前列腺神经内分泌癌1例

前列腺神经内分泌癌临床罕见，我院收治1例，报告如下。     

前列腺小细胞神经内分泌癌一例报告

分析1例前列腺小细胞神经内分泌癌临床资料。患者60岁,因排尿困难1个月入院,直肠指检发现前列腺质硬肿块。前列腺穿刺活检病理诊断为小细胞神经内分泌癌。行化疗和放疗联合治疗有效,患者症状明显改善,患者确诊后15个月死亡。前列腺小细胞神经内分泌癌预后差,化疗在治疗中占有重要地位。     

前列腺小细胞神经内分泌癌诊治特点分析

目的 探讨前列腺小细胞神经内分泌癌(SCPCa)的临床特征和诊疗方法.方法 SCPCa患者4例,平均年龄62(25～77)岁.表现进行性排尿困难4例,慢性尿潴留2例,上尿路积水2例.直肠指检前列腺巨大、质硬包块;血tPSA 0.57～6.36 ng/ml,f/tPSA 0.26～0.63.B超、CT、MRI检查见前列腺区3.9 cm×3.9 cm× 1.6 cm～11.3 cm× 7.9 cm×9.5 cm肿块,形态不规则,侵犯精囊2例、直肠2例、单侧输尿管下端2例、骶骨1例,盆腔淋巴结转移3例、肝转移1例、肺转移1例;全身骨扫描示多处骨转移3例.结果 4例均经前列腺穿刺活检确诊,光镜下见癌细胞呈卵圆形或梭形,体积小、胞质少,界限欠清,核分裂相多见,染色质深染;免疫组化染色:ChA(+)4例、NSE(+)2例、PSA(-)4例.采用以顺铂为基础的化疗、放疗、化疗加放疗各1例,近期疗效较好,但分别于6、9、11个月出现全身广泛转移;放弃治疗1例;1年内死亡3例,失访1例.结论 SCPCa临床罕见,肿瘤恶性度高、生长快,发生转移早且严重,诊断依靠病理检查,综合治疗效果不佳,预后极差.     

前列腺小细胞神经内分泌癌诊治特点分析

Objective To review the clinical features of small cell neuroendocrine carcinoma of the prostate (SCPCa). Methods The ages of 4 cases were 25-77 years. Four cases had progressive dysuria with 2 cases had chronic urinary retention and 2 had upper urinary tract hydronephrosis. On admission, all cases were palpated a hard prostate mass in digital rectal examination. Serum tPSA were 0. 57-6.36 ng/ml with a ratio f/t PSA 0. 26-0.63. B ultrasound, CT and MRI detected 3.9 cm×3. 9 cm×1.6 cm-11.3 cm×7. 9 cm×9. 5 cm irregular shape mass in prostate. 2 cases had seminal vesicle involved, 2 cases had rectum involved, 2 had unilateral ureter involved, and 1 case had sacrum involved. Pelvic lymphonodes metastasis were seen in 3 cases. Bone scan detected multiple bone metastasis in 3 patients. Results The final diagnoses were accomplished by prostate biopsy. Under light microscope, tumor cells were orbivular-ovate or fusiform shape, small volume, and had little cytoplasm. The margin of tumor cells was not clear. Caryokinesis phase could be found with hyperchromatic chromatin. Immunohistochemistry showed positive ChA staining in 4 eases, positive NSE expression in 2 patients and negative PSA in 4 cases. 3 cases were given cisplatin-based chemotherapy, pelvic radiation, or chemotherapy plus radiotherapy. All patients appeared widespread metastasis quickly and died or lost visit within one year. Conclusions SCPCa is a rare, poor prognosis malignancy with early extensive metastasis. The diagnosis is based on pathology.     

