高校知识分子非酒精性脂肪肝与心血管及代谢性疾病的关系

目的　探索知识分子群体非酒精性脂肪肝与心血管及代谢性疾病的关系和流行病学意义。方法　对粤西两所高校 86 2名教师进行体检。采用对照研究的方法 ,抽取年龄、性别一致的非酒精性脂肪肝和非脂肪肝各 16 6例 ,分析非酒精性脂肪肝与肥胖、2型糖尿病、高脂血症、高血压、冠心病的相关性。回顾近 5年的体检资料 ,研究非酒精性脂肪肝与相关疾病的因果关系。结果　知识分子群体非酒精性脂肪肝患病率为 2 2 74 % ,男、女患病率间差别有显著性意义 (P <0 0 1) ;非酒精性脂肪肝与肥胖、高脂血症、2型糖尿病、高血压、冠心病密切相关 (P <0 0 1)。 2型糖尿病、高血压、冠心病的患病率有逐年增长趋势。结论　肥胖与高脂血症是知识分子群体非酒精性脂肪肝的重要病因 ;非酒精性脂肪肝是 2型糖尿病、高血压的危险因素 ,与冠心病关系密切。有效防治非酒精性脂肪肝可减少 2型糖尿病、高血压、冠心病的发生。     

四川省川西北高原藏区136例单纯性酒精性脂肪肝分析

随着四川省阿坝藏区医疗检测条件的改善以及 B 超在健康检查中的广泛应用,脂肪肝的检出率也明显增高。为了解位于青藏高原边缘的川西北阿坝高原藏区单纯性酒精性脂肪肝的发病情况和特点,我们通过调查分析,现报道如下。1 资料与方法1.1 一般资料:全部病例是2004年1月～2004年12月在门诊诊断为单纯性酒精性脂肪肝的136例患者。患者均为生活在高原藏区的人群。2.2 方法:B 超检查为脂肪肝,有长期大量饮酒史(每日饮酒80～150g,连续5年以上),排除肥胖、高脂血症、糖尿病、病毒、药物或其他原因所致的脂肪肝;统计分析采用     

脂肪肝临床特点分析

目的 :了解本地区脂肪肝患者的临床特点。方法 :对 1 87例经 B超和 /或 CT证实的脂肪肝患者进行病例分析。结果 :本地区脂肪肝患者主要是非酒精性脂肪肝 (86.1 )。酒精性脂肪肝只有4.3。相关病因是肥胖、高血脂、糖尿病。多数患者伴有高血压、冠心病、动脉硬化等疾病。本组患者临床症状不明显 ,肝功能很少改变。结论 :诊断脂肪肝靠 B超或 CT,而不是血生化检查 ,临床表现及肝功能改变与脂肪肝病因有关。     

非酒精性脂肪肝纤维化倾向的初步观察

近年来随着肥胖、高脂血症、糖尿病等患者的增多 ,非酒精性脂肪肝有上升趋势。目前认为非酒精性脂肪肝可以发展为肝纤维化和肝硬化 [1 ] ,而血清标志物 型前胶原肽 (P P)和透明质酸 (HA)是目前判断慢性肝病有无纤维化的敏感指标 [2 ]。本研究检测 6 2例非酒精性脂肪肝患者 P P和HA含量 ,探讨非酒精性脂肪肝纤维化倾向。1　材料和方法1.1　一般资料　 6 2例为 1999年 1月至 1999年 6月在我院消化科门诊就诊患者 ,男 5 0例 ,女 12例 ,年龄 2 6～ 73岁 ,平均 (43.8± 10 .6 )岁。所有患者均经 B超和 (或 ) CT确诊脂肪肝 ,并排除酒精性、…     

