Enteroclysis findings of intestinal Behcet disease: a comparative study with Crohn disease

Background: The aim of this study was threefold; to define the enteroclysis (EC) findings of intestinal involvement in Behcet disease (BD), to compare these findings with those seen in Crohn disease (CD), and to determine the relation between the duration of BD and severity of the EC findings. Methods: From 1997 to 2000, 17 BD and 50 CD cases were examined by EC examination. EC was performed with a 13-F balloon catheter via transnasal entubation. Mucosal and mural changes were evaluated. Statistical analysis was performed with the Mann-Whitney U test to determine the relation between duration of BD and severity of the EC findings. P ≤ 0.05 was considered statistically significant. Results: In 12 (70.58%) of 17 BD cases, EC demonstrated intestinal pathologic findings such as ulcerations, fold thickening, granular pattern, pseudopolyp formation, and bowel wall thickening. No statistical correlation between the severity of EC findings and the duration of BD was found. Conclusion: EC should be the radiologic method to evaluate the intestinal pathology in symptomatic BD patients. The main EC finding in BD was ulceration mostly in the aphthous form. The EC findings in BD, even in longstanding cases, are usually mild when compared with those seen in CD.     

Gaucher disease of the spleen: CT and MR findings

We present a 26-year-old male patient with Gaucher disease who presented with epigastric pain and a palpable mass in the left abdomen. Ultrasound, abdominal computed tomography, and magnetic resonance imaging showed massive splenomegaly with multiple splenic nodules up to 7 cm in diameter. Splenic nodules should be included in the differential diagnosis of splenic masses. Follow-up is necessary because of the increased incidence of hematologic malignancies in Gaucher disease. Received: 28 September 1999/Accepted: 20 October 1999     

Evaluation of Crohn disease activity with magnetic resonance imaging

Background: The purpose of this study was to assess the accuracy of magnetic resonance imaging (MRI) in evaluating Crohn disease (CD) activity. The intestinal inflammatory activity is usually present in patients under pharmacologic treatment, despite their clinical remission. Methods: Twenty patients with CD, all under pharmacologic treatment, were prospectively studied by MRI at 1.5 T as a periodic control. Positivity of three acute-phase reactants was considered an index of biologic activity (BA). T2-weighted, T2-weighted fat-suppressed turbo spin-echo, and breath-hold T1-weighted turbo field-echo sequences, before and after gadolinium intravenous injection, were obtained. A negative superparamagnetic contrast agent was orally administered. The following MRI parameters were qualitatively evaluated by three radiologists at the level of the affected bowel and compared with clinical data: wall thickness (WT), wall T2-weighted signal (T2W), wall contrast enhancement (WE), amount of fibrofatty proliferation (FP), and T2-weighted signal of fibrofatty proliferation on fat-suppressed images (T2FP). The κ coefficient of agreement was calculated. The Spearman rank correlation was used for the analysis of clinical and radiologic data. Results: Nineteen of 20 patients were in clinical remission (Crohn Disease Activity Index < 150). On the basis of laboratory tests, nine of 20 patients had biologically active disease. An excellent correlation was found between BA and WE, T2W, and T2FP (0.900, 0.927 and 0.961, respectively; p < 0.0001), and a lower correlation was found between BA and WT and between BA and FP (0.78 and 0.62). Excellent statistical correlation was also found between WE and T2W and between WE and T2FP (0.876 and 0.892). Conclusions: An excellent statistical correlation was found between biologically “active” disease and the following MRI parameters: wall gadolinium enhancement, wall hyperintensity on T2-weighted fat-suppressed images, and hyperintensity of fibrofatty proliferation on T2-weighted fat-suppressed images. Therefore, MRI can be valuable in assessing CD activity. Received: 22 January 1999/Revision accepted: 3 November 1999     

Magnetic resonance imaging of Crohn disease: early recognition of treatment response and relapse

A patient with active Crohn disease was evaluated by MRI at admission, clinical remission, and a new relapse. The MRI-estimated disease extension correlated with surgical findings, whereas ultrasonography underestimated and a small bowel series overestimated the extension. MRI disclosed the disappearance of intestinal edema at the time of clinical remission and, in contrast to ultrasonography, showed an abscess and a fistula, confirmed by surgery, at the new relapse. Received: 30 August 1995/Accepted: 20 September 1995     

Adult Crohn disease: can ileoscopy replace small bowel radiology?

