山苦茶的利胆作用和毒性

<正> 海南山苦茶,为大戟科灌木,野桐属植物.产于海南各地,为民间一种茶饮料。分布我国南部。本研究用山苦茶醇提物配制成乳剂,对大白鼠进行利胆和急性毒性实验。药物与配制山苦茶干燥簇叶,为海南省万宁县东山岭夏季购买。经粉碎。95％热乙醇提成含生药33.7%的山苦茶酊、实验前蒸发为醇提物,与小磨芝麻油吐温80、蒸馏水,按1:1:1:8的比例配制成山苦茶乳剂。1克醇提物相当山苦茶生药5.62g。对照组(基质乳剂)不含山苦茶醇提     

山苦茶的镇痛作用

山苦茶是海南民间喜用的茶饮料 ,大戟科灌木 ,野桐属植物 ,学名Ｍａｌｌｏｔｕｓｆｕｒｅｔｉａｎｕｓ(Ｂａｉｌｌ.)Ｍｕｅｌｌ. Ａｒｇ .别名禾姑茶 ,鹧鸪茶等。分布我国南部 ,生长海南各地 ,并与东山羊驰名海南。笔者通过动物实验研究山苦茶药理 ,已发表论文两篇[1] 。此次 ,继续用山苦茶醇提物配制成乳剂 ,进行镇痛实验研究。1　实验材料1 1　药物与配制　山苦茶干燥簇叶 ,海南省万宁市东山岭夏季购买。经粉碎 ,体积分数为 0 95的热乙醇提成含生药3 3 7 0 ｇ·Ｌ-1的山苦茶酊剂。实验前蒸发为醇提物 ,与小磨芝麻油、吐温 80、蒸馏水 ,…     

山苦茶提取物对豚鼠离体胆囊肌条的作用及其机制

目的研究山苦茶提取物对豚鼠离体胆囊肌条的作用及作用机制.方法将肌条置于恒温浴槽,以BL-410生物功能实验系统记录肌条张力变化.结果山苦茶提取物对离体胆囊肌条具有剂量依赖的收缩作用,最大效应为乙酰胆碱(10 μmo·L-1)的76%±8%,EC50为0.14～0.30 mg·mL-1(n=8),阻滞药吲哚美辛和维拉帕米显著降低其缩胆囊作用.结论山苦茶提取物可通过增加前列腺素的释放以及直接作用于钙通道对豚鼠离体胆囊产生收缩作用.     

海南山苦茶的研究进展

山苦茶（Mallotus furetianus）系大戟科野桐属植物，主要分布于我国的海南岛、中印半岛和苏门答腊岛。     

山鸡血藤的研究进展

山鸡血藤为常用中药,民间将其作为鸡血藤的地方习用品。其各个部位含有多种化学活性成分,具有舒经活络,补血行血等功效。本文通过对山鸡血藤的化学成分研究、药理活性研究、生物活性研究、光合特性研究、繁殖技术、园林应用等进行了综述,为深入研究和合理开发利用山鸡血藤提供科学依据。     

HPLC法测定黎药山苦茶中没食子酸的含量

目的:建立以高效液相色谱法测定黎药山苦茶中没食子酸含量的方法。方法:色谱柱为C18(250mm×4.6mm,5μm),流动相为甲醇-0.1%磷酸(5:95),检测波长为272nm,柱温为30℃,流速为1.0mL.min-1;以外标法计算样品含量。结果:没食子酸检测浓度在5～60μg.mL-1范围内与峰面积积分值呈良好线性关系(r=0.9992);平均回收率为99.07%,RSD=2.80%(n=9)。结论:本方法简便、快捷,可用于山苦茶中没食子酸的含量测定。     

昆明山海棠片

本品系由卫茅科雷公藤属植物昆明山海棠的乙醇提取物经加工制成的棕色糖衣片剂。【作用特点】昆明山海棠为云南民间中草药,具有祛风利湿、舒筋活络、清热解毒的功用。近年来的临床研究,发现本品是多功效的治疗药物,服用后,有止痛、消肿、改善体征     

1,3,7,9-四甲基尿酸的研究进展

摘 要 1,3,7,9 四甲基尿酸是天然存在的嘌呤类生物碱,主要存在于苦茶中,具有抗抑郁、镇静催眠和抗炎镇痛等药理作用。本文结合最近十几年的文献,对1,3,7,9 四甲基尿酸的资源、制备、检测方法及药理作用等进行综述,并探讨了1,3,7,9 四甲基尿酸的应用前景。     

番茄醋对自发性高血压大鼠的抗高血压作用

泰国山黄皮Randia siamensis多个部位在泰国民间有多种治疗用途。然而对其治疗作用的研究鲜有报道。探讨了该植物鲜果提取物对心血管的作用及其机制。     

山荷叶入药部位的讨论

山荷叶 Dysosma pleiantha(Hance)Woodson,又名六角莲、六角金盘,其地下根茎性温,味甘微辛,有毒,具消瘿解毒、散结祛瘀的功效,民间用于治疗跌打损伤、筋骨疼痛、毒蛇咬伤、热毒肿痛、尿路结石等疾病。然而民间习惯将其地上部分的叶片和叶柄废弃不用。为此,笔者采用山荷叶的叶片和叶柄,对照地下根茎进行薄层层析。     

GC-MS测定白背叶中的挥发油

目的 分析白背叶挥发油的化学成分并用归一化法测定各成分的质量分数.方法 采用水蒸气蒸馏法提取白背叶中的挥发油.用GC-MS法鉴定其化学成分.结果 共鉴定了41个成分,占挥发油总成分的90%以上.结论 白背叶挥发油的主成分为橙花叔醇、1,6-辛二烯-3-醇、冰片基胺、己二酸二异辛酯和2,7-二甲基-1,6-辛二烯.     

