金栀含漱液用于感染根管冲洗消毒的细菌学观察

目的:观察金栀含漱液对感染根管冲洗消毒的抗菌效果。方法:选择27例患者的感染根管患牙30颗,随机分为实验组和对照组,每组15颗。实验组采用金栀2倍稀释液冲洗根管,浓缩液作为根管消毒药物。对照组采用氯亚明冲洗根管,氢氧化钙药尖消毒根管。根管预备冲洗前、预备冲洗后、封药后分别取细菌样本进行厌氧培养、分离和鉴定,计算并采用重复测量的方差分析比较2组细菌检出率、CFU随时间的变化趋势。结果:实验组专性厌氧菌的检出率由73.3%下降到预备冲洗后的46.7%和封药后的13.3%,对照组厌氧菌的检出率由73.3%下降到预备冲洗后的20.0%和封药后的26.7%,2组细菌检出率无统计学差异(P=0.9721)。实验组专性厌氧菌CFU由1462.9下降为预备冲洗后的27.9和封药后的15.7,对照组厌氧菌CFU由1402.8下降到预备冲洗后的14.0和封药后的45.1,2组细菌检出量无统计学差异(P=0.688)。结论:金栀含漱液对感染根管内厌氧菌有良好的抗菌效果。     

复合替硝唑液冲洗消毒根管的疗效观察

目的 评价复合替硝唑液冲洗消毒根管的临床疗效。方法 用替硝唑液、庆大霉素、地塞米松配制成复合替硝唑液。共１７２颗需根管治疗的患牙随机分成两组，试验组用复合硝唑液冲洗根管并封入消毒根管，对照组用３％Ｈ２Ｏ２和生理盐水联合冲洗后用甲酚甲醛（ＦＣ）消毒根管。结果 经统计学分析，试验组在缓解患者临床症状方面与常规治疗组有显著差异。结论 用复合替硝唑液冲洗并消毒根管是一种可行性方法之一。     

碘复冲洗消毒根管的临床疗效观察

评价磺复冲洗消毒根管的临床效果。方法１４７颗作根管治疗的患牙,随机分为２组。试验组０．０５％碘复冲洗根管并用０．５％碘复消根管;对照组用３％Ｈ２Ｏ２和生理盐水联合冲洗根管及用甲酚醛液消毒根管。     

二种氢氧化钙制剂消毒根管的临床疗效评价

目的 评价HY-CALTMMT氢氧化钙糊剂消毒根管的临床疗效.方法 选择76颗需做根管治疗的患牙随机分为两组,实验组使用HY-CALTMMT氢氧化钙糊剂进行根管内消毒,对照组使用Reoko氢氧化钙药尖消毒根管,分别对患牙根管封药后的临床疗效评价并比较.结果 两组根管消毒剂的临床疗效无统计学差异.结论 HY-CALTMMT氢氧化钙糊剂作为根管消毒剂疗效良好,能有效地起到杀菌效果,并且操作简便.     

碘复应用于根管治疗中的临床疗效观察

目的观察碘复在根管治疗中的临床疗效。方法将128颗有急慢性根尖周炎需作根管治疗的患牙，随机分成两组。试验组用3％H2O2及0.5％碘复原液交替冲洗根管，并用0.5％碘复原液消毒根管；对照组用3％H2O2及生理盐水交替冲洗根管后用甲醛甲酚液（Fc）消毒根管。结果经统计学分析，碘复组与Fc组在治疗疗程、疗效及根管治疗间疼痛方面均无显著性差异(P>0.05)。结论开碘复作为一种新型消毒剂应用于根管冲洗、消毒是可行的，值得在口腔科临床推广。     

HY-CALMT氢氧化钙糊剂与传统根管消毒剂的临床疗效比较

目的 评价HY-CALMT氢氧化钙糊剂消毒根管的临床疗效。方法 选择207颗患有慢性根尖周炎的患牙随机分为HY-CALMT氢氧化钙组、传统氢氧化钙组、甲醛甲酚组进行根管消毒。封药后1周评价临床疗效并比较。结果 氢氧化钙根管消毒剂的临床疗效要比甲醛甲酚要好(P<0.05),HY-CALMT氢氧化钙和传统氢氧化钙相比无统计学差异。结论 HY-CALMT氢氧化钙糊剂能有效地起到根管内杀菌效果。     

