A Review of: “Analysis of Clinical Trials Using SAS: A Practical Guide,by A. Dmitrienko,G. Molenberghs,C. Chuang-Stein,and W. Offen”

A testing procedure is proposed to assess the consistency of noninferiority from a collection of trials based on simultaneous t lower confidence bounds or Scheffé's lower confidence bounds. Methods for simultaneous inferences on pairwise or many-to-one comparisons among multiple noninferiority trials are also discussed. To avoid bias due to subjective trial exclusion a tuning parameter k is embedded into the testing procedure to provide flexibility to quantify the “consistency of noninferiority” when the total number of trials is large. The size and power of the proposed test are discussed. The method is illustrated using simulations and real data analysis.     

A new subspecies of Streptomyces clavuligerus,S.clavuligerus subsp.Jinyunensis subsp.nov.

从我国重庆缙云山土壤中分离到一株链霉菌，编号为３．０４８。其代谢产物中具有抑制β－内酰胺酶活性的物质——克拉维酸。该菌株的形态培养特征和生理生化特征与棒状链霉菌标准菌株ＡＴＣＣ２７０６４相似，但又有差别，故定名为棒状链霉菌缙云亚种。     

A Review of: “Design and Analysis of Vaccine Studies,by M. E. Halloran,I. M. Longini,Jr., and C. J. Struchiner,”

Joint modeling of longitudinal measurements and time to event data is often performed by fitting a shared parameter model. Another method for joint modeling that may be used is a marginal model. As a marginal model, we use a Gaussian model for joint modeling of longitudinal measurements and time to event data. We consider a regression model for longitudinal data modeling and a Weibull proportional hazard model for event time data modeling. A Gaussian copula is used to consider the association between these two models. A Monte Carlo expectation-maximization approach is used for parameter estimation. Some simulation studies are conducted in order to illustrate the proposed method. Also, the proposed method is used for analyzing a clinical trial dataset.