共查询到20条相似文献,搜索用时 78 毫秒
1.
目的 探讨血清胆固醇及纤维蛋白原(FIB)在评估肾病综合征患儿肾小球硬化风险中的意义。方法 将63例原发性肾病综合征患儿按其病理类型分为微小病变肾小球病(MCG,n=39)组及局灶节段性肾小球硬化症(FSGS,n=24)组,回顾性分析两组患儿血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、非高密度脂蛋白胆固醇(non-HDL-C)、FIB及24 h尿蛋白定量的水平。结果 FSGS组中TC、non-HDL-C及LDL-C水平均较MCG组增高(均PP>0.05)。Logistic回归分析结果显示LDL-C、non-HDL-C和TC是影响肾小球硬化的危险因素(均PPP>0.05)。结论 血清胆固醇水平尤其是non-HDL-C对评估肾小球硬化的风险有重要意义;血浆FIB的水平尚不足以来评估或预测肾小球硬化的风险。 相似文献
2.
Magdalena Kwiatkowska-Gruca Beata Sadownik Beata Wnęko Jakub Behrendt Łukasz Sędek Urszula Godula-Stuglik 《Pediatria polska》2012,87(3):255-261
IntroductionThe existence of a relation between the leptin concentration – a hormone taking part in the metabolism of the organism, and the lipids and lipoproteins seems undoubted, till now it has not yet been defined for newborns.AimThe aim of the study was to determine the value of the lipid profile parameters: ApoA, ApoB, TC, LDL-C, HDL-C, TG, albumines and leptin in healthy, full-term newborns, as well as to analyze the relation between leptin concentration and the values of the lipids parameters.Material and MethodsSerum Concentrations of TC, HDL-C, LDL-C, TG, ApoA, ApoB, albumines and leptin were assesed in the serum between 3–7 day of life 35 healthy, full term newborns with appropriate birth weight.ResultsIn female newborns significantly higher LDL-C concentration was found (p=0.03). The girls had a higher concentration of ApoA, ApoB, TC, HDL-C and leptin than boys (p=0,03). Positive correlation between the leptin serum concentrations and body weight (r=0.3681, p=0.03) and length of newborns (r=0.4714, p=0.004) was stated. Numerous correlations between the lipids parameters and a significant (p<0.5) decrease of ApoA (r = ?0.4598), TC (r = ?0.3635), HDL-C (r = ?0.3473) and LDL-C (r = ?0.3398) in serum concentrations accompanied by an increase in leptin concentrations were found.Conclusions1. The full-term healthy newborns have a significant correlation between leptin concentration and the values of ApoA, TC, HDL-C and LDL-C. 2. Newborns show a positive correlation between leptin concentration and body weight and length at birth. 3. The sex of full-term healthy newborn may be the factor modulatory the values of the lipid profile parameters. 相似文献
3.
D. T. Sözüer D. Atakli O. Dogu S. Baybas B. Arpaci 《European journal of pediatrics》1997,156(7):565-567
Serum total cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C) and very low-density lipoprotein
cholesterol, triglyceride, apolipoproteins A1 and B levels were studied in 57 healthy children and in 39 children with epilepsy
who had been receiving carbamazepine (CBZ) (23 children) for 1.58 ± 1.10 years or valproic acid (VPA) (16 children) for 1.34 ± 1.11
years. In patients receiving CBZ, mean TC level, mean LDL-C level, mean TC/HDL-C ratio and mean LDL-C/HDL-C ratio were significantly
higher than controls. None of the mean levels of serum lipids evaluated in patients receiving VPA was significantly different
from the corresponding control group mean. Changes in serum lipids correlated with neither duration of therapy or plasma antiepileptic
levels nor age or gender.
Conclusion Our results suggested that CBZ, a hepatic-enzyme-inducing drug, affects serum lipid status. Long-term prospective studies
are necessary to determine whether chronic CBZ therapy is a risk factor for atherosclerotic disorders.
