膝上外侧动脉穿支螺旋桨皮瓣的解剖及在膝前外侧软组织缺损修复中的应用

目的对膝上外侧动脉穿支螺旋桨皮瓣进行解剖研究,并探讨其修复膝关节前外侧软组织缺损的手术方法及临床效果。方法 2019年9月至2021年9月,宁波市第一医院整形修复重建外科对4例8侧成人下肢冰鲜标本进行解剖,观测膝上外侧动脉穿支并记录穿支蒂长、穿支起始部外径及皮肤穿出点位置。临床应用膝上外侧动脉穿支螺旋桨皮瓣修复5例膝关节前外侧软组织缺损患者,男3例,女2例,年龄25～48岁,平均33.4岁;其中2例合并韧带损伤和(或)骨关节外露,软组织缺损面积4.0 cm×4.0 cm～8.0 cm×5.0 cm,切取膝上外侧动脉穿支螺旋桨皮瓣面积10.0 cm×5.0 cm～13.0 cm×6.0 cm,术前行微泡超声造影寻找膝上外侧动脉优势穿支血管并标记皮肤穿出点,术中使用CDU确认优势血管皮肤穿出点,根据膝前外侧软组织缺损的面积设计膝上外侧动脉穿支螺旋桨皮瓣,制备皮瓣并转移至缺损区。术后门诊随访,观察皮瓣的成活情况,并按照Bai-ly膝关节评分标准进行膝关节功能评定。结果解剖发现,膝上外侧动脉穿支蒂长(8.2±0.9)cm,起始部外径(1.1±0.2)mm。临床5例皮瓣全部成活,术后均获得随访,...     

超薄型胫后动脉穿支皮瓣的解剖学观察与临床应用

目的 探讨游离超薄型胫后动脉穿支皮瓣修复手部皮肤软组织缺损的可行性与临床效果.方法 用红色乳胶经股动脉灌注的6侧成人下肢标本,观测胫后动脉在小腿内侧的皮穿支数目、分布、分支、外径等指标.结合解剖学观察结果设计皮瓣,在切取穿支皮瓣后修剪掉多余的脂肪,保留皮瓣的营养血管系统,用来修复手背、腕背等创面.临床应用11例,皮瓣面积最大10 cm×14 cm,最小2 cm×5 cm.结果 在6侧标本中,观测到胫后动脉的皮肤穿支43条,穿深筋膜平面时外径≥0.5 mm者有29条,平均每侧4.8条.穿支血管起始点的平均外径为(1.8±0.5) mm,长度(44±15) mm,在小腿近端第2段、第5段内出现穿支各6条,口径较粗,可以提供吻合.所有皮瓣均完全成活,其中7例随访3 ～12个月,皮瓣质地柔软,外形不臃肿,供区无并发症,手部功能、外形均满意.结论 超薄型胫后动脉穿支皮瓣血供可靠、修复创面后外形美观,是一种修复手背部中、小面积软组织缺损的较好方法.     

游离比目鱼肌穿支皮瓣的应用解剖与临床应用

目的 探讨比目鱼肌肌皮穿支应用解剖特点及比目鱼肌穿支皮瓣游离移植在临床中的应用. 方法 6例12侧下肢标本经灌注后解剖观测小腿外侧穿支特点及比目鱼肌皮穿支血管的走行分布特点.自2002年7月至2010年10月,应用比目鱼肌肌皮穿支为蒂的比目鱼肌穿支皮瓣游离移植修复体表皮肤软组织缺损14例,其中前足及足背侧皮肤组织缺损8例,踝前部组织缺损2例,手部缺损2例,肘部缺损2例.皮瓣面积5 cm×6cm～12cm×20cm. 结果 小腿外侧中上段恒定存在比目鱼肌皮穿支,多在腓骨头下5～ 24 cm,位置恒定.肌皮穿支外径在动脉起始部为(1.08±0.12)mm,静脉外径(1.20±0.32)mm.14例比目鱼肌肌皮穿支供血的穿支蒂皮瓣均成活,经6～12个月(平均8个月)随访,皮瓣质地优良,外观及功能恢复良好. 结论 直接肌支供血的比目鱼肌穿支皮瓣游离移植避免了暴露腓动脉,且切取简便,吻合管径适宜,是修复组织缺损的一种理想选择.     

