角膜内皮面硅油的形态学及定量分析

目的观察贴附在角膜内皮面的硅油形态学变化及对角膜内皮细胞损害的形态学定量分析。方法选择已行经睫状体平部玻璃体手术联合硅油玻璃体腔内注射手术后1周～1a并出现硅油进入前房且已贴附在内皮面的患者11例(11眼,有晶状体眼),应用角膜内皮细胞分析系统(角膜内皮镜)观察进入前房并已贴附在内皮面的硅油,手术取出前后角膜内皮细胞形态学改变及形态定量指标的变化。结果硅油取出术前角膜内皮镜检查,镜下清晰可见贴附在内皮面的硅油液面与内皮细胞层紧密粘贴,并形成特殊的明亮反光,内皮细胞边界发亮(即“亮度颠倒”现象),在角膜后表面皱褶的边缘有亮暗相间的轮廓线;角膜内皮细胞四项形态定量指标中:细胞面积和细胞密度2项手术前后(术后4～7d)改变无统计学差异,六棱细胞比率和变异系数2项改变有统计学差异。结论角膜内皮面贴附硅油时,出现特有的角膜内皮镜下改变,且在短期内即可直接造成内皮细胞的损害,应尽早取出。     

眼内炎患者硅油充填前房后眼压升高对角膜内皮的影响

 目的 评价眼内炎玻璃体切除术后硅油充填前房后眼压升高对角膜内皮细胞计数的影响。设计 回顾性病例系列研究。研究对象 2006年11月至2011年11月于北京同仁医院眼科中心眼外伤组就诊的眼内炎患者19例（19眼）均行晶状体玻璃体切除联合硅油注入术,术后硅油完全充填前房。方法 对19例（19眼）患者行硅油取出术。依据硅油取出术前眼压分组：眼压＞21 mm Hg为高眼压组（A组）（12眼）;眼压≤21 mm Hg为正常眼压及低眼压组（B组）（7眼）。硅油取出术后1个月行角膜内皮细胞计数检查,并进行统计学分析。主要指标 硅油取出术前眼压及硅油取出术后1个月角膜内皮细胞密度。结果 硅油取出术后1个月,角膜内皮细胞密度≥1000个/mm2者：A组2眼（2/12,16.7%),B组5眼（5/7,71.4%）;角膜内皮细胞密度<1000个/mm2者：A组10眼（10/12,83.3%),B组2眼(2/7,28.6%）;两组比较差异有统计学意义（P=0.045）。角膜内皮细胞密度≥1400个/mm2者：A组1眼（1/12,8.3%）,B组5眼（5/7,71.4 %）;角膜内皮细胞密度＜1400个/mm2者：A组11眼（11/12,91.6%）,B组2眼（2/7,28.6%）。两组比较差异具有统计学意义（P=0.01）。结论 硅油充填前房合并眼压升高可以导致角膜内皮细胞严重丢失。 （眼科, 2012, 21: 348-351）     

超声乳化术对低密度角膜内皮细胞眼的影响

目的观察晶状体超声乳化人工晶状体植入术对角膜内皮细胞密度低眼的损害程度。方法前瞻性病例对照研究。将晶状体超声乳化人工晶状体植入术的患者按年龄及核硬度匹配后分为两组。试验组,角膜内皮细胞密度600～1000个／mm2;对照组,角膜内皮细胞密度〉2300个／mm2。每组35例（35只眼）。术前及术后3个月、6个月测量角膜内皮细胞密度和中央角膜厚度,对角膜内皮细胞丢失率和中央角膜厚度增加率进行比较。结果术后3个月平均角膜内皮细胞丢失率两组差异无统计学意义（x2=1．97,P=0．16）,术后6个月两组差异也无统计学意义（X2=0．50,P=0．48）。术后3个月试验组中央角膜厚度增加率高于对照组（X2=10．83,P=0．00）,但术后6个月两组差异无统计学意义（X2=1．27,p=0．26）。结论角膜内皮细胞密度低的患者超声乳化人工晶状体植入术后,角膜内皮细胞的损害程度与角膜内皮细胞密度正常的患者相当,并且中央角膜厚度呈一过性增加,大部分患者术后6个月恢复。     

