克林霉素磷酸酯搽剂治疗寻常型痤疮的临床疗效

目的评价克林霉素磷酸酯搽剂治疗寻常型痤疮的有效性和安全性.方法采用随机单盲对照方法,验证组60例外用克林霉素磷酸酯搽剂,对照组60例外用特丽仙痤疮液,bid,疗程4周.结果验证组、对照组有效率分别为85%及83.3%,细菌清除率分别为81.3%及83.3%.2组治疗寻常型痤疮的有效率、细菌清除率比较均无显著性差异(P＞0.05).结论克林霉素磷酸酯搽剂是一种治疗寻常型痤疮比较安全、有效的外用制剂.     

克林霉素磷酸酸搽剂治疗寻常型痤疮的临床疗效

目的：评价克林霉素磷酸酸搽剂治疗寻常型痤疮的有效性和安全性。方法：采用随机单盲对照方法，验证组60例外用克林霉素磷酸酸搽剂,对照组60例外用特丽仙痤疮液，bid，疗程4周。结果：验证组、对照组有效率分别为85％及83．3％，细菌清除率分别为81．3％及83．3％。2组治疗寻常型痤疮的有效率、细菌清除率比较均无显著性差异（P＞0．05）。结论：克林霉素磷酸酸搽剂是一种治疗寻常型痤疮比较安全、有效的外用制剂。     

HPLC法测定复方克林霉素搽剂中甲硝唑和克林霉素的含量

根据药物之间的协同作用及药效学、药动学性质而研制的复方克林霉素搽剂 (痤康王 )是以克林霉素、甲硝唑为主要成分的制剂 ,是广谱强效抗菌杀虫药[1～ 3 ] ,用于痤疮、脂溢性皮炎、酒渣鼻、毛囊炎及其它多种细菌性皮肤感染的治疗和预防。搽剂中克林霉素的含量采用ＨＰＬＣ法 ,甲硝唑的含量采用紫外分光光度法[4 ] ,操作繁琐、费时。而文献报道甲硝唑的含量测定方法很多 ,其中有紫外分光光度法[5] 、非水滴定法[5] 、ＨＰＬＣ法[6,7] ,克林霉素测定法有ＨＰＬＣ法[8] ,但同时测定两组分的方法未见报道。本文采用的ＨＰＬＣ法能同时测定两组分…     

甲硝唑克林霉素凝胶治疗痤疮临床观察

目的：了解院自制制剂甲硝唑克林霉素凝胶治疗痤疮的疗效及安全性。方法：将患者分为治疗组与对照组，治疗组外搽由本院制剂室配制的甲硝唑克林霉素凝胶，每日早晚各搽1次，涂搽患处，对照组为外搽必麦森凝胶(过氧化苯甲酰 红霉素)，治疗方法同治疗组，两组均停用其他外用药及内服药，连续观察2周。结果：治疗组总有效率为92．5％，对照组总有效率为87．5％。结论：甲硝唑克林霉素凝胶是一种疗效高、安全性较好的治疗痤疮的药物，适合临床应用。     

盐酸克林霉素凝胶治疗寻常性痤疮的临床研究

目的:评价盐酸克林霉素凝胶在治疗寻常性痤疮中的疗效和安全性.方法:寻常性痤疮患者200例,采用严格的多中心、双盲、随机平行对照试验的方法.治疗组100例应用1%盐酸克林霉素凝胶治疗,对照组100例应用1%克林霉素磷酸酯凝胶治疗,比较两组疗效.结果:治疗组有效率为84.0%,对照组为78.0%,经Ridit检验,两组疗效差异不显著;两组的不良反应均较轻.结论:1%盐酸克林霉素凝胶治疗寻常性痤疮是安全、有效的.     