膝上外侧动脉穿支髂胫束皮瓣的解剖特点与临床应用

目的 探讨膝上外侧动脉穿支髂胫束皮瓣的解剖学基础与临床应用效果.方法 自1999年9月至2009年7月,在40侧经动脉灌注红色乳胶的成人下肢标本上,解剖、观测膝上外侧动脉的起源、走行、分支、分布、吻合以及髂胫束的血供来源,临床应用吻合膝上外侧动脉穿支髂胫束瓣移植5例、髂胫束皮瓣4例.结果 80%(35侧)膝上外侧动脉单独起自腘动脉,起始外径(1.8±0.4)mm.该动脉向外蜿蜒上行分为升、降支,从股外侧肌与股二头肌短头肌之间的股外侧肌间隔穿出形成肌间隙(隔)筋膜皮肤穿支,或与膝上最外侧动脉在股外侧肌内吻合后发出肌皮穿支,供养大腿中下段髂胫束和前外侧皮肤,其中较粗大穿支起始外径(1.0±0.2)mm,并在深筋膜浅层或深层于近端与旋股外侧动脉降支吻合,远端与膝关节网吻合.临床应用9例,其中修复单纯跟腱缺损5例,跟腱伴皮肤缺损2例;修复小腿、足软组织缺损各1例.随访6个月～7年8个月,带血供髂胫束修复跟腱缺损功能恢复良好,4例髂胫束皮瓣全部成活.结论 吻合膝上外侧动脉穿支髂胫束皮瓣是一种新型、简便、实用的复合(软组织)缺损修复方法,适于临床推广应用.     

游离股前外侧穿支皮瓣或隐动脉穿支皮瓣修复足踝部软组织缺损

目的 探讨利用游离股前外侧穿支皮瓣或隐动脉穿支皮瓣修复足踝部软组织缺损的效果及手术技术.方法 2006年8月至2012年4月,对足踝部软组织缺损患者25例,创面范围4.0cm×5.5 cm～11.0 cm×23.0 cm.其中,足背软组织缺损采用游离股前外侧穿支皮瓣修复20例,足底软组织缺损采用游离隐动脉穿支皮瓣修复5例.结果 术后25例皮瓣全部成活.术后随访3～ 50个月,平均(18.0±0.8)个月.皮瓣修复后外形大部满意,皮瓣末梢二点辨别觉为10～22 mm,股前外和隐动脉穿支皮瓣组术后3个月随访,恢复S2+以上感觉分别为13/20和5/5例.结论 股前外穿支皮瓣修复足背软组织缺损较合适,隐动脉穿支用于修复足底软组织缺损.避免受区二次手术整形,重视皮瓣供区处理.负压封闭引流技术对开放性损伤导致创面的皮瓣成活有明显促进作用.     

应用足底角形穿支皮瓣修复足跟及前跖底缺损

目的 探讨应用足底角形穿支皮瓣修复足跟及前跖底缺损的方法及临床效果.方法 以缺损部位为皮瓣头端设计角形穿支筋膜皮瓣,弓形侧及凹陷侧均应切开深筋膜,并携带跖腱膜,将其旋转推进覆盖创面,皮瓣内尽可能包含2～3个穿支血管,必要时可结扎源血管(足底外侧动脉或足底内侧动脉),以利于增加皮瓣旋转推进距离.2010年1月至2012年10月,设计应用角形穿支皮瓣修复7例足底皮肤缺损,缺损范围约1.5 cm×2.0 cm～4.0 cm×5.0cm,皮瓣切取面积为7 cm×3 cm～13 cm× 7 cm.结果 术后6例角形穿支皮瓣全部成活,另1例皮瓣远端出现裂开坏死,残留小创面经换药、二期全层皮片移植愈合.供、受区伤口愈合良好,经3个月至2年随访,色泽、质地、外形及功能均恢复较好.结论 应用足底角形穿支皮瓣,供区缺损无需切取皮片移植,由足底同源性厚实坚韧皮肤修复,是修复足底部负重区软组织缺损的一种较优越方法.     

