Otitis media – eine Erbkrankheit?

Für Eltern, Kinder?rzte und HNO-?rzte bedeuten die Infektionen des Mittelohres und ihre Folgen gro?e Belastung und Herausforderung. Das h?ufige Kranksein, die langwierigen Verl?ufe, die notwendigen medikament?sen und chirurgischen Behandlungen, die m?glichen Komplikationen und Residuen, und neuerdings auch die zunehmenden antibiotischen Resistenzen der als Erreger in Frage kommenden respiratorischen Bakterien erkl?ren die enorme Bedeutung der Otitis media im S?glings- und Kleinkindesalter. Die mit Spannung erwarteten Resultate einer 1982 bis 1995 am renommierten “Otitis Media Research Center” in Pittsburgh durchgeführten prospektiven Mehrlingsstudie wurden im Dezember 1999 im JAMA publiziert [1, 2]. Der seit langem vermutete, relevante genetische Anteil in der komplexen Pathogenese der Otitis media wurde nun wissenschaftlich einwandfrei best?tigt.     

Facial neuromas in children: delayed or immediate surgery?

OBJECTIVE: The objective of this study was to investigate the clinical characteristics and outcome of facial nerve neuromas in children. To date, no specific study has focused on children, and the management of these tumors is not codified. DESIGN AND SETTINGS: A review of case series treated in a tertiary care center of pediatric otolaryngology. SUBJECTS: The treatment and outcomes for 7 children (4 infants and 3 adolescents) were analyzed. RESULTS: Six patients underwent complete removal of tumor and immediate restoration of the nerve continuity. The grade of facial palsy improved in 4 of the 6 children, but did not get better than grade 3 (House classification). The remaining patient was managed conservatively and remained stable clinically and radiologically after 9 years follow-up. CONCLUSIONS: These findings support the reasonable strategy of combining conservative assessment of these slow-growing tumors with regular clinical and radiologic evaluations and radical surgery using various procedures. The choice depends on the age of the child, the extent and growth rate of the tumor, the grade of facial palsy, and the hearing function.     

Otitis media with effusion: disease or defense? A review of the literature

Many studies of otitis media with effusion (OME) have been published, most of them dealing with risk factors. The literature correlates this condition with various patient characteristics and socio-economic factors, but none of these have been identified as the sole causative factor. A review of the literature suggests that otitis media with effusion is a response to pathogenic bacteria and thus a normal protective reaction of the body. Therefore, the decision on whether or not treatment is indicated should take the natural course of that response into account. In light of the literature reviewed here, we conclude that there is usually no need to treat middle ear effusion in young children.     

Is Gastric Reflux a Cause of Otitis Media With Effusion in Children?

OBJECTIVES/HYPOTHESIS: Otitis media with effusion is the most common cause of childhood deafness. Gastroesophageal reflux has been implicated in the disease pathogenesis; therefore, it is necessary to identify the presence or absence of gastric juice in the middle ear. STUDY DESIGN: Middle ear effusions were collected from children undergoing myringotomy. If gastric reflux has occurred, effusions should contain pepsin protein. METHODS: Total pepsin/pepsinogen protein, fibrinogen, and albumin content of effusions were measured in enzyme-linked immunosorbent assays using antibodies to porcine pepsin, human albumin, and human fibrinogen. Proteolytic activity of each effusion was measured at pH 2. The pH of effusions was measured. RESULTS: Fifty-nine of 65 effusion samples gave a positive result with the antipepsin antibody, which also recognized pepsinogen. Pepsin/pepsinogen levels ranged from 0.8 to 213.9 microg/mL (serum reference levels, 49.8-86.6 ng/mL). All effusions contained albumin and fibrinogen with respective ranges of 1.77 to 95.75 and 0.30 to 2.30 mg/mL (serum reference levels, 35-45 and 2.2 to 4.6 mg/mL, respectively). Acidic protease activity occurred in 19 of 65 effusion samples. The pH of effusion samples was 7 to 9. CONCLUSIONS: The majority of effusion samples contained pepsin/pepsinogen protein; only 29% were active. The pepsin level in effusion samples based on activity is substantially lower than levels based on antibody detection; however, the pH present would irreversibly inhibit pepsin, which would explain the low levels of active enzyme. Pepsin/pepsinogen levels in the effusion samples were up to 1000 times higher than serum levels, whereas albumin and fibrinogen levels were of the same magnitude. The pepsin in middle ear effusions is almost certainly due to reflux of gastric contents, and there may be a role for antireflux therapy in the treatment of otitis media with effusion.     