丹参酮联合克林霉素凝胶治疗寻常痤疮临床疗效观察

目的探讨丹参酮联合克林霉素凝胶治疗寻常痤疮的临床疗效。方法回顾性分析本中心皮肤科门诊近年来收治的160例寻常性痤疮患者的临床资料,根据治疗方法不同将患者随机分为2组,比较2组患者的疗效及不良反应差异。结果对照组患者,总有效率为81．25％;治疗组患者,总有效率为88．75％;两组患者的临床疗效经统计学分析,有显著性差异,P〈0．05。但治疗组有9例患者发生局部不良反应,不良反应发生率为11．25％;对照组也有11例发生局部不良反应,不良反应发生率为13．75％;两组患者的不良反应发生情况经统计学分析,无明显差异性,P〉0．05。结论丹参酮联合林霉素凝胶治疗寻常痤疮疗效确切,不良反应小,值得临床推广使用。     

克林霉素磷酸脂搽剂治疗痤疮临床及细菌学疗效观察

从 1 999年 6月～1 0月 ,我们对华北制药集团公司生产的克林霉素磷酸脂搽剂进行了细菌学及临床疗效观察 ,取得了良好疗效。现报告如下。1　资料与方法1 .1　病例标准　本组共 40例 ,其中男 2 1例 ,女 1 9例。年龄 1 3～ 35岁。皮疹特点 :40例中全部有炎性丘疹 ,伴有脓疱者 39例 ,白头粉刺者 36例 ,黑头粉刺者 2 6例。明确诊断的轻度或中度型痤疮患者。排除标准 :患结节囊肿型痤疮 ;痤疮部位有开放性伤口或重度痤疮有糜烂面者 ;入选前 2周内正在使用其他口服或外用治疗痤疮药物者 ;患有其他可能影响观察的皮肤病及肝肾功能异常者 ;妊娠或哺乳…     

克林霉素磷酸酯外用治疗寻常痤疮疗效观察

克林霉素磷酸酯外用治疗痤疮,使用方便,疗效确切且无明显不良反应。我科于2003～2004年外用克林霉素磷酸酯凝胶治疗寻常型痤疮100例,观察其疗效及安全性,现将结果报道如下。     

罗红霉素、葡萄糖酸锌片口服联合外用克林霉素甲硝唑搽剂治疗痤疮

目的探讨罗红霉素、葡萄糖酸锌片口服联合外用克林霉素甲硝唑搽剂治疗痤疮临床疗效。方法采用回顾性分析的方法,分析我院收治的痤疮患者临床资料,依据治疗方式不同分为对照组(口服米诺环素胶囊组)30例和观察组(罗红霉素、葡萄糖酸锌片口服联合外用克林霉素甲硝唑搽剂治疗组)40例。结果观察组治疗痤疮临床总有效率明显高于对照组,P<0.05,差异有统计学意义。结论罗红霉素、葡萄糖酸锌片口服联合外用克林霉素甲硝唑搽剂治疗痤疮效果明显,值得临床借鉴应用。     

Topical clindamycin in the management of acne vulgaris

A small cadre of antimicrobials are commonly used and regarded as effective and safe, as systemic and topical treatments of acne vulgaris. These include oral tetracycline, doxycycline, minocycline and topical clindamycin and erythromycin. Topical antimicrobials work via both antimicrobial and non-antimicrobial mechanisms: the former due to suppression of the growth of propionibacterial species (especially Propionibacterium acnes and P. granulosum). Clindamycin appears to be superior in efficacy compared with erythromycin and tetracycline. However, the emergence and spread of resistance among propionibacteria to both erythromycin and clindamycin calls into question their long-term viability as topical anti-acne therapies. Only through judicious use of combination topical therapies (e.g., topical retinoid, benzoyl peroxide or azelaic acid plus clindamycin or erythromycin) and the practice of effective infection control (i.e., handwashing between seeing patients in the clinic) can both clindamycin's and erythromycin's widespread utility be preserved in this disorder.     