腓肠外侧动脉穿支与腓肠外侧皮神经营养血管联合蒂肌皮瓣的临床应用

目的 观察腓肠外侧动脉穿支与腓肠外侧皮神经营养血管的解剖位置关系,并设计二者联合蒂肌皮瓣,通过临床应用探讨其临床效果.方法 在5具(10侧)成人下肢新鲜标本上,观测记录腓肠外侧动脉穿支与腓肠外侧皮神经营养血管的解剖位置关系;并据此设计二者联合近端蒂肌皮瓣,临床应用5例,皮瓣大小6cm ×9 cm～9cm×12cm.结果 腓肠外侧动脉入肌后沿途发出3～5支外径为0.2～1.8 mm的肌皮穿支,营养腓肠肌外侧头及周围皮肤,并与腓肠外侧皮神经营养血管参与形成浅、深筋膜血管网.自2009年2月至2011年11月,临床应用5例腓肠外侧动脉与腓肠外侧皮神经营养血管轴联合蒂肌皮瓣修复膝前及胫骨上端皮肤缺损,4例一期愈合,1例远端部分浅表坏死,经换药逐渐愈合.结论 设计的联合蒂肌皮瓣有两套血供,血运丰富,扩大了皮瓣切取面积;同时皮瓣内带有感觉神经,保证了皮瓣感觉,可以修复膝关节周围较复杂皮肤软组织缺损.皮瓣蒂部不臃肿,转移方便,不损伤主要血管,创伤小,易于临床推广应用.     

股前外侧穿支皮瓣修复小腿及足部软组织缺损

目的 报道股前外侧穿支皮瓣修复小腿及足部软组织缺损的临床效果. 方法 应用逆行股前外侧穿支皮瓣转移修复小腿上段软组织缺损22例,皮瓣面积16cm×10 cm～25 cm×14 cm;应用游离股前外侧穿支皮瓣移植修复小腿中下段及足部软组织缺损6例,皮瓣面积11 cm×7 cm～18cm× 10 cm. 结果 28例皮瓣全部成活,无并发症发生,合并骨折病例骨折愈合,经10个月～5年随访,皮瓣色泽好、质地优良,除2例足背受区皮瓣外观较为臃肿需二期手术修薄外,皮瓣功能及外观满意.结论 根据伤情,灵活应用股前外侧穿支皮瓣不同术式修复小腿及足部软组织缺损可获得良好的临床效果.     

游离股内侧肌穿支皮瓣的解剖研究与临床应用

目的研究股内侧肌肌皮穿支解剖学特征,设计游离股内侧肌穿支皮瓣,为临床修复软组织缺损提供一种新的皮瓣。方法取6具自愿捐献的新鲜成人下肢标本,以氧化铅混合红色乳胶灌注,解剖股内侧肌肌皮穿支,并通过血管造影技术观测股内侧肌肌皮穿支的起源、走行、分布情况。根据解剖研究,于2009年6月-2011年8月,临床采用大小为14 cm×6 cm～20 cm×5 cm的股内侧肌穿支皮瓣修复4例足部皮肤软组织缺损,缺损范围8 cm×6 cm～12 cm×8 cm。结果股动脉恒定发出的股内侧肌动脉在内侧肌内下行至髌旁,终末支与旋股外侧动脉终末支吻合形成髌周血管网。沿途发出3～5支粗大肌皮穿支达深筋膜内,并浅出至股内侧肌表面皮肤,构成股内侧血管网。临床应用4例股内侧肌穿支皮瓣均成活,受区创面及供区切口均Ⅰ期愈合;患者均获随访,随访时间6～12个月,皮瓣色泽、质地良好,踝关节背伸、跖屈活动范围正常。结论游离股内侧肌穿支皮瓣切取简便,皮瓣供区隐蔽,质地优良,是理想的皮瓣供区。     

游离下腹部皮动脉穿支皮瓣修复手背部缺损简

目的探讨游离下腹部皮动脉穿支皮瓣修复手背部软组织缺损的临床疗效。方法对8例手背部软组织缺损伴深部组织外露,应用游离下腹部皮动脉穿支皮瓣进行修复。皮瓣面积最小5cm×6cm,最大10cm×7cm。结果本组8例,1例皮瓣远端部分坏死,坏死组织清除植皮愈合,另7例成活。随访6个月～1年,外观及功能满意。结论应用游离下腹部皮动脉穿支皮瓣修复手背部软组织缺损,皮瓣质地良好、切取方便、设计灵活、供区隐蔽,是修复手背部软组织缺损的方法之一。     

Vasopressor hormone response following mesenteric traction during major abdominal surgery