Is Otalgia be a symptom of anxiety in children?

One of the common causes of ear pain (Otalgia) in children is the pain felt in the temporomandibular region due to bruxism, usually accompanied by stress and anxiety. The diagnosis and treatment of anxiety at an early age will affect the future lives of children.Our aim in the study was to investigate the presence and subtypes of anxiety in children with otalgia due to bruxism. In our study, 86 children aged between 6 and 16 years old who had ear pain and whose pain and tenderness were detected in the temporomandibular joint area and 40 healthy children were included as the control group. The children in both study groups were administered the Spence Children's Anxiety Scale (SCAS) test by the clinical psychologist. There was no statistical correlation between the children with bruxism and normal children (p > 0.05). While anxiety rate was 82% in children with bruxism, this rate was found to be 12.5% in normal children, this result was also statistically significant (p < 0.01). According to the SCAS test, when the subscales of anxiety detected in children with bruxism were evaluated, According to the SCAS test, when the subscales of anxiety detected in children with bruxism were evaluated, it was observed that the performance anxiety was high in the 6–12 and 12–16 age group. However, obsessive symptoms were mostly observed in the 12–16 age group while separation anxiety was detected in children in the 6–12 age group.     

Recurrent acute otitis media and gastroesophageal reflux disease in children. Is there an association?

Objective

To investigate whether there is a relationship between gastroesophageal reflux disease (GERD) and recurrent acute otitis media (RAOM) in infants and children. Possible risk factors are also explored.

Material and methods

221 consecutive children who had symptoms and signs associated with GERD and had undergone a prolonged ambulatory 24-h esophageal pH-monitoring. Thirty-four children were excluded from the study due to age, neurological deficits, congenital abnormalities, immunodeficiency syndromes or other chronic systemic disorders. The remaining 187 children (96 boys and 91 girls), aged between 40 days and 33 months (mean age of 18.3 months) were assigned into three groups according to their Reflux Index (RI%). Group A: 49 children (26.2%) without GERD (control group); Group B: 78 children (41.7%) with low to moderate RI; and Group C: 60 children (32.1%) with severe GERD. Parental interviews and personal medical files of the National Health System were used for data collection. However, episodes of acute otitis media were taken into account only if they were diagnosed by a physician. The follow-up period ranged from 6 to 8 years in order to cover the peaks of otitis media incidence in childhood.

Results

The results revealed that 6 children from Group A (12.24%), 11 from Group B (14.1%) and 19 from Group C (31.67%) presented episodes of RAOM. The difference was statistically significant (p = 0.01). Furthermore, in children who received anti-reflux treatment, the incidence of RAOM substantially decreased and eventually became approximate to that of the control Group A (12.32%). Logistic regression revealed that the strongest risk factor for recurrent otitis media was severe GERD (odds ratio, 4), then attendance at day-care centres (odds ratio, 3), followed by allergies (odds ratio, 2.7).

Conclusions

Severe GERD could be implicated in the multifactorial etiology of RAOM in infants and children.     

Is visual perception of hearing-impaired children different from healthy children?

