颜面部多发性复发性嗜酸性粒细胞增生性淋巴肉芽肿1例及文献复习

嗜酸性粒细胞增生性淋巴肉芽肿又称木村病（Kimura disease,KD）,发病率低,病因不明,其确诊依靠组织病理学检查,镜下有显著生发中心的淋巴组织增生及淋巴滤泡形成,嗜酸性粒细胞在淋巴结内灶性聚集,形成嗜酸性微脓肿。临床上对于头颈部无痛性皮下肿物及局部淋巴结肿大的患者,尤其是伴外周血嗜酸性粒细胞及血清IgE增高者,应考虑KD可能,手术和放疗可取得一定疗效,但复发率较高。笔者报道颜面部多发性复发性KD1例。     

儿童全身多发性嗜酸性淋巴肉芽肿1例

“嗜酸性淋巴肉芽肿”又称“嗜伊红淋巴肉芽肿”，常发生于20～40岁的成年人，以男性为主。我科收治1例3岁男童，累及全身皮下淋巴结及骨髓，报告如下。     

软组织嗜酸性淋巴肉芽肿

软组织嗜酸性淋巴肉芽肿是皮下软组织单发或多发性、无痛性的生长缓慢的肿块。血液中成熟的嗜酸粒细胞明显增多。病理学检查以嗜酸粒细胞浸润与淋巴细胞增生为特征的肉芽肿性病变。本病在临床上少见,欧美有相似疾病。     

颌面部嗜酸性淋巴肉芽肿17例报告

目的：探讨颌面部嗜酸性淋巴肉芽肿（ELG）的临床特点和诊治方法。方法：对17例ELG患者的临床特点、实验室检查、病理、治疗及疗效进行总结，并结合文献进行分析。结果：ELG17例主要表现为多发性皮肤软组织肿块和淋巴结肿大，颌面部畸形，患者均无肝脾大，生长发育良好。单纯手术5例术后均复发，采用手术及局部放疗后未见复发。结论：ELG单纯手术切除易复发，采用手术及放疗综合治疗可提高临床疗效。     

颌面部嗜酸性淋巴肉芽肿12例临床及病理分析

目的 探讨嗜酸性淋巴肉芽肿的临床特点和诊治方法。方法 结合复习文献,对１２例颌面部嗜酸性淋巴肉芽肿患者的临床资料进行回顾分析。结果 病史较短者诊断困难,病史较长者易于诊断。单纯手术治疗１０例复发３例,手术结合术后治疗１例追踪８年未见复发。结论 了解嗜酸性淋巴肉芽肿临床病理特征有利于正确诊断,行以手术为主的综合治疗疗效较好。     

嗜酸性淋巴肉芽肿四例误诊报告

嗜酸性淋巴肉芽肿四例误诊报告湖北医科大学口腔医学院·口腔医院（邮４３００７０）江波，赵怡芳嗜酸性淋巴肉芽肿亦称嗜伊红细胞增生性淋巴肉芽肿，是一种好发于颌面部软组织和淋巴结的肉芽肿性疾病，临床上易误诊为肿瘤等病奕。现就我科４例误诊病例报告如下，并对有关...     

嗜酸性淋巴肉芽肿临床病理分析及电镜观察

对８例嗜酸性淋巴肉芽肿进行临床病理分析及电镜观察。结果表明，其病理特征有：１大量不典型增生的血管内皮细胞。２大量嗜酸性粒细胞及淋巴细胞浸润。３淋巴滤泡形成。电镜下，不公观察到血管内皮细胞及嗜酸性粒细胞的变化而且发现许多肥大细胞脱颗粒及一种类似含有大量扩张粗面内质网的浆细胞。患者经放疗后，放疗区标本不典型，毛细血管内皮细胞转化为正常，嗜酸性粒细胞消失，淋巴细胞量显著减少。     

嗜酸性淋巴肉芽肿16例报告

目的 为进一步探讨嗜酸性淋巴肉芽肿的诊断和治疗方法,提高临床医生对该病的认识和诊治水平。方法 通过对收治的16例嗜酸性淋巴肉芽肿病例分析及资料复习并加以讨论。结果 本组病例以青壮年男性为多,平均35.5岁,病程较长,对放疗敏感,可采用手术和化疗治疗。结论 嗜酸性淋巴肉芽肿是非肿瘤性疾病,易误诊,应以手术为主的综合治疗疗效较好。     

头颈部嗜酸性淋巴肉芽肿14例临床分析

目的 探讨头颈部嗜酸性淋巴肉芽肿（ELG）的临床特点,以提高临床诊治水平。方法 回顾性分析中山大学孙逸仙纪念医院口腔颌面外科2003 - 2012年14例头颈部ELG的临床资料,分别从研究对象的发病年龄、性别、发病部位、实验室检查、病理、临床表现、治疗及预后等方面进行总结。结果 所有病例均经病理检查确诊。治疗后随访时间为1 ~ 13个月,其中1例经肿块切除术,术后5个月复发;1例经药物治疗,治疗后4个月复发。其余12例患者预后良好,随访期间未出现病情进展或复发。结论 ELG常表现为一种无痛的软组织病变,好发于男性,多见于中青年人,好发部位为腮腺区、颈部等。主要依靠病理确诊,最佳治疗方案是手术切除结合适当剂量的放疗。     

颌面部嗜酸性淋巴肉芽肿15例临床病理分析

目的:探讨嗜酸性淋巴肉芽肿临床和病理特征,以利于正确诊治.方法:对我院19年来治疗的15例颌面部嗜酸性淋巴肉芽肿患者的临床资料进行分析.结果:5例术前正确诊断者中4例都有嗜酸细胞增高,1例有病理诊断;误诊以多形性腺瘤最多见,达6例.结论:末梢血嗜酸粒细胞增高对诊断本病有较高的参考价值,确诊靠病理检查,皮肤瘙痒则有一定参考作用;单靠临床检查易误诊.     

