抗心磷脂抗体、抗子宫内膜抗体与复发性流产的相关性研究

目的探讨AcAb和EmAb与育龄妇女人流或药流后复发性流产的相关性。方法以318例主诉反复流产且具有药物或人工流产史的妇女为观察组,以276名同龄已育妇女为对照,ELISA法检测血清中的AcAb和EmAb,χ2检验比较组间阳性率差异。结果流产组AcAb和EmAb单项、双项阳性率分别为21.7%、32.1%和11.6%,均显著高于对照组(P<0.01)。把流产组按人流或药流再分组后统计显示,人流组单项AcAb、EmAb、双项抗体阳性率分别为25.0%、39.9%和15.4%,显著高于药流组(P<0.01)。分析流产次数与抗体阳性率的关系可以看出,随着流产次数增加,AcAb和EmAb阳性百分率逐步增加。结论药物或人工流产可能是诱发机体产生AcAb和EmAb的重要诱因,而AcAb和EmAb可能是复发性流产的直接原因之一。     

不孕不育患者免疫抗体分析

目的探讨四种免疫抗体（AsAb、EmAb、AcAb、AoAb）的产生导致不孕不育的机制及有效治疗方法。方法对我院优生优育门诊3509例不孕不育患者的血清用酶联免疫吸附法（ELISA）进行四种抗体的检测。结果检测原发不孕组309例,AsAb、EmAb、AcAb、AoAb阳性检出率分别为9.4%、19.6%、13.96%、12.82%。继发不孕组1009例,As-Ab、EmAb、AcAb、AoAb阳性检出率为30.11%、47.1%、17.0%、53.6%;孕早期胚胎发育停止不育组461例,AsAb、EmAb、AcAb、AoAb阳性检出率分别为8.7%、24.2%、17.6%、13.4%;反复流产不育患者1730例,AsAb、EmAb、AcAb、AoAb阳性检出率分别为8.7%、24.2%、17.6%、37.9%。结论ASAb、EMAb、AcAb、AOAb的存在与女性不孕有明显关系,免疫性不孕抗体的检测对临床不孕不育患者的诊疗以及预后的判断可以提供有价值的指标。     

抗生殖免疫抗体与不明原因反复自然流产的关系

目的：为探讨抗生殖免疫抗体与不明原因反复自然流产的关系。方法：采用ELISA法检测52例不明原因反复自然流产(流产组)血清抗精子抗体(AsAb)、抗子宫内膜抗体(EmAb)、抗卵巢抗体(AovAb)、抗心磷脂抗体(AcAb)和抗绒毛膜促性腺激素抗体(AhcGAb)的含量。结果：流产组AsAb阳性26．92％,EmAb阳性42．30％,AovAb阳性30．76％,AcA阳性46．15％和AhcGAb阳性48．07％;流产组的各项抗生殖免疫抗体检出率均明显高于对照组。结论：以上5种抗生殖免疫抗体可干扰卵的发育成熟、排卵、受精、胚泡着床和胚胎发育等过程。抗生殖免疫抗体与不明原因反复自然流产关系十分密切。     

女性不孕不育者免疫抗体检测情况分析

目的了解陕西地区女性不孕不育者免疫抗体的存在情况,为诊断和治疗提供科学依据。方法用ELISA法检测不孕不育者血清中AsAb、AcAb和EmAb。结果 AsAb、AcAb、EmAb的阳性率分别为5.02%(53/1056)、3.49%(33/946)和2.11%(29/1375)。结论陕西地区女性不孕不育者血清中免疫抗体的阳性率低于其他地区。     

