白介素35在支气管哮喘中的作用机制

支气管哮喘(简称哮喘)是由多种细胞和细胞因子参与的慢性呼吸道炎症性疾病,发病机制可能与Th1/Th2细胞因子失衡、CD4+ CD25+T细胞(调节性T细胞,简称Tregs)及Th17/IL-17等异常有关.白介素35是一种新发现的细胞因子,其与Tregs及Th17/IL-17等免疫调节功能密切相关,通过多种途径参与哮喘的发病和调节,有望成为哮喘的治疗新靶点.本文对此相关研究作一综述.     

白介素35在支气管哮喘中的作用机制

支气管哮喘（简称哮喘）是由多种细胞和细胞因子参与的慢性呼吸道炎症性疾病,发病机制可能与Th1/Th2细胞因子失衡、CD4＋CD25＋ T细胞（调节性T细胞,简称Tregs）及Th17/IL-17等异常有关。白介素35是一种新发现的细胞因子,其与Tregs及Th17/IL-17等免疫调节功能密切相关,通过多种途径参与哮喘的发病和调节,有望成为哮喘的治疗新靶点。本文对此相关研究作一综述     

IL-35在HBV感染所致疾病中的调控作用和相关机制

IL-35主要是由调节性T淋巴细胞和调节性B淋巴细胞分泌的抑制性细胞因子,参与感染、肿瘤、自身免疫性疾病的发病。本文归纳了IL-35在HBV感染所致的乙型肝炎、肝硬化、肝衰竭和肝细胞癌中的免疫调节作用和机制。分析表明IL-35在HBV感染所致疾病中发挥双刃剑作用,促进感染慢性化和肝细胞癌疾病进展,也可降低肝脏炎症损伤,抑制肝纤维化。     

Th17细胞与Ⅰ型变态反应性疾病

Th17细胞是近年来发现的一种新的CD4+T细胞亚型.该细胞能产生以IL-17为主的多种细胞因子,参与炎症反应,与自身免疫性疾病、感染性疾病和变态反应性疾病等的发病关系密切.本文综述Th17细胞及其产生的细胞因子在Ⅰ型变态反应性疾病中的作用及研究进展.     

2型糖尿病患者相关细胞因子的变化

糖尿病(DM)是一种常见的以慢性高血糖为特征的代谢性疾病[1].在DM患者中,2型DM(T2DM)占90％以上[2].T2DM的病因尚未完全阐明,已经证实DM是一种自身免疫和低度炎症性疾病,存在着细胞因子介导的急性相反应,细胞因子在其中起重要作用.本研究主要测定T2DM患者、健康对照者血浆中细胞因子白细胞介素(IL)-6、IL-8、IL-17、IL-23含量,并对其变化进行分析,从细胞因子等方面分析DM的可能致病机制.     

IL-27在结核性胸腔积液的诊断价值探讨

结核性胸腔积液(tuberculous pleural effusion,TPE)是一种临床呼吸科常见症状,是由多种细胞因子和多种细胞参与的病理性免疫反应.已有研究表明,与非TPE相比,TPE中腺苷脱氨酶、干扰素-γ、IL-27的含量显著增加.IL-27是最近发现的一种与IL-12相关的细胞因子,它由抗原提呈细胞产生,通过其对免疫反应的促炎和抗炎的双重作用调节各种免疫疾病.近年来,IL-27在TPE中的诊断价值的研究愈来愈受到关注.本文就IL-27的生物作用及其在TPE中诊断价值方面的研究进展作一综述.     

Th2细胞因子与支气管哮喘发病机制的研究进展

支气管哮喘(简称哮喘)是由多种细胞和细胞因子参与的肺部慢性炎症性疾病.发病机制尚未完全清楚.目前认为Th1/Th2反应失衡导致Th2细胞过度激活是其重要的免疫学机制之一.Th2细胞产生的多效性细胞因子白介素4(IL-4)、IL-5和IL-13在此过程中发挥巨大作用,与哮喘发病密切相关.     