植物多酚在保健食品方面的应用

本文简介了植物多酚的分布与分类,及其在食品方面的应用包括:食品添加剂、酒类澄清剂,保健食品。由于植物多酚具有防龋、抗衰老、防辐射、抗过敏等多种生理活性,使得其在保健糖果、饮料等方面有着广阔的开发前景。     

Food effects on tablet disintegration.

The aims of the present study was to investigate if food components, as represented by a multi-component nutritional drink for tube feeding, could affect tablet disintegration of standard tablets in vitro as well as in vivo and propose a mechanism for potential food effects on tablet disintegration. The tablet disintegration was delayed between 5 min and more than 1h in the simulated gastric fed medium compared to a simple buffer. This effect was dependent on the tablet composition. A similar delay in tablet disintegration was also found in vivo after administration of the nutritional drink to three Labradors as observed by removing the tablet from the stomach at different times through a gastric fistula. The delay in tablet disintegration appeared to be caused by precipitation of a film, mainly consisting of protein, on the tablet surface as indicated by disintegration studies with pure nutrients, identification by IR spectroscopy of contents of precipitates obtained in a model study were the nutrients were incubated with different tablet excipients and visual observations of tablets exposed to the simulated fed medium. The drug dissolution of a soluble compound, metoprolol tartrate, from a standard tablet was also strongly delayed in the simulated fed medium. In conclusion, food, could significantly delay tablet disintegration and drug dissolution in the stomach by formation of a film around the tablets. This effect could be monitored by a simple in vitro disintegration test using a test medium based on a nutritional drink. More studies are needed to investigate the significance of the slow tablet disintegrations on bioavailability and for which types of food the present effect occurs.     

锈毛野桐中的两个新二萜anomalusin A和anomalusin B(英文)

从锈毛野桐中分离得到两个新的ent-rosane型二萜anomalusin A(1)和anomalusin B(2),以及10个已知化合物。化合物1和2的结构和相对构型通过波谱学方法确定,它们的绝对构型通过CD谱确定。     

Two new diterpenoids from Mallotus apelta Muell.Arg

Two new diterpenoids, malloapeltene (6,8-dihydroxy-cembrene-5-one) and malloapeltin (4alpha,15,16-trihydroxy-dolabradane) were isolated and characterized from the petroleum ether fraction of the alcoholic extract of Mallotus apelta Muell.Arg. Their structures were determined by spectral methods.     

Three new diterpenoids from Mallotus apelta Muell.Arg

Three new diterpenoids, 10-hydroxy-cembrene-5-one, 6-hydroxy-cembrene-5,10-dione and 2alpha,4beta,15,16-tetrahydroxyl-dolabradane were isolated from the petroleum ether fraction of the alcoholic extract of Mallotus apelta Muell.Arg. Their structures were determined by spectral methods.     

Two New Diterpenoids from Mallotus apelta Muell.Arg.

Abstract

Two new diterpenoids, malloapeltene (6,8-dihydroxy-cembrene-5-one) and malloapeltin (4α,15,16-trihydroxy-dolabradane) were isolated and characterized from the petroleum ether fraction of the alcoholic extract of Mallotus apelta Muell.Arg. Their structures were determined by spectral methods.     

“If I wanna get really drunk I would drink vodka”: drink choices associated with acute intoxication for young Australians

Background: While survey data can provide information on alcohol products favoured by those who drink to intoxication, it is more difficult to get information on what they drink when they are consuming at a level which places them at high risk of harm. Objectives: To use complementary quantitative and qualitative data to investigate what young risky drinkers drink, and what they drink when they are drinking heavily. Methods: Three thousand, two hundred and twenty-six respondents aged 18–24 from the Australian state of Victoria answered questions in the Victorian youth alcohol and drug survey on their drinking habits and usual drinking choice. Sixty qualitative interviews were also conducted with Victorian 18–24-year olds. In each study, regular drinkers to acute intoxication (RDAIs), those who drank more than 10 Australian standard drinks in a session and drank to the point of forgetting afterwards, were compared to those who did not meet both of these criteria. Results: RDAIs were more likely to drink beer, cask wine, spirits and ready to drink spirits; however, they also consumed more drink types than non-RDAIs. Qualitative interviews highlighted spirits, particularly shots, as a popular drink of choice when intoxication was the aim and or/outcome. Conclusion: Young people appear to prefer spirits when intending to get drunk, however, there is also evidence to show that RDAIs will drink whatever is to hand. Motives behind drink choice for RDAIs include the value for money, where the value is gauged by the amount of alcohol per drink or by the speed of intoxication.     

消脂益肝饮降血脂作用的实验研究

目的：研究消脂益肝饮的降血脂作用。方法：采用小鼠腹腔注射蛋黄乳剂造成急性高胆固醇血症模型，进行正交L^12(2^11)拆方实验并观察消脂益肝饮对小鼠高胆固醇血症的预防作用；高脂饲料诱导鹌鹑高脂血症模型，观察消脂益肝饮对鹌鹑高脂血症的治疗作用。结果：消脂益肝饮全方降低血清三酰甘油(TG)和血清总胆固醇(TC)水平优于其他组方，能对抗小鼠高胆固醇血症模型的血清TC和血清TG水平的升高，也能显著地降低鹌鹑高脂血症模型的血清TC和TG水平。结论：消脂益肝饮组方合理，具有明显的降血脂作用。