晶状体在玻璃体切割手术中对角膜内皮损伤的防范作用

目的　探讨晶状体在玻璃体切割手术中对角膜内皮损伤的防范作用。方法　对 5 6例 ( 5 6眼 )患者分别行单纯玻璃体切割术、玻璃体切割联合六氟化硫 (SF6)填充术、玻璃体切割联合硅油填充术及玻璃体切割 晶状体切割联合硅油填充术。测定手术前和手术后 2周角膜内皮细胞的密度。结果　玻璃体视网膜手术可以引起角膜内皮细胞密度的下降。玻璃体切割 晶状体切割联合硅油填充术引起角膜内皮细胞密度下降 ( 2 4 79%± 10 90 % ) ,与其他各组相比差异有显著性 (P <0 0 1)。结论　在玻璃体视网膜手术中保留晶状体对保护角膜内皮有重要意义。     

玻璃体手术方式对角膜内皮细胞的影响

目的:探讨不同的玻璃体手术方式对角膜内皮细胞计数的影响,提示硅油取出的最佳时机。方法:根据手术方式及硅油填充情况,对符合本研究条件37例40眼的玻璃体视网膜疾病患者进行分组,分别为单纯玻璃体切割术组(A组)、玻璃体切割联合硅油填充术组(B组)及玻璃体与晶状体切割联合硅油填充术组(C组)。用角膜内皮镜分别测量这三组病例术前1d和术后1wk;1,3,6mo的角膜内皮细胞计数,比较手术前后以及同一时期不同组间角膜内皮细胞计数的变化。结果:三组病例术后1wk及1mo的角膜内皮细胞计数较术前相比无统计学上的差异;单纯玻璃体切割术组术后3,6mo的角膜内皮细胞计数较术前相比亦无统计学上的差异;玻璃体切割联合硅油填充术组术后3mo的角膜内皮细胞计数较术前相比无统计学上的差异,而术后6mo的角膜内皮细胞计数较术前相比明显减少,在统计学上有差异;玻璃体与晶状体切割联合硅油填充术组术后3,6mo的角膜内皮细胞计数较手术前明显减少,统计学上有差异。结论:在眼压控制良好的情况下,有晶状体眼行玻璃体切割硅油填充术后6mo角膜内皮细胞计数明显减少;而无晶状体眼行玻璃体切割硅油填充术后3mo时角膜内皮细胞计数即显著减少。这一结果说明玻璃体腔内硅油填充能够明显减少角膜内皮细胞数,而我们在玻璃体切割硅油填充术组保留了晶状体,这时我们观察玻璃体腔中硅油填充6mo时角膜内皮细胞计数才明显减少,表明晶状体的存留对于角膜内皮的保护具有积极的意义。     

人工晶状体缝线固定联合硅油取出治疗无晶状体硅油填充眼的临床观察

目的观察折叠型人工晶状体缝线固定联合硅油取出治疗无晶状体硅油填充眼的临床效果。方法回顾性病例系列研究。收集2017年1月至2022年3月在深圳市眼科医院收治的未保留囊袋的晶状体玻璃体切除联合硅油填充的患者33例(33只眼)的临床资料。所有患者行折叠型人工晶状体缝线固定联合硅油取出术。术后观察最佳矫正视力(log MAR)、人工晶状体位置、角膜内皮细胞密度及视网膜情况, 随访6个月。结果 33例均顺利完成硅油取出联合折叠型人工晶状体缝线固定, 术后1个月及6个月的最佳矫正视力(BCVA, logMAR)分别为1.05±0.19, 1.05±0.18, 与术前视力1.06±0.17相比无统计学意义(F=0.96, P=0.360);术后1个月及6个月角膜内皮细胞密度分别为(2 192.27±208.70)个/mm2, (2 114.94±239.45)个/mm2, 与术前(2 146.85±254.02)个/mm2相比无统计学意义(F=1.55, P=0.230)。术后6个月, 33例均无人工晶状体偏位或脱位、无缝线暴露或感染等并发症的发生。结论无晶状体硅油填充眼采用折叠型人工晶状体缝线固...     