继发免疫性不孕与终止妊娠方式间的关系

目的 :分析免疫性因素与终止妊娠方式间的相关性。方法 :对 2 0 6例非自然流产组、72例自然流产组人群进行抗精子抗体 (AsAb)、抗子宫内膜抗体 (EmAb)和抗心磷脂抗体 (ACL)检测 ,AsAb检测采用试管一玻片凝集试验 ,EmAb、ACL采用ELISA法 ,并以 4 5例正常生育妇女 (对照组 )作对照。结果 :生殖免疫性抗体为终止妊娠后引起继发不孕的主要原因之一( 4 1 75 % ) ;非自然流产组EmAb的产生率和自然流产组相比无差异性 (P >0 0 5 ) ,非自然流产组和自然流产组与正常生育组相比 ,免疫抗体的产生均有显著性差异 (P <0 0 0 1)。药物流产组EmAb的产生率高于人工流产组 (P <0 0 5 ) ;药物流产十清宫术组中EmAb的产生率最高 ( 6 2 5 0 % )。免疫性抗体的产生与流产次数多少不成比例。结论 :生殖免疫性抗体为终止妊娠后引起继发不孕的主要因素之一 ,药物流产方式EmAb的产生率高于人工流产组 ;免疫性抗体的产生与流产次数多少无关     

不孕及反复自然流产患者血清抗精子抗体分析

目的：探讨不孕及反复自然流产与抗精子抗体（AsAb）的关系。方法：用金标法检测有反复自然流产史患者245例（流产组）、原发或继发不孕患者164例（不孕组）及正常妇女40例（对照组）血清中的AsAb。结果：不孕组AsAb总阳性率52.44%,流产组总阳性率48.57%,与对照组比较差异均有统计学意义（P〈0.05）。结论：AsAb与不孕及反复自然流产有着密切关系。     

血清leptin、AsAb、EmAb检测在女性不孕不育症中的临床意义

目的：检测女性不明原因不孕、不育症血清瘦素（leptin）、AsAb、EmAb（均为IgG抗体）及其临床意义,为女性不明原因不孕不育症患者提供诊断和治疗依据。方法：临床选择32例女性不明原因不孕不育症患者应用放免法和ELISA进行血清leptin、AsAb、EmAb三项技术统计分析并与35名正常健康妇女作比较。结果：32例女性不明原因不孕不育症患者血清leptin水平均显著低于正常妇女组（P〈0.01）,而AsAb、EmAb两项阳性者占78.1%,EmAb阳性者占21.9%。结论：leptin水平低下和免疫因素为女性不明原因不孕不育症的主要原因。     

血清抗体对体外受精--胚胎移植治疗结局的影响

目的探讨血清抗体抗精子抗体（ASAb）、抗内膜抗体（EmAb）、抗心磷脂抗体（AcA）对体外受精-胚胎移植（IVF-ET）中胚胎着床的影响。方法患者为2001年1月至2002年10月所有行IVF—ET治疗的患者，采用酶联免疫吸附法（EHSA）法检测静脉血ASAb、EmAb、AcA水平，同时观察IVF-ET周期的妊娠结局。筛选出AsAb阳性30周期（30例），EmAb阳性30周期（30例），AcA阳性30周期（30例），做为观察组。抗体阴性30周期（30例）做为对照组，观察120个IVF-ET周期受精率、卵裂率、妊娠率及流产率等。结果30个As址阳性周期受精率64．21％，卵裂率73．64％都低于对照组。30个EmAb阳性周期的妊娠率16．67％，明显低于对照组的11例36．33％。30个AcA阳性周期流产率25％，明显高于对照组1例10％。生化妊娠30个AcA阳性周期37．53％明显高于对照组25％。未妊娠30个EmAb阳性周期最高为31．27％，高于对照组22．07％。生化妊娠与未妊娠者两组比较无显著差异（P〉0．05）。结论妇女体内AsAb、EmAb、AcA可能干扰受精卵的早期发育和早期着床．干扰胚胎发育、胎盘的形成，引起流产等。女性体内的自身抗体也是IVF—ET治疗失败的重要原因之一。     