Background : We investigated the vasopressor hormone response following mesenteric traction (MT) with hypotension due to prostacyclin (PGI₂) release in patients undergoing abdominal surgery with a combined general and epidural anesthesia. Methods : In a prospective, randomized, placebo-controlled study we administered 400 mg ibuprofen (i.v.) in 42 patients scheduled for abdominal surgery. General anesthesia was combined with epidural anesthesia (T4-L1). Before as well as 5, 15, 30, 45, and 90 min after MT we recorded plasma osmolality, hemodynamics and measured 6-keto-PGFlα (stabile metabolite of PGI₂), TXB₂ (stabile metabolite of thromboxane A₂) active renin, and arginine vasopressin (AVP) plasma concentrations by radioimmunoassay. Catecholamine levels were assessed by high-pressure liquid chromatography (HPLC) with electrochemical detection. Results : Following MT, arterial hypotension occurred along with a substantial PGI₂ release. This was completely abolished by ibuprofen administration. Although plasma levels of 6-keto-PGF_1α (1133 (708) vs. 60 (3) ng/L, median (median absolute deviation), P=0.0001, placebo vs. ibuprofen) remained significantly elevated, blood pressure was restored within 30 min after MT in the placebo group. At the same point in time plasma concentrations of TXB² (164 (87) vs. 58 (1) ng/L, P=0.0001), epinephrine (46 (33) vs. 14 (6) ng/L, P=0.001), AVP (41 ± (18) vs. 12 (7) ng/L, P=0.0004), and active renin (27 (12) vs. 12 (4) ng/L, P = 0.001) were significantly higher in placebo-treated patients. Conclusion : Under combined general and epidural anesthesia arterial hypotension following MT due to endogenous PGI₂ release is associated with enhanced release of AVP, active renin, epinephrine and thromboxane A₂, presumably contributing to hemodynamic stability within 30 min after MT.     

A Teaspoon Pump for Pumping Blood with High Hydraulic Efficiency and Low Hemolysis Potential

Abstract: Virtually all blood pumps contain some kind of rubbing, sliding, closely moving machinery surfaces that are exposed to the blood being pumped. These valves, internal bearings, magnetic bearing position sensors, and shaft seals cause most of the problems with blood pumps. The original teaspoon pump design prevented the rubbing, sliding machinery surfaces from contacting the blood. However, the hydraulic efficiency was low because the blood was able to "slip around" the rotating impeller so that the blood itself never rotated fast enough to develop adequate pressure. An improved teaspoon blood pump has been designed and tested and has shown acceptable hydraulic performance and low hemolysis potential. The new pump uses a nonrotating "swinging" hose as the pump impeller. The fluid enters the pump through the center of the swinging hose; therefore, there can be no fluid slip between the revolving blood and the revolving impeller. The new pump uses an impeller that is comparable to a flexible garden hose. If the free end of the hose were swung around in a circle like half of a jump rope, the fluid inside the hose would rotate and develop pressure even though the hose impeller itself did not "rotate"; therefore, no rotating shaft seal or internal bearings are required.     

A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits

Background: Halothane inhibits in vitro and in vivo activity of cytochrome P-450 (CYP) 2E1. There are several fluorinated volatile anaesthetics besides halothane, and most of them are defluorinated by CYP2E1. It is unclear whether other fluorinated anaesthetics inhibit the in vivo activity of CYP2E1.
Methods: We compared the inhibitory effects of therapeutic concentrations of four inhalational anaesthetics, halothane, enflurane, isoflurane, and sevoflurane, on chlorzoxazone metabolism in rabbits receiving artificial ventilation.
Results: All four inhalational anaesthetics decreased arterial blood pressure and increased plasma chlorzoxazone concentration. However, no significant differences in the plasma chlorzoxazone concentration were found between the four anaesthetics. The estimated chlorzoxazone clearance increased after beginning inhalation with all four agents, but no significant difference in clearance was noted between agents.
Conclusions: At therapeutic concentrations, the in vivo inhibitory effect on chlorzoxazone metabolism was similar for all four inhalational anaesthetics examined, even though their chemical characteristics and extent of hepatic metabolism differ considerably.     