玻璃体视网膜手术后角膜内皮细胞的形态学改变

目的：观察不同术式的玻璃体视网膜手术（vitreoretinal surgery,VRS)后角膜内皮细胞的形态学改变。方法：采用Topcon SP9000型非接触型角膜内皮显微镜对66例66眼行玻璃体视网膜手术前，术后1、3个月角膜内皮细胞的4项形态学定量指标（角膜内皮细胞密度，角膜内皮细胞平均面积、内皮细胞面积变异系数，六角形细胞比率）进行观测，结果：VR术未摘除晶状体组，手术前后角膜内皮4项形态学定量指标相比较，差异均无显著性（P＞0．05），晶状体玻璃体视网膜联合手术（lenticular vitreoretinal surgery,LVRS)组术后角膜内皮细胞密度，六角形细胞比率明显降低，平均细胞面积和变异系数明显增大，与术前相比差异有极显著性（P＜0．001）。结论：LVR术损伤角膜内皮，VR术未摘除晶状体，对角膜内皮无显著影响，为减少手术对角膜内皮的损伤，术前检查角膜内皮，选择合适的手术方式，提高手术技巧，积极控制炎症是十分必要的。     

硅油对角膜内皮的影响

目的：探讨硅油在不同情况下对角膜内皮的影响。方法;对１７０只眼行不同手术术前,术后２周,４周,８周及３个月时的角膜内皮细胞密度进行观察记录,同时对硅油人前房的２０只眼进行观察。结果;在眼压控制良好的情况下,有晶体眼行单纯玻璃体和切割术及玻璃体切割硅的填充术,无晶体眼行玻璃体切割硅油填充术。有晶体眼及无晶体眼行硅油取出术手术后各期内皮细胞密度与术前相比均无显著差异,有晶体眼行玻璃体切割晶体切割硅油填     

晶状体超声乳化术前前房空间与术后角膜内皮变化相关性研究

目的探讨晶状体超声乳化术前前房空间状态与术后角膜内皮细胞变化之间的相关性。方法对19例(20眼)老年性白内障行晶状体超声乳化吸出人工晶状体植入术。术前以OrbscanⅡ测定前房容积、前房深度,使用A超测定眼轴长度,并分别于术前和术后1周使用非接触型角膜内皮显微镜观察中部角膜内皮细胞的密度变化。结果术前的平均前房容积为(158.66±29.14)mm3,前房深度为(2.69±0.41)mm。眼轴长度为(23.79±2.43)mm。术后1周平均中部角膜内皮细胞损失率为31.27%±16.11%;术前的前房容积与术后1周角膜内皮细胞损失率呈显著负相关(r=-0.726,P<0.001),前房深度与术后1周角膜内皮细胞损失率亦呈显著负相关(r=-0.764,P<0.001);术前的眼轴长度与角膜内皮细胞损失率(r=-0.123,P=0.606)之间无相关性。结论晶状体超声乳化人工晶状体植入术后损伤术眼的角膜内皮细胞,术前前房空间状态的测定为临床评估预后提供重要参考。     

准分子激光角膜上皮下磨镶术对角膜内皮细胞的影响

目的探讨准分子激光角膜上皮下磨镶术(laser-assisted subepithelial keratomileusis,LASEK)对角膜内皮细胞的影响.方法收集2002年1月至7月在我所行LASEK治疗的近视眼患者90例病例资料(158只眼),按术前是否配戴角膜接触镜分为A、B两组A组未配戴CL,共65例(111只眼);B组配戴CL并于停戴2 w后接受手术,共25例(47只眼).术前等效球镜屈光度-6.00～-19.50 D,平均为(-10.23±1.29)D,术中激光切削深度72～203 μm,平均为(126.82±29.79)μm.分别于术前和术后3个月行角膜内皮显微镜检查,观察角膜内皮细胞密度和形态,并分析切削深度与内皮细胞密度的相关性.结果A组术前平均角膜内皮细胞密度为(2939.50±344.92)个/mm2,术后3个月为(2975.10±371.38)个/mm2,两者比较差异无显著性(t=0.74,P＞0.05).B组术后平均角膜内皮细胞密度较术前增加(251.6±107.5)个/mm2,差异有非常显著性(t=3.648,P<0.01).术后角膜内皮细胞形态结构无明显改变.A组角膜切削深度与术后平均角膜内皮细胞密度无显著相关性(r=0.0297,P＞0.05).结论LASEK术后早期不引起中央部角膜内皮细胞密度和形态的改变,是一种矫正高度近视眼安全的角膜屈光手术,但其对角膜内皮细胞的远期影响有待于进一步观察研究.     