Received: 15 October 1996 / Accepted: 5 February 1997 相似文献
4.
Karande S Sawant S Kulkarni M Kanchan S Sholapurwala R 《Indian journal of pediatrics》2005,72(12):1029-1033
Objective : To compare the cognition abilities of children with specific learning disability (SpLD) viz. dyslexia, dysgraphia and dyscalculia
with those of non-impaired children.Methods : The study group consisted of 95 newly diagnosed SpLD children (aged 9–14 years) and the control group consisted of 125
non-impaired children (aged 9–14 years). An academic achievement of two years below the actual grade placement on educational
assessment with a Curriculum-Based test was considered diagnostic of SpLD. A battery of 13 cognition function tests based
on Guilford’s Structure of Intellect Model was administered individually on each child in four areas of information viz. fieural,
symbolic, semantic and behavioral. Mean scores ±SD obtained in these four areas were calculated in both groups and compared
using Independent Samples t-test. A P value < 0.05 was considered significant.Results : Children with SpLD had significantly lower scores (mean ±SD) in all four areas of information: maximally in the symbolic
area (18.66 ±4.83 vs. 28.30 ±4.29, mean difference 9.64, P< 0.0001, df = 218,95% Cl 8.43-10.86), followed by semantic (18.72
±5.07vs 27.36 ±4.17, mean difference 8.64, P< 0.0001, df=218, 95% Cl 7.40 9.87), figurai (17.10 ±5.24 vs 25.14 ±3.36, mean difference
8.04, P< 0.0001, df=218, 95% CI 6.89-9.19), and behavioral (5.68 ±2.10vs 7.54 ±1.46, mean difference 1.86, P< 0.0001, df = 218, 95% C11.39-2.33) areas.Conclusion : Cognition abilities are significantly impaired in children with SpLD. 相似文献
5.
目的:了解早产儿早期血脂代谢特点及其与新生儿呼吸窘迫综合征(RDS)的关系。方法:将100例适于胎龄早产儿按胎龄或出生体重分组,并以40例足月适于胎龄儿作为对照组,于出生后12 h内静脉采血,测定血浆总胆固醇(TC)、甘油三脂(TG),低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)水平;另外,分别根据胎龄及出生体重进一步比较发生RDS与未发生RDS早产儿的血脂水平。结果:随胎龄及体重增加,TG水平呈递增趋势,28~30周组及31~33周组早产儿血浆TG水平均明显低于34~36周早产儿及足月儿(P<0.01);出生体重≤1499 g组及1500~2499 g组早产儿血浆TG水平均明显低于出生体重≥2500 g早产儿及足月儿(P<0.05),且出生体重≤1499 g组与1500~2499 g组早产儿之间TG水平差异亦有统计学意义(P<0.01);而各组新生儿HDL-C、LDL-C及TC水平差异无统计学意义。RDS与非RDS早产儿血浆TC、LDL-C及HDL-C水平差异亦无统计学意义;但在胎龄28~30周组,RDS早产儿的TG水平比非RDS早产儿明显降低(P<0.05);体重≤1499 g RDS早产儿TG水平低于非RDS早产儿(P<0.05)。结论:早产儿血脂水平与胎龄及体重相关,低TG水平可能是胎龄28~30周及体重≤1499 g早产儿出现RDS的原因之一。 相似文献
6.
Fesharakinia Azita Zarban Asghar Sharifzadeh Gholam-Reza 《Indian journal of pediatrics》2009,76(7):729-731
Objective To determine the relationship of body mass index with serum lipids in elementary students.
Methods This prospective analytic study was conducted among 954 elementary school students (9–11years), selected by multi stage random
systematic method from 6 cities and their rural areas from The South Khorasan province (eastern Iran) from September to December
2006. Height and weight was measured and Body mass index was calculated. Total cholesterol (TC), triglyceride (TG), low-density
lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were determined.