Microspheres Based Detoxification System: A New Method in Convective Blood Purification

Abstract: A variety of protein-bound or hydrophobic substances, accumulating as a result of pathologic conditions such as exogenous or endogenous intoxications, are removed poorly by conventional detoxification methods because of low accessibility (hemodialysis), insufficient adsorption capabilities (hemosorption), low efficiency (peritoneal dialysis), or economic limitations (high-volume plasmapheresis). Combining advantages of existing methods with microspheric technology, a module-based system was designed. Major operating parameters of the latter can be modified to allow for adjustment to individual clinical situations. An extracorporeal blood circuit including a plasmafilter is combined with a secondary high-velocity plasma circuit driven by a centrifugal pump. Different microspheric adsorbers can be combined in one circuit or applied in sequence. Thus, a prolonged treatment can be tailored using specially designed selective adsorber materials. Comparing this system with existing methods (high-flux hemodialysis, molecular adsorbent recycling system), results from our in vitro studies and animal experiments demonstrate the superior efficiency of substance removal.     

Tissue perfusion in relation to cardiac output during continuous positive-pressure ventilation and administration of propranolol or verapamil

Background : Our objective was to determine whether administration of propranolol or verapamil modifies the hemodynamic adaptation to continuous positive-pressure ventilation (CPPV), in particular the regional distribution of cardiac output (CO).
Methods : General hemodynamics and regional blood flows assessed by microsphere technique (15 (μm) were recorded in 16 anesthetized pigs during spontaneous breathing (SB) and CPPV with 8 cm H₂O end-expiratory pressure (CPPV8) before and after intravenous administration of propranolol (0.3 mg · kg⁻¹ followed by 0.15 mg · kg⁻¹ · h⁻¹, n=8) or verapamil (0.1 mg · kg⁻¹ followed by 0.3 mg · kg⁻¹ · h⁻¹, n=8).
Results : CPPV8 depressed CO by 25% without shifts in its relative distribution with the exception of a noteworthy increase in adrenal perfusion. Propranolol increased arterial blood pressure, and due to a fall in heart rate, CO dropped by 25%. The kidneys and, to a lesser extent, the splanchic region and central nervous system received increased fractions of the remaining CO at the expense of skeletal muscle flow. Similar patterns were seen during SB and CPPV8 such that the combination of propranolol and CPPV8 depressed CO by 50%. The circulatory effects of verapamil were less evident but myocardial perfusion tended to increase.
Conclusions : The combination of propranolol or verapamil with CPPV does not result in any specific hemodynamic interaction in anesthetized pigs, except that the combined effect of propranolol and CPPV may severely reduce CO.     

Volatile anaesthetics reduce adhesion of blood platelets under low-flow conditions in the coronary system of isolated guinea pig hearts

Background : Inhibitory effects of volatile anaesthetics on platelet aggregation have been demonstrated in several studies. However, the influence of volatile anaesthetics on intracoronary platelet adhesion has not been elucidated so far.
Methods : Isolated hearts of guinea pigs were perfused with buffer in the absence or presence of volatile anaesthetics (0.5 and 1 MAC) at constant coronary flow rates of 5 ml/min for 25 min, then 1 ml/min for 30 min and again 5 ml/min for 10 min. Before, during and after low-flow perfusion, a bolus of human platelets was applied into the coronary system. To simulate thrombogenic conditions, 0.3 U/ml human thrombin was infused during low-flow perfusion and reperfusion. The number of platelets sequestered to the endothelium was calculated from the difference between coronary in- and output of platelets. The myocardial production of lactate and consumption of pyruvate and coronary perfusion pressure were also determined.
Results : At a flow rate of 5 ml/min only about 3% of the applied platelets did not emerge from the coronary system, in any group. In contrast, 13.1±1.2% (mean±SEM) of infused platelets became adherent in low-flow perfusion in the control group without anaesthetic. The adherence was reduced with each 1 MAC isoflurane (to 6.2±1.2%), sevoflurane (to 4.4±0.9%) or halothane (to 3.2±1.5%) (each P <0.05 vs. control). Volatile anaesthetic, 0.5 MAC, did not inhibit platelet adhesion to a statistically significant extent in any case. Perfusion pressure and metabolic parameters were not statistically different between the control and the hearts exposed to anaesthetics.
Conclusion : Volatile anaesthetics in a concentration of 1 MAC can reduce the adhesion of platelets in the coronary system under reduced flow conditions. This action does not arise from vasodilation or inhibition of ischaemic stress.     