Evaluation of limbal and pars plana silicone oil removal in aphakic eyes

Purpose: To compare limbal and pars plana silicone oil removal (SOR) in aphakic eyes and to evaluate the acute effect of silicone oil flow to the corneal endothelium. Methods: Sixteen aphakic patients with silicone oil endotamponade requiring SOR were recruited for this prospective study and randomly scheduled for limbal or pars plana SOR. The central corneal thickness (CCT), visual acuity (VA) and intraocular pressure were measured preoperatively, on the first postoperative day and 4 months after surgery. Endothelial cell density (ECD) was measured preoperatively and at the end of follow‐up. The in vitro study was performed on ten enucleated porcine eyes. Corneoscleral discs were prepared and fixed on artificial anterior chamber followed by 2.5‐mm limbal incision and 5‐ml silicone oil injection in six cases and 5 ml balanced salt solution (BSS) in four cases. Results: The ECD decreased by 239.2 ± 86.7 (13.9%) and 86.7 ± 22.4 cells/mm² (5%) after limbal (n = 8) and pars plana SOR (n = 8), respectively (p < 0.001 for both). The difference between the groups was significant (p < 0.001). A significant increase in CCT and corresponding decrease in VA was noted on the first postoperative day using both procedures. At the end of follow‐up, the CCT and VA were comparable to initial values. Postoperative hypotony (≤6 mmHg) was observed more frequently after limbal SOR. In the experiment, lamellar abrasions of corneal endothelium were observed after silicone oil injection, whereas no changes were observed after BSS injection. Conclusion: Limbal SOR causes more considerable damage to the corneal endothelium than the pars plana approach because of mechanical abrasion.     

Endothelial involvement of injection of silicone into the vitreous body

Intraocular silicone oil tamponade is used as an adjunct to vitrectomy in the treatment of proliferative vitreoretinopathy. The authors analyzed the effect of silicone oil on the corneal endothelium in 28 patients (10 phakic and 18 aphakic). In the phakic group, the endothelial cellular loss is small, no significant. In the aphakic group, the endothelial cellular loss is 20%.     

不同晶状体状态的硅油眼行Ahmed阀植入术的有效性及安全性

目的 探讨不同晶状体状态下Ahmed阀植入治疗硅油充填术后继发性青光眼的有效性及安全性。设计回顾性病例系列。研究对象2015年6月至2021年12月山东中医药大学附属眼科医院玻璃体切除联合硅油充填术后继发性青光眼Ahmed阀植入患者62例（62眼）。方法回顾患者术前及术后3个月的病历资料。分为有晶状体眼组26例（26眼）、人工晶状体（introcular lens,IOL）眼组16例（16眼）、无晶状体眼组20例（20眼）。手术成功定义为术后使用或不使用抗青光眼药物情况下眼压6～21 mmHg、无严重并发症、不需实施其他抗青光眼手术。主要指标手术成功率、眼压、降眼压药物的数量、硅油是否进入引流管、并发症发生率。结果术后3个月时手术成功率为85.5%,有晶状体眼组、IOL眼组、无晶状体眼组手术成功率分别为96.2%、87.5%、70.0%（P=0.041）。有晶状体眼手术成功率高于无晶状体眼（P=0.033）,其他组间两两比较差异无统计学意义。术后3个月眼压有晶状体眼组（16.93±1.75） mmHg、IOL眼组（18.45±2.78） mmHg均低于无晶状体眼组（22.56±3.10...     

Usefulness and limit of silicone in management of complicated retinal detachment

Among various substances used for intraocular tamponade in the treatment of vitreous opacity and complicated retinal detachment, silicone oil is superior to hyaluronic acid or sulfur hexafluoride. Its low gravity and hydrophobic nature permit good tamponade effect to be obtained and its high transparency allows us to detect remnant vitreous traction in the far periphery and/or retinal tears. Furthermore, preretinal membrane can be peeled off easily after silicone oil removal. The hydrophobic nature of silicone prevents clouding due to postoperative hemorrhage and fibrin reaction. It should also be stressed that intravitreal silicone oil suppresses iridial rubeosis or prevents its development. However, the use of silicone has limitations, since it gives rise to various complications that include pupillary block glaucoma, secondary glaucoma, cataract formation and corneal complications including band-shaped keratopathy. Pupillary block in aphakic eyes can be prevented by placing peripheral iridectomy at the 6 o'clock position, since silicone is lighter than water. After silicone injection, glaucoma is more often seen in diabetic aphakic eyes than in phakic or nondiabetic eyes. On the other hand, corneal complications were less frequent in diabetic than in nondiabetic eyes; in nondiabetic eyes the complications were more frequent in aphakic than in phakic eyes. Due to possible complications, silicone should be removed after a certain follow-up period, during which time detection and management of the causes of redetachment of the retina are possible due to the high transparency of silicone.     

