新生儿唇裂修复的探讨

目的 探讨新生儿唇裂修复的治疗要点及效果。方法 采用眶下孔阻滞麻醉行新生儿唇裂修复术120例，结果 手术成功率100%，效果欠佳为15%。无麻醉并发症发生。结论 局麻下行新生儿唇裂修复安全可行，其缺点是手术操作要求高，疤痕形成与婴幼儿期唇裂修复者无明显差异。     

新生儿单侧唇裂修复术25例

目的探讨新生儿单侧唇裂修复术的可行性及其术后效果。方法对25例新生儿唇裂在行双侧眶下神经阻滞及局部肿胀麻醉下,采用Millard法或Tennison法进行修复。结果手术麻醉安全,伤口愈合良好．术后效果满意。结论严格掌握手术适应症．并具有娴熟的唇裂修复技巧,在眶下神经阻滞及局邵肿胀麻醉下,新生儿唇裂修复是安全可行的。     

52例小儿唇裂修补术麻醉的临床观察

口腔外科手术麻醉处理的关键是确保呼吸道通畅，防止术中出血吸入气管，以及口腔分泌物吸入。小儿唇裂修补术由于手术时间较长，需要在全麻插管下进行手术。本文通过52例患儿，分别采用氯胺酮羟丁酸钠复合和氯胺酮咪唑安定复合麻醉，并进行比较。     

新生儿唇裂修复16例体会

目的:探讨新生儿唇裂手术修复的可行性。方法:在静脉麻醉下对出生后1d~14d的先天性单双侧唇裂新生儿16例进行手术修复,术后6d~7d拆线出院。结果:16例患儿均无麻醉意外,手术顺利,除1例出现部分唇缘裂开外,未见明显并发症。结论:静脉复合麻醉下新生儿唇裂修复安全可行。     

新生儿唇裂修复术的麻醉处理

目的探讨新生儿唇裂修复术的麻醉方法。方法对19例新生儿唇裂修复术的麻醉处理进行回顾性分析。结果19例采用非气管插管全麻，以眯唑安定和氯胺酮联合麻醉完成手术。结论 此麻醉方法既便于术中呼吸、循环管理，又避免了气管插管全麻的并发症。合理的麻醉用药及术中严密的监测是手术成功的关键。     

非报管内插管行小儿唇裂修补术的呼吸道管理

探索非气管内插管行小儿唇裂修补术的呼吸道管理。方法：观察１５７例患儿非气管内插管氯胺酮静脉复合麻醉状态下心律，心率，心音，呼吸频率和强弱及脉搏血氧饱和度。结果：患儿生命体征平稳，麻醉达到满意效果结论：可采用非气管内插管的麻醉方法进行小儿唇裂修补术。     

麻醉期间22例心跳骤停原因分析与处理

我院自１９９１年～１９９７年间发生围手术期心跳骤停２２例，其中死亡６例，复苏成功１５例，遗留后遗症１例，现分析总结如下。１临床资料２２例中男１４例，女８例，年龄２月～７２岁，体重３．２～１０２ｋｇ。其中硬膜外麻醉８例，静吸复合全身麻醉１２例，氯胺酮麻醉２例。手术种类：心血管手术５例，颅脑手术２例，普外科手术１０例，颌面部手术３例，骨科手术２例。２２例均采用常规心肺复苏。胸外心脏按压１９例，直接心脏按压３例为心内直视手术。除１例体重１０２ｋｇ气管插管困难外均在１５ｓ内完成气管内插管人工通气。静注肾…     

非气管内插管行小儿唇裂修补术的呼吸道管理

目的：探索非气管内插管行小儿唇裂修补术的呼吸道管理。方法：观测１５７例患儿非气管内插管氯胺酮静脉复合麻醉状态下心律、心率、心音、呼吸频率和强弱及脉搏血氧饱和度。结果：患儿生命体征平稳，麻醉达到满意效果。结论：可采用非气管内插管的麻醉方法进行小儿唇裂修补术。     

氯胺酮应用于36例小儿唇裂修复术的体会

我院多年来采用氯胺酮分离麻醉加双眶下神经阻滞，行婴幼儿先天性唇裂修复术，无1例发生误吸或呼吸障碍等不良情况。1！简床资料36例中，男20例，女16例。年龄5－12月24例，l－6岁12例；体重6－20Kg；1度唇裂6例，11度唇裂对例，皿度唇裂10例。其中唇裂并腊裂7例，其它合并症：脐征1例，窦性心律不齐1例。均为捍期手术，手术时间80－130ban不等。2麻醉方法术前3Ondn肌肉注射安定0．2－0．3twkg，阿托品0．02ndkg。患儿入室均肌注氯胺酮7lug／kg，然后行静脉穿刺1条供输液和单次推麻醉药用。大龄患儿可以清醒穿刺，术前准备完毕。氯胺酮7mg…     

新生儿期唇裂整复术的临床评价

目的 探讨新生儿期行唇裂整复术的可行性及安全性。方法 对11例新生儿患采用气管插管全麻下行唇裂整复术，单侧唇裂采用旋转推进法或下三角瓣法，双侧唇裂采用前唇原长法，术后随访观察手术的近期效果。结果 11例患术中麻醉平稳，未出现术中及术后并发症，术后伤口均为Ⅰ期愈合；随访1年以上的患可见唇部形态及吮吸功能良好。结论 新生儿期行唇裂整复术是安全可行的。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.