柞蚕蛹虫草对老龄大鼠LPO含量和SOD、GSH-Px

目的　探讨柞蚕蛹虫草对老龄雄性 Wistar大鼠 LPO含量和 SOD、GSH- Px活性的影响。方法　经口给药 1 4 d后 ,用 NBA法测定红细胞中的 SOD活性 ;DTNB法测定全血中 GSH- Px活性 ;TBA法测定肝脏中 LPO含量。结果　柞蚕蛹虫草对 SOD活性的影响除 1 2 .5mg/ kg体重剂量组与对照组比较差异显著 (P <0 .0 5)外 ,其余 2个剂量组与对照组比较均有极显著性差异 (P <0 .0 1 ) ,柞蚕蛹虫草对 GSH- PX的活性和 LPO含量的影响除 50 .0 mg/ kg体重剂量组与对照组比较均有极显著性差异 (P<0 .0 1 )外 ,其余 2个剂量组与对照组比较差异显著 (P<0 .0 5)。结论　柞蚕蛹虫草具有提高老龄大鼠 SOD,GSH- Px活性和明显降低 LPO含量的作用     

乙脑患儿血清和脑脊液中IL-18含量变化及其临床意义

目的检测乙型脑炎患儿血清和脑脊液中白细胞介素-18(IL-18)的水平,并探讨其临床意义。方法采用双抗夹心酶联免疫吸附实验检测33例乙脑患儿血清及脑脊液中IL-18含量。结果乙脑患儿急性期血清及脑脊液中IL-18含量均明显高于对照组(P<0.01),差异有显著性。重型患儿血清及脑脊液中的IL-18含量明显高于普通型患儿(P<0.01),且恢复期血清中IL-18含量仍高于对照组(P<0.01)。普通型患儿血清恢复期IL-18含量与对照组比较无显著差异性(P>0.05)。结论IL-18在乙脑的发病过程中起到了一定的抗病毒的作用,但IL-18含量过高也与乙脑脑实质损伤程度密切相关,其含量增高可作为估计乙脑免疫状况、病情及预后的一项重要指标,并对乙脑免疫调节方面的治疗具有一定的参考价值。     

乙脑患儿血清及脑脊液中LPO含量变化与临床关系

流行性乙型脑炎 (epidemicencephalitisB) ,简称乙脑 ,是由乙脑病毒 (encephalitisBvirus)引起的以中枢神经系统损害为主的急性传染病 ,尽管普及了疫苗接种 ,但近年其流行分布范围有不断扩大的趋势〔1,2 ,3〕,每年估计有乙脑病人4 5 0 0 0例〔4〕。为了对本病发病因素及脑损伤程度的判断 ,我们对乙脑患儿血清及脑脊液中过氧化脂质 (lipedperoxidation ,LPO)含量进行了检测和研究 ,以探讨对脑损伤的关系 ,报道如下 :1　材料与方法1 1　研究对象　 (1)乙脑组 :36例 ,男 ,17例 ,女 ,19,均为2 0 0 2年 7～ 9月在我科收治的乙脑患儿 :年龄 1～ …     

乙脑患儿血浆和脑脊液中内皮素-1含量变化及其临床意义

目的 探讨内皮素（ET）与流行性乙型脑炎的关系。方法 采用放射免疫分析（RIA）法检测52例乙脑患儿血浆及脑脊液中内皮素-1（ET-1）含量。结果 乙脑患儿极期血浆及脑脊液中ET-1含量均明显高于对照组（P〈0．001），有显著统计学意义。重型乙脑患儿血浆及脑脊液中的ET-1含量均值明显高于普通型乙脑患儿（血浆P〈0．01，脑脊液P〈0．05）。结论 血浆及脑脊液中ET-1含量增高与脑实质损伤程度密切相关，其含量增高可作为脑实质损伤程度的一个重要指标。     