前列腺小细胞神经内分泌癌诊治特点分析

Objective To review the clinical features of small cell neuroendocrine carcinoma of the prostate (SCPCa). Methods The ages of 4 cases were 25-77 years. Four cases had progressive dysuria with 2 cases had chronic urinary retention and 2 had upper urinary tract hydronephrosis. On admission, all cases were palpated a hard prostate mass in digital rectal examination. Serum tPSA were 0. 57-6.36 ng/ml with a ratio f/t PSA 0. 26-0.63. B ultrasound, CT and MRI detected 3.9 cm×3. 9 cm×1.6 cm-11.3 cm×7. 9 cm×9. 5 cm irregular shape mass in prostate. 2 cases had seminal vesicle involved, 2 cases had rectum involved, 2 had unilateral ureter involved, and 1 case had sacrum involved. Pelvic lymphonodes metastasis were seen in 3 cases. Bone scan detected multiple bone metastasis in 3 patients. Results The final diagnoses were accomplished by prostate biopsy. Under light microscope, tumor cells were orbivular-ovate or fusiform shape, small volume, and had little cytoplasm. The margin of tumor cells was not clear. Caryokinesis phase could be found with hyperchromatic chromatin. Immunohistochemistry showed positive ChA staining in 4 eases, positive NSE expression in 2 patients and negative PSA in 4 cases. 3 cases were given cisplatin-based chemotherapy, pelvic radiation, or chemotherapy plus radiotherapy. All patients appeared widespread metastasis quickly and died or lost visit within one year. Conclusions SCPCa is a rare, poor prognosis malignancy with early extensive metastasis. The diagnosis is based on pathology.     

前列腺小细胞癌1例

<正>1病例报告患者男,84岁,因前列腺增生手术后排尿困难6个月,加重伴血尿1周至我院泌尿外科就诊。既往有高血压、脑梗塞病史。10年前因前列腺增生行经耻骨上前列腺剜除术,术后病理示:前列腺结节性增生,部分组织低级别前列腺上皮内瘤((prostatic intraepithelial neoplasm,PIN)。手术后排尿功能恢复可,门诊随访偶有尿频,予托特罗定4mg口服,1次/d,复查PSA4ng/mL。本次门诊予多沙唑嗪4mg口服,1     

前列腺小细胞神经内分泌癌1例并文献复习

前列腺小细胞神经内分泌癌非常罕见,在所有前列腺癌种类中,它是一种不常见类型并且预后较差。2016年7月1日本院收治78岁男性患者,既往有两年的排尿不畅伴尿频的病史,入院时患者的总PSA为8.76 ng/mL。前列腺穿刺活检病理提示前列腺小细胞神经内分泌癌,Gleason评分:5+5=10,全身骨显像显示弥漫性骨转移。建议患者采取双侧睾丸切除术行去势治疗,但是患者拒绝该治疗方案。之后患者接受了体外放射治疗和全身化疗。最终,该患者于前列腺小细胞神经内分泌癌诊断后的第17个月去世。     

前列腺小细胞癌

前列腺小细胞癌临床罕见,在所有前列腺肿瘤中不超过1%,是前列腺癌高恶性度的组织病理学类型。国内外文献报道很少。确诊主要依赖免疫组织化学。治疗提倡化疗加放疗与激素及手术的联合治疗,预后极为不佳,本文将对这一罕见疾病作一综述。     

前列腺小细胞癌长期生存1例

<正>患者,男,70岁。因"排尿困难伴无大便10余天"于2007年7月6日入院。直肠指诊前列腺Ⅲ度增大,不光滑,中央沟消失,上方可扪及巨大肿块,向肠腔突出,质地硬,移动度差,指套未见明显染血。检查PSA为15.67ng/ml;生化电解质检查:肌酐807μmol/L,尿素22.9mmol/L,钾4.2mmol/L,钠136mmol/L,余正常;血常规检查:血红蛋白107g/L,白细胞3.8×109/L,中性80%。     

前列腺小细胞神经内分泌癌诊疗特点分析

目的:探讨前列腺小细胞神经内分泌癌(SCPCa)的临床表现、病理特点及治疗进展.方法:报告SCPCa患者1例,并收集国内已报道57例SCPCa患者资料进行综合分析.结果:52例(91.2％)患者伴有尿路症状,其中尿路梗阻症状患者40例,53例(93.0％)患者前列腺触及明显异常结节,17例(29.8％)患者PSA＞4 ...     

