冰硝散塌渍合空气波压力治疗糖尿病肾病双下肢水肿的疗效观察

目的:观察冰硝散塌渍联合空气波压力治疗仪对临床糖尿病肾病患者双下肢水肿的疗效。方法:将120例早中期糖尿病肾病伴双下肢水肿患者随机分为治疗组与对照组,每组60例,对照组给予常规对症治疗,治疗组在对照组基础上给予中药塌渍联合空气波压力治疗仪治疗双下肢水肿,每日1次,每次30 min,14 d为1个疗程,治疗1疗程,通过观察治疗前后两组患者体重及双下肢肢围等变化,评价水肿消退的疗效。结果:治疗组总有效率高达91. 7%,患肢肢围(P 0. 01)、体重(P 0. 01)均较对照组显著改善,其疗效明显优于对照组。结论:冰硝散塌渍联合空气波压力治疗仪能对糖尿病肾病患者的肿肢具明显改善作用,其疗效确切。     

乳腺癌术后患者患肢水肿的护理干预

目的探讨乳腺癌患者行腋窝淋巴结清扫术后患肢水肿的护理策略及效果。方法按入院时间将腋窝淋巴结清扫术后乳腺癌患者进行分组。对照组(122例)实施常规护理;改进组(125例)在常规护理的基础上,对患肢肿胀实施预见性护理,包括有氧患肢训练、渐进性放松疗法以及穴位按摩,应对术后初期出现的患肢血液循环障碍相关肿胀;借助压力治疗仪、手法淋巴引流、瘢痕护理应对潜在淋巴泵衰竭导致的早期淋巴水肿问题。结果改进组术后1、3、6个月患肢水肿发生率显著低于对照组(P0.05,P0.01)。结论针对患肢水肿的护理干预能降低乳腺癌术后患肢水肿发生率。     

中药离子喷雾治疗带状疱疹的观察与护理

将 178例带状疱疹病人随机分成两组 ,治疗组 91例 ,对照组 87例。对照组用病毒唑治疗 ,治疗组在上述治疗基础上采用中药离子喷雾局部治疗。结果治疗组水疱干涸结痂、局部止疼、病程均较对照组缩短 (P <0 .0 5 ,P <0 .0 1) ,提示中药离子喷雾治疗带状疱疹方便 ,有效且无副作用 ,病人易于接受     

结肠灌洗联合中药保留灌肠辅助治疗重型肝炎疗效观察

目的了解结肠灌洗联合中药保留灌肠的临床应用价值。方法将 6 0例重型肝炎病人随机分为两组各 30例 ,治疗组采用结肠途径治疗仪行结肠灌洗联合中药保留灌肠 ,对照组单纯进行结肠灌洗 ,比较两组病人的症状、体征及实验室检查指标。结果治疗组症状、体征及实验室检查指标的改善程度明显优于对照组 (均P <0 .0 5 )。结论结肠灌洗联合中药保留灌肠可降低病人的黄疸程度 ,改善临床症状。     

乳腺癌术后预防上肢淋巴水肿专用软枕的研制与应用

目的预防乳腺癌术后病人患侧上肢淋巴水肿的发生.方法选择临床诊断(经病理证实)为乳腺癌行乳腺癌改良根治术后病人70例,随机分为观察组和对照组,各35例.观察组术后给予自制专用软枕,抬高患侧上肢;对照组按常规方法抬高患肢.比较两组病人术后患侧上肢淋巴水肿发生率.结果观察组病人术后患侧上肢淋巴水肿11例(占31.43%),对照组20例(占57.14%),两组比较,差异有显著性意义(P＜0.05).结论乳腺癌术后病人使用自制专用软枕,能降低术后患侧上肢淋巴水肿发生率,病人感觉舒适,易接受.     

晚期胰腺癌围手术期免疫调节治疗的疗效评价

目的　探讨晚期胰腺癌围手术期免疫调节治疗效果。方法　 43例晚期胰腺癌随机分为香菇多糖综合治疗组和对照组 ,动态观察术后T细胞亚群、NK细胞活性的变化 ,比较两组病人的生存期。结果　香菇多糖综合治疗组术后NK活性 ,CD3,CD4细胞数和CD4/CD8比值较对照组明显升高 (P <0 .0 5 ) ;术后平均生存期 (14.9± 8.5 )月 ,明显高于对照组 (7.7± 3.5 )月 (P <0 .0 0 1)。结论　晚期胰腺癌病人围手术期免疫调节综合治疗 ,有助于提高机体细胞免疫功能和改善病人生存期     

手法淋巴引流护理缓解乳腺癌患者术后淋巴水肿与腋网综合征的效果分析

目的 分析手法淋巴引流护理缓解乳腺癌术后淋巴水肿与腋网综合征的干预效果。方法 选取湛江市妇幼保健计划生育服务中心2018年1月至2020年1月收治乳腺癌术后并发淋巴水肿与腋网综合征患者50例,按随机双盲法分为两组,对照组25例,常规护理;观察组25例,基于对照组采用手法淋巴引流护理;比较两组患者干预效果及症状缓解情况。结果 观察组患者干预3个月、6个月、12个月的有效率分别为72.0%、80.0%、100.0%,均高于对照组的44.0%、56.0%、72.00%,差异有显著性(P <0.05)。观察组患者干预3个月、6个月、12个月的周径差值减少幅度高于对照组,干预后1个月、3个月、6个月、12个月时的患肢肩关节外展角度高于对照组,术后患肢紧绷感、条索结构、患肢麻木、患肢疼痛消失时间短于对照组(P <0.05)。观察组患者干预1个月后日常社会功能、上肢活动功能、上肢症状评分低于对照组(P <0.05)。结论 手法淋巴引流护理可缓解乳腺癌术后淋巴水肿与腋网综合征临床症状,增加患肢活动范围,干预效果好。     