白介素-32的研究进展

白介素-32（IL-32）是新近发现的一种促炎细胞因子,研究发现：无论在抗病原微生物还是在自身免疫性疾病的炎症反应中,IL-32都发挥着重要作用。本文就其生物学特性、功能及其与临床的关系做一综述。     

辅助性T17细胞与系统性红斑狼疮相关性研究进展

系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种多系统受累的自身免疫性疾病,发病与遗传、病毒感染、环境等多种因素有关.效应性CD4+T细胞即辅助性T细胞(Thelper,Th)在机体免疫应答和免疫调节中发挥着重要作用.根据发育、功能及分泌细胞因子的作用不同,CD4+T细胞分为Th1细胞、Th2细胞、调节性T细胞和Th17细胞4个亚群.Th17细胞分泌白细胞介素(IL)-17A、IL-17F、IL-21及IL-22等细胞因子,在许多自身免疫性疾病的发病机制中起作用[1].本文就近几年来对Th17细胞的发育分化机制、免疫调节、分泌细胞因子及与SLE相关性的研究进展总结如下.     

辅助性T17细胞与系统性红斑狼疮相关性研究进展

系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种多系统受累的自身免疫性疾病,发病与遗传、病毒感染、环境等多种因素有关.效应性CD4+T细胞即辅助性T细胞(Thelper,Th)在机体免疫应答和免疫调节中发挥着重要作用.根据发育、功能及分泌细胞因子的作用不同,CD4+T细胞分为Th1细胞、Th2细胞、调节性T细胞和Th17细胞4个亚群.Th17细胞分泌白细胞介素(IL)-17A、IL-17F、IL-21及IL-22等细胞因子,在许多自身免疫性疾病的发病机制中起作用[1].本文就近几年来对Th17细胞的发育分化机制、免疫调节、分泌细胞因子及与SLE相关性的研究进展总结如下.     

IL-35在心血管疾病中的研究进展

心血管疾病是当前威胁全民健康的一类常见病,也是主要致死病因之一。细胞因子在心血管疾病发病过程中发挥重要作用。作为白细胞介素（interleukin, IL）-12家族的一员,白细胞介素35(interleukin 35, IL-35)是一种主要由调节性T细胞分泌的、具有免疫抑制功能的细胞因子。近期研究表明,IL-35也参与心血管疾病的发生、发展。本文综述了IL-35的结构、信号通路与功能,总结了IL-35在心血管疾病发病中的调控作用与机制的相关研究进展,旨在为心血管疾病预防和治疗提供新的思路和方向。     

Roles of the novel interleukin-12-associated cytokine, interleukin-23, in the regulation of T-cell-mediated immunity

Interleukin (IL)-12 is a heterodimeric proinflammatory cytokine formed by a 35-kDa light chain (p35) and a 40-kDa heavy chain (p40). This cytokine is a key regulator of cell-mediated immunity, and therefore should have therapeutic potential in infectious diseases and tumors. Recently, a novel IL-12-associated cytokine, IL-23 has been discovered. IL-23 is also a heterodimer that consists of the p40 subunit of IL-12 and a novel subunit, p19. Several studies have shown that IL-23 possesses immunoadjuvant activity against tumor and infectious diseases as well as IL-12. On the other hand, there is increasing evidence that IL-12 and IL-23 have discrete roles in the regulation of T-cell-mediated immunity despite their structural similarities. IL-12 leads to the development ofinterferon-γ-producing T-helper type 1 (Th1) cells, whereas IL-23 amplifies and stabilizes a new CD4⁺ T-cell subset, Th17 producing IL-17. The IL-23/Th17 axis rather than the IL-12/Th1 axis contributes to several immune-mediated inflammatory autoimmune diseases. Furthermore, IL-23/IL-17 promotes tumor incidence and growth. Therefore, IL-23 and Th17 are attracting considerable attention at present. Taken together, these findings suggest that IL-23 may be an immunoadjuvant against infectious diseases and tumors, and a viable target for the treatment of inflammatory diseases.     