重症病毒性脑炎患儿脑损伤与NSE的相关性及MPPT对脑损伤修复的影响

目的　探讨重症病毒性脑炎患儿脑损伤与 NSE的相关性 ,以及甲基强的松龙 (MPPT)对脑损伤修复的影响。方法　将 5 4例重症病毒性脑炎昏迷患儿随机分为 A、B两组 ,对照组为脑脊液常规正常的非昏迷患儿。患儿均给予抗病毒药物或足量抗生素、脱水剂、营养支持等治疗 ,A组加用 MPPT10～ 2 0 mg/ kg,B组加用地塞米松(DXM) 0 .5～ 1mg/ kg,均每日 1次 ,连用 5天。以改良的 Glasgow昏迷量表评分、双抗体夹心酶标免疫法测定的脑脊液神经元特异性烯醇化酶 (NSE)含量作指标并比较。结果　 A、B组治疗前 NSE含量及 Glasgow评分与对照组比较有显著性差异 (P<0 .0 1) ,NSE含量与 Glasgow分值呈负相关 (r=- 0 .92 85 ,P<0 .0 1)。A、 B组治疗前 Glasgow评分及 NSE含量无明显差异 (P>0 .0 5 ) ,治疗后 1天差异有显著性 (P<0 .0 1) ,2周后 Glasgow评分比较差异有显著性 (P<0 .0 1)。不良反应无明显差异 (P>0 .0 5 )。结论　NSE含量变化是判定重症病毒性脑炎患儿脑损伤程度及修复的客观、敏感指标 ;MPPT是其治疗的安全有效措施 ,可避免或减轻神经系统后遗症的发生。     

肾上腺皮质激素在重型乙型脑炎中的作用

目的探讨地塞米松对乙型脑炎患儿的病情、预后及脑脊液α-肿瘤坏死因子(TNF-α)与干扰素(IFN)的影响。方法把33例重型极期乙脑患儿随机分为两组,地塞米松组18例给予静脉地塞米松针4~5d;对照组15例则不用地塞米松。观察比较两组的临床过程和脑脊液TNF-α与IFN的变化。结果入院时两组的主要临床特点和脑脊液TNF-α与IFN的水平相似,4~5d后地塞米松组的临床症状改善情况优于对照组,但两组的脑脊液TNF-α与IFN的水平却无明显改变,并经过一个月的观察地塞米松组的恢复期症状发生率也低于对照组。结论对重型极期乙脑患儿给予静脉地塞米松可以改善病情,减轻症状,减少恢复期症状的发生。     

乙脑病毒核酸诊断方法的建立及应用

目的 建立一种新的乙脑病毒基因诊断方法，并进行大样本检测。方法 使用一步反转录巢式PCR进行乙脑患者血液及脑兴液的病毒核酸检测，并与2－巯基乙醇耐性试验进行对比检测。结果 216例乙脑就中层得血清的PCR阳性率为77.8%，2－ME阳性率为45.37%，脑脊液的PCR阳性率为93.20%，2－M阳性率为37.38%，有显著性差异。对不同病程日乙脑患者的检测，在初期和极期早期PCR的阳性检测率高，在极期后期和恢复期2－ME的阳性检测率高。结论 PCR法为一种适合于乙脑早期特异性诊断原新型基因诊断技术。     

阿片多肽参与流行性乙型脑炎发病机制的临床研究

目的研究内源性阿片多肽参与流行性乙型脑炎的发病机制与病理意义.方法采用改良放射免疫法分别测定乙脑患者极期及恢复期血及脑脊液中亮氨酸-脑啡肽、β-内啡肽、强啡肽值进行统计学分析.并分别设立阿片多肽特异对抗剂一纳络酮治疗组与对照组,进行疗效比较.结果乙脑患者极期时血及脑脊液中阿片多肽显著升高,进入恢复期下降至正常水平.纳络酮治疗组优于对照组,各症状疗效统计学分析有显著差异.结论乙脑患者极期时血及脑脊液中显著升高的阿片多肽与乙脑发病有关,并证实纳络酮治疗有效,值得推广.     

肝硬化患者β-胡萝卜素的变化及意义

目的　探讨肝硬化患者血浆 β 胡萝卜素 (P β CAR)含量及其临床意义。 方法　测定 6 3例肝硬化患者和 6 3例年龄及性别配对的正常人P β CAR和血浆过氧化脂质 (P LPO)、红细胞超氧化物歧化酶 (E SOD)、红细胞过氧化脂质 (E LPO)和血清C 反应蛋白 (CRP)的含量 ,并对肝硬化患者的多个因素进行Pearson相关和多元线性回归统计分析。结果　与正常对照组比较 ,肝硬化组P β CAR和E SOD含量明显降低 (P值均 <0 .0 1) ,而P LPO、E LPO和CRP含量明显升高 (P值均 <0 .0 1)。在血吸虫病性肝纤维化、肝炎后肝硬化和酒精性肝硬化中P β CAR和E SOD依次降低 ,而P LPO、E LPO和CRP依次升高 ,三组间差异有显著性 (P值均 <0 .0 1)。相关分析提示肝硬化患者P β CAR与年龄、E SOD、P LPO、E LPO和CRP含量相关 (P值均 <0 .0 1) ,而与患者Child Pugh积分无关 (P >0 .0 5 )。进一步的多元线性回归分析提示肝硬化患者P β CAR含量与E SOD和CRP的关系最密切。 结论　肝硬化患者P β CAR含量显著下降 ,与肝硬化病因和体内氧化抗氧化系统密切相关。     