颌骨嗜酸性肉芽肿的临床特点——文献复习及1例报告

目的分析颌骨嗜酸性肉芽肿的临床特点。方法报告1例多发性颌骨嗜酸性肉芽肿,并复习相关文献。结果检索收集中文文献15篇,英文文献61篇。颌骨嗜酸性肉芽肿主要发生在下颌骨,男女比大约2∶1,临床表现和X线片改变与病变的发生部位有关。治疗以外科刮除为主,必要时可行放疗或化疗。有一定的复发率。结论颌骨嗜酸性肉芽肿,临床积极治疗和密切随访十分必要。     

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目的探讨舌溃疡性嗜酸性肉芽肿(UEGT)的临床病理特点,提高对本病的认识,防止误诊,避免过治疗。方法对2006年6月至2008年5月中国医科大学口腔医学院外科门诊收治的5例UEGT患者病变标本常规石蜡切片,HE染色,光镜下观察,结合临床表现和文献复习进行比较分析。结果溃疡面积较小,边缘隆起,较硬。镜下可见以嗜酸细胞为主的多种炎症细胞浸润,常深达小涎腺和肌层。有时易误诊为鳞状细胞癌或恶性淋巴瘤。结论UEGT为一种良性的自限性疾病,局部切取或切除病变组织送检病理即可。创伤可能是发病的重要因素,发病机制不清。     

Oral traumatic granuloma: report of a case and review of literature

Abstract –  Traumatic granuloma is an uncommon condition considered to be a benign, reactive lesion that usually affects the tongue. The exact pathogenesis implicated in the development of this lesion is not clear. However, trauma has been found to be a contributing factor in a majority of the cases. Clinically, it often presents as an ulceration or an indurated submucosal mass. Microscopically, it is characterized by a diffuse polymorphic cell infiltrate composed predominantly of eosinophils extending deep into the submucosa causing degeneration of the underlying muscle. Recognition of the lesion is important because it often mimics oral squamous cell carcinoma. But traumatic granuloma is self-limiting and tends to resolve spontaneously. This paper describes a case of traumatic granuloma on the dorsal surface of tongue in a 62-year-old woman. The clinical aspects, pathogenesis and histopathology of this uncommon lesion are discussed with an emphasis on its benign, self-limiting nature.     

Labial pyogenic granuloma related to trauma: A case report and mini‐review

This paper reports a case of a labial pyogenic granuloma in the lower lip of a 15‐year‐old boy due to chronic trauma from the maxillary left central incisor. The case report is based on the CARE (CAse REport) Checklist developed by the Joanna Briggs Institute. A further aim is to present a mini‐review about the link between labial pyogenic granuloma and trauma, through searching in three databases (MEDLINE, EMBASE, and Global Health) using a predefined search strategy and keywords. The Cochrane Library and PROSPERO were also searched for published and ongoing systematic reviews, respectively. Only five case reports were found that discussed the link between labial pyogenic granuloma and trauma. Chronic trauma was found to be the most common cause of pyogenic granuloma affecting the lip. Excisional biopsy was the preferable treatment due to the advantage of allowing histopathologic assessment, which is necessary to establish a definitive diagnosis. Dentists advise to include labial pyogenic granuloma in their differential diagnosis (ie, mucocele, cyst, abscess, hematoma, minor salivary gland trauma or tumor) when assessing lesions in the upper and lower lips, in particular when related to a history of trauma.     

Polyostotic eosinophilic granuloma of the jaws treated by chemotherapy. A case report

Eosinophilic granuloma is classified as a Langerhans cell histiocytosis. Although considered a rare pathology, up to 20% of all cases occur in the jaw bones, and radiographically may mimic odontogenic cysts or benign and malignant tumours. Different protocols have been suggested in the literature for treating eosinophilic granuloma. We report a case of polyostotic eosinophilic granuloma in a 34-year-old man showing ill defined mandibular and palatal radiolucencies. Due to the presence of multiple jaw lesions the treatment choice was chemotherapy. The clinical and radiographic feature are described, as well as treatment, complications and patient's follow-up.     

Benign lymphoid hyperplasia of the tongue masquerading as carcinoma: case report and literature review

Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. Microscopy showed typical histologic features of multiple germinal centers with a rim of small mature lymphocytes together with a mixed, mainly mononuclear infiltrate which clinched the diagnosis of benign lymphoid hyperplasia. This diagnosis averted extensive investigations and major surgery. The etiology of these lesions is unknown. Their distinction from carcinoma and lymphoma is discussed.     

涎腺黏膜相关淋巴组织型淋巴瘤报告1例及文献系统分析

涎腺黏膜相关淋巴组织型淋巴瘤（Salivary glands mucosa-associated lymphoid tissue lymphoma ,SGML）,为无痛性,进展缓慢的恶性肿瘤,较少发生于头颈部。口腔颌面外科医生因认识不足,临床上易误诊。本文报告以1例典型多发性涎腺黏膜相关组织型淋巴瘤为案例,结合文献分析探讨涎腺黏膜相关淋巴组织型淋巴瘤的发病机制及诊疗方法。