Bariatric Surgery in Some "Central and East-European (former Eastern bloc)"Countries - Current Status and Prediction for the Next Millennium

Background: Obesity is increasing globallly, including in the formerly "Eastern Bloc" countries. Methods: A survey was made of obesity and bariatric surgery. Results: In the 8 East and Central European countries studied, with total population 300 million, roughly 43% of the population was overweight (BMI 25-30), 23% obese (BMI > 30), with about 15 million people morbidly obese (BMI > 40). From 0-10 morbidly obese individuals/100,000/year undergo bariatric surgery. Conclusion: Most countries were found to provide inadequate treatment for obesity.The majority of the morbidly obese are not treated effectively. However, health-care awareness of obesity and bariatric surgeons are slowly increasing.     

Synergistic interaction between the effects of propofol and midazolam with fentanyl on phrenic nerve activity in rabbits

Background: It has been shown that the depressive effects of both propofol and midazolam on consciousness are synergistic with opioids, but the nature of their interactions on other physiological systems, e. g. respiration, has not been fully investigated. The present study examined the effect of propofol and midazolam alone and in combination with fentanyl on phrenic nerve activity (PNA) and whether such interactions are additive or synergistic. Methods: PNA was recorded in 27 anaesthetised and artificially ventilated rabbits. In three groups, propofol, fentanyl and midazolam were administered intravenously in incremental doses to construct dose-response curves for the depressant effects of each one on PNA. In another two groups, the effect of pretreatment with either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. on the effects of propofol and fentanyl respectively on PNA were studied. Results: Propofol and fentanyl caused a dose-dependent depression of PNA with complete abolition at the highest total doses of 16 mg · kg^?1 i. v. and 32 μg · kg^?1 i. v., respectively. In contrast, midazolam in incremental doses to a total of 0.8 mg · kg^?1 reduced mean PNA by 63%, but approximately 12% of PNA remained at a total dose as high as 6.4 mg · kg^?1. The mean ED₅₀s, calculated from dose-response curves, were 5.4 mg · kg^?1, 3.9 μg · kg^?1 and 0.4 mg · kg^?1 for propofol, fentanyl and midazolam, respectively. Initial doses of either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. acted synergistically with subsequent doses of either propofol or fentanyl to abolish PNA at total doses of 8 mg · kg^?1 and 8 μg · kg^?1, respectively. Conclusion: Fentanyl has a synergistic interaction with both propofol and midazolam on PNA and hence potentially on respiration.     

Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Background: Catecholaminergic support is often used to improve haemodynamics in patients undergoing major abdominal surgery. Dopexamine is a synthetic vasoactive catecholamine with beneficial microcirculatory properties. Methods: The influence of perioperative administration of dopexamine on cardiorespiratory data and important regulators of macro- and microcirculation were studied in 30 patients undergoing Whipple pancreaticduodenectomy. The patients received randomized and blinded either 2 μg · kg^?1 · min^?1 of dopexamine (n=15) or placebo (n=15, control group). The infusion was started after induction of anaesthesia and continued until the morning of the first postoperative day. Endothelin-1 (ET-1), vasopressin, atrial natriuretic peptide (ANP), and catecholamine plasma levels were measured from arterial blood samples. Measurements were carried out after induction of anaesthesia, 2 h after onset of surgery, at the end of surgery, 2 h after surgery, and on the morning of the first postoperative day. Results: Cardiac index (CI) increased significantly in the dopexamine group (from 2.61±0.41 to 4.57±0.78 1 · min^?1 · m^?2) and remained elevated until the morning of the first postoperative day. Oxygen delivery index (DO₂I) and oxygen consumption index (VO₂I) were also significantly increased in the dopexamine group (DO₂I: from 416±91 to 717±110 ml/m² · m²; VO₂I: from 98±25 to 157±22 ml/m² · m²), being significantly higher than in the control group. pHi remained stable only in the dopexamine patients, indicating adequate splanchnic perfusion. Vasopressive regulators of circulation increased significantly only in the untreated control patients (vasopressin: from 4.37±1.1 to 35.9±12.1 pg/ml; ET-1: from 2.88±0.91 to 6.91±1.20 pg/ml). Conclusion: Patients undergoing major abdominal surgery may profit from prophylactic perioperative administration of dopexamine hydrochloride in the form of improved haemodynamics and oxygenation as well as beneficial influence on important regulators of organ blood flow.