogenesis of EPD.     

肿瘤细胞检查法诊断Paget氏病一例报告

我院外科收住1例乳头湿疹样癌病人,未前曾行皮肤细胞刮片,找到典型的肿瘤细胞,提前获得诊断,作了乳腺根治术,现简述如下.     

乳房外佩吉特病中囊泡病液体蛋白15的表达及其意义

目的：分析乳房外佩吉特（Paget）病中囊泡病液体蛋白（GCDFP）-15的表达及其意义。方法：应用免疫组化方法对20例乳房外Paget病患者的GCDFP-15和细胞角蛋白20（CK20）进行检测。结果：20例患者CK20均为阴性,8例呈侵袭性生长的患者GCDFP-15表达为强阳性或阳性,12例呈原位生长的患者GCDFP-15表达为弱阳性或阴性。结论：GCDFP-15的表达对于判断乳房外Paget病是否呈侵袭性生长有一定意义。     

Expression and prognostic significance of Stat5a and E-cadherin in extramammary Paget's disease

BACKGROUND: Stat5 has been shown to regulate the proliferation and inhibition of apoptosis in cancer cells. E-cadherin plays an important role in maintaining epithelial stability and is widely regarded as a prognostic marker in many types of human cancers. The expression of Stat5 has not been investigated in extramammary Paget's disease (EMPD). OBJECTIVES: To study the expression of Stat5a and E-cadherin protein in EMPD and to evaluate the relationships between them. METHODS: Thirty-six tissue samples from 34 cases with primary EMPD were subjected to immunohistochemical staining for Stat5a and E-cadherin. RESULTS: Twenty-nine of 30 in situ EMPD specimens were positive for Stat5a expression, and the staining pattern for Stat5a was mainly nuclear in the majority of Paget's cells. All four invasive specimens and two metastatic lymph node specimens were negative for Stat5a. Twenty-six of 30 in situ EMPD specimens expressed E-cadherin in more than 50% of tumor cells, and three of 30 in situ EMPD specimens expressed E-cadherin in less than 50% of tumor cells. One in situ EMPD specimen and one invasive specimen expressed E-cadherin in less than 25% of tumor cells. Three invasive specimens and two metastatic lymph node specimens were negative, with occasional membranous staining for E-cadherin. There is a significant correlation between the expression of Stat5a and E-cadherin. CONCLUSIONS: Our results showed that these proteins were found in in situ lesions, and it is speculated that these proteins may play some role in the prognosis/invasion of EMPD.     

三种性激素受体在原发性乳房外Paget病中的表达及意义

目的 研究探讨3种性激素受体在原发性乳房外Paget病中表达的特点及意义.方法 免疫组化法检测雄激素受体、雌激素受体和孕激素受体在30例原发性乳房外Paget病中的表达.结果 30例原发性乳房外Paget病中19例雄激素受体表达阳性.阳性率为63.3％,其中25例男性患者中阳性率为72％,5例女性患者中阳性率为20％.所有病例中雌激素受体和孕激素受体均阴性表达.结论 原发性乳房外Paget病有性激素依赖性,雄激素及其受体可能参与原发性乳房外Paget病的发生和发展.     

乳房外Paget病的研究进展

乳房外Paget病是一种少见的表皮内腺癌.检查方法有组织病理、免疫组化、非侵入性检查(包括皮肤镜和反射式共聚焦激光扫描显微镜).Mohs显微外科手术被认为是首选治疗方法,其他疗法有咪喹莫特、光动力疗法、曲妥珠单抗以及全身化学疗法等.本文对乳房外Paget病的流行病学、发病机制和诊治等内容进行综述,以期提高临床诊治水平.     

乳房外Paget病的病理学研究进展

乳房外Paget病（extramammary Paget′s disease,EMPD）是一种表皮内腺癌,分为原发性和继发性［1］。原发性EMPD好发于50 ~ 80岁的老年人,在欧美的报道中男女性别比例为1 ∶ 2 ~ 1 ∶ 7）［2-3］;然而在亚洲人群中男性患者所占比例高于女性［4-7］。原发性EMPD发病部位常见于大汗腺丰富的区域［1,8］,包括外阴和肛周部位,少见部位包括腹部、大腿、外耳道等［9-10］。继发性EMPD多来源于消化道或泌尿生殖道肿瘤［11］,诊断后患者往往需要进行系统检查。本文综述EMPD的病理学研究进展,提高对本病的认识……     

Expression of differentiation antigens in mammary and extramammary Paget''s disease

Seven cases of mammary and twelve cases of extramammary Paget's disease were studied for the presence of carcinoembryonic antigen (CEA) and apocrine epithelial antigen (AEA) using the immunoperoxidase technique. CEA was found in the Paget cells in five out of seven mammary and in all twelve cases of extramammary Paget's disease, whereas the AEA reaction was positive in six mammary and all extramammary cases. The same antigens were also found in the cells of intraductal or ductal adenocarcinomas of the breast associated with mammary Paget's disease, suggesting a common origin for the cells. In the cases of extramammary Paget's disease studied no underlying malignant neoplasms could be detected. Our findings support the suggestion that Paget cells originate in sweat gland ducts and undergo an apocrine differentiation.     

色素性乳房外Paget病一例

患者女,66岁。因左侧外阴斑块5年,近1年加重于2016年7月8日至重庆市第一人民医院皮肤科就诊。患者于2011年发现左侧外阴出现蚕豆大红斑,无自觉症状,未重视,后红斑逐渐扩大,中间部位出现较多点状或小片状黑色斑片,偶有轻度瘙痒及渗液,搔抓后浅表糜烂。曾多次至外院就诊,妇科、泌尿及肛肠科检查未发现肿瘤,先后诊断为外阴湿疹、脂溢性角化,外用糖皮质激素软膏治疗后症状无明显缓解。近1年皮疹明显扩大……