自身抗体与不孕及自发性流产关系的探讨

目的检测抗心磷脂抗体(ACA)和抗精子抗体(AsAb)两种自身抗体在不孕及自发性流产患者中存在的情况,并观察应用阿司匹林治疗ACA阳性反复流产患者的临床效果。方法应用酶联免疫吸附(ELISA)法检测150例原发或继发不孕患者(不孕组)、198例自发性流产或有胚胎停育史患者(流产组)及40例正常对照组血清中的ACA及AsAb抗体。对其中53例ACA阳性反复流产患者在孕前一个月或孕早期采用低剂量阿司匹林治疗。结果不孕组及流产组ACA总阳性率分别为48.00%和50.51%,与对照组(7.50%)相比有非常显著性差异(P<0.001);不孕组及流产组AsAb阳性率分别为31.33%和25.25%,与对照组(10.00%)比较亦有显著性差异(P<0.05)。53例经治疗患者活产婴儿48例,妊娠成功率为90.57%。结论ACA和AsAb等自身抗体是导致不孕及自发性流产的免疫学因素之一,应用低剂量阿司匹林治疗ACA阳性反复流产患者是保证其妊娠成功的有效方法。     

反复自然流产患者血清ThAb、AsAb、EMAb和AoAb检测的临床意义

目的:探讨了反复自然流产患者血清ThAb、AsAb、EMAb和AoAb水平的变化及临床意义。方法:应用放射免疫分析和斑点免疫法对84例反复自然流产患者进行了血清ThAb、AsAb、EMAb和AoAb的检测,并与35名健康孕妇作比较。结果:反复自然流产患者血清ThAb、AsAb、EMAb和AoAb的阳性率显著地高于正常孕妇组(P<0.05)。结论:检测反复自然流产患者血清ThAb、AsAb、EMAb和AoAb水平的变化对疾病的诊断和发病机制有一定的临床价值。     

Level of functioning of siblings and parents of probands of varying degrees of retardation

A further analysis of already published data supports the position that retardates of low ability level less frequently have retarded siblings, retarded parents, and parents low in occupational level than do retardates higher in ability level. The analysis supports the position that there are two types of retarded individuals, persons retarded as a result of gene or chromosomal anomalies, brain injury, etc., who more frequently occur in the lower-level retardate group, and persons whose retardation represents polygenic segregation, who more frequently occur in the higher-level group.     

局部注射辛伐他汀对骨质疏松大鼠股骨髁骨小梁的改建效应

背景：局部注射具有成骨作用的辛伐他汀,可显著增加骨质疏松大鼠股骨颈及股骨髁部的骨密度及力学强度,分析局部注射辛伐他汀对股骨髁骨小梁的影响。 目的：进一步研究骨质疏松大鼠股骨内局部注射辛伐他汀对股骨髁骨小梁的影响。为将辛伐他汀应用于临床骨质疏松局部治疗提供实验基础。 方法：18只雌性SD大鼠双侧卵巢切除后3个月,制备大鼠骨质疏松模型。实验大鼠随机数字表法均分为3组,分别在实验大鼠的右侧股骨髓腔内单次注射辛伐他汀溶液5 mg、10 mg,对照组单纯注射空白载体。分别在注射后1个月处死大鼠并取材。Micro-CT扫描并定量分析骨组织形态变化。 结果与结论：给药后1个月,Micro-CT扫描结果显示,辛伐他汀治疗组的骨微结构参数如骨皮质厚度、骨小梁密度及连接率明显优于对照组。说明疏松骨骼单次注射小剂量辛伐他汀可显著促进股骨髁部骨小梁改建,改善骨骼微结构,可为强化局部、防治骨质疏松骨折的新选择进一步提供实验基础。     

石斛属民族药用植物的分类及生药学研究

中药石斛早在《神农本草经》中就被列为上品,其应用历史悠久,具有养阴生津、补肾益气、润喉护嗓、活血明目、抗癌防老等功效。本文对国内外石斛属民族药用植物的分类及生药学研究进行了综述。     