Combination of azelaic acid 5% and clindamycin 2% for the treatment of acne vulgaris

Context and objective: Acne vulgaris, an inflammatory skin disease with different clinical appearances, is a common problem in most adolescents. It seems that using combinations of topical agents can decrease resistance to the treatment and improve the efficacy. Therefore, we evaluated the effects of azelaic acid (AA) 5% and clindamycin (Clin) 2% combination (AA-Clin) on mild-to-moderate acne vulgaris.

Materials and methods: The efficacy and safety of 12-week treatment with AA-Clin in patients with mild-to-moderate facial acne vulgaris were evaluated by a multicenter, randomized, and double-blind study. A total of 88 male and 62 female patients were randomly assigned to one of these treatments: AA 5%, Clin 2%, and combination of them. Every 4 weeks, total inflammatory and noninflammatory lesions were counted, acne severity index (ASI) was calculated, and patient satisfaction was recorded.

Results: Treatment for 12 weeks with combination gel significantly reduced the total lesion number compared with baseline (p?<?0.01), as well as Clin 2% or AA 5% treatment groups (p?<?0.05 or p?<?0.01). The percentage of reduction in ASI in combination treated group (64.16?±?6.01) was significantly more than those in the Clin 2% (47.73?±?6.62, p?<?0.05) and 5% AA (32.46?±?5.27, p?<?0.01) groups after 12 weeks. Among the patients in the AA-Clin group, 75.86% of males were satisfied or very satisfied and 85.71% of females were satisfied or very satisfied. This trend was significant in comparison to the number of patients who were satisfied with AA 5% or Clin 2% treatment (p?<?0.01). Seven patients in AA-Clin group (incidence?=?22%) showed adverse effects that were not statistically significant compared to treatment with individual active ingredients.

Discussion and conclusion: The profound reduction in lesion count and ASI by combination therapy with AA-Clin gel in comparison to individual treatment with 5% AA or Clin 2% suggested the combination formula as an effective alternative in treatment of acne vulgaris.     

克林霉素磷酸酯凝胶治疗痤疮

目的：观察克林霉素磷酸酯凝胶治疗痤疮的疗效。方法：痤疮１５４例随机分成３组,克林霉素磷酸酯凝胶１０４例,其中试验组５０例（男性１３例,女性 ３７例;年龄 ２３ ａ＋ ｓ ６ ａ）,开放组 ５４例（男性 １３例,女性 ４１例;年龄 ２４ ａ＋ ７ ａ）。磷酸克林霉素洗液５０例为对照组（男性 １８例,女性 ３２例;年龄２６ ａ±７ ａ）。上述药物每日早晚各 １次涂于患部,疗程均 ４ ｗｋ。结果： ３组治疗后炎性丘疹、脓疱改善较治疗前差异有显著意义（Ｐ＜０．０５或Ｐ＜０．０１）。试验组与对照组症状改善及疗效比较,差异无显著意义（Ｐ＞０．０５）。结论：克林霉素磷酸酯凝胶治疗痤疮疗效佳。     

Clindamycin phosphate/tretinoin gel formulation in the treatment of acne vulgaris

Clindamycin phosphate 1.2% together with tretinoin 0.025% as a gel (CTG) is a topical formulation of a fixed and stable combination approved by the FDA for the treatment of acne vulgaris in patients 12 years of age or older. The main indication of CTG is the management of moderate comedonal and mild-to-moderate papulopustular acne, an acne form which is present in more than 50% of acne patients. CTG can also be combined with systemic antiacne therapy, such as systemic isotretinoin, in nodulocystic acne. The product combines the anti-inflammatory and antibacterial properties of clindamycin with the well proven and beneficial comedolytic and anticomedogenic effects of tretinoin (all-trans retinoic acid). The addition of clindamycin to tretinoin enhances the comedolytic efficacy of tretinoin in moderate-to-severe acne of the face. The comedolytic activity of tretinoin and the anti-inflammatory efficacy of clindamycin accelerate resolution of all types of acne lesions without affecting the safety of both compounds. Discontinuation rates due to adverse events related to this formulation were found to be low (≤ 1%). Safety of CTG use in pregnancy has not been established. The combination formulation is mainly designed to enhance effectiveness and minimize irritation. The once daily use of CTG, its rapid and dual effect and good tolerability have a positive impact on the duration of disease, patients' compliance and overall costs of therapy.     