Results 954 students 9–11 years old were studied. 45.4% were boys. 76.5% were living in the city. 1.8% of students were obese and
3.4% were over weight. There was no significant relation between obesity and overweight with sex, age and the area of residence.
There was significant relation between BMI with TC (P= 0.003), TG (P< 0.001) and LDL-C (P= 0.04). TG was significantly higher
in obese and overweight students than in normal weight students (P< 0.001). TC (0.002) and LDL-C (0.01) were significantly
higher in obese students than normal weight students. The prevalence of high TG was significantly higher in obese and overweight
students than normal weight students (0.003). There was no significant difference between different kinds of dyslipidemia
with area of residence.
Conclusion it is necessary to measure serum lipid profile in obese and overweight children. 相似文献
7.
??Abstract?? Objective??To explore the normal value of serum lipids and the correlation between atherogenic index and serum lipid in healthy children aged 2 to 14. Methods??The serum TG?? TC?? HDL-C and LDL-C were detected by Siemens 2400 automatic biochemical analyzer in 988 healthy children. The atherogenic index LDL-C/ HDL-C and ??TC??HDL-C??/HDL-C were calculated. Results????1??The diagnostic criteria of lipid disorder were as follows?? 2?? < 4-year-old?? TC > 4.02 mmol / L?? TG > 1.25 mmol / L?? HDL-C < 0.83 mmol / L?? LDL-C > 2.26 mmol / L?? 4?? < 7-year-old?? TC > 4.47mmol / L?? TG > 1.35mmol / L?? HDL-C < 0.90 mmol / L?? LDL-C > 2.55 mmol / L?? 7?? < 10-year-old?? TC > 4.78 mmol / L?? TG > 1.42 mmol / L?? HDL -C < 0.99 mmol / L?? LDL-C > 2.49 mmol / L?? 10?? < 13 -year-old?? TC > 4.71 mmol / L?? TG > 1.49 mmol/L?? HDL-C < 0.89 mmol / L?? LDL-C > 2.44 mmol / L?? 13??14 -year-old?? TC > 5.00 mmol / L?? TG > 1.48 mmol / L?? HDL-C < 0.95 mmol / L?? LDL-C > 2.96 mmol/L. ??2??The criteria of atherosclerosis index in children aged 2 ????4?? ?? 7 ?? ?? 10 ?? and 13 ?? 14-year-old were?? LDL-C/HDL-C > 2.38?? > 1.98?? > 1.95?? > 2.35 and > 2.28?? ??TC??HDL-C??/ HDL-C > 2.59?? > 2.55?? > 2.11?? > 2.46 and > 2.50?? respectively. ??3??The levels of serum TC?? TG?? HDL-C and LDL-C increased with age. ??4??The atherosclerosis index had significant positive correlation with TG and LDL-C. Conclusion??Criteria of serum lipids for children aged 2 to 14 years in Chongqing are established. The level of serum lipids is a dynamic process for children. The predictive value of atherosclerosis index should be noted in children with lipid disorder. 相似文献
8.
《European journal of paediatric neurology》2014,18(4):489-494
BackgroundKetogenic diet is a well-established treatment in children with difficult to treat epilepsy. Very little is known about the long-term effects on vascular atherogenic and biochemical processes of this high-fat and low carbohydrate and protein diet.MethodsWe evaluated 26 children after one year and 13 children after two years of ketogenic diet. High resolution ultrasound-based assessment was used for carotid artery intima-media thickness (cIMT), carotid artery distensibility and carotid artery compliance. Blood lipids including high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol, (LDL-C), total cholesterol (TC), apolipoprotein A (apoA), apolipoprotein B (apoB) and high-sensitivity C-reactive protein (hsCRP) were analysed.ResultsA gradual decrease in carotid distensibility and an increase in LDL-C, apoB and the TC:LDL-C and LDL-C:HDL-C ratios were seen at three and 12 months of KD-treatment. These differences were not significant at 24 months. cIMT, BMI and hsCRP did not show any significant changes.ConclusionsThe initial alterations in lipids, apoB and arterial function observed within the first year of KD-treatment appear to be reversible and not significant after 24 months of treatment. 相似文献
9.