膝关节骨性关节炎的关节镜治疗体会

目的我科自2001～2005年4月对59例67膝的骨性关节炎（0A），进行关节镜检查及镜下清理术。方法镜检：膝关节骨性关节炎伴不同程度滑膜炎，滑膜皱壁粘连纤维片，关节软骨不同程度破坏。镜下清除增生滑膜，松解粘连，去除剥脱软骨、修复关节面。结果随访2月～4年，平均1.5年，术后综合评估2月～1年，优良率94％；1～2年，优良率79.2％；2年以上优良率54.8％。结论关节镜对膝关节骨性关节炎诊断能提供了比较全面的资料，并对骨性关节炎早期有良好疗效，具有创伤小、恢复快、并发症少和重复治疗等优点。     

Anatomical study of distribution of valves of the cutaneous veins of adult''s limbs

Since the cutaneous veins of the four limbs have been used as autogenous grafts in the treatment of cardiovascular disorders, knowledge of distribution of the valves is increasingly required depending upon the use. In the gross anatomical study of distribution of valves of the trunci venae, there has been argument about locational relationships between the venous roots and the valves in the vicinity of the roots and the inter-valvular distance. However, there have been only few reports discussing detailed information about valves of the cutaneous veins of the four limbs. The authors observed patterns of distribution of the cutaneous venous valves of the four limbs of cadavers prepared for practice in anatomy. The following parts were excised from each cadaver: the cephalic, basilic, and the great saphenous veins, which originate from the acral venous network and flow into the proximal deep veins, and the venous roots communicating with these veins. An incision was made on each excised vein in the direction of the long axis under observation with a stereoscopic microscope, and the inter-valvular distance and the distance between the valve and the orifice of venous root in the vicinity of the valve were measured. The inter-valvular distance varied with type of the truncus venae, and it varied according to area even in the same truncus venae.     

Pathways of the realization of immunomodulating effects of neurotransmitters

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 115, N ^o 4, pp. 401–404, April, 1993     

Characterization of sterols of three digenetic trematodes of buffalo

Sterols of three digenetic trematodes were isolated and characterized by infrared and 1H nuclear magnetic resonance spectroscopies, and gas-liquid chromatography and gas chromatography-mass spectrometry. Sterols identified were cholesterol, cholestanol, 24-methylcholesterol, 24-methylcholestanol, 24-ethyl-22-dehydrocholesterol, 24-ethyl-22-dehydrocholestanol, 24-ethylcholesterol and 24-ethylcholestanol.     

Mechanisms of generation of slow components of bioelectric activity in diagnostics of functional state of the gastrointestinal tract

New electrophysiologic devices were used for the diagnostics of the state of excitable structures in the gastrointestinal tract and correction of their motor functions. Bioelectrical and biomechanical activities form the basis of functioning of internal organs. The mechanisms of generation of slow bioelectrical activity that are important for clinical and physiological studies are described. One of these mechanisms is a capacitance parametric transducer converting the energy of contractions into specific electric signals reflecting muscle functions. Another mechanism results from slow oscillations of resting potentials of interrelated excitable cells in large neuromuscular structures of internal organs. The elaborated procedure is efficient for preventing early postoperative paresis of the gastrointestinal tract. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 10, pp. 448–452, October, 1999     

胃小弯侧血管弓的MDCT解剖

目的：研究正常胃小弯侧血管弓及其属支血管的多排螺旋CT表现。方法：回顾性分析51例正常成人的上腹部CT资料,观察胃小弯侧血管弓及其属支血管的显示情况、血管弓形态及其与胃壁的关系。结果：51例均显示胃小弯侧血管弓,血管弓贲门部属支、胃体部属支和幽门部属支分别显示46例、15例和10例;血管弓与胃壁紧邻41例。结论：MDCT检查可良好显示正常胃小弯侧血管弓及其属支血管。     

Assessment of the efficacy of treatment of hemangiomas

Assessment of the aftereffects of cryoexposure and ultrahigh-frequency cryoexposure on hemangioma tissue of various types, cavernous and squamous, showed a higher cryogenic effect in hemangiomatous tissue preexposed to ultrahigh-frequency waves. A quantitative criterion is proposed for assessing the efficacy of the studied methods of exposure. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 6, pp. 669–672, June, 1995