几种贫血疾患血液过氧化脂质、超氧化物歧化酶及谷胱甘肽过氧化物酶的测定及意义

本文报道22例三种不同类型贫血的血清过氧化脂质(LPO)、红细胞超氧化物歧化酶(SOD)、全血谷胱甘肽过氧化物酶(GSH-PX)测定结果。血清 LPO 在再障、溶贫及缺铁性贫血均呈显著性增加(P<0.001～0.01),其增加程度与贫血基本病因的严重度有关;各类贫血的 SOD活力与正常人无明显差异;GSH-PX 在各型贫血呈非常显著性降低(P<0.001)。溶贫患者在疾病活动阶段,LPO 明显增加,SOD 显著降低,提示脂质过氧化物对红细胞膜的损害效应。文中对 LPO、SOD、GSH-PX 变化机制及意义进行了讨论。     

Three Japanese encephalitis cases in Okinawa, Japan, 1991

Since 1974, no Japanese encephalitis (JE) case had been reported on Okinawa island in either Okinawan people or US servicemen. In 1991, three US marines stationed on Okinawa island developed encephalitis symptoms. Neutralization (N) test and IgM-capture ELISA were carried out on the serial samples of serum and cerebrospinal fluid (CSF) taken from the patients. In each patient N test on both serum and CSF samples gave a significant rise in JE antibody titer in the comparison between the acute and convalescent phases, indicating that all the cases were infected with JE virus. The IgM-capture ELISA also showed a significant rise of antibody titer of the serum and CSF samples in the convalescent phase in patients 2 and 3, while in patient 1 a significant rise in IgM antibody was observed in the serum sample, but not in the CSF sample. None of the patients had been administered JE vaccine. This report underscores the importance of JE vaccination.     

Possible relevance of lipid peroxidation and thromboxane production to the initiation and/or evolution of microangiopathy in non-hyperlipidemic type 2 diabetes mellitus.

To investigate the possible relevance of free radicals and prostanoids to the mode of initiation and/or evolution of microangiopathy in diabetes mellitus, we measured serum lipid peroxides (LPO), an accepted index of intravascular free radicals, and plasma 11-dehydrothromboxane B2 (11-dehydro-TXB2), a stable metabolite of vasoactive thromboxane A2 released from platelets, in 95 patients with normolipidemic type 2 (non-insulin-dependent) diabetes mellitus at different stages of the disease. In general, either LPO or 11-dehydro-TXB2 was significantly greater in the patients, as a group, than in the matched controls (3.82 vs. 2.65 nmol/ml, P < 0.01 for LPO; and 17.3 vs. 5.8 pg/ml, P < 0.01 for 11-dehydro-TXB2). In patients, both LPO and 11-dehydro-TXB2 increased according to the severity of their diabetic retinopathy. A highly significant positive correlation existed between the LPO values and 11-dehydro-TXB2 in the patients (r = 0.64, P < 0.0001), while there was no such relationship in the controls (r = 0.18, P = NS). No difference in serum levels of apolipoproteins A-I, A-II, B, C-II, C-III, or E was observed between the patients and controls. Short-term glycemic control (25 cal/kg of standardized body weight/day, for 8 weeks) resulted in a small but significant reduction in LPO (4.2 vs. 4.6 nmol/ml, control; P < 0.05) without alteration in 11-dehydro-TXB2. There was a tendency towards deterioration in LPO according to the improvement in glycemic control. These results appear consistent with the view that, in addition to LPO, the release of TXA2 from activated platelet in the human circulation could be an important factor for the initiation and/or evolution of microangiopathy in diabetic patients even when they are not apparently hyperlipidemic. Further, the results of the present study emphasize the notion that more tight control of serum lipids is worthy of serious consideration in preventing the advance of diabetic microangiopathy.     