胆囊小细胞神经内分泌癌1例

患者,女,39岁。因“剑突下疼痛1个月,眼睛发黄伴发热2周”于2005年1月8日入院。入院查体：体温38．3℃,脉搏84次／分,呼吸20次／min,血压120／70咄（1mmHg=0．133kda）。皮肤、巩膜黄染,全身浅表淋巴结未触及肿大。腹部平坦,触诊全腹软,无压痛,肝脾肋下未及,肝区无叩击痛,移动性浊音阴性,肠鸣音正常。总胆红素／直接胆红素151．8／129．7（μmol／L）,白蛋白傅蛋白40／34（g／L）,凝血酶原时问10．78（参考值10—13s）;CAl9—9439．50U／ml（参考值0—27U／m1）,乙型肝炎标志物仅HBsAb阳性,AFP和CEA均阴性。MRI考虑胆囊癌伴肝转移,肝门区及后腹膜淋巴结肿大,门脉主干受累;B超示肝实质占位,考虑胆囊癌肝浸润可能;肝门区淋巴结肿大,肝内胆管轻度扩张。     

前列腺基底细胞癌1例

患者,60岁。于1周前无明显诱因出现肉眼血尿,为初始及终末血尿,尿色暗红,伴有血块。无尿频、尿急及尿痛,无排尿困难,无腰腹部疼痛,进食正常,无消瘦。自行应用抗生素后,血尿好转。     

膀胱小细胞神经内分泌癌1例报告

膀胱小细胞神经内分泌癌（small cell neuroendocrine carcinoma of the bladder,SCNECB）是罕见的高度恶性肿瘤,自1981年CRAMER首先报道以来至今不足200例.我院2011年1月收治1例,现报告如下.     

食管小细胞神经内分泌癌2例

例 1　男 ,6 1岁。进食梗咽感 2月余 ,加重 7ｄ。上消化道钡餐检查示食管中段肿瘤。纤维胃镜检查示食管肿瘤。2 0 0 1年 7月手术。手术切除食管长 15ｃｍ ,中部可见一3 0ｃｍ× 2 0ｃｍ× 1 4ｃｍ大小盘状溃疡型肿瘤 ,质硬 ,切面呈灰白色鱼肉状 ,部分淡黄色。病理检查 ,光镜下见肿块为癌组织 ,呈片状、束状弥散分布。癌细胞小 ,圆或卵圆形 ,大小较一致 ,胞浆极少 ,核小深染 ,两端切缘未见癌组织。癌细胞侵及肌层和外膜。胃左动脉旁 2枚肿大淋巴结均可见癌组织转移。特殊单克隆或多克隆抗体标记免疫组化染色阳性。病理诊断 :食管中段小细胞…     

前列腺小细胞癌靶向精准治疗1例报告

患者,68岁。因尿频、尿急、肉眼血尿1个月就诊。初诊PSA 72.72 ng/ml,碱性磷酸酶(ALP)114 U/L。前列腺穿刺活检病理：前列腺小细胞神经内分泌癌。患者即刻接受药物去势治疗基础上的依托泊苷联合顺铂化疗,累计化疗6次。后外周血游离DNA(cfDNA)基因检测结果示CDK4基因扩增1.99倍。化疗后加用哌...     

前列腺小细胞神经内分泌癌1例并文献复习

正前列腺小细胞癌(small cell carcinoma of prostate,S C P C a)又叫神经内分泌前列腺癌,其为罕见恶性肿瘤,进展快,早期易转移,预后极差。检索Pubmed、万方及中国知网等数据库,全世界近20年关于前列腺小细胞癌报到不足400例,而国内报到不足40例,且大部分前列腺小细胞癌常与前列腺腺癌混合存在,完全性前列腺小细胞癌不足2%[1]。2015年我院     

肾透明细胞癌合并前列腺腺癌1例

患者,男,65岁。因“体检B超发现右肾实质性占位病变19天”于2012年4月22日人院。患者平素无明显肉眼血尿,夜尿1～2次,无明显排尿困难,无全身或局部疼痛不适。查体：肾区无叩击痛,未触及明显包块。直肠指检前列腺Ⅱ度增生,     

原发性胆囊小细胞神经内分泌癌1例报告

正1病例资料患者,男性,65岁,因"反复右上腹疼痛半月"入院。患者无明显诱因出现右上腹阵发性疼痛半个月,为阵发性绞痛,多于夜间发作,持续1～2小时后可自行缓解,无伴畏寒发热、黄疸、腹胀、恶心呕吐、呼吸困难等症状。行B超可见胆囊结石,结石大小约59 mm×15 mm。为求治疗,于2018年3月21日入院。既往史无特殊,个人史无特殊。入院查体:皮肤、巩膜无黄染,腹平软,右上腹压痛,无反跳痛,Murphy征(+),移动性浊音(-)。肿瘤标志物CA199:336.49 U/mL(正常值0～35 U/mL)、