中西医结合治疗慢性溃疡性结肠炎疗效观察

将 4 1例慢性溃疡性结肠炎病人随机分为观察组与对照组。对照组 (19例 )常规口服柳氮磺胺嘧啶 (SASP)治疗 ;观察组 (2 2例 )在此基础上加服中药 ,同时中药保留灌肠。结果观察组与对照组总有效率分别为 90 .5 %和6 4 .5 % ,两组比较 ,差异有显著性意义 (P <0 .0 5 )。提示中西医结合治疗慢性溃疡性结肠炎效果明显优于单纯西医治疗。     

精氨酸联合纳洛酮治疗肝硬化性肝性脑病疗效观察

将 10 6例肝硬化并发肝性脑病病人随机分为观察组和对照组各 5 3例 ,观察组采用精氨酸加纳洛酮、对照组仅用精氨酸治疗 ,两组其它基础治疗相同。结果有效率观察组为 90 .6 % ,对照组为 6 0 .4 % ,两组比较 ,差异有显著性意义 (P <0 .0 1) ;两组治疗前后血氨水平比较 ,差异无显著性 (P >0 .0 5 ) ;观察组治疗后血浆内啡肽 (β EP)水平较对照组显著降低 ,两组比较 ,差异有显著性意义 (P <0 .0 1) ;病人清醒时间观察组 (10 .4± 4 .2 )h ,对照组 (2 8.5± 5 .7)h ,两组比较 ,差异有显著性意义 (P <0 .0 1)。提示精氨酸联合纳洛酮治疗肝硬化并发肝性脑病疗效确切。     

中药雾化治疗慢性咽炎疗效观察

将 4 6例慢性咽喉炎病人随机分为观察组和对照组 ,各 2 3例 ,观察组用自配的中药雾化液进行雾化治疗 ,对照组用常规的西药雾化液进行雾化治疗。结果观察组有效率为 95 .6 5 % ,对照组为 73.19% ,两组比较 ,差异有显著性意义 (P <0 .0 1)。提示中药雾化液治疗慢性咽喉炎能有效提高治愈率。     

杭州健康女性定量骨超声测定原发性骨质疏松

目的 评价杭州健康女性骨超声速度(SOS)值随增龄减少和骨质疏松患病率，建立杭州地区女性骨超声速度值参考数据库。方法 定量超声法测定1208例杭州地区健康女性桡骨远端(RAD)，第3指骨近节(PLX)，第V跖骨(MTR)和胫骨中段(TIB)的超声速度值。结果 RAD、PLX、MTR和TIBSOS峰值(Peak of SOS)均出现在40-45岁，TJB的SOS峰值出现在35—40岁，此后随年龄增长而下降。绝经后妇女在绝经后早期和晚期各有1个SOS快速减少期，前见于桡骨近端，平均年减少率为2．4％，后见于胫骨中段，平均年减少率为1．8％。各部位骨SOS累积减少率随年龄增长而增加，到85岁4部位累积减少为13％-18％。60岁以后骨质疏松性症(OP)检出率为45％-70％，OP检出率以桡骨远端最高，60-70岁平均为67％，第3指骨近端次之约50％，胫骨中段最低为36％；75岁以后分别为70％，65％和45％。结论 全身各部位骨超声速度值到达峰值的年龄不同，峰值也各有差异。绝经后妇女骨超声速度值随年龄增加减少较快，应予激素和补钙治疗，桡骨远端为本地区SOS检测和OP检出的敏感部位。     

Importance of echocardiography in prognosis of surgical outcomes in cholecystitis in elderly patients

The authors propose to use more often echocardiography (EchoCG) in examination of elderly (over 60 years) of age patients with cholecystitis that permits to increase surgical activity to 92.4%. Left ventricular ejection fraction is the most informative. When this fraction is lower than 45% surgery must be recommended on vital indications only. EchoCG was used in 155 patients with cholecystitis, 131 of them were operated. 2 (1.52%) patients died due to acute cardio-vascular insufficiency and pulmonary artery thromboembolism.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

目的 评价脊髓胶质细胞在小鼠骨癌痛形成中的作用.方法 健康雄性C3H/He小鼠40只,周龄8～10周,体重18～22 g,随机分为4组(n=10):假手术组(S组)、骨癌痛组(B组)、PBS组(P组)和米诺环素组(M组).S组跟骨骨髓腔内注射PBS 10 μl;余3组跟骨骨髓腔内注射含2×105个骨纤维肉瘤细胞的PBS 10 μl制备骨癌痛模型,于造模前即刻开始PBS组鞘内注射PBS 5μl,M组鞘内注射米诺环素(用PBS溶解为0.2 mmol/L)5μl,1次/d,连续11 d.于造模前1 d、造模后即刻、3、5、7、9、11 d时测定机械痛阈;于造模后3、7、9、11 d机械痛阈测定结束后测定冷痛阈.痛阈测定结束后处死小鼠,取脊髓组织,测定神经胶质纤维酸性蛋白(GFAP)和CD11b的表达水平.结果 与S组比较,B组和P组造模后3-11 d时、M组造模后3、5 d时机械痛阈升高,B组、P组和M组造模后7～11 d时冷痛阈升高,脊髓CD11b和GFAP表达上调(P<0.05).与B组比较,M组造模后3-11 d时机械痛阈降低,造模后7-11 d时冷痛阈降低,脊髓CD11b和GFAP表达下调(P<0.05).结论 脊髓胶质细胞(星形胶质细胞和小胶质细胞)的激活参与了小鼠骨癌痛的形成.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.