冠状动脉慢血流现象与血清脂质过氧化水平的关系

目的: 观察冠状动脉慢血流现象（CSF）患者血清脂质过氧化水平的变化,并探讨CSF的影响因素。方法: 采用TIMI帧计数（TFC）法作为测定CSF的指标,将入选病例分为两组:CSF组35例,正常对照组35例,均排除既往冠心病、心肌病及其他类型心脏病。采用生化法测定血清中超氧化物歧化酶（SOD）,谷胱甘肽过氧化物酶（GSH-PX）,丙二醛（MDA）,过氧化脂质（LPO）的含量。结果: CSF组的血清MDA、LPO明显高于对照组［MDA:（18.9±2.0）μmol/L vs.（10.5±1.3）μmol/L,P<0.01］,［LPO:（2.8±0.4）μmol/L vs.（1.9±0.2）μmol/L,P<0.01］;CSF组血清GSH-PX明显高于对照组［GSH-PX:（0.22±0.04）μmol/L vs.（0.20±0.03）μmol/L,P<0.05］。CSF组血清SOD明显低于对照组［SOD:（72±11）kU/L vs.（79±10）kU/L,P<0.01］。在校正体质量指数、总胆固醇、尿素氮等后CSH-PX、MDA、LPO是CSF的危险因素（分别OR=3.987、4.782、3.381;分别为P<0.05、P<0.01、P<0.01）。SOD则是其保护因素（OR=0.892,P<0.05）。结论: CSF患者血清SOD下降,MDA、LPO、GSH-PX上升,体内氧化应激增强。     

前列腺素E1对肺心病心衰疗效的观察

探讨前列腺素Ｅ１静脉滴注对肺心病心衰的疗效。方法对３０例肺心病心衰患者，应用前列腺素Ｅ１（ＰＧＥ１）２００μｇ／ｄ静脉滴注，疗程５天。于治疗前后同步检测内源性洋地黄因子（ＥＤＦ）、过氧化脂质（ＬＰＯ）、超氧化物歧化酶（ＳＯＤ）及动脉血氧分压（ＰａＯ２）、动脉血二氧化碳分压（ＰａＣＯ２）和观察症状体征变化，并与对照组（不用ＰＧＥ１）的３０例肺心病心衰患者及２０例健康者进行比较。结果两组肺心病心衰患者的ＥＤＦ、ＬＰＯ显著高于健康组（Ｐ＜０．００１），ＳＯＤ含量则显著降低（Ｐ＜０．００１）。治疗组病例治疗后ＥＤＦ、ＬＰＯ较治疗前显著降低（Ｐ＜０．００１），ＳＯＤ含量则显著升高（Ｐ＜０．００１），症状体征及血气参数显著改善（Ｐ＜０．０１～０．００１）。对照组（不用ＰＧＥ１）病例的ＥＤＦ、ＬＰＯ、ＳＯＤ、血气参数及症状体征，于治疗前、后无显著变化（Ｐ＞０．０５）。结论ＰＧＥ１对肺心病心衰患者确有较好的疗效。     

Facial herpes zoster complicated by varicella zoster virus (VZV) encephalitis: The diagnostic significance of atypical lymphocytes in cerebrospinal fluid (CSF)

Background

In general, viral infections of the central nervous system (CNS) manifest as encephalitis and, less commonly, as meningoencephalitis or aseptic meningitis. Varicella zoster virus (VZV) is an uncommon cause of encephalitis.

Methods

Herpes zoster (shingles) is a cutaneous reactivation of previous chickenpox infection due to VZV. Herpes zoster may be dermatomal (ie, <3 dermatomes) or disseminated (ie, >3 dermatomes). Decreased cell-mediated immunity from stress, steroids, or immunosuppressive drugs often precede dermatomal/disseminated herpes zoster. With herpes zoster, the closer the dermatomal involvement is to the CNS (ie, head/neck shingles), the more likely a patient will have symptomatic CNS involvement (eg, encephalitis). Except for the association of the herpes zoster rash and the simultaneous/subsequent encephalitis, there are few clinical features that distinguish VZV encephalitis from that due to other viruses. The cerebrospinal fluid (CSF) profile of VZV encephalitis is usually clinically indistinguishable from that due to of other causes of viral encephalitis. In VZV meningoencephalitis or encephalitis, the CSF typically shows a modest lymphocytic pleocytosis with normal CSF glucose levels, variably elevated CSF protein levels, and normal CSF lactic acid levels. Atypical lymphocytes are rare in the CSF with VZV encephalitis.