不同根管消毒方法对慢性根尖周炎根管内毒素 清除效果的临床研究

目的 研究Nd:YAG激光照射、超声冲洗及氢氧化钙封药等根管消毒方法对慢性根尖周炎患牙根管内毒素的清除效果.方法 选择临床诊断为慢性根尖周炎的上颌单根管前牙30颗,随机分为3组,镍钛器械常规预备后,分别采用Nd:YAG激光照射(A组)、超声冲洗(B组)及常规氢氧化钙封药(C组)等方法进行根管消毒,检测各组患牙治疗前后根管内内毒素的含量变化.结果 3组患牙治疗前内毒素含量的差异无统计学意义(P>0.05);A、B、C 3组患牙治疗前、预备后、治疗后内毒素含量差异均有统计学意义(P<0.05);治疗后3组间差异无统计学意义(P>0.05).结论 Nd:YAG激光照射、超声冲洗、氢氧化钙封药3种消毒方法均有较强清除灭活根管内毒素作用;50mjNd:YAG激光消毒1min或无菌蒸馏水超声冲洗1min可起到与氢氧化钙封药相同的根管内毒素清除效果.     

根管治疗期间急症应用氢氧化钙复合剂根管封药的疗效观察

目的 研究根管治疗期间急症应用氢氧化钙复合剂根管封药的疗效.方法 选择常规根管治疗过程中出现根尖周明显疼痛的患牙101颗.试验组54颗,应用氢氧化钙复合剂根管封药;对照组47颗,用樟脑酚开放,对比两组疗效.结果 试验组疼痛缓解率92.6%,对照组72.3%,两组差异有统计学意义.结论 根管治疗期间急症应用氢氧化钙复合剂根管封药有明显缓解作用.     

声波根管器械联合ProTaper锉治疗残髓炎临床疗效评价

目的 评价声波根管器械联合ProTaper锉治疗残髓炎的临床疗效。方法 选择2011年2月至2012年2月在南平市妇幼保健院牙体牙髓科门诊就诊的残髓炎患者78例（共78颗患牙）,随机分为试验组（41例）和对照组37例。试验组采用声波根管器械联合ProTaper锉进行根管预备,对照组采用单纯的ProTaper锉进行根管预备。两组患者根管预备完成后均用氢氧化钙封药1周,然后行根管充填。比较两组患者根管预备后24 h、根管充填1周后的术后反应及1年后的疗效。结果 试验组患者根管预备后24 h、根管充填1周后的疼痛反应均较对照组轻;试验组1年后的疗效亦优于对照组。结论 声波根管器械联合ProTaper锉治疗残髓炎,可减少预备后的疼痛反应,同时提高根管充填的质量,保证根管治疗的成功率,值得临床推广应用。     

氢氧化钙-ZOE糊剂用于乳牙根管治疗术的疗效

目的：观察氢氧化钙-ZOE糊剂作为乳牙根管充填材料的疗效。方法：用3种根管充填材料对223个乳磨牙进行根管充填治疗，试验组用氢氧化钙-ZOE糊剂根管充填（A组），对照组用氢氧化钙糊剂（B组）和ZOE糊剂（C组）根管充填，观察6个月后的疗效。结果：A、B、C3组的成功率分别为90．2％、88％和71．1％。A、B两组的疗效相似（x^2检验，P〉0．05），A与C、B与C两组之间有明显差异（P〈0．05）。结论：氢氧化钙-ZOE糊剂用于乳牙根管充填的临床疗效比较理想，是一种可选择的乳牙根充材料。     

Suitability of controlled release delivery system for root canal disinfection

Abstract The purpose of the present study was to assess the bacteriologic status of the root canal after disinfection with a quaternary ammonium compound in a controlled release system. Root canal infection was induced in 57 single root teeth in dogs. The canals were then instrumented under aseptic conditions and irrigated with sodium hypochlorite and sterile saline. After the instrumentation, 10 canals were treated with the quaternary ammonium compound in the controlled release system, 9 canals with the quaternary ammonium compound on a cotton pellet, 10 canals with formocresol, 10 canals with a paste of calcium hydroxide. In 18 canals, no intracanal medicament was used. Bacteriologic samples were taken after 14 days using an anaerobic technique. The results indicated that the quaternary ammonium compound in the controlled release system was as effective as formocresol and calcium hydroxide in rendering the root canal free of bacteria. The advantages of an antiseptic with a long-lasting effect for the elimination of bacteria from the root canal and for the prevention of culture reversals were stressed.     