Background: This study aimed to document the radiological features and distribution of small bowel Crohn disease (CD) in adults by using a barium follow-through (BaFT) technique and to determine whether disease would be missed or its distribution underestimated if only colonoscopy with ileoscopy were performed. Methods: The BaFT examinations of 121 adults with proven CD were reviewed retrospectively with respect to the stage and distribution of disease. Colonoscopy with attempted ileoscopy was performed in 37 of these subjects, and the results were compared with radiological findings. Results: A normal villous pattern was visualized in 89 studies (74%). BaFT showed small bowel CD in 71 (59%) of 121 patients studied. The terminal ileum (TI) was the most common site of disease, affecting 62 (87%) of patients with small bowel CD. Forty-six patients (65%) had more proximal small bowel disease, including nine (13%) with a normal TI. BaFT showed early mucosal changes of CD in 52 subjects (73%), which was the sole manifestation in 15 (21%). Ileoscopy was possible in the majority of patients colonoscoped but was not achieved in 14 (38%), nine of whom had CD on BaFT. Of the 23 patients in whom ileoscopy was performed, findings agreed with BaFT assessment of the TI in 22. Conclusion: BaFT adequately demonstrates the stage and extent of small bowel CD. The majority of patients with small bowel CD have disease proximal to the TI, which cannot be diagnosed by ileoscopy. Received: 27 August 1996/Accepted: 16 October 1996     

Helical CT of the small bowel with an alternative oral contrast material in patients with Crohn disease

Background: We assessed the usefulness of helical computed tomography (CT) with a negative oral contrast material for detecting Crohn disease. Methods: Thirty-eight patients with proven Crohn disease were examined. We administered a large volume of a new negative oral contrast material (Mucofalk suspended in water) and then proceeded with helical CT scanning. This technique is an alternative to CT and conventional enteroclyses that use a nasojejunal tube. Two radiologists interpreted the scans, and patients were interviewed about their tolerance of the procedure. We created multiplanar reformatted images in all cases. Potential of small bowel distention by Mucofalk was evaluated by two observers on a three-point scale, and interobserver agreement was calculated with κ statistics. Results: All patients who underwent enteroclysis stated that CT was the more comfortable method, the taste of the peroral contrast medium was considered good by 52.6% and acceptable by 47.4%. Small bowel distention was excellent in 55% of cases, moderate in 26%, and poor in 19%, with an interoberserver agreement of 78%. CT findings correlated with enteroclysis in 27 patients who underwent both methods. Analysis of CT versus enteroclysis showed a sensitivity of 89% for CT versus 78% for small bowel enteroclysis. Conclusion: Mucofalk CT is a simple, rapid, noninvasive, and accurate method of evaluating extramucosal manifestations of Crohn disease. The tubeless procedure improved patients' comfort and decreased time, cost, and radiation exposure.     

Infiltrative subcutaneous metastases from ovarian carcinoma after paracentesis: CT findings

Implantation subcutaneous metastases from ovarian cancer are an uncommon event in surgery, and diagnostic procedures such as laparoscopy, fine-needle biopsy, and intraperitoneal catheter access are usually used. Findings of tumor implantations are rarely reported with diagnostic imaging techniques. In this case, an infiltrative subcutaneous metastasis appeared on computed tomography 4 months after paracentesis in a patient with untreated ovarian cancer. Differential diagnostic problems are discussed. Received: 19 April 1996/Accepted: 22 May 1996     

Paratesticular aggressive fibromatosis: CT findings

Aggressive fibromatoses commonly originate from the musculoskeletal system, mesentery, and retroperitoneum. We report a case of aggressive fibromatosis arising from the spermatic cord. On helical computed tomography, the lesion appeared as a solid mass with well-defined borders in the scrotum and with infiltrative features in the retroperitoneum. Received: 20 April 1999/Accepted: 2 June 1999     

Complications after laparoscopic gynecologic procedures: CT findings

Laparoscopic gynecologic surgery has gained worldwide popularity in the past few years, but complications of this new technique do occur. We encountered three patients who developed major complications after laparoscopic gynecologic procedures including perforation of the sigmoid colon, urinary bladder, and ureter. We report the computed tomographic findings of these cases and the diagnostic dilemmas they posed. Received: 9 November 1999/Accepted: 15 December 1999     

Torsion of a wandering accessory spleen: CT findings

Torsion of an accessory spleen is a rare entity that can have a variable clinical presentation. We report the computed tomographic (CT) findings of an acute torsion of an accessory spleen in a 13-year-old girl. CT disclosed a hypodense mesenteric mass with peripheral inflammatory changes. Received: 20 November 1996/Accepted: 24 December 1996     

Acute diverticulitis of the small bowel: CT findings

We present the computed tomographic (CT) findings in two cases of small bowel diverticulitis, one affecting the jejunum and the other a Meckel's diverticulum. The main CT finding was that of a mass with an air–fluid collection in contiguity with small bowel loops. Received: 18 September 1998/Accepted: 2 December 1998     

Complications of prostate cryosurgery: CT findings in three patients

We present the computed tomographic (CT) findings of complications of prostate cryosurgery in three patients. One patient had injury to the bladder base and rectum, which resulted in ureteral obstruction and vesicorectal fistula. The other two patients had urethral injuries. All three patients had CT evidence of prostate necrosis. If utilization of prostate cryosurgery increases, complications will be encountered more frequently on imaging studies. Received: 12 December 1996/Accepted: 30 January 1997     

Adenocarcinoma arising in colonic duplication cysts with calcification: CT findings of two cases

We report the computed tomographic findings of mucinous adenocarcinoma with calcification arising from duplication cyst of the colon in two adult cases. In both cases, serum levels of carcinoembryonic antigen (CEA) were high. Differential diagnosis of intraperitoneal or retroperitoneal cystic tumors with mucinous density includes duplication cyst, and its malignant change should be considered when serum level of CEA is high. Received: 20 November 1996/Accepted: 24 December 1996     