Results

We present the case of a 75-year-old woman who developed VZV encephalitis after having herpes zoster on her forehead. Except for facial herpes zoster, there were no clinically distinguishing features to determine the cause of her encephalitis. Her CSF had 800 white blood cells/high power field with 26% lymphocytes (17% atypical lymphocytes). The patient’s CSF glucose and CSF lactate dehydrogenase levels were normal, and her CSF protein was elevated. The CSF lactic acid was minimally elevated secondary to red blood cells in the CSF. Electroencephalogram showed general background slowing bilaterally, typical of viral encephalitis. The absence of unilateral focal frontotemporal/parietal lobe focus on electroencephalogram argued against the diagnosis of herpes simplex encephalitis. CSF atypical lymphocytes provided the key clue to the etiology of her encephalitis. CSF atypical lymphocytes are not uncommon in Epstein-Barr virus or cytomegalovirus encephalitis. Less commonly, atypical lymphocytes may be present in the CSF with enteroviruses, West Nile encephalitis, and Japanese encephalitis. VZV is a rare cause of atypical lymphocytes in the CSF but was the clue to the diagnosis before CSF polymerase chain reaction results for VZV were available. Her CSF polymerase chain reaction was negative for Mycobacterium tuberculosis, herpes simplex virus, human herpesvirus-6, cytomegalovirus, enteroviruses, and West Nile virus, but was positive for VZV. She made an uneventful recovery with acyclovir.

Conclusion

CSF atypical lymphocytes, if present, are an important diagnostic clue in some causes of viral encephalitis. The most common cause of nonseasonal viral encephalitis is herpes simplex virus, which is not associated with CSF atypical lymphocytes. Patients with Epstein-Barr virus, cytomegalovirus, West Nile encephalitis, and enteroviruses usually have extra-CNS signs and symptoms which should suggest the cause of the patient’s encephalitis. CSF atypical lymphocytes limit the differential diagnostic possibilities in patients with viral encephalitis and may be the key clue to the diagnosis, as in the case presented.     

血清维生素D水平在儿童细菌性脑膜炎中的临床意义

目的研究血清维生素D在儿童细菌性脑膜炎病程中的水平变化及其与患儿的临床关系。 方法选择广东省廉江市人民医院儿科自2018年1月至2019年9月收治的43例细菌性脑膜炎患儿作为研究对象,液相色谱-串联质谱法检测患儿在第1、14、28天时血清维生素D水平,分析血清维生素D水平的变化特征。根据血清维生素D水平变化特征将患儿分为观察组和对照组,比较2组患儿在第1、14、28天时GCS评分、小儿危重症评分（PCIS）、脑脊液生化（白细胞、蛋白、葡萄糖）水平差异。 结果29例患儿血清维生素D水平连续性下降,作为观察组;14例患儿血清维生素D水平变化趋势无规律或持续性升高,作为对照组。2组患儿维生素D水平差异具有统计学意义（t=5.600,P<0.05）。观察组患儿GCS评分、PCIS评分在第1天时与对照组比较,差异无统计学意义（P>0.05）,在第14、28天时均小于对照组,差异具有统计学意义（P<0.05）。观察组患儿脑脊液白细胞数在第1天时与对照组比较,差异无统计学意义（P>0.05）,在第14、28天时均高于对照组,差异具有统计学意义（P<0.05）。观察组患儿脑脊液蛋白量在第1、14天时与对照组比较,差异无统计学意义（P>0.05）,在第28天时高于对照组,差异具有统计学意义（P<0.05）。观察组患儿脑脊液葡萄糖量在第1天与对照组比较,差异无统计学意义（P>0.05）,在第14、28天时低于对照组,差异具有统计学意义（P<0.05）。观察组患儿出现并发症、需要手术治疗的例数均少于对照组,差异具有统计学意义（P<0.05）。 结论部分细菌性脑膜炎患儿可出现血清维生素D水平的异常降低,临床治疗中较正常血清维生素D水平患儿更易出现并发症,需要手术治疗的概率更高,且患儿的康复较慢,应引起重视。     