硅油填充手术后继发性青光眼的临床观察

目的 探讨硅油填充手术后继发性青光眼(SOG)的危险因素和治疗方法.方法 玻璃体切割手术同时眼内硅油填充的93例患者95只眼纳入本研究.其中,手术中保留晶状体37只眼,摘除晶状体58只眼;摘除晶状体眼中,植入人工晶状体10只眼.硅油填充时间≤6个月者32只眼,＞6个月者63只眼.手术后1、2周,1个月时复查眼底和眼压,均随访至硅油取出.随访时间2～25个月,平均随访时间(9.5±5.1)个月.手术后1个月眼压高于21 mm Hg(1 mm Hg=0.133 kPa),同时排除有明显原发因素及新生血管性青光眼等其他继发因素所引起的眼压升高者诊断为SOG.SOG确诊后,立刻给予盐酸卡替洛尔、布林佐胺滴眼液、甘露醇静脉滴注降眼压治疗,治疗1周眼压仍不能降至正常者行硅油取出手术,仍不能降至正常者行小梁切除手术.结果 21只眼发生SOG,占总眼数的22.1%.21只眼的平均硅油填充时间为(10.8±5.1)个月.其中,16只眼为无晶状体眼,占无晶状体眼的33.3%;5只眼为有晶状体眼或人工晶状体眼,占有晶状体眼或人工晶状体眼的10.6%.18只眼的硅油填充时间＞6个月,占硅油填充时间＞6个月眼的28.6%;3只眼的硅油填充时间≤6个月,占硅油填充时间≤6个月眼的9.4%.17只眼查见硅油乳化,占81.0%.行硅油取出手术后17只眼1周内眼压恢复正常,占SOG眼的81.0%.结论 无晶状体眼、硅油填充时间长是SOG发病的危险因素,硅油乳化是主要的发病原因,及时取出硅油是有效的治疗方法.

Abstract：

Objective To investigate the risk factors and treatment of silicone oil glaucoma (SOG).Methods Ninety-five eyes of 93 patients who underwent pars plana vitrectomy and silicone oil tamponade were evaluated in this study. The lens was removed in 58 eyes in which intraocular lens (IOL) was implanted in 10 eyes, so 48 eyes were aphakic. Silicone oil tamponade time was ≤6 months in 32 eyes,and ＞6 months in 63 eyes. The follow-up time ranged from 2 to 25 months, with a mean of (9.5±5.1)months. The fundus and intraocular pressure (IOP) were evaluated at 1 week, 2 weeks and 1 month after surgery. The diagnosis of SOG was established if the one-month postoperative IOP ＞ 21 mm Hg (1 mm Hg=0.133 kPa), and primary and neovascular glaucoma were excluded. After the diagnosis of SOG, carteolol hydrochloride and brinzolamide solution were immediately applied to the eye, and intravenous mannitol infusion was performed. If the IOP still can not be controlled after 1 week of such treatment, silicone oil removal surgery will be performed. If removal of silicone oil can not control the IOP,trabeculectomy surgery will be performed. Results SOG occurred in 21 eyes (22.1%), including 5 phakic eyes (10.6% of 47 phakic eyes) and 16 aphakic eyes (33.3% of 48 aphakic eyes) , 3 eyes (9.4% of 32 eyes)with short tamponade time (≤6 months) and 18 eyes (28.6% of 63 eyes) with long tamponade time (＞6months). The average silicone oil tamponade time was (10.8±5.1) months. Emulsification of the silicone oil occurred in 17 eyes (81.0%). After silicone oil removed, IOP was controlled in 17 eyes (81.0%) within one week. Conclusions Aphakic eye and the duration of silicone oil tamponade are the risk factors of SOG.Emulsification of silicone oil is the main cause. Silicone oil removal is an effective way to treat SOG.     