氢氧化钙治疗根尖周炎过程中根管渗出液内毒素含量的变化

目的：检测氢氧化钙封药前后尖周病患牙根管内细菌内毒素的变化。方法：取20个急性尖周病患牙根管渗出液，建立内毒素标准曲线，鲎试剂检测内毒素含量。结果：根管内封氢氧化钙2周后，内毒素含量明显降低（P〈0．01）。结论：氢氧化钙可以明显降低感染根管中的内毒素含量。     

�������ƺͼ�ȩ�׷����ڸ������׻��������ڷ�ҩ��Ч�Ƚ��о�

目的对比观察氢氧化钙和甲醛甲酚用于根尖周炎患牙根管内封药的疗效。方法选择2008年1月到2009年12月在中国医学科学院整形外科医院口腔中心就诊的135例牙根尖周炎患者的156颗患牙,随机分为A组(81颗)和B组(75颗)。步退法根管预备后分别于根管内封入氢氧化钙(A组)和甲醛甲酚(B组)进行消毒。于封药后1周、根充后1周和治疗后3个月对两组疗效进行观察并作出相应评价。结果根管封药后1周A组的有效率为92.59%,B组的有效率为78.67%,两组间差异有统计学意义(P<0.05);根管充填后1周,A、B两组的急症发生率(3.70%对12.0%)差异有统计学意义(P<0.05)。治疗后3个月A组的成功率为91.36%;B组为84.00%,两组间差异有统计学意义(P<0.05)。结论氢氧化钙用于根尖周炎患牙根管内消毒的疗效优于甲醛甲酚。     

干髓术失败患牙的根管再治疗

目的:通过对干髓术失败患牙进行根管再治疗,探讨此类病例的特点及再治疗方法.方法:选取干髓术失败的磨牙63个,采用小号K锉配合次氯酸钠溶液和EDTA溶液探查根管并清理根管内的感染物质,封入氢氧化钙糊剂1～2周,采用机动镍钛器械Hero642进行根管预备,侧向加压技术充填根管,记录治疗过程中患牙症状的改善程度,根管疏通情况,根管预备和充填的效果.结果:62个患牙的根管疏通成功,治疗过程中症状明显缓解或完全消失,瘘管明显减小或消失,根管预备时无根管偏移、根尖阻塞、台阶等并发症发生,根管形态良好.结论:干髓术失败患牙在根管治疗时强调彻底清除根管内的感染物质,采用次氯酸钠和EDTA溶液清理根管,氢氧化钙消毒根管,机用镍钛器械进行根管预备能取得良好的治疗效果.     

氯化镧对根管内粪肠球菌抗菌效果的体外实验

目的:研究氯化镧、FC、CP、氢氧化钙丙二醇糊剂4种根管消毒剂对离体牙根管内粪肠球菌的抗菌性能。方法:选取72个新鲜拔除的单根管前磨牙,随机分为4个实验组(氯化镧组、FC组、CP组、氢氧化钙丙二醇糊剂组)、1个阴性对照组和1个阳性对照组,每组12个牙。所有牙清理根管后灭菌,除阴性对照组不感染细菌外,其余各组均建立粪肠球菌感染根管模型。建模后,4个实验组分别在根管内放置氯化镧药液、FC、CP、氢氧化钙丙二醇糊剂;阴性和阳性对照组放置生理盐水,37℃、50 mL/L CO2培养箱内培养。分别于培养后3 d和7 d时,取各组根管内壁牙本质粉末用BHI培养基继续培养72 h,比浊仪检测各样本的浊度。结果:①药物处理第3天时,氯化镧组牙本质小管中残留菌量较阳性对照组少,但高于阴性对照组和FC组、氢氧化钙丙二醇糊剂组(P<0.05),与CP组无显著性差异(P>0.05);②药物处理第7天时,FC组、CP组、氢氧化钙丙二醇糊剂组和氯化镧组4种消毒剂牙本质小管内残留细菌量较阳性对照组有明显减少(P<0.05),与阴性对照组相比,差异均无统计学意义(P>0.05)。结论:根管内放置氯化镧药液7 d可有效抑制粪肠球菌生长。     