目的研究儿童原发性高血压血清游离脂肪酸(free fatty acid,FFA)的水平,探讨其在儿童原发性高血压发病和防治中的临床意义。方法回顾性选取2021年1—6月首都儿科研究所附属儿童医院初治的34例原发性高血压儿童为高血压组,以同期体检的血压正常儿童32例为对照组。比较2组的空腹血清FFA、空腹血清三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)和非高密度脂蛋白胆固醇(non-high-density lipoprotein cholesterol,non-HDL-C)水平。采用多因素logistic回归分析探讨血清FFA对原发性高血压发病的影响。结果高血压组体重指数(body mass index,BMI)、收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)高于对照组,差异有统计学意义(P<0.05)。高血压组血清FFA、TG、LDL-C、non-HDL-C高于对照组,而血清HDL-C低于对照组,差异均有统计学意义(P<0.05)。高血压组血清FFA升高(女性>0.45 mmol/L,男性>0.60 mmol/L)率和传统血脂异常(血清TG、TC、LDL-C、HDL-C、non-HDL-C中至少一项异常)率均高于对照组,差异有统计学意义(P<0.05)。纳入年龄、性别、BMI、血清FFA升高、传统血脂异常等指标构建多因素logistic回归方程,结果显示血清FFA升高是儿童原发性高血压的独立危险因素(OR=17.560,95%CI:1.964~157.003,P<0.05)。结论原发性高血压儿童血清FFA明显升高;血清FFA升高可增加儿童原发性高血压的发病风险。 相似文献
10.
Background
In this study, we aimed to investigate the relationship between single-gender Korean references for non-high-density lipoprotein cholesterol (non-HDL-C) and metabolic syndrome (MetS) in childhood.Methods
A total of 5742 Korean children aged 10–18 years who participated in a national survey were included. The subjects were classified into three groups based on single-gender non-HDL-C levels as follows: <?120 mg/dL (desirable), ≥?120 and <?150 mg/dL (borderline high), and ≥?150 mg/dL (high).Results
Males in the borderline high non-HDL-C group had odds ratios (ORs) of 2.86 (95% confidence interval, 2.30–3.56) for elevated triglycerides (TG), 1.73 (1.08–1.79) for reduced high-density lipoprotein cholesterol (HDL-C) and 1.73 (1.08–2.78) for MetS compared with males in the desirable non-HDL-C group after adjusting for covariates. Males in the high non-HDL-C group had ORs of 1.65 (1.14–2.41) for elevated blood pressure (BP), 6.21 (4.27–9.05) for elevated TG, and 3.29 (1.49–7.26) for MetS compared with males in the desirable non-HDL-C group. Females in the borderline high non-HDL-C group had ORs of 3.03 (2.43–3.76) for elevated TG, 1.63 (1.13–2.35) for reduced HDL-C, and 4.53 (2.47–8.31) for MetS compared with females in the desirable non-HDL-C group. Females in the high non-HDL-C group had ORs of 1.43 (1.00–2.04) for elevated BP, 6.36 (4.45–9.08) for elevated TG, and 7.64 (3.65–15.96) for MetS compared with females in the desirable non-HDL-C group.Conclusion
Our results suggest that, in a Korean population, a non-HDL-C level of 120 mg/dL for males and 150 mg/dL for females is the threshold between borderline high and high risk for MetS.11.