Interleukin-10 and chronic liver disease

Interleukin (IL)-10 is an important immunoregulatory cytokine produced by many cell populations. Numerous investigations suggest that IL-10 plays a major role in chronic liver diseases. IL-10 gene polymorphisms are possibly associated with liver disease susceptibility or severity. Recombinant human IL-10 has been produced and is currently tested in clinical trials. These trials may give new insights into the immunobiology of IL-10 and suggest that the IL-10/IL-10 receptor system may become a new therapeutic target.     

The role of interleukin-10 in critical illness

Interleukin-10 is the most potent anti-inflammatory cytokine yet identified. It has multiple actions affecting the innate immune system as well as humoral and cellular immune responses. It occupies a pivotal role in the regulation of the immune response to microbial pathogens in health and disease. Knowledge gained in the molecular biology of IL-10 and its complex immune effects in experimental infection models are leading to new insights into therapeutic manipulation of IL-10 in patients with systemic inflammatory diseases.     

IL-33/ST2轴在呼吸道病毒感染免疫中的作用

IL-33是 IL-1家族的新成员,它能通过结合 IL-1受体家族中的孤儿受体 ST2发挥其生物学效应。很多研究证实呼吸道病毒感染可刺激机体多种细胞显著表达及分泌 IL-33,IL-33作用于靶细胞表面 ST2受体,从而启动 T 辅助细胞(T helper,Th)2型免疫反应,介导呼吸道病毒感染相关疾病。抗 IL-33抗体或抗 ST2抗体阻断 IL-33/ST2轴及上述免疫反应,从而有可能为治疗呼吸道病毒感染相关疾病提供新靶点。     

Mouse models of allergic diseases: TSLP and its functional roles

The cytokine TSLP was originally identified in a murine thymic stromal cell line as a lymphoid growth factor. After the discovery of TSLP, extensive molecular genetic analyses and gene targeting experiments have demonstrated that TSLP plays an essential role in allergic diseases. In this review, we discuss the current status of TSLP and its functional role in allergic diseases particularly by focusing on effects of TSLP on haematopoietic cells in mouse models. It is our conclusion that a number of research areas, i.e., a new source of TSLP, effects of TSLP on non-haematopoietic and haematopoietic cells, synergistic interactions of cytokines including IL-25 and IL-33 and a regulation of TSLP expression and its function, are critically needed to understand the whole picture of TSLP involvement in allergic diseases. The mouse models will thus contribute further to our understanding of TSLP involvement in allergic diseases and development of therapeutic measures for human allergic diseases.     

白细胞介素17在神经系统疾病中的作用

白细胞介素17(IL-17)是近年来新发现的促炎细胞因子,具有广泛的生物学活性,因此可能是某些疾病发生和发展的重要因素之一。文章主要综述了IL-17在相关神经系统疾病中的作用的研究现状。     

Allergy and asthma: classic TH2 diseases (?).

More than a decade of cytokine immunology has revealed a central role for pro-allergic TH2-like cytokines in the immune pathogenesis of allergic diseases and asthma. Of these, IL-4, IL-5, and IL-13 are produced mostly by T lymphocytes; more recently, numerous other immune cell types have been found capable of producing these cytokines as well, although their role in mediating atopic disease pathogenesis is less well understood. In contrast, the counterregulatory cytokine IFN-gamma can inhibit both the production and activities of the pro-allergic cytokines; therefore, central to the atopic diseases is a paradigm of cytokine imbalance, with overproduction of the TH2-like cytokines, and a relative deficiency of IFN-gamma production. Intriguing recent evidence is that all humans are TH2-like cytokine "skewed" at birth, due to maternal-fetal immune biology imperatives. However, further investigations suggest that IFN-gamma is likely to be pro-inflammatory in many if not most aspects of chronic allergic inflammation. Therefore, our understanding of these "classic TH2" diseases evolves, with important insights that will serve to optimize therapeutic strategies and investigations in the new millennium.