OBJECTIVE: The purpose of this study was to evaluate visual perception of hearing-impaired children, and to determine their insufficiency in rehabilitation programs. METHODS: Forty children with hearing impairment aged 8-10 years were evaluated, and were compared with age matched 40 healthy children. Children having 71 dB and over sensorineural auditory impairment in both ears were included in this study. Figure-ground perception, position in space, and design copying tests were used to evaluate the visual perception of the subjects (Ayres Southern California Sensorial Integration tests). RESULTS: The mean hearing impairment level was 95.5 +/- 13.86 dB for the right ear, and 92.25 +/- 14.3 dB for the left. There were no significant differences by mean of age, height, and body weight between the groups (P > 0.05). All of the test scores of the control group were significantly higher than those of hearing-impaired children (P < 0.05). However there was no significant difference in the completion time of the design copying test between the groups (P > 0.05). CONCLUSIONS: Motivation insufficiency and learning difficulty may be developed in hearing-impaired children depending on the communication problems. The result of this study may bring light into literature about the development of new assessment techniques, and proper rehabilitation programmes for hearing-impaired children or adults in different age groups.     

Adenotomie und Adenotonsillektomie – sinnvoll bei rezidivierender akuter Otitis media?

Die Adenotomie (AT) und Adenotonsillektomie (TEAT) geh?ren zu den am h?ufigsten durchgeführten Operationen im Kindesalter. Die Arbeitsgruppe um J. Paradise aus der Kinderklinik Pittsburgh untersuchte die Effektivit?t der (Adeno-)Tonsillektomie bei Kindern mit rezidivierenden akuten Otitiden [8]. Die Autoren der im Journal of the American Medical Association (JAMA) ver?ffentlichten Studie kommen zu dem Schluss, dass sowohl die Adenotomie (AT) als auch die Adenotonsillektomie (TEAT) lediglich im ersten postoperativen Jahr zu einer Reduktion der H?ufigkeit der Otitiden führt, dieser Effekt in den nachfolgenden Jahren jedoch nicht mehr gesehen wird. Die Autoren folgern daraus, dass aufgrund der Operationsmorbidit?t sowie Komplikationsrate und nicht zuletzt auch der Kosten auf eine operative Therapie zugunsten einer gezielten Antibiotikatherapie sowie ggf. der Einlage von Paukenr?hrchen verzichtet werden sollte. Diese Betrachtungsweise erscheint einseitig und soll im nachfolgenden Beitrag diskutiert werden.     

Cervicofacial nontuberculous mycobacterium lymphadenitis in children: Is surgery always necessary?

Introduction

The optimal treatment of cervicofacial nontuberculous mycobacterium lymphadenitis (CFNTB) in children is yet to be established. There is a general consensus that surgical excision results in a definitive resolution of the disease. The main aim of surgery is to remove affected nodes so that they do not discharge through the skin. Recently there are some investigators who are reporting successful antibiotic treatment and advocating medical therapy as the first line treatment.

Methods

16 children consecutively presenting to otolaryngology in a tertiary referral centre over an 8-year period with CFNTB. Inclusion criteria were chronic cervicofacial lymphadenitis with either: (1) a culture positive for atypical mycobacteria (from either a lymph node or fine needle aspirate (FNA) specimen); or (2) acid-fast bacilli identified (from either a lymph node or FNA specimen); or (3) post excision histological findings consistent with mycobacterial infection (i.e. non-caseating granulomas) in the absence of other clinical features suggestive of other granulomatous conditions. Lesions with superficial skin change were treated preferentially with surgery. Children presenting with lymph nodes contained deep to sternocleidmastoid were assessed with FNA cytological and microbiological analysis and MRI or CT, and treated preferentially with antibiotics or watchful waiting.

Results

4 children (2 culture positive, 2 with acid-fast bacilli on needle aspirate) presented with lymphadenopathy deep to sternocleidmastoid and were managed non-surgically. All 4 resolved without cutaneous involvement. 11 children with a clinical presentation of CFNTB underwent complete excision of all involved nodes for superficial lesions (6 were culture positive, and all had granulomatous histology). None recurred. 1 patient presented late with a mature, discharging parotid sinus, which was managed with watchful waiting as the lesion was clinically close to natural resolution.