Objective: Considering the importance of primary prevention of Cardiovascular Disease (CVD) from childhood, especially in children
with high family risk for premature atherosclerosis, and also the importance of oxidized LDL in the process of atherosclerosis,
the main metabolites of ox-LDL i.e. Malondialdehyde (MDA) and Conjugated diene (CDE) have been measured in children of high
risk families and compared with a control group.Methods: Children and adolescents (6–18 years) of parents with premature myocardial infarction (Ml ≤ 55y in men and ≤ 65y in women),
were selected as the case group. The control group included neighbors of the case group matched for age and socioeconomic
status. All samples have been selected by simple random sampling. Both the case and control groups were divided in two subgroups
: those with a total cholesterol and/or LDL-C ≥95th centile and those with normal lipid levels. Each subgroup consisted of
32 subjects, so 128 subjects were studied (64 in the case and 64 in the control group). MDA and CDE were measured by spectrophotometry
using molar absorbivity. Data were analyzed by SPSSv10/Win software using ANOVA, Bon-ferroni, Scheffe-Duncan, Tukey-HSD, and the Student’s t-test.Result: The mean MDA value in the case and control groups was significantly different (1.84 ± 0.43 vs. 1.67 ± 0.41 Μmol/L, p=0.03),
but this difference was not significant regarding the mean CDE level (0.50 ± 0.05 vs. 0.47 ± 0.04 Μmol/ L, p>0.05). The mean
MDA level in the case group with hyperlipidemia was significantly higher than that in the case group without hyperlipidemia
(1.985 ± 0.516 vs. 1.690 ± 0.366, Μmol/L, P=0.02) and also higher than control group with or without hyperiipidemia (1.985
± 0.516 vs. 1.720 ± 0.389,1.615 ± 0.429 Μmol/L respectivety, P<0.05). The mean CDE level in the case group with hyperiipidemia
was significantly higher than the case group without hyperlipidemia (0.542 ± 0.034 vs. 0.494 ± 0.049 Μmol/L, P=0.04) and higher
than the control group with or without hyperiipidemia (0.542 ± 0.034 vs. 0.464 ± 0.051, 0.484 ±0.048 Μmol/L respectively,
p<0.05). In case boys with hyperiipidemia, the mean MDA (2.03 ± 0.2 Μmol/L) and the mean of CDE (0.56 ± 0.04 Μmol/L) was significantly
higher than other subgroups (P<0.05).Conclusion: Considering the increased susceptibility of LDL to oxidation in children with high family risk for premature CVD, special
attention should be paid to consumption of foods and seasoning containing antioxidants from childhood especially in high risk
families. 相似文献
12.
LIU Qian-Qi CHEN Rong-Hua GUO Xi-Rong FEI Li GONG Hai-XiaDepartment of Pediatrics Second Clinical College Nanjing Medical University Nanjing China 《中国当代儿科杂志》2001,(4)
Withtheimprovementoflivingstandard ,obesi tyinchildhood ,the prevalenceofwhichhasbeenprogressivelyincreasingworldwide ,iscloselyassoci atedwiththeincreasedmorbidityandmortalitycausedbyseveralofthemostcommondiseasesinadults ,includingdiabetes ,hypertension ,… 相似文献
13.