克林霉素磷酸酯外用溶液剂联合重组人表皮生长因子凝胶外用治疗轻中度痤疮疗效观察

目的：探讨克林霉素磷酸酯外用溶液剂联合重组人表皮生长因子凝胶外用治疗轻中度痤疮疗效.方法：将80例患者随机分为两组,治疗组40例采用克林霉素磷酸酯外用溶液剂涂擦皮损处,早晚各1次,重组人表皮生长因子凝胶外用皮损处,每日中午1次;对照组40例采用克林霉素磷酸酯外用溶液剂外涂皮损处,早晚各1次.8周后进行疗效判断.结果：治疗组和对照组总有效率分别为92.5％和82.5％,痊愈率分别为45％和30％,差异均有统计学意义（P＜0.05）.结论：克林霉素磷酸酯外用溶液剂联合重组人表皮生长因子凝胶治疗轻中度痤疮疗效优于单用克林霉素磷酸酯外用溶液剂.     

分光光度法测定克林霉素擦剂的含量

目的：建立一种分光光度法测定克林霉素擦剂的含量。方法：通过氧化法利用克林霉素将碘酸钾还原成碘后，测定碘液吸收度，求得克林霉素含量。结果：本方法平均回收率为100．7％，RSD为0．99％(n=6)。结论。本法灵敏快速．准确可靠。     

红霉素醋酸锌凝胶和软膏治疗寻常型痤疮

目的：评价红霉素醋酸锌凝胶和软膏治疗寻常型痤疮的疗效和安全性。方法：采用随机、双盲、平行对照试验。以1%克林霉素磷酸酯凝胶为对照,设红霉素醋酸锌凝胶和红霉素醋酸锌软膏2个试验组,用药后6 wk评价疗效,并观察不良反应。结果：共入选60例病人。58例完成试验,对照组、软膏组和凝胶组各有19例,20例和19例。治疗6 wk后3组病人的黑头粉刺、白头粉刺、炎性丘疹和脓疱数较治疗前均有显著下降(P＜0.01),3组间变化无差异(P＞0.05)。对照组、软膏组和凝胶组有效率分别为58%,65%和63%,各组间疗效比较差异无显著意义(P＞0.05)。3组皮肤局部不良反应发生分别为3例,1例和1例,无全身不良反应发生。结论：红霉素醋酸锌凝胶和软膏是安全有效的治疗寻常型痤疮的外用药。     

紫外分光光度法测定痤疮搽剂中甲硝唑和氯霉素的含量

本文应用差示分光光度法和单波长分光光度法，在３２２ｎｍ和２７８ｎｍ波长处，测定痤疮搽剂中甲硝唑和氯霉素的含量。回收率分别为１００．５±０．７％和１００．４±１．３％。此法适宜于医院制剂分析。     

阿达帕林凝胶治疗寻常痤疮临床观察

目的 :观察 0 1%阿达帕林凝胶治疗寻常痤疮的临床疗效和安全性。方法 :16 0例寻常痤疮患者 ,分别给予外涂 0 1%阿达帕林凝胶 (80例 )及 0 0 2 5 %全反维A酸凝胶 (80例 )。根据治疗前后炎性损害和非炎性损害总数减少的百分率评价疗效。结果 :两组痊愈率、显效率、有效率均无统计学差异 ,阿达帕林组不良反应率明显低于全反维A酸组。结论 :0 1%阿达帕林是一种局部治疗寻常痤疮的有效的安全的药物