广州市中老年干部脂肪肝临床流行病学研究

目的　探讨脂肪肝在广州市机关干部群体中发病率和流行病学。方法　对广州市 1 2 2 7例体检的中老年干部资料进行分析。脂肪肝诊断由常规B超作出。结果　脂肪肝总体发病率为 1 3 5 3%。男性发病率高于女性 (1 5 1 0 %vs 9 5 4 % ,P <0 0 5 )。 5 0～ 5 9岁年龄组总发病率最高。 6 0岁以后 ,女性发病率上升 ,男性发病率下降。单因素分析脂肪肝与性别、年龄、体质指数、腰臀比、甘油三酯、胆固醇、血糖、尿酸、肝炎病史、长期嗜酒及高血压相关 (P <0 0 5 )。经多因素逐步分析脂肪肝危险因素依次为体质指数、甘油三酯、腰臀比、胆固醇及血糖。结论　脂肪肝是广州市中老年机关干部的常见病 ,与肥胖、高脂血症、高血糖密切相关。合理饮食、加强体力劳动和锻炼有益于控制脂肪肝的流行     

凯西莱治疗酒精性脂肪肝60例疗效观察

酒精性脂肪肝在我国发病率日趋增高,但缺乏特异性治疗手段。近年我们应用凯西莱(硫普罗宁)治疗酒精性脂肪肝获得较好效果,现报告如下。1　资料与方法1.1　临床资料　116例患者均为我院住院患者,随机分为治疗组6 0例,平均年龄4 4 .2岁;对照组5 6例,平均年龄4 2 .6岁,两组均为男性患者。诊断符合:2 0 0 0年10月南京会议酒精性脂肪肝的诊断标准[1 ] ,并除外由于肥胖、糖尿病、营养缺乏等造成的脂肪肝及合并病毒感染者。1.2　治疗方法　两组病例治疗前均戒酒、低脂饮食,常规均给予维生素B族、维生素C及门冬钾镁治疗,治疗组另加凯西莱(河南新谊…     

胆宁片治疗非酒精性脂肪肝32例疗效观察

目的:观察胆宁片对非酒精性脂肪肝的近期疗效和不良反应.方法:基础疾病均为肥胖和(或)高脂血症、糖尿病的非酒精性脂肪肝患者32例,口服胆宁片3个月治疗.结果:经胆宁片治疗3个月后,临床症状改善率78.57%,其中以便秘改善效果最为明显;转氨酶异常改善率76.92%,血脂异常改善率43.75%;B超复查发现31.25%脂肪肝程度下降1个或1个以上等级.结论:胆宁片对非酒精性脂肪肝的防治有一定疗效.     

脂肪肝患者血清脂类酶类分析

目的 :探讨脂肪肝的形成对肝脏的不良影响。方法 :对 96例临床表现符合并经 B超明确诊断为脂肪肝的患者采用酶动力学法 ,测定血清酶和脂类含量水平。结果 :肥胖性脂肪肝 ,糖尿病性脂肪肝 ,酒精性脂肪肝 ,血清γ- GT、AST升高伴 TG升高是诊断脂肪肝较有价值的指标。结论 :应用血清和酶类分析的方法 ,再结合 B超诊断即可作出脂肪肝的明确诊断     

健康体检人群中脂肪肝发病率及其易患因素调查分析

目的 了解脂肪肝易患因素,以便为针对性的健康教育提供依据.方法 对在安阳市疾病预防控制中心体检的2 372人,进行身高、体重、血压、实验室检测指标和B超及心电图检查.结果 查出脂肪肝患者266人(11.21%).患者年龄分布在18～78岁,男性发病率高于女性213:53(4:1).男女患病率比较差异有显著性意义(P＜0.01);脂肪肝患者与非脂肪肝者生活习惯比较差异有显著性意义(P＜0.01).结论 脂肪肝的发生与年龄、性别有关,随着患者年龄增长而增高,患病原因与某些易患因素如肥胖、高脂血症、糖尿病、不良饮食习惯、饮酒、活动少等有关.     

慢性脂肪肝90例临床分析

通过对本地区816名机关人员,教师体检调查,共发现脂肪肝90例（11．0％）,以同期体检无脂肪肝者90例为对照组。结果：本地区脂肪肝病因分布以肥胖症、糖尿病、高脂血症等引起的非酒精性脂肪肝为主,占84．4％,血甘油三酯和总胆固醇水平均显著高于对照组;肥胖症比例明显高于对照组;肝酶学改变与对照组无差异。结论：本地区脂肪肝病因以非酒精性脂肪肝为主,多合并有高血压,冠心病等多种疾病。B超作为诊断脂肪肝的主要方法,特别适用于健康普查。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.