Marta Flor-Alemany Pedro Acosta-Manzano Jairo H. Migueles Laura Baena-García Pilar Aranda Virginia A. Aparicio 《Maternal & child nutrition》2023,19(2):e13454
To examine the association of Mediterranean diet (MD) adherence during pregnancy with maternal and neonatal lipid, glycemic, and inflammatory markers. This study included 152 women from the GESTAFIT trial and a subsample of 35 newborns. The Mediterranean Diet Score, derived from food frequency questionnaires, was employed to assess MD adherence. Total cholesterol, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglycerides, and glucose were assessed in the mother (at the 16th and 34th gestational weeks [g.w.]) and in cord arterial and venous serum with standard procedures using an autoanalyzer. Pro-inflammatory and anti-inflammatory cytokines (interleukin [IL]−6, IL-8, IL-10, IL-1beta, interferon gamma, and tumour necrosis factor alpha [TNF-α]) were measured with Luminex xMAP technology. A greater MD adherence was associated with higher HDL-C and lower LDL-C, LDL-C/HDL-C ratio, triglycerides, triglycerides/HDL-C ratio, and TNF-α in the mother at the 16th and the 34th g.w. (|β|: 0.191–0.388, p < 0.05). A higher intake of whole grain cereals, fruits, vegetables and fish and a lower intake of sweets were associated with higher HDL-C and lower LDL-C, LDL-C/HDL-C ratio, triglycerides, triglycerides/HDL-C ratio, and TNF-α at the 16th and 34th g.w. (|β|: 0.188–0.334, p < 0.05). No associations were found with the cord arterial and venous serum markers (p > 0.05). A greater MD adherence during pregnancy, driven by a higher intake of whole grain cereals, fruits, vegetables and fish, and a lower intake of sweets, was positively associated with the maternal lipid and inflammatory serum markers throughout gestation. MD adherence during pregnancy was not associated with cord serum markers. 相似文献
14.
E. Hershkovitz O. Belotserkovsky Y. Limony E. Leiberman S. Shany M. Phillip 《European journal of pediatrics》1997,157(1):4-7
We studied the effect of growth hormone (GH) therapy on serum lipoprotein levels and the atherogenic index in short children
without GH deficiency. Fasting blood samples were collected from ten (eight males) normal, short, prepubertal children, aged
6–12 years, before, during a 1-year course of GH therapy (0.1 IU/Kg/day), and 3 months after the cessation of GH administration.
An increase in serum lipoprotein(a) [Lp(a)] levels of (mean% ± SEM) 43 ± 14, 58 ± 18, 61 ± 17 above the baseline levels was
noted at 3 months (P<0.05), 6 months (P<0.01), and 1-year (P<0.01) respectively after the beginning of GH administration. (ANOVA, P<0.01). An inverse relationship between baseline serum Lp(a) concentrations and the percentage increment in Lp(a) after 9
months of GH therapy (r=−0.65,P<0.05) was observed. GH therapy over a period of 1 year had no effect on plasma cholesterol, triglycerides, low density lipoprotein-cholesterol
(LDL-C), high density lipoprotein cholesterol [HDL-C] concentrations and the atherogenic index. Three months after the cessation
of GH therapy, serum Lp(a) levels were not significantly different from the pre-treatment values.
Conclusions Serum Lp(a) concentrations remained above pretreatment values during a 1-year period of GH treatment in short children without
GH deficiency and declined shortly after cessation of therapy. Since GH therapy for short children without GH deficiency usually
continues for several years, we suggest that serum Lp(a) levels should be determined and followed regularly in such children
under prolonged GH therapy.
Received: 11 February 1997 and in revised form: 10 June 1997 / Accepted: 6 July 1997 相似文献
15.
Premature coronary artery disease (CAD) and its risk factors are highly prevalent in Iran. It is well documented that atherosclerosis
starts in childhood and there is evidence that this association with adult levels may originate at birth, so assessment of
serum lipid levels in neonates might be of importance. In this study we aimed to measure serum lipoprotein and apolipoprotein
levels in a representative sample of Iranian newborns. Cord blood lipid profile, apolipoprotein A, apolipoprotein B, and lipoprotein
a (LPa) were analyzed in 378 full-term, Iranian newborns. The mean values of total cholesterol (TC), low-density lipoprotein
cholesterol, high-density lipoprotein cholesterol (HDL-C), apolipoprotein A, apolipoprotein B, and Lpa in girls were 81.4 ± 28.3,
35.9 ± 22.4, 31.1 ± 9.9, 87.9 ± 20.2, 34.2 ± 18.2, and 21.0 ± 2.8 mg/dL, respectively; these values in boys were 75.2 ± 21.1,
32.1 ± 16.3, 28.8 ± 8.7, 84.3 ± 16.0, 32.6 ± 14.2, and 19.5 ± 2.7 mg/dL, respectively. Median values of triglycerides (TGs)
in boys and girls were 61 and 62 mg/dL, respectively. Female neonates had significantly higher concentrations of TC and HDL-C
than males (81.4 ± 28.3 vs. 75.2 ± 21.1, p = 0.02, and 31.18 ± 9.97 vs. 28.8 ± 8.7, p = 0.02, respectively). Other biochemical factors were not significantly different between genders. The mean and median concentrations
of LPa were 20.3 and 18.7 mg/dL, respectively, which are almost five times higher than those reported in some other studies.