Periodontal response to two intracanal medicaments in replanted monkey incisors

Abstract – Intracanal medicaments are recommended for use in replanted teeth to inhibit inflammatory root resorption. This study compared the effect of calcium hydroxide (Pulpdent^®) and a corticosteroid-antibiotic paste (Ledermix^®) on periodontal healing and root resorption following replantation. Incisors of eight Macaca fascicularis monkeys were extracted, stored dry for 15 min and replanted. After 11 days, root canals in two adjacent maxillary incisors were treated with one medicament and contralateral incisors with the other medicament, or left as untreated controls. Animals were sacrificed 8 weeks later and the teeth prepared for histomorphometric evaluation of periodontal ligament inflammation and root resorption. Periodontal ligament inflammation and inflammatory root resorption were markedly inhibited by both calcium hydroxide and corticosteroid-antibiotic relative to untreated controls. Replacement resorption was lowest in the corticosteroid-antibiotic group, and significantly ( P <0.05) more normal periodontal ligament was present in this group (79.6%) than in calcium hydroxide and control groups (64.6% and 62.7%, respectively). Treatment with the corticosteroid-antibiotic inhibited inflammatory resorption and was slightly more effective than calcium hydroxide in producing a periodontal healing response.     

Antimicrobial potential of medicaments used in healing process in dogs' teeth with apical periodontitis

The objective of this study was to evaluate the influence of irrigants on the antimicrobial potential of calcium hydroxide paste in dogs' teeth with apical periodontitis. Forty-eight premolar teeth of adult mongrel dogs had their root canals opened to the oral environment for 6 months. The root canals were prepared and treated with different irrigating solutions and intracanal medicaments, according to the following groups: 1) 2.5% sodium hypochlorite (NaOCl) + calcium hydroxide paste (CHP); 2) 2% chlorhexidine (CHX) + CHP; 3) vinegar + CHP; 4) vinegar + vinegar. In group 4, both the irrigating solution and intracanal medicament were vinegar, which was renewed every 7 days. Each sample was collected by using two paper points maintained in position for 1 min, and individually transported and immersed in 7 mL of Letheen broth (LB), followed by incubation at 37 masculineC for 48 h. Microbial growth was analyzed by two methods: turbidity of the culture medium and subculture on a specific nutrient broth (brain heart infusion). After 21 days, all experimental groups had microbial growth, however, in different percentages: group 1 - 30%; group 2 - 30%; group 3 - 40%; group 4 - 60%. All materials tested had antimicrobial potential; however, the influence of calcium hydroxide paste on the control of microorganisms must be remembered.     

抗生素糊剂诱导根尖形成的临床研究

目的：利用抗生素糊剂充填牙根尚未发育完成的患牙，诱导根尖继续发育形成。方法：实验组用抗生素糊剂，对照组用氢氧化钙糊剂充填根管，并于0．5—2年后复查，观察疗效。结果：实验组临床疗效理想，有效率达97％。根据统计学检验，实验组与对照组有显著差异。结论：抗生素糊剂有效地控制了根尖周组织的炎症，促使牙根继续发育，在根尖诱导形成中疗效显著。     

Bacteriologic status of the root canal after sonic, ultrasonic and hand instrumentation

Abstract The purpose of this study was to assess the bacteriologic status of the root canal after sonic, ultrasonic and hand instrumentation. Root canal infection was induced in 50 single-rooted teeth in young dogs by removing the pulp and filling the canals with dental plaque. After 7 clays the root canals were instrumented under aseptic conditions with conventional hand instruments, a sonic vibratory device or an ultrasonic device. Sterile saline or 2.5% sodium hypochlorite was used as irrigating solution. Following instrumentation a sterile paper point was sealed into the root canals. After 7 d the root canals were reopened under aseptic conditions and the paper points were incubated for the demonstration of bacteria, using pre-reduced thioglycolate culture medium and anaerobic chambers. The results obtained with the different instrumentation techniques and irrigating solutions were compared by means of the Chi-square test. The results indicated that the sonic and ultrasonic devices were not more effective in the elimination of bacteria from the root canal than conventional hand instrumentation. Irrigation with sodium hypochlorite appeared to be more effective than saline in producing bacteria-free root canals; however, this difference was not statistically significant. Thus, it appeared that more than one appointment and the supporting action of an antibacterial medicament between appointments would be necessary to achieve bacteria-free root canals in infected teeth in a predictable manner.