Acute corneal decompensation after silicone oil removal

Purpose: To assess acute corneal decompensation after silicone oil removal in some aphakic eyes with clear corneas whose anterior chambers were completely filled with silicone oil for a considerable period of time. Methods: Eight eyes of 8 patients who underwent vitrectomy and intraocular silicone oil injection were studied. All the eyes were aphakic and anterior chambers were completely filled with silicone oil. In all eyes, corneas were clear and no corneal finding indicating keratopathy was detected by slit-lamp microscopy before silicone oil removal. The mean silicone oil removal time was 4 months (range 2–7 months). A specular microscope was used for the evaluation of corneal endothelial changes and corneal pachometry was performed to observe corneal changes before and after the silicone oil removal in 5 eyes besides slit-lamp microscopy. The follow up period after silicone oil removal was 2–12 months (mean 6 months).Results: In all eyes severe corneal stromal edema and clouding was detected in the first day following silicone oil removal. Increased corneal thickness was seen in all eyes. Decreased (at or below critical levels) corneal cell density was detected by specular microscopy before and after silicone oil removal. No significant improvement was observed during the follow up period. Conclusion: Eyes whose anterior chambers completely filled with silicone oil could be evaluated as clear corneas by slit lamp microscopy despite severe endothelial damage. We recommend that eyes with silicone oil in the anterior chambers should be monitored by a combination of slit-lamp microscopic examination and specular microscopy to determine the relative corneal endothelial tolerance to the silicone oil and endothelial damage. Early removal of the silicone oil can be considered when the retinal adhesion allows.     

玻璃体切割术后早期角膜内皮细胞形态学改变

目的研究玻璃体切割术对晶体完整者角膜内皮细胞的早期影响。方法122例（131眼）行玻璃体切割术，其中无眼内充填46例（47眼），C3F8充填36例（38眼），硅油充填40例（46眼），分别在术前、术后1天、3天、5天和15天测量眼压、角膜内皮细胞密度、六角形细胞比例和变异系数。结果与术前相比，无眼内充填者眼压无明显改变，术后1天角膜六角形细胞百分数下降；C3F8充填术后1天眼压升高，角膜六角形细胞百分数术后1、3天下降；硅油充填术后1、3天眼压升高，角膜六角形细胞百分数术后1、3、5天下降；眼压升高与六角形细胞百分数下降显著相关。结论对于晶体完整者，玻璃体切割术后早期角膜内皮形态会受到一定的影响，可能主要由眼压及手术操作所致，在将眼压控制后，短期内即可恢复正常。     

硅油取出前后联合超声乳化白内障摘除术的临床分析

目的:对硅油填充眼硅油取出前后联合超声乳化白内障摘除手术的临床分析。 方法:玻璃体切割术后硅油填充眼并发白内障患者36例36眼,随机分为两组,一组硅油取出前行超声乳化白内障摘除术, 二组在硅油取出后联合超声乳化白内障摘除术。观察两组患者术中、术后并发症、术后前房反应、眼压、角膜内皮情况等。 结果:两组患者硅油均取出顺利,超声乳化白内障摘除植入人工晶状体,术中术后并发症对症处理。两种联合手术后角膜内皮细胞密度及六角形细胞比例下降,术后1wk六角形细胞比例、术后1mo细胞数量及形态均有显著差异（P<0.05）。 结论:硅油取出前联合超声乳化白内摘除术有相对轻的术后反应,术中并发症及更小的角膜内皮损伤。     

硅油填充对中央角膜厚度的影响

目的:观察硅油填充对中央角膜厚度的影响。方法:根据不同的病变,对37例40眼玻璃体视网膜疾病的患者进行分组,分别行单纯玻璃体切除术,玻璃体切除联合硅油填充术及玻璃体与晶状体切除联合硅油填充术。用A型超声仪分别测量术前1d和术后1wk;1,3及6mo的角膜中央厚度,比较手术前后角膜中央厚度的变化。结果:三组术后1wk角膜中央厚度均较术前明显增加,其差异在统计学上有意义,考虑系术后短期炎症反应所致;行单纯玻璃体切除术及玻璃体切除硅油填充术手术后1～6mo各期角膜中央厚度与术前相比无显著增加,其差异在统计学上无意义;玻璃体切除联合晶体切除及硅油填充术后1～3mo各期角膜中央厚度与术前相比其差异在统计学上无意义;术后6mo其角膜中央厚度与术前相比显著增加,其差异在统计学上有意义。结论:眼压控制良好的情况下,保留晶状体行玻璃体切除硅油填充术对角膜中央厚度无显著影响而切除晶状体后行玻璃体切除硅油填充术6mo时角膜中央厚度却显著增加。