The TG concentration was 1.5–2 times higher than those previously reported. Our findings indicate that serum concentrations
of LPa and TG in Iranian neonates are higher than those in previous studies; this disorder, which is likely placing Iranians
at increased risk for future CADs, needs to be assessed in longitudinal studies. 相似文献
16.
载脂蛋白E基因多态性与原发性肾病综合征脂质代谢紊乱的关系 总被引:1,自引:0,他引:1
目的研究原发性肾病综合征(PNS)患儿载脂蛋白E(apoE)主要等位基因和基因型的分布规律,探讨apoE基因多态性与PNS脂质代谢紊乱的关系。方法检测PNS患儿46例和正常小儿39例血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、apoA1、apoB和apoA1/B,同时用聚合酶链反应-单链构象多态性(PCR-SSCP)结合测序的方法确定apoE基因型,并根据平衡法计算出各等位基因频率。结果1.肾病组TC、TG、HDL-C、LDL-C、apoB、apoA1/B均明显高于对照组(P均<0.01);2.肾病组apoE2/2频率显著高于对照组(χ2=4.50 P<0.05);3.肾病组不同基因型和等位基因各项血脂指标均未见明显差异。结论PNS患儿存在明显脂质代谢紊乱,apoE2/2频率显著增高,apoE基因多态性对PNS患儿血脂水平未见明显影响。 相似文献
17.
Sittisak Honsawek Tawatchai Chaiwatanarat Paisarn Vejchapipat Voranush Chongsrisawat Nutchanart Thawornsuk Yong Poovorawan 《Pediatric surgery international》2009,25(3):261-267
Purpose Osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL) have been implicated in osteoclastogenesis.
However, the relationship between the OPG–RANKL system and bone status in biliary atresia (BA) has not, as yet, been clarified.
Thus, the aim of this study has been to evaluate the relationship between the OPG–RANKL system and bone mineral metabolism
in patients with BA.
Methods Fifty patients with BA and 13 healthy controls were investigated. The mean age of BA patients and controls was 7.3 ± 0.6 and
8.0 ± 1.1 years, respectively. Serum levels of OPG, RANKL, osteocalcin, and C-terminal telopeptide of type I collagen (CTX)
were measured by sandwich enzyme-linked immunosorbent assay. Bone mineral density (BMD) of the lumbar spine was determined
by dual energy X-ray absorptiometry.
Results Biliary atresia patients had significantly elevated serum OPG levels compared with controls (4.0 ± 0.3 vs. 3.0 ± 0.3 pmol/L,
P = 0.02) and serum OPG levels in BA patients with jaundice were higher than in those without jaundice (4.6 ± 0.4 vs. 3.6 ± 0.4 pmol/L,
P = 0.04). Likewise, serum RANKL levels were significantly higher in BA patients than in controls (2.9 ± 0.2 vs. 1.2 ± 0.7 pmol/L,
P = 0.001). In addition, serum RANKL levels were increased in BA patients with jaundice compared to those without jaundice,
but this difference was not statistically significant (3.2 ± 0.3 vs. 2.7 ± 0.2 pmol/L, P = 0.2). The serum osteocalcin levels in BA patients were not significantly different from those in the healthy controls, whereas
the serum CTX levels were elevated in BA patients compared with the controls (0.4 ± 0.1 vs. 0.2 ± 0.1 ng/mL, P = 0.02). Furthermore, BMD of BA children with jaundice was significantly lower than that of BA children without jaundice (P = 0.0005). BMD of BA patients was inversely correlated with serum levels of OPG (r = −0.452, P < 0.001).