Conclusions

Depth at presentation may help decide which patients with CFNTB can be treated non-surgically without cutaneous sequelae. We propose that a watch and wait management is an option for deep nodes.     

Is immune system influenced by adenotonsillectomy in children?

OBJECTIVE: Tonsils and adenoids are lymphoid tissues that are located in the pharynx and play an important role against invading antigens of the upper respiratory tract. The present study analyses serum immunoglobulin levels and peripheral blood (PB) lymphocyte subsets in children, 24-48 h prior to and 4-6 weeks after adenotonsillectomy, in order to determine early effects of adenotonsillectomy on the immune system. METHODS: The study population consists of 15 children (aged 4-10 years) who underwent adenotonsillectomy because of adenoidal hypertrophy and chronic tonsillitis and 15 age-matched healthy children without a history of adenotonsillectomy. Serum IgG, IgA and IgM levels were measured by nephelometry. PB lymphocyte subsets were analysed by using monoclonal antibodies and flow cytometry. RESULTS: Children with chronic tonsillitis have increased levels of CD19+ B lymphocytes compared to healthy controls in the pre-operative period. The percentage of B lymphocytes bearing CD23 was found to be significantly higher in patients, most likely representing in vivo B lymphocyte activation due to chronic antigenic stimulation. After the adenotonsillectomy, despite ongoing B lymphocyte activation, CD8+ T lymphocyte levels increased and B cell levels returned to normal. A slight decrease in serum IgG, IgA and IgM levels was detected in the post-operative period compared to prior levels. CONCLUSION: Adenotonsillectomy performed in children leads to alterations that may reflect a compensatory response of the developing immune system after the removal of the lymphoid tissue in the setting of chronic antigenic stimulation. However, these changes do not cause significant immune deficiency.     

Pneumococcal conjugate vaccination in children with recurrent acute otitis media: a therapeutic alternative?

BACKGROUND: Based on two clinical trials in healthy infants the American Academy of Pediatrics (AAP) advices immunization with a 7-valent pneumococcal conjugate vaccine in children with recurrent acute otitis media (AOM). OBJECTIVE: To study the efficacy of a 7-valent pneumococcal conjugate vaccine on acute otitis media recurrences, its immunogenicity and impact on nasopharyngeal Streptococcus pneumoniae carriage in children with a history of frequent acute otitis media. METHODS: In this double-blind, randomized study, 74 Belgian children, aged 1-7 years, with at least 2 clinically diagnosed episodes of acute otitis media in the previous year were enrolled. Children were immunized with either a 7-valent pneumococcal conjugate vaccine followed by a 23-valent pneumococcal polysaccharide booster or a control hepatitis A vaccine. Total follow-up was 26 months. RESULTS: Despite adequate serum IgG responses to all conjugate vaccine pneumococcal serotypes, no reduction of acute otitis media episodes was observed in the pneumococcal vaccine group as compared to the control group (rate ratio: 1.16; 95% CI: 0.69-1.96). Overall nasopharyngeal pneumococcal carriage remained stable. However, a transient shift from conjugate vaccine related S. pneumoniae serogroups to non-vaccine related serogroups was noted following conjugate vaccination. CONCLUSION: Clinically no protective effect of pneumococcal conjugate vaccination on acute otitis media recurrences was found in children with a history of frequent AOM.     

Do Staphylococcus aureus superantigens play a role in the pathogenesis of otitis media with effusion in children?

