房室结折返性心动过速的电生理特点及其射频消融

目的：本文报道射频消融（ＲＦＣＡ）治疗２３例房室结折返性心动过速（ＡＶＮＲＴ）的经验和结果，并对ＡＶＮＲＴ的电生理特点及射频治疗ＡＶＮＲＴ的方法学进行探讨。方法：本研究男性１０例，女性１３例，电生理检查证实为慢－快型ＡＶＮ－ＲＴ者２１例，快－慢型ＡＶＮＲＴ者２例。均在ＤＳＡ下采用下位法消融慢征，以放电初始出现交界区性心律作为成功靶点标志，以心内电刺激加异丙肾上腺素激发试验不能再诱发出ＡＶＮＲＴ作为其ＲＦＣＡ治疗终点。结果：２０例获成功，３例未成功者中有１例因术中发作房颤而另１例因靶点太靠近希氏束而被迫放弃治疗。结论：本文结果表明，下位法消融慢征作房室结改良术治疗ＡＶＮＲＴ是一种安全有效的方法     

房室结慢径消融前房室阻滞的预测

目的 研究心脏电生理指标在普通型房室结折返性心动过速（ＡＶＮＲＴ）慢径消融前,预测消融后房室传导阻滞（Ａ－ＢＶ）发生的可能性。方法 １０９例普通型ＡＶＮＲＴ病人依消融过程中出现交界性心动过速（ＪＴ）、无室房传导的ＪＴ及随后Ａ－ＶＢ发生与否分为３组;（１）无室房传导ＪＴ和随后Ａ－ＶＢ组（组：１．１６例次）;（２）无室房传导ＪＴ而无Ａ－ＶＢ组（组２．２６例次）;（３）单纯ＪＴ组（组３．３８例次）;比较     

射频消融慢径治疗房室结折返性心动过速术后晚期并发完全性房室阻滞

完全性房室阻滞（Ｃｏｍｐｌｅｔｅａｔｒｉｏｖｅｎｔｒｉｃｕｌａｒｂｌｏｃｋ,ＣＡＶＢ）是射频消融治疗房室结折返性心动过速（Ａｔｒｉｏｖｅｎｔｒｉｃｕｌａｒｎｏｄａｌｒｅｅｎ ｔｒａｎｔｔａｃｈｙｃａｒｄｉａ,ＡＶＮＲＴ）的严重并发症 ,发生率为０ %～３ % ,多发生于消融过程之中。本组报道３例ＡＶＮＲＴ患者在慢径消融术后出现的晚期ＣＡＶＢ。１资料与方法１．１临床资料１９９６年８月至１９９８年１２月本院对６０例ＡＶＮＲＴ患者进行房室结慢径的射频消融治疗 ,其中３例于术后第２～３天发生ＣＡＶＢ。３例患者（男…     

导管射频消融治疗房室结折近性心动过速

８２例病人经导管射频消融（ＲＦＣＡ）治疗房室结折近性心动过速（ＡＶＮＲＴ），成功率９６．３％，无１例发生Ⅲ度房室传导阻滞（ＡＶＢ）。随访２－３６个月，复发１例．ＲＦＣＡ治疗ＡＶＮＲＴ是安全有效的方法，保持消融导管稳定、间断放电并连续监测Ｘ线影像和心电变化是避免Ⅲ度ＡＶＢ发生的关键。     

导管射频消融治疗房室结折返性心动过速(附82例报告)

８２例病人经导管射频消融（ＲＦＣＡ）治疗房室结折返性心动过速（ＡＶＮＲＴ），成功率９６．３％，无１例发生Ⅲ度房室传导阻滞（ＡＶＢ）。随访２～３６个月，复发１例。ＲＦＣＡ治疗ＡＶＮＲＴ是安全有效的方法。保持消融导管稳定、间断放电并连续监测Ｘ线影像和心电变化是避免Ⅲ度ＡＶＢ发生的关键。     

射频消融房室结慢径治疗室上性心动过速

２６例室上性心动过速（ＳＶＴ）采用导管射频消融（ＲＦＣＡ）房室结（ＡＶＮ）慢径治疗。２６例均为慢快型房室结折返性心动过速（ＡＶＮＲＴ），其中１例合并Ⅰ型心房扑动（ＡＦ），１例合并房室折返性心动过速（ＡＶＲＴ）。结果全部成功，无并发症出现，随访１～２０月无复发。结论：经导管ＲＦＣＡ房室结慢径是治疗ＡＶＮＲＴ首选的非药物根治方法，采用下位法定位简单、成功率高、复发率低。ＡＶＮＲＴ合并Ⅰ型ＡＦ者根治ＡＶＮＲＴ后ＡＦ同时也可能得到根治。     

房室结折返性心动过速的电生理特点及其射频消融

目的：本文报道射频消融（ＲＥＣＡ）治疗２３例房室结折返性心动过速（ＡＶＮＲＴ）的经验和结果，并对ＡＶＮＲＴ的电生理特点及射频治疗ＡＶＮＲＴ的方法学进行探讨。方法：本研究男性１０例，女性１３例，电生理检查证实为慢－快型ＡＶＮＲＴ者２１例，快－慢ＡＶＮＲＴ者２例。均在ＤＳＡ下采用下位法消融慢征，以放民初始出现交界区性心律失作为成功靶点标志以人电刺激加异丙肾上腺素激发试验不能再诱发出ＡＶＮＲＴ作为其ＲＦ     

两种不同机制心动过速并存的射频消融治疗

目的：观察两种不同机制心动过速并存的心内电生理特点射频消融的疗效。方法：８例患经全面的心内电生理检查,确定存在两种不同机制的心动过速,常规消融一种心动过速后,重复电生理检查,诱发第２种心动过速;,再次消融治疗。结果：房室结折性心动过速;＋房室折返性心动过速３例,ＡＶＮＲＴ＋房内折返性心动过速３例,ＡＶＮＲＴ＋室性心动过速１例,ＡＶＲＴ＋ＩＡＲＴ１例。     

射频消融治疗房室结折返型心动过速

目的：旨在研究和评价射频导管消融治疗房室结返型心动过速的安全性和有效性。方法：病例来源于１９９３年４月至１９９７年４月在心内科住院治疗的心动过速病人，共２８例，男性１５例，女性１３例，年龄１２至６７岁，患者均经心电生理盐证实后行射频导管消融。结果：所有患者经射频导管消融后均获成功，随访３～６个月无１例复发，１例出现Ⅲ度房室传导阻滞，结论：射频过程中出现交界性心律并逐渐减少是成功的征象，消融治疗房室     

中间隔法射频消融慢径路治疗房室结折返性心动过速

射频消融术（ＲＦＣＡ）已成为房室结折返性心动过速（ＡＶＮＲＴ）和房室折返性心动过速（ＡＶＲＴ）安全而有效的根治方法。房室结双径路的射频消融,从过去的快径路改良到目前提倡的慢径路改良,以达到安全有效的目的。作者报告２５例ＡＶＮＲＴ的ＲＦＣＡ结果,并对其消融方法及消融终点进行讨论。１　资料和方法１．１　一般资料　本组２５例患者中男８例,女１７例。年龄１５～６０岁,平均年龄（３５±２０）岁。发作时心电图呈窄ＱＲＳ心动过速,频率１５０～２２０次·ｍｉｎ１。常规检查未发现器质性心脏病。１．２　方法　经…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.