Conclusion Elevated serum OPG levels are associated with reduced BMD and the outcome of BA. The increase of serum OPG in BA patients
with severe disease could reflect a compensatory response to bone loss.
Presented at the 30th American Society for Bone and Mineral Research (ASBMR) annual meeting, Montreal, Quebec, Canada, 12–16
September 2008. 相似文献
18.
This study aimed to assess the efficacy and tolerability of atorvastatin in Tanner stage (TS) 1 patients ages 6 to 10?years and TS ??2 patients ages 10 to <18?years with genetically confirmed heterozygous familial hypercholesterolemia (HeFH) and a low density lipoprotein cholesterol (LDL-C) level of 4?mmol/l (155?mg/dl) or higher. In this open-label, 8-week study, 15 TS 1 children were treated initially with atorvastatin 5?mg/day and 24 TS ??2 children with 10?mg/day. Doses were doubled at week 4 if the LDL-C target (<3.35?mmol/l [130?mg/dl]) was not achieved. The efficacy variables were the percentage change from baseline in LDL-C, total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), very low density lipoprotein cholesterol (VLDL-C), and apolipoprotein (Apo) A-I and Apo B. Safety evaluations included clinical monitoring, subject-reported adverse events (AEs), vital signs, and clinical laboratory tests. The mean values for LDL-C, TC, VLDL-C, and Apo B decreased by week 2 among all TS 1 and TS ??2 patients, whereas TG, HDL-C, and Apo A-I varied considerably from week to week. After 8?weeks, the mean reduction in LDL-C was ?40.7%?±?8.4 for the TS 1 children and ?39.7%?±?10.3 for the TS ??2 children. For the TS 1 patients, the mean reductions were ?34.1%?±?6.9 for TC and ?6.0%?±?32.1 for TG. The corresponding changes for the TS ??2 patients were ?35.6%?±?9.5 for TC and ?21.1%?±?29.7 for TG. Four patients experienced mild to moderate treatment-related AEs. No serious AEs or discontinuations were reported. Overall, no difference in safety or tolerability was observed between the younger and older cohorts. Across the range of exposures after atorvastatin 5 to 10?mg (TS 1) or atorvastatin 10 to 20?mg (TS ??2) doses for 8?weeks, clinically meaningful reductions in LDL-C, TC, VLDL-C, and Apo were observed with atorvastatin in pediatric patients who had HeFH. Atorvastatin also was well tolerated in this population. 相似文献
19.
Orkide Donma M.D. Füsun Atlihan M.D. Mehmet Ali Tas M.D. M. Metin Donma M.D. 《Pediatrics international》1990,32(5):540-542
Serum levels of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and fructosamine (FA) were determined in thirty–three children with malignant diseases and twenty healthy controls aged 1–14 years. Of them, FA was the parameter measured in children with malignancy for the first time. Mean serum TC, HDL-C, LDL-C and FA showed statistically significant decreases in malignancy compared to healthy children, whereas a statistically significant increase was observed for TG concentrations in serum. From these data, we conclude that significant relations between serum lipids and lipoproteins and the state of malignancy exist in the children studied, and it should be remembered that serum FA concentrations are affected by abnormal serum protein turnover when one deals with any type of neoplastic disease. 相似文献
20.
Ruo-Lin Hou Huan-Huan Zhou Xiao-Yang Chen Xiu-Min Wang Jie Shao Zheng-Yan Zhao 《World journal of pediatrics : WJP》2014,10(2):175-181