Hepatic veno-occlusive disease: MRI findings

We present magnetic resonance imaging findings in a patient with proven hepatic veno-occlusive disease (VOD) caused by the use of “poppers,” a recreational drug used during anal intercourse. Although this report emphasizes the differential magnetic resonance imaging features between VOD and Budd–Chiari syndrome, our case is unique because the VOD was induced by unrelated substances. Received: 15 May 2001/Revision accepted: 6 June 2001     

Acute gastroduodenal peptic ulcer perforation: contrast-enhanced and thin-section spiral CT findings in 10 patients

Background: To describe contrast-enhanced and thin-section spiral computed tomography (SCT) findings in patients with acute gastroduodenal peptic ulcer perforation (GPUP). Methods: Abdominal SCTs in 10 patients with confirmed acute perforated gastroduodenal (GD) peptic ulcer were retrospectively reviewed. Patients were 24–76 years old (mean = 44 years); seven were men and three were women. Diagnosis of GD peptic ulcer was done by endoscopy or surgery. Eleven ulcers were identified, two in the antrum and nine in the duodenum. SCTs were obtained after intravenous contrast medium without oral administration. Slice thickness was 3 or 5 mm. CT findings were correlated with surgical (n= 5) or endoscopic (n= 5) findings. Results: Eight patients had pneumoperitoneum. All patients had evidence of GD wall thickening and enhancement and inflammatory changes in perigastroduodenal soft tissues or organs. Discontinuity in the GD wall and/or tiny air bubbles in close proximity indicated the site of perforation in eight cases. Conclusions: Abdominal SCT enables diagnosis and location of GPUP. A well-controlled prospective study with a larger group is needed to determine the sensitivity and specificity of this technique. Received: 8 June 1998/Accepted: 29 July 1998     

Mycotic aneurysm of the abdominal aorta:CT findings in three patients

We present three cases of mycotic aneurysms of the abdominal aorta that were initially diagnosed with computed tomography (CT). The accuracy of CT as the first imaging technique in the diagnosis of this condition is reviewed in light of our results and those reported in the literature. Received: 7 November 1995/Accepted: 6 December 1995     

Mesenteric Castleman's disease: case report

An asymptomatic case of hyaline vascular–type Castleman's disease localized to the mesentery and detected incidentally by ultrasound is presented. Computed tomographic, angiographic, and histologic findings are reported. This type of Castleman's disease predominates in the thorax and is very rare in the mesentery. Received: 5 January 2000/Accepted: 26 January 2000     

Abdominal visceral calcification in primary amyloidosis: CT findings

The computed tomographic (CT) findings of extensive visceral calcification involving both the liver and spleen in a patient with primary amyloidosis are presented. Although the CT imaging appearances of amyloidosis are often nonspecific, visceral calcification represents an important diagnostic clue for differentiating this entity from other infiltrative parenchymal diseases. Received: 19 March 1996/Accepted: 10 April 1996     

Lymphoepithelial cysts of the pancreas: CT and sonographic findings

Two cases of rare lymphoepithelial cyst (LEC) of the pancreas are presented. Although the histogenesis of this lesion is not known, it can be histologically differentiated from other pancreatic and retropancreatic cysts. The importance of its recognition is in the distinction from cystic neoplasm of the pancreas. Received: 24 October 1996/Accepted: 27 November 1996     

Synchronous mucinous tumors of the ovary and the appendix associated with pseudomyxoma peritonei: CT findings

Background: To present the computed tomographic (CT) findings of synchronous mucinous tumors of the ovary and the appendix associated with pseudomyxoma peritonei (PMP). Methods: Imaging studies, mainly abdominal CT scans, of three women aged 49–75 years were reviewed. Attention was directed to the ovarian masses, peritoneal seeding, and the presence of an appendiceal mucocele. Results: The ovarian tumors and the appendiceal mucocele were clearly demonstrated in two cases, and they were part of the extensive PMP in the third patient. Ascites was found in all cases, with internal septation in one. Associated scalloping of the liver margins and hypodense peritoneal implants, with extensive bowel involvement, were seen in another one. Pathologically, there was one case of right ovarian mucinous cystadenoma and villous adenoma of the appendix, one case of right ovarian and appendiceal mucinous cystadenocarcinoma, and one case of bilateral metastatic ovarian implants of appendiceal mucinous cystadenocarcinoma. PMP was found in all. In the case with benign tumors of the ovary and the appendix, the PMP was classified as a benign mucinous spillage. This patient returned 33 months after surgery with PMP, in which epithelial cells were found. Conclusions: Radiologists should be familiar with the clinical occurrence of synchronous mucinous tumors of the ovary and the appendix associated with PMP and with the typical CT findings of the latter two entities. Alternatively, when the imaging findings suggest ovarian cystic tumor with PMP, the radiologist should be alerted to the probability of a clinically unsuspected appendiceal mucocele and should search for it. Received: 10 August 1999/Accepted: 22 September 1999