慢性乙型肝炎患者血清HBV DNA水平与HBsAg和HBeAg水平的相关性分析

目的探讨慢性乙型肝炎患者血清HBV DNA水平与HBsAg和HBeAg滴度的关系。方法在951例慢性乙型肝炎患者,采用FQ-PCR法和Abbott化学发光微粒子免疫分析技术分别测定血清HBV DNA水平及HBsAg和HBeAg滴度,分析HBV DNA水平与HBsAg和HBeAg滴度的相关性。结果在951例患者中,HBVDNA阳性率为53.83%(512/951);患者血清HBV DNA水平与HBsAg和HBeAg滴度呈正相关(rs=0.45和re=0.49,P<0.05);在HBV DNA水平≥7lg拷贝/毫升患者,血清HBsAg和HBeAg滴度高于HBV DNA为3～7lg拷贝/毫升患者,HBV DNA为3～7lg拷贝/毫升患者血清HBsAg和HBeAg滴度大于HBV DNA<3lg拷贝/毫升患者,差异均有统计学意义(P<0.05);将HBsAg分为<1000 IU/ml、1000～10000 IU/ml和≥10000 IU/ml3组,结果不同HBsAg滴度患者血清HBV DNA水平差异有统计学意义(P<0.05)。结论在血清HBV DNA≥7lg拷贝/毫升和HBsAg滴度≥10000 IU/mL患者,HBV DNA水平与HBsAg滴度呈正相关,在HBV DNA>3 lg拷贝/毫升患者,血清HBV DNA水平与HBeAg滴度呈正相关。     

Serum S100B levels in patients with cerebral and extracerebral infectious disease

S100B has been shown to increase in cerebrospinal fluid (CSF) and serum after various neurological diseases and it has been postulated that S100B could serve as a serum marker for brain damage. However there is limited information concerning serum S100B levels in infectious diseases of the brain. Blood samples were collected from patients at the Department of Infectious Diseases at or soon after admission. The different diagnoses studied were bacterial meningitis, pneumonia, viral meningitis, cerebral abscess, enteritis, erysipelas, viral encephalitis and neuroborreliosis. A serum S100B level > 0.15 microg/l was defined as increased. 57 patients were included in the study. S100B was elevated in 33% of patients (19/57). 73% (8/11) of patients with bacterial meningitis showed increased levels compared to 7% (1/14) of patients with viral meningitis. Viral encephalitis showed the highest mean S100B levels (mean 0.58 microg/l). 25% (6/24) of patients with extracerebral infections showed raised S100B levels. S100B levels were generally higher in patients with cerebral infections than in extracerebral infections. However, both false negative and false positive S100B levels were observed which may limit the use of S100B as a brain specific serum marker.     

Fatal outcome in Japanese encephalitis

Forty-nine consecutive patients with laboratory-confirmed acute Japanese encephalitis were studied to identify risk factors present at hospital admission which were associated with a fatal outcome. Sixteen patients (33%) died. The following constellation of findings correlated with a fatal outcome: infectious virus in cerebrospinal fluid (CSF), low levels of Japanese encephalitis virus-specific IgG and IgM in both CSF and serum, and a severely depressed sensorium. Age, sex, days ill before admission, distance from home to the hospital, past medical history, CSF protein content, and CSF leukocyte count were not significant risk factors. Among patients hospitalized for acute Japanese encephalitis, a vigorous virus-specific immunoglobulin response, both systemically and locally within the central nervous system, is a good marker for survival, and may be an inherently important factor in recovery from illness.     

心血管疾病患者血清NO与SOD,LPO水平变化及其相互关系的研究

对23例原发性高血压（EH）、36例冠心病（CHD）和30例健康人血清NO、SOD和LPO其中CHD组包括15例急性心肌梗塞（AMI）和21例非梗塞性CHD水平的测定．结果表明，EH组血清NO水平较健康对照组显著降低（P＜0.01），而SOD活性无显著性差异；在CHD组中，与健康对照组比较，NO和SOD水平均显著降低（P＜0．01），其中，非梗塞性CHD组的NO和SOD水平也均显著降低（P＜0.01），AMI组与对照组间均无显著性差异（P＜0．01）；另外，AMI组较非梗塞组SOD活住显著位增高（P＜0.01），NO水平虽有增高但无显著性意义；所有各患者组血清LPO均显著高于健康对照组（P＜0．01）．结果提示，在心血管疾病发生发展过程中，NO与氧自由基之间存在着相互关系。