ObjectivesStaphylococcal enterotoxins (SEs), acting as superantigens, have been reported to be involved in the pathogenesis of chronic inflammatory diseases of the upper and lower airway. There has been no previous study investigating the role of SEs in otitis media with effusion (OME). Therefore, this study was designed to analyze middle ear aspirates from children with and without OME for the presence of SEs.MethodsMiddle ear aspirates were obtained from 24 patients and 24 controls. All samples were processed for bacterial culture and detection of five staphylococcal SEs (SEA, SEB, SEC and SED) and toxic shock syndrome toxin-1 using the Rapid Latex Agglutination Test.ResultsIn bacterial culture assays, six samples (25%) of the study group and five samples (20.8%) of the control group showed bacterial growth. At least one SE was demonstrated in 6 of 24 patients and in 3 of 24 controls. There was no statistically significant difference between the two groups with respect to the presence of SEs.ConclusionAlthough there is evidence that SEs have a potential role in the pathogenesis of chronic inflammatory diseases, there is no evidence that the inflammation process is initiated by SEs in patients with OME.     

Is the use of factor XIII for delayed wound healing in patients with head-neck tumors of value?

BACKGROUND: Factor XIII is known to play an important role in wound healing. In patients with head and neck carcinomas there is an accumulation of risk factors for factor XIII deficiency such as chronic liver disease, extensive tissue lesions, and high intraoperative blood loss. METHOD: Serum levels of factor XIII in 22 patients who had undergone tumor surgery for head and neck carcinoma were measured preoperatively and daily up to 1 week following surgery. Factor XIII was measured with the Berichrome assay as part of our routine laboratory studies. The results were correlated with preoperative pseudocholinesterase (PChe). Factor XIII was substituted for 3 days in 8 patients with persistent wound healing problems that did not improve after two weeks of conservative treatment. RESULTS: We found that PChe levels are a predictor for the development of factor XIII levels during this period. In patients (n = 14) with normal PChe, factor XIII levels reached 86% of the preoperative values 1 week after operation (group 1). In patients (n = 8) with low PChe, the levels reached only 65% (group 2). The rate of wound healing problems was higher in group 2 (6/8) than in group 1 (2/14). In 6 patients treated with factor XIII, the wounds healed within 3 to 7 days. In two cases revision operation was necessary. CONCLUSION: We conclude that the therapy with factor XIII may be successful in patients with wound healing problems. Further studies will be necessary to find out whether prophylactic substitution of factor XIII in patients with low preoperative pseudocholinesterase levels is useful.     

Do children with reading delay benefit from the use of personal FM systems in the classroom?

Abstract

FM systems have been used to compensate for poor signal-to-noise ratios in classrooms. This study evaluates benefits of a 6-week trial of personal FM systems used during the school day for children with reading delay aged 6–11 years, using a randomized control design. Teachers and children completed the LIFE-UK questionnaire. Test-retest reliability of the LIFE-UK children's version was confirmed in a separate group of 18 children from the same school. The 23 children in the FM group had significantly improved teacher ratings, and the children's ratings of classroom listening for difficult situations were significantly better after the trial. These changes did not occur for the 23 control-group children. Most children (92%) commented positively about the FM after the trial. It is likely that a longer FM trial or a specific reading intervention combined with FM will be required for the benefits of enhanced listening to affect performance on standardized reading tests.

Sumario

Los sistemas FM han sido utilizados para compensar las tasas pobres de señal-ruido en el salón de clases. Este estudio evalúa los beneficios de un ensayo de 6 semanas usando sistemas personales FM durante el día escolar en niños con retardo en la lectura, en edades de 6 a 11 años, usando un diseño de control aleatorio. Tantos los niños como los maestros llenaron un cuestionario LIFE-UK. La confiabilidad test-retest de la versión infantil del LIFE-UK fue confirmada en un grupo separado de 18 niños de la misma escuela. Los 23 niños del grupo FM lograron apreciaciones significativamente mejoradas de sus maestros, y la apreciación de los propios niños sobre su audición en clase para situaciones difíciles fue significativamente mejor después del ensayo. Estos cambios no ocurrieron para el grupo control de 23 niños. La mayoría de los niños (92%) comentaron positivamente después del estudio acerca del sistema FM. Es posible que una prueba más larga con un sistema FM o una intervención específica en cuanto a la lectura combinada con un sistema FM se requiera para que los beneficios de una lectura mejorada afecten el desempeño en